scholarly journals Quantum Dots: An Emerging Tool for Point-of-Care Testing

Micromachines ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1058
Author(s):  
Suchita Singh ◽  
Aksha Dhawan ◽  
Sonali Karhana ◽  
Madhusudan Bhat ◽  
Amit Kumar Dinda
Keyword(s):  
Quantum Dots ◽  
Biomedical Applications ◽  
Bulk Material ◽  
Point Of Care ◽  
Diagnostic Systems ◽  
Point Of Care Testing ◽  
Size Dependent ◽  
Semiconductor Crystals ◽  
Optical And Electronic Properties ◽  
Narrow Emission

Quantum dots (QDs) are semiconductor crystals in the nanodimension having unique optical and electronic properties that differ from bulk material due to quantum mechanics. The QDs have a narrow emission peak, size-dependent emission wavelength, and broad excitation range which can be utilized for diverse biomedical applications such as molecular imaging, biosensing, and diagnostic systems. This article reviews the current developments of biomedical applications of QDs with special reference to point-of-care testing.

scholarly journals Application of quantum dots as fluorescent maker in cell labeling

2019 ◽  
Vol 2 (6) ◽  
pp. 57-65
Author(s):  
Hong Diep Thi Tran ◽  
Cao Tri Nguyen ◽  
Khanh Thien Le ◽  
Ngoc Thuy Thi Vo ◽  
Hieu Van Tran
Keyword(s):  
Quantum Dots ◽  
T Cells ◽  
Phosphate Buffer ◽  
Light Emission ◽  
Protein A ◽  
Adaptor Protein ◽  
Cell Labeling ◽  
Jurkat T Cells ◽  
Optical And Electronic Properties ◽  
Narrow Emission

Quantum dots (QDs) have the potential to be used as a marker in research and supporting for medical treatment because of their unique optical and electronic properties such as size-tuneable light emission, narrow emission, high photostability, etc. With the goal of applying for biomarkers, QDs are often attached with antibodies. In order to simplify the binding process, we experimented to attach adaptor protein, namely protein A/G to CdSe/ZnS QDs covered by 3-mercaptopropionic acid (MPA). 80.7 % and 51.2 % of protein A/G at the concentration of 60 μg/mL and 20 μg/mL, respectively, conjugated with QDs in phosphate buffer saline (PBS) without supporting of N-Ethyl-N’-(3dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS). After attaching to protein A/G, anti-pan T antibody could recognize and visualize Jurkat T cells. In conclusion, protein A/G was conjugated successfully on QDs and initially support for application in cell labeling.

Point-of-care testing (POCT) diagnostic systems using microfluidic lab-on-a-chip technologies

2015 ◽  
Vol 132 ◽  
pp. 46-57 ◽  
Author(s):  
Wooseok Jung ◽  
Jungyoup Han ◽  
Jin-Woo Choi ◽  
Chong H. Ahn
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
Diagnostic Systems ◽  
Point Of Care Testing

Silicon Quantum Dots: Promising Theranostic Probes for the Future

2019 ◽  
Vol 20 (12) ◽  
pp. 1255-1263 ◽  
Author(s):  
Vishnu Sankar Sivasankarapillai ◽  
Jobin Jose ◽  
Muhammad Salman Shanavas ◽  
Akash Marathakam ◽  
Md. Sahab Uddin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Optical Properties ◽  
Biomedical Applications ◽  
Medical Diagnostics ◽  
Silicon Quantum Dots ◽  
The Past ◽  
Research Areas ◽  
Semiconductor Crystals ◽  
New Generation

Nanotechnology has emerged as one of the leading research areas involving nanoscale manipulation of atoms and molecules. During the past decade, the growth of nanotechnology has been one of the most important developments that have taken place in the biomedical field. The new generation nanomaterials like Quantum dots are gaining much importance. Also, there is a growing interest in the development of nano-theranostics platforms in medical diagnostics, biomedical imaging, drug delivery, etc. Quantum dots are also known as nanoscale semiconductor crystals, with unique electronic and optical properties. Recently, silicon quantum dots are being studied extensively due to their less-toxic, inert nature and ease of surface modification. The silicon quantum dots (2-10nm) are comparatively stable, having optical properties of silicon nanocrystals. This review focuses on silicon quantum dots and their various biomedical applications like drug delivery regenerative medicine and tissue engineering. Also, the processes involved in their modification for various biomedical applications along with future aspects are discussed.

scholarly journals Superior Properties and Biomedical Applications of Microorganism-Derived Fluorescent Quantum Dots

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4486
Author(s):  
Mohamed Abdel-Salam ◽  
Basma Omran ◽  
Kathryn Whitehead ◽  
Kwang-Hyun Baek
Keyword(s):  
Quantum Dots ◽  
Biomedical Applications ◽  
Light Emission ◽  
Distinctive Features ◽  
Energy Applications ◽  
Size Dependent ◽  
Microrna Detection ◽  
Wide Range ◽  
Noxious Chemicals ◽  
Physical And Chemical

Quantum dots (QDs) are fluorescent nanocrystals with superb photo-physical properties. Applications of QDs have been exponentially increased during the past decade. They can be employed in several disciplines, including biological, optical, biomedical, engineering, and energy applications. This review highlights the structural composition and distinctive features of QDs, such as resistance to photo-bleaching, wide range of excitations, and size-dependent light emission features. Physical and chemical preparation of QDs have prominent downsides, including high costs, regeneration of hazardous byproducts, and use of external noxious chemicals for capping and stabilization purposes. To eliminate the demerits of these methods, an emphasis on the latest progress of microbial synthesis of QDs by bacteria, yeast, and fungi is introduced. Some of the biomedical applications of QDs are overviewed as well, such as tumor and microRNA detection, drug delivery, photodynamic therapy, and microbial labeling. Challenges facing the microbial fabrication of QDs are discussed with the future prospects to fully maximize the yield of QDs by elucidating the key enzymes intermediating the nucleation and growth of QDs. Exploration of the distribution and mode of action of QDs is required to promote their biomedical applications.

Magnetic Digital Microfluidics for Point-of-Care Testing: Where Are We Now?

2020 ◽  
Vol 27 ◽  
Author(s):  
Yi Zhang
Keyword(s):  
System Integration ◽  
Diagnostic Tests ◽  
Point Of Care ◽  
Digital Microfluidics ◽  
Controlled Environment ◽  
Point Of Care Testing ◽  
Microfluidic Platforms ◽  
Interface System ◽  
Technical Issues ◽  
Sample System

: Point-of-care (POC) testing decentralizes the diagnostic tests to the sites near the patient. Many POC tests rely microfluidic platforms for sample-to-answer analysis. Compared to other microfluidic systems, magnetic digital microfluidics demonstrate compelling advantages for POC diagnostics. In this review, we have examined the capability of magnetic digital microfluidics-based POC diagnostic platforms. More importantly, we have categorized POC settings into three classes based on “where is the point”, “who to care” and “how to test”, and evaluated the suitability of magnetic digital microfluidics in various POC settings. Furthermore, we have addressed other technical issues associated with POC testing such as controlled environment, sample-system interface, system integration and information connectivity. We hope this review would provide a guideline for the future development of magnetic digital microfluidics-based platforms for POC testing.

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