scholarly journals Obesity as a Neuroendocrine Reprogramming

Medicina ◽  
2021 ◽  
Vol 57 (1) ◽  
pp. 66 ◽  
Author(s):  
Abdelaziz Ghanemi ◽  
Mayumi Yoshioka ◽  
Jonny St-Amand
Keyword(s):  
Metabolic Phenotype ◽  
Metabolic Functions ◽  
Main Challenge ◽  
Obesity Status ◽  
Hormonal Interaction ◽  
Metabolic Imbalance ◽  
Cellular Pathways ◽  
Underlying Mechanisms ◽  
Neuroendocrine Systems

Obesity represents a health problem resulting from a broken balance between energy intake and energy expenditure leading to excess fat accumulation. Elucidating molecular and cellular pathways beyond the establishment of obesity remains the main challenge facing the progress in understanding obesity and developing its treatment. Within this context, this opinion presents obesity as a reprogrammer of selected neurological and endocrine patterns in order to adapt to the new metabolic imbalance represented by obesity status. Indeed, during obesity development, the energy balance is shifted towards increased energy storage, mainly but not only, in adipose tissues. These new metabolic patterns that obesity represents require changes at different cellular and metabolic levels under the control of the neuroendocrine systems through different regulatory signals. Therefore, there are neuroendocrine changes involving diverse mechanisms, such as neuroplasticity and hormonal sensitivity, and, thus, the modifications in the neuroendocrine systems in terms of metabolic functions fit with the changes accompanying the obesity-induced metabolic phenotype. Such endocrine reprogramming can explain why it is challenging to lose weight once obesity is established, because it would mean to go against new endogenous metabolic references resulting from a new “setting” of energy metabolism-related neuroendocrine regulation. Investigating the concepts surrounding the classification of obesity as a neuroendocrine reprogrammer could optimize our understanding of the underlying mechanisms and, importantly, reveal some of the mysteries surrounding the molecular pathogenesis of obesity, as well as focusing the pharmacological search for antiobesity therapies on both neurobiology synaptic plasticity and hormonal interaction sensitivity.

scholarly journals Towards a contemporary approach for understanding personality pathology in developmental context: An integrative model

2021 ◽  
pp. 1-10
Author(s):  
Melody R. Altschuler ◽  
Robert F. Krueger
Keyword(s):  
Personality Disorders ◽  
Personality Pathology ◽  
Integrative Model ◽  
Research Domain Criteria ◽  
Developmental Context ◽  
Dimensional Classification ◽  
Developmental Theories ◽  
Underlying Mechanisms ◽  
Research Domain

Abstract Traditional categorical approaches to classifying personality disorders are limited in important ways, leading to a shift in the field to dimensional approaches to conceptualizing personality pathology. Different areas of psychology – personality, developmental, and psychopathology – can be leveraged to understand personality pathology by examining its structure, development, and underlying mechanisms. However, an integrative model that encompasses these distinct lines of inquiry has not yet been proposed. In order to address this gap, we review the latest evidence for dimensional classification of personality disorders based on structural models of maladaptive personality traits, provide an overview of developmental theories of pathological personality, and summarize the Research Domain Criteria (RDoC) initiative, which seeks to understand underlying mechanisms of psychopathology. We conclude by proposing an integrative model of personality pathology development that aims to elucidate the developmental pathways of personality pathology and its underlying mechanisms.

scholarly journals Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marianna Caterino ◽  
Monica Gelzo ◽  
Stefano Sol ◽  
Roberta Fedele ◽  
Anna Annunziata ◽  
...  
Keyword(s):  
Virus Entry ◽  
Critical Role ◽  
Membrane Vesicles ◽  
Virus Propagation ◽  
Lipidomic Analysis ◽  
Key Factor ◽  
Patient Profiles ◽  
Cellular Pathways ◽  
Severity Degree

AbstractIn recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infections, pathogenesis and progression have not been clearly elucidated yet, thus forcing the development of many complementary approaches to identify candidate cellular pathways involved in disease progression. Host lipids play a critical role in the virus life, being the double-membrane vesicles a key factor in coronavirus replication. Moreover, lipid biogenesis pathways affect receptor-mediated virus entry at the endosomal cell surface and modulate virus propagation. In this study, targeted lipidomic analysis coupled with proinflammatory cytokines and alarmins measurement were carried out in serum of COVID-19 patients characterized by different severity degree. Serum IL-26, a cytokine involved in IL-17 pathway, TSLP and adiponectin were measured and correlated to lipid COVID-19 patient profiles. These results could be important for the classification of the COVID-19 disease and the identification of therapeutic targets.

scholarly journals Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Musa Ozturk ◽  
Ashwin Viswanathan ◽  
Sameer A. Sheth ◽  
Nuri F. Ince
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pharmacological Treatment ◽  
High Frequency ◽  
High Frequency Stimulation ◽  
High Frequency Oscillations ◽  
Stimulation Pulse ◽  
Main Challenge ◽  
Frequency Stimulation ◽  
Underlying Mechanisms

AbstractDespite having remarkable utility in treating movement disorders, the lack of understanding of the underlying mechanisms of high-frequency deep brain stimulation (DBS) is a main challenge in choosing personalized stimulation parameters. Here we investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and non-therapeutic frequencies in Parkinson’s disease patients undergoing DBS surgery. We find that therapeutic high-frequency stimulation (130–180 Hz) induces high-frequency oscillations (~300 Hz, HFO) similar to those observed with pharmacological treatment. Along with HFOs, we also observed evoked compound activity (ECA) after each stimulation pulse. While ECA was observed in both therapeutic and non-therapeutic (20 Hz) stimulation, the HFOs were induced only with therapeutic frequencies, and the associated ECA were significantly more resonant. The relative degree of enhancement in the HFO power was related to the interaction of stimulation pulse with the phase of ECA. We propose that high-frequency STN-DBS tunes the neural oscillations to their healthy/treated state, similar to pharmacological treatment, and the stimulation frequency to maximize these oscillations can be inferred from the phase of ECA waveforms of individual subjects. The induced HFOs can, therefore, be utilized as a marker of successful re-calibration of the dysfunctional circuit generating PD symptoms.

Color naming, unique hues, and hue cancellation predicted from singularities in reflection properties

2006 ◽  
Vol 23 (3-4) ◽  
pp. 331-339 ◽  
Author(s):  
DAVID L. PHILIPONA ◽  
J. KEVIN O'REGAN
Keyword(s):  
Color Naming ◽  
Surface Reflection ◽  
Unique Hues ◽  
Neuronal Representation ◽  
Underlying Mechanisms ◽  
The One ◽  
Unique Green ◽  
Psychophysical Studies ◽  
Hue Cancellation

Psychophysical studies suggest that different colors have different perceptual status: red and blue for example are thought of as elementary sensations whereas yellowish green is not. The dominant account for such perceptual asymmetries attributes them to specificities of the neuronal representation of colors. Alternative accounts involve cultural or linguistic arguments. What these accounts have in common is the idea that there are no asymmetries in the physics of light and surfaces that could underlie the perceptual structure of colors, and this is why neuronal or cultural processes must be invoked as the essential underlying mechanisms that structure color perception. Here, we suggest a biological approach for surface reflection properties that takes into account only the information about light that is accessible to an organism given the photopigments it possesses, and we show that now asymmetries appear in the behavior of surfaces with respect to light. These asymmetries provide a classification of surface properties that turns out to be identical to the one observed in linguistic color categorization across numerous cultures, as pinned down by cross cultural studies. Further, we show that data from psychophysical studies about unique hues and hue cancellation are consistent with the viewpoint that stimuli reported by observers as special are those associated with this singularity-based categorization of surfaces under a standard illuminant. The approach predicts that unique blue and unique yellow should be aligned in chromatic space while unique red and unique green should not, a fact usually conjectured to result from nonlinearities in chromatic pathways.

scholarly journals mtDNA in the Pathogenesis of Cardiovascular Diseases

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Lili Wang ◽  
Qianhui Zhang ◽  
Kexin Yuan ◽  
Jing Yuan
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Heart Diseases ◽  
Mtdna Copy Number ◽  
Cardiac Inflammation ◽  
Ischemic Heart Diseases ◽  
Metabolic Functions ◽  
Underlying Mechanisms

The incidence rate of cardiovascular disease (CVD) has been increasing year by year and has become the main cause for the increase of mortality. Mitochondrial DNA (mtDNA) plays a crucial role in the pathogenesis of CVD, especially in heart failure and ischemic heart diseases. With the deepening of research, more and more evidence showed that mtDNA is related to the occurrence and development of CVD. Current studies mainly focus on how mtDNA copy number, an indirect biomarker of mitochondrial function, contributes to CVD and its underlying mechanisms including mtDNA autophagy, the effect of mtDNA on cardiac inflammation, and related metabolic functions. However, no relevant studies have been conducted yet. In this paper, we combed the current research status of the mechanism related to the influence of mtDNA on the occurrence, development, and prognosis of CVD, so as to find whether these mechanisms have something in common, or is there a correlation between each mechanism for the development of CVD?

scholarly journals Identifying functional metabolic shifts in heart failure with the integration of omics data and a cardiomyocyte-specific, genome-scale model

2020 ◽  
Author(s):  
Bonnie V. Dougherty ◽  
Kristopher D. Rawls ◽  
Glynis L. Kolling ◽  
Kalyan C. Vinnakota ◽  
Anders Wallqvist ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Specific Model ◽  
Metabolic Phenotype ◽  
Scale Model ◽  
Metabolic Markers ◽  
Metabolic Functions ◽  
Carbon Substrates ◽  
End Stage ◽  
Genome Scale

SummaryThe heart is a metabolic omnivore, known to consume many different carbon substrates in order to maintain function. In diseased states, the heart’s metabolism can shift between different carbon substrates; however, there is some disagreement in the field as to the metabolic shifts seen in end-stage heart failure and whether all heart failure converges to a common metabolic phenotype. Here, we present a new, validated cardiomyocyte-specific GEnome-scale metabolic Network REconstruction (GENRE), iCardio, and use the model to identify common shifts in metabolic functions across heart failure omics datasets. We demonstrate the utility of iCardio in interpreting heart failure gene expression data by identifying Tasks Inferred from Differential Expression (TIDEs) which represent metabolic functions associated with changes in gene expression. We identify decreased NO and Neu5Ac synthesis as common metabolic markers of heart failure across datasets. Further, we highlight the differences in metabolic functions seen across studies, further highlighting the complexity of heart failure. The methods presented for constructing a tissue-specific model and identifying TIDEs can be extended to multiple tissue and diseases of interest.

Electroceutically induced subthalamic high frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson's Disease

2020 ◽  
Author(s):  
Musa Ozturk ◽  
Ashwin Viswanathan ◽  
Sameer Sheth ◽  
Nuri Ince
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pharmacological Treatment ◽  
High Frequency ◽  
High Frequency Stimulation ◽  
High Frequency Oscillations ◽  
Stimulation Pulse ◽  
Main Challenge ◽  
Frequency Stimulation ◽  
Underlying Mechanisms

Abstract Despite having remarkable utility in treating movement disorders, the lack of understanding of the underlying mechanisms of high-frequency deep brain stimulation (DBS) is a main challenge in choosing personalized stimulation parameters. Here we investigate the modulations in local field potentials induced by therapeutic and non-therapeutic electrical stimulation of the subthalamic nucleus (STN) in Parkinson’s disease patients undergoing DBS surgery. We find that therapeutic high-frequency stimulation (130-180 Hz) induces high-frequency oscillations (~300 Hz, HFO) similar to those observed with pharmacological treatment. Along with HFOs, we also observed evoked compound activity (ECA) after each stimulation pulse. While ECA was observed in both therapeutic and non-therapeutic (20Hz) stimulation, the HFOs were induced only with therapeutic frequencies and the associated ECA were significantly more resonant. The relative degree of enhancement in the HFO power was related to the interaction of stimulation pulse with the phase of ECA.We propose that high-frequency STN-DBS tunes the neural oscillations to their healthy/treated state, similar to pharmacological treatment, and the stimulation frequency to maximize these oscillations can be inferred from the phase of ECA waveforms of individual subjects. The induced HFOs can, therefore, be utilized as a marker of successful re-calibration of the dysfunctional circuit generating PD symptoms.

Plant Ecophysiology: Linking Pattern and Process—a Review

1997 ◽  
Vol 45 (2) ◽  
pp. 351
Author(s):  
Jann Williams ◽  
Derek Eamus
Keyword(s):  
Plant Ecophysiology ◽  
Elevated Atmospheric Co2 ◽  
Pattern And Process ◽  
Ecological Society ◽  
Technological Advances ◽  
Ecological Patterns ◽  
Underlying Mechanisms ◽  
Underlying Processes

Introduction The Symposium ‘Plant Ecophysiology: Linking Pattern and Process’ was held as part of the 1995 meeting of the Ecological Society of Australia (ESA). The aim of the Symposium was to highlight work that examined mechanisms underlying ecological patterns and linked them to ecological and/or evolutionary processes. Another aim was to expose ecologists to the methods available to examine the mechanistic and functional basis of the organisms and systems under study. Much early ecological research has been concerned with the description and classification of vegetation types, with relatively little effort devoted to understanding the underlying processes that determined distribution. A more quantitative approach based on knowledge of the underlying mechanisms can further improve understanding of systems. This was amply demonstrated in a Symposium on the effects of elevated atmospheric CO2 on vegetation dynamics, also held in conjunction with an ESA meeting (see papers in Australian Journal of Botany, Volume 40(2)). Recent technological advances have stimulated rapid progress in the field of ecophysiology and hence an increasing process-based understanding is developing. The 1995 Symposium was seen as an opportunity to highlight more recent work in what is a relatively new field in Australia (albeit a well-established field in Europe and America), especially in situ studies and research from relatively little studied areas like northern Australia. The response to the Symposium was encouraging, with 25 spoken papers and poster-papers presented. In this paper, some of the unifying aspects of the papers presented in the symposium are drawn together, and placed in the context of likely future developments in ecophysiology in Australia. Based on this analysis, future directions and gaps are identified.

p97 and close encounters of every kind: a brief review

2004 ◽  
Vol 32 (5) ◽  
pp. 715-720 ◽  
Author(s):  
I. Dreveny ◽  
V.E. Pye ◽  
F. Beuron ◽  
L.C. Briggs ◽  
R.L. Isaacson ◽  
...  
Keyword(s):  
Structural Elucidation ◽  
Interacting Proteins ◽  
Future Studies ◽  
Aaa Atpase ◽  
Close Encounters ◽  
Functional Features ◽  
Cellular Pathways ◽  
First Time

The AAA (ATPase associated with various cellular activities) ATPase, p97, is a hexameric protein of chaperone-like function, which has been reported to interact with a number of proteins of seemingly unrelated functions. For the first time, we report a classification of these proteins and aim to elucidate any common structural or functional features they may share. The interactors are grouped into those containing ubiquitin regulatory X domains, which presumably bind to p97 in the same way as the p47 adaptor, and into non-ubiquitin regulatory X domain proteins of different functional subgroups that may employ a different mode of interaction (assuming they also bind directly to p97 and are not experimental artifacts). Future studies will show whether interacting proteins direct p97 to different cellular pathways or a common one and structural elucidation of these interactions will be crucial in understanding these underlying functions.

Legal Problems of Corruption Crimes Classification

2016 ◽  
Vol 4 (9) ◽  
pp. 0-0
Author(s):  
Екатерина Черепанова ◽  
Ekaterina Cherepanova
Keyword(s):  
Law Enforcement ◽  
Correct Classification ◽  
Legal Assessment ◽  
Legal Problems ◽  
Legal Science ◽  
Current Activity ◽  
Main Challenge ◽  
Criminal Legislation

The main goal of criminal legal science is determination of correlation between action and characteristics of corpus delicti which is constituted by criminal legislation. Only correct classification of crimes can guarantee justice preserved by law. The criminal legal assessment of corruption crimes is a separate problem of classification. Classification of such crimes is difficult in current activity of lawenforcement authorities and courts because of the conflict of law, redundancy of estimation definitions, etc. Besides the problem of counteraction of corruption was formulated as the main challenge of state. In the article are analyzed the legislation and law-enforcement practice. The conclusion contains recommendations which can lower the amount of mistakes in corruption crimes classification.

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