scholarly journals Prevalence of Adverse Reactions to Glutenand People Going on a Gluten-Free Diet:A Survey Study Conducted in Brazil

Medicina ◽  
2020 ◽  
Vol 56 (4) ◽  
pp. 163 ◽  
Author(s):  
Jesús Gilberto Arámburo-Gálvez ◽  
Carlos Eduardo Beltrán-Cárdenas ◽  
Tatiane Geralda André ◽  
Itallo Carvalho Gomes ◽  
María Auxiliadora Macêdo-Callou ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Wheat Gluten ◽  
Brazilian Population ◽  
The Self ◽  
Gluten Free Diet ◽  
Self Report ◽  
Survey Study ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Related Disorder

Background: The prevalence of gluten-related disorders (GRD) and adherence to a gluten-free diet (GFD) remains unknown in Brazilian population and there is no published information on the scientific literature about the proportion of Brazilians that were diagnosed with a gluten-related disorder. Thus, the aim of this work was to estimate the prevalence of GRDs and adherence to a GFD by self-report in adult Brazilian population. Materials and Methods: A questionnaire-based cross-sectional study was conducted in two Brazilian cities. Results: The response rate was 93.2% (1630/1749). The self-reported prevalence rates were (95% CI): adverse reactions to gluten 10.06% (8.64–11.62); gluten sensitivity 2.33% (1.65–3.18); physician-diagnosed celiac disease 0.3% (0.09–0.71); non-celiac gluten sensitivity 1.71% (1.14–2.47); wheat allergy 0.79% (0.42–1.36); adherence to gluten-free diet 7.48% (6.25–8.87); gluten avoiders 15.21% (13.5–17.05). Among those who were following a GFD (n = 122), 65.6% (n = 80) of them reported that they did not develop symptoms after wheat/gluten ingestion and 50% (n = 61) were following the diet without medical/dietitian advice. The main motivation for following a GFD in the self-reported and non-self-reported gluten sensitivity groups were the symptoms triggered after wheat/gluten ingestion (86.8%) and weight control (57.1%), respectively. Conclusions: Implementation of programs to increase awareness about GRDs among healthcare professionals and giving scientifically sound information to the general population about the risks and benefits for following a GFD are desirable actions in Brazil. The results also add to the growing body of evidence for highlighting the under-diagnosis of GRD and the trend for following a GFD in Latin America.

scholarly journals Self-Reported Prevalence of Gluten-Related Disorders and Adherence to Gluten-Free Diet in Colombian Adult Population

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Francisco Cabrera-Chávez ◽  
Diana María Granda-Restrepo ◽  
Jesús Gilberto Arámburo-Gálvez ◽  
Alejandro Franco-Aguilar ◽  
Dalia Magaña-Ordorica ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Adverse Reactions ◽  
Adult Population ◽  
Wheat Gluten ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Prevalence Rates ◽  
Cross Sectional ◽  
Physician Diagnosis

Background. Celiac disease seems to be rare in Colombians, but there are currently no data about the prevalence rates of symptomatic adverse reactions to gluten or adherence to gluten-free diet (GFD) in this population.Aim. to evaluate the self-reported prevalence rates of adverse reactions to gluten, adherence to GFD, and gluten-related disorders at population level in Colombia.Methods. A self-administered questionnaire-based cross-sectional study was conducted in a population from Northwest Colombia.Results. The estimated prevalence rates were (95% CI) 7.9% (6.5–9.6) and 5.3% (4.1–6.7) for adverse and recurrent adverse reactions to wheat/gluten, respectively, adherence to GFD 5.9% (4.7–7.4), wheat allergy 0.74% (0.3–1.4), and nonceliac gluten sensitivity 4.5% (3.5–5.8). There were no self-reported cases of celiac disease. Prevalence of self-reported physician-diagnosis of gluten-related disorders was 0.41% (0.17–0.96). Most respondents reported adherence to GFD without a physician-diagnosis of gluten-related disorders (97.2%). The proportion of gluten avoiders was 17.2% (15.2–19.5). Most of them did not report recurrent adverse reactions to wheat/gluten (87.0%).Conclusions. Nonceliac gluten sensitivity is rarely formally diagnosed in Colombia, but this population has the highest prevalence rate of adherence to GFD reported to date. Consequently, most respondents were avoiding wheat- and/or gluten-based products for reasons other than health-related symptoms.

scholarly journals GLUTEN-FREE DIET IN NON-CELIAC ATHLETES - BENEFITS AND POTENTIAL HARMFUL EFFECTS

2020 ◽  
pp. 509
Author(s):  
Ljiljana Bjelaković ◽  
Milovan Bratić ◽  
Saša Pantelić ◽  
Nebojša Ranđelović ◽  
Ana Lilić ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Chronic Fatigue ◽  
Scientific Data ◽  
Gluten Free Diet ◽  
Survey Study ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Advantages And Disadvantages ◽  
Long Run ◽  
Intestinal Symptoms

The aim of this paper is to present the latest scientific data related to a gluten-free diet, the justification of the introduction of a diet, the advantages and disadvantages of this dietary approach in the population of athletes. Non-celiac gluten sensitivity, previously defined as gluten sensitivity, is a relatively new clinical entity first defined in 2011. This disorder is characterized by intestinal symptoms (abdominal pain, bloating, diarrhea, and constipation) and extra intestinal symptoms such as headache, chronic fatigue, impaired concentration or “brain fog”, numbness and muscle or bone pain are frequently reported. Since most of the symptoms are subjective without accompanying clinical signs, and since no specific biomarker for diagnostics exists in clinical practice, there is always a dilemma whether this is really a health problem. A gluten-free diet has become popular among athletes due to the opinion that it has ergogenic effects. It should also be borne in mind that the introduction of a gluten-free diet has its drawbacks. Several studies suggest that a gluten-free diet is deficient in whole grains, dietary fiber, micronutrients and minerals. The data collected from the National Health and Nutrition Examination Survey study indicate the existence of higher concentrations of heavy metals in urine and blood samples taken from people following a gluten-free diet as a result of narrowed food choices. These data remind us to keep in mind the justification of the introduction of a gluten-free diet and the potential damage to health when observed adherence to this pattern of nutrition in the long run.

Pilot study on non-celiac gluten sensitivity: effects of Bifidobacterium longum ES1 co-administered with a gluten-free diet

2020 ◽  
Vol 66 (3) ◽  
Author(s):  
Francesco Di Pierro ◽  
Francesca Bergomas ◽  
Paolo Marraccini ◽  
Maria R. Ingenito ◽  
Lorena Ferrari ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bifidobacterium Longum ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free

scholarly journals Prevalence of Wheat/Gluten-Related Disorders and Gluten-Free Diet in Paraguay: An Online Survey-Based Study

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 396
Author(s):  
Noé Ontiveros ◽  
Raúl Emilio Real-Delor ◽  
José Antonio Mora-Melgem ◽  
Carlos Eduardo Beltrán-Cárdenas ◽  
Oscar Gerardo Figueroa-Salcido ◽  
...  
Keyword(s):  
Latin American ◽  
Weight Control ◽  
Online Survey ◽  
Adult Population ◽  
Wheat Gluten ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Questionnaire Response ◽  
Face To Face ◽  
Validated Questionnaire

Gluten-related disorders (GRDs) are increasing around the world, but their magnitude and relevance remain unknown in most Latin American countries. Thus, an online survey was conducted to estimate the prevalence of GRDs as well as adherence to a gluten-free diet (GFD) in Paraguayan adult population. There were 1058 individuals surveyed using a validated questionnaire (response rate of 93.9%). The self-reported prevalence rates were as follows (95% CI): gluten sensitivity (GS), 10.30% (8.53–12.29); non-celiac GS (NCGS), 5.19% (3.94–6.71); physician-diagnosed celiac disease (PD-CD), 3.11% (2.15–4.35); wheat allergy (WA), 2.07% (1.30–3.13); and adherence to GFD, 15.69% (13.55–18.02). Excluding CD, more women than men met the criteria for GRDs, adverse food reactions, and GFD (p < 0.05). Eight respondents reported the coexistence of NCGS with PD-CD and/or WA. Most cases on a GFD indicated medical/dietitian advice for following the diet (68.07%). Non-self-reported GS individuals indicated weight control (46.4%) and the notion that the GFD is healthier (20.2%) as the main motivations for following the diet. GRDs are not uncommon in Paraguayan adult population. It seems that there is awareness about GRDs and the GFD, but training about the diagnosis of GRDs is desirable because of the informed overlapping diagnoses of CD or WA with NCGS. Future studies involving face-to-face interviews are necessary.

scholarly journals Emerging concepts: from coeliac disease to non-coeliac gluten sensitivity

2012 ◽  
Vol 71 (4) ◽  
pp. 576-580 ◽  
Author(s):  
Imran Aziz ◽  
David S. Sanders
Keyword(s):  
Coeliac Disease ◽  
Deleterious Effect ◽  
Healthcare Professionals ◽  
Clinicopathological Features ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Free Products ◽  
Related Disorder ◽  
Historical Relationship ◽  
Serological Biomarkers

The rise in gluten consumption over time has led to the increasing recognition of coeliac disease (CD) with associated complications. However, only recently has there been an appreciation that the spectrum of gluten-related disorders is greater than just CD, which may explain the growing global popularity in gluten-free products. Current literature suggests that a newly recognised clinical entity in the form of non-coeliac gluten sensitivity (NCGS) may be the most common gluten-related disorder encountered by healthcare professionals, although its exact prevalence is as yet unknown. This article will review the historical relationship between mankind and gluten as well as the progressive recognition that it is possible for gluten to have a deleterious effect on our health. To this effect we discuss the prevalence, diagnosis and complications of CD including the benefits derived from a gluten-free diet (GFD). Finally, we discuss our current understanding of NCGS, in addition to highlighting the need for further research to determine the extent, clinicopathological features and serological biomarkers to help recognise this emerging condition in clinical practice.

scholarly journals Neurological disorders associated with gluten sensitivity

2017 ◽  
Vol 89 (2) ◽  
pp. 99-102
Author(s):  
D A Degterev ◽  
I V Damulin ◽  
A I Parfenov
Keyword(s):  
Clinical Features ◽  
Neurological Disorders ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Gluten Ataxia

The review considers the pathogenetic, clinical, and therapeutic aspects of neurological disorders associated with gluten sensitivity. Gluten ataxia and polyneuropathy are most common. The clinical features of neurological disorders in patients with gluten sensitivity and the effects of a gluten-free diet are described.

scholarly journals Self-Reported Prevalence of Symptomatic Adverse Reactions to Gluten and Adherence to Gluten-Free Diet in an Adult Mexican Population

Nutrients ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 6000-6015 ◽  
Author(s):  
Noe Ontiveros ◽  
Jesús López-Gallardo ◽  
Marcela Vergara-Jiménez ◽  
Francisco Cabrera-Chávez
Keyword(s):  
Adverse Reactions ◽  
Mexican Population ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals The Relationship of Perceived Health Benefits and Information Sources to Following a Gluten-Free Diet Among People Without Celiac Disease or Non-Celiac Gluten Sensitivity

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 704-704
Author(s):  
Kristina Arslain ◽  
Pratiksha Baishya ◽  
Christopher Gustafson ◽  
Devin Rose
Keyword(s):  
Celiac Disease ◽  
Information Sources ◽  
Agricultural Research ◽  
Health Benefits ◽  
Perceived Health ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Relationship Of ◽  
The Relationship

Abstract Objectives The gluten-free diet (GFD) has been adopted by many people who do not have Celiac disease or non-Celiac gluten sensitivity, but no studies examine the relationship of perceived health benefits of, and the sources that recommend trying, the GFD to the decision to follow the diet. Methods We surveyed a large, nationally representative sample of 3051 US residents about their attitudes, perceptions, and experiences with the GFD. Logistic regression was used to compare respondents who had no diagnosed need for a GFD but were currently avoiding or had avoided gluten previously (GF-Consumer) to the consumers that had never tried a GFD. Results Over one-fifth of our respondents were GF-Consumers. Beliefs that “a gluten-reduced diet is healthier for people than a full-gluten containing diet” (OR 1.55; P &lt; 0.01), that “gluten-free products are generally more nutritious than their gluten-containing variant” (OR 1.53; P &lt; 0.01) and that a GFD can help clear acne (OR 1.44; P &lt; 0.01) were all positively associated with trying a GFD. The most influential source that suggested the diet was oneself who learned about a GFD through personal research (OR 3.35; P &lt; 0.01). This was followed by “family member or friend” (OR 2.68; P &lt; 0.01) and “healthcare center or health professional (doctor, dietitian, etc.)” (OR 2.10; P &lt; 0.01). Conclusions Positive, but scientifically unsubstantiated, beliefs about the benefits of the GFD were strongly associated with trying a GF diet. Both conventional and unconventional sources of information about the GFD were positively associated with following the diet. These findings about beliefs and information sources highlight potential barriers to the promotion of scientifically based nutritional recommendations to consumers. Funding Sources University of Nebraska Agricultural Research Division Innovation Fund for Wheat/Cereal Crops.

scholarly journals Clinical Characteristics and Management of 50 Patients with Anti-GAD Ataxia: Gluten-Free Diet Has a Major Impact

2020 ◽  
Author(s):  
M. Hadjivassiliou ◽  
P. G. Sarrigiannis ◽  
P. D. Shanmugarajah ◽  
D. S. Sanders ◽  
R. A. Grünewald ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Clinical Characteristics ◽  
Age At Onset ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Progressive Ataxia ◽  
Progressive Cerebellar Ataxia ◽  
Limb Ataxia ◽  
History Of

Abstract The objective of this study is to report the clinical characteristics and treatment of patients with progressive cerebellar ataxia associated with anti-GAD antibodies. We performed a retrospective review of all patients with anti-GAD ataxia managed at the Sheffield Ataxia Centre over the last 25 years. We identified 50 patients (62% females) with anti-GAD ataxia. The prevalence was 2.5% amongst 2000 patients with progressive ataxia of various causes. Mean age at onset was 55 and mean duration 8 years. Gaze-evoked nystagmus was present in 26%, cerebellar dysarthria in 26%, limb ataxia in 44% and gait ataxia in 100%. Nine patients (18%) had severe, 12 (24%) moderate and 29 (58%) mild ataxia. Ninety percent of patients had a history of additional autoimmune diseases. Family history of autoimmune diseases was seen in 52%. Baseline MR spectroscopy of the vermis was abnormal at presentation in 72%. Thirty-five patients (70%) had serological evidence of gluten sensitivity. All 35 went on gluten-free diet (GFD). Eighteen (51%) improved, 13 (37%) stabilised, 3 have started the GFD too recently to draw conclusions and one deteriorated. Mycophenolate was used in 16 patients, 7 (44%) improved, 2 stabilised, 6 have started the medication too recently to draw conclusions and one did not tolerate the drug. There is considerable overlap between anti-GAD ataxia and gluten ataxia. For those patients with both, strict GFD alone can be an effective treatment. Patients with anti-GAD ataxia and no gluten sensitivity respond well to immunosuppression.

scholarly journals A Gluten Free Diet in the Management of Epilepsy in People with Coeliac Disease or Gluten Sensitivity

2020 ◽  
Vol 2 (3) ◽  
pp. 281-299
Author(s):  
Zoë Gilbey ◽  
Justine Bold
Keyword(s):  
Coeliac Disease ◽  
Small Sample ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Exclusion Criteria ◽  
Search Terms ◽  
Small Sample Sizes ◽  
Eeg Pattern

The aim of this review was to assess the effects of a gluten free diet (GFD) in the management of epilepsy in people with coeliac disease (CD) or gluten sensitivity (GS). A systematic approach was used to undertake a literature review. Five electronic databases (PubMed; Scopus; Google Scholar; Cochrane Epilepsy Group specialised register; Cochrane Register of Controlled Trails (CENTRAL) via the Cochrane Register of Online Trials) were searched using predetermined relevant search terms. In total, 668 articles were identified. Duplicates were removed and predefined inclusion and exclusion criteria were applied, and a PRISMA flow chart was produced. Data was extracted using Covidence software. Twelve studies on Epilepsy and CD involving a total of 70 participants were selected for analysis; narrative synthesis was used owing to the small sample sizes in the selected studies. None of the 12 studies meeting inclusion criteria investigated gluten sensitivity and epilepsy. All the included studies support a link between epilepsy and CD. GFD was effective in 44 out of 70 participants across the studies in terms of a reduction of seizures, reduction of antiepileptic drugs (AEDs) or normalisation of EEG pattern. A total of 44 participants showed a reduction in seizures (across eight studies) and complete cessation of seizures was reported in 22 participants. In general, the earlier the GFD is implemented after the onset of seizures, the better the likelihood of the GFD being successful in supporting control of seizures. Mechanisms linking gluten with epilepsy are not fully understood; possible hypotheses include gluten mediated toxicity, immune-induced cortical damage and malabsorption. Evidence suggests the effectiveness of a GFD in supporting the management of epilepsy in patients with CD, although the quality of evidence is low. There appears to be a growing number of neurologists who are prepared to advocate the use of a GFD. A multidisciplinary approaches and further research are recommended. It could be argued that when balancing potential treatments such as AEDs or surgery, a GFD has a low likelihood of harm.

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