scholarly journals Assessment of Pb(II), Cd(II), and Al(III) Removal Capacity of Bacteria from Food and Gut Ecological Niches: Insights into Biodiversity to Limit Intestinal Biodisponibility of Toxic Metals

2021 ◽  
Vol 9 (2) ◽  
pp. 456
Author(s):  
Fanny George ◽  
Séverine Mahieux ◽  
Catherine Daniel ◽  
Marie Titécat ◽  
Nicolas Beauval ◽  
...  
Keyword(s):  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Metal Removal ◽  
Heavy Metal Removal ◽  
Ecological Niches ◽  
Inductively Coupled ◽  
Lead And Cadmium ◽  
Removal Capacity ◽  
Plasma Mass Spectrometry

Toxic metals (such as lead, cadmium, and, to a lesser extent, aluminum) are detrimental to health when ingested in food or water or when inhaled. By interacting with heavy metals, gut and food-derived microbes can actively and/or passively modulate (by adsorption and/or sequestration) the bioavailability of these toxins inside the gut. This “intestinal bioremediation” involves the selection of safe microbes specifically able to immobilize metals. We used inductively coupled plasma mass spectrometry to investigate the in vitro ability of 225 bacteria to remove the potentially harmful trace elements lead, cadmium, and aluminum. Interspecies and intraspecies comparisons were performed among the Firmicutes (mostly lactic acid bacteria, including Lactobacillus spp., with some Lactococcus, Pediococcus, and Carnobacterium representatives), Actinobacteria, and Proteobacteria. The removal of a mixture of lead and cadmium was also investigated. Although the objective of the study was not to elucidate the mechanisms of heavy metal removal for each strain and each metal, we nevertheless identified promising candidate bacteria as probiotics for the intestinal bioremediation of Pb(II) and Cd(II).

scholarly journals Assessment of Pb(II), Cd(II) and Al(III) Removal Capacity of Bacteria From Food and Gut Ecological Niches: Insights Into Biodiversity to Limit Intestinal Biodisponibility of Toxic Metals

2021 ◽  
Author(s):  
Fanny George ◽  
Séverine Mahieux ◽  
Catherine Daniel ◽  
Marie Titécat ◽  
Nicolas Beauval ◽  
...  
Keyword(s):  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Metal Removal ◽  
Heavy Metal Removal ◽  
Mass Spectrometry Analysis ◽  
Ecological Niches ◽  
Spectrometry Analysis ◽  
Lead And Cadmium ◽  
Removal Capacity

Hazardous toxic metals, such as lead and cadmium, and to a lesser extent aluminum, are extensively recognized as detrimental for health following ingestion within food and water, or following inhalation. Gut and food-derived microbes, by interacting with heavy metals, may actively or passively modulate their bioavailability inside the gut, either by adsorption or by sequestration. Such a bioremediation within the gut implies the selection of safe microbes, based on their specific capacities to immobilize metals. We investigated the metal removal ability of 225 bacteria toward the potential harmful trace elements lead, cadmium and aluminum in vitro, using Inductively Coupled Plasma Mass Spectrometry analysis. Interspecies and intraspecies comparisons were addressed and discussed among bacteria from the phylum Firmicutes, which are mostly lactic acid bacteria, including Lactobacillus spp, with some Lactococcus, Pediococcus and Carnobacterium representatives, Actinobacteria as well as Proteobacteria. The effect on mixture of lead and cadmium was also investigated. Although the purpose of such a screening is so far not to elucidate each of the various strain specific- and metal dependent- mechanisms of heavy metal removal, we identified potential bacteria which are able to alleviate Pb(II) and Cd(II) concerns in order to propose performing candidate probiotics for metal xenobiotic bioremediation.

Evaluation of the nanodebris produced by in vitro degradation of titanium-based dental implants in the presence of bacteria using single particle and single cell inductively coupled plasma mass spectrometry.

2021 ◽  
Author(s):  
Marzia Cosmi ◽  
Nathaly Gonzalez-Quiñonez ◽  
Pablo Tejerina Díaz ◽  
Ángel Manteca ◽  
Elisa Blanco González ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Dental Implants ◽  
Inductively Coupled Plasma ◽  
Metallic Materials ◽  
In Vitro Degradation ◽  
Inductively Coupled ◽  
Oral Environment ◽  
Plasma Mass Spectrometry ◽  
Materials Used

The bio-tribocorrosion of metallic materials used for dental implants (Ti and alloys) in the oral environment involves the production of metallic debris in the ionic, but also in the nanoparticulated...

scholarly journals Comparison of Selected Metals Content in Cambodian Striped Snakehead Fish (Channa striata) Using Solar Drying System and Open Sun Drying

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Dayang Fredalina Basri ◽  
Nur Faizah Abu Bakar ◽  
Ahmad Fudholi ◽  
Mohd Hafidz Ruslan ◽  
Im Saroeun
Keyword(s):  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Solar Drying ◽  
Conventional System ◽  
Skin Sample ◽  
Sun Drying ◽  
Inductively Coupled ◽  
Cu Content ◽  
Plasma Mass Spectrometry ◽  
Drying System

The content of 12 elements in Cambodian dried striped snakehead fish was determined using inductively coupled plasma mass spectrometry. The present study compares the level of the trace toxic metals and nutritional trace elements in the fish processed using solar drying system (SDS) and open sun drying (OSD). The skin of SDS fish has lower level of As, Pb, and Cd compared to the OSD sample. As such, the flesh of the fish accumulated higher amount of toxic metals during OSD compared to SDS. However, arsenic was detected in both samples within the safe limit. The nutritional elements (Fe, Mn, Mg, Se, Mo, Cu, Ni, and Cr) were higher in the skin sample SDS fish compared to OSD fish. These beneficial metals were not accumulated in the flesh sample SDS fish demonstrating lower level compared to drying under conventional system. The reddish coloration of the SDS fish was due to the presence of high Cu content in both the skin and flesh samples which possibly account for no mold formation 5 days after packaging. As conclusion, drying of CambodianC. striatausing solar-assisted system has proven higher content of the nutritious elements compared to using the conventional system despite only slight difference in the toxic metals level between the two systems.

scholarly journals Profiling metals in Cordyceps sinensis by using inductively coupled plasma mass spectrometry

2017 ◽  
Vol 9 (4) ◽  
pp. 724-728 ◽  
Author(s):  
Xin Wei ◽  
Hankun Hu ◽  
Baogeng Zheng ◽  
Zikri Arslan ◽  
Hung-Chung Huang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Cordyceps Sinensis ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
First Time ◽  
Assay Protocol

In this work an assay protocol based on the ICP-MS technique was developed and validated to simultaneously determine 24 essential, non-essential, and toxic metals for the first time in C. sinensis.

scholarly journals Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in Mice

2021 ◽  
Vol 14 (2) ◽  
pp. 173
Author(s):  
Martin Vojtek ◽  
Salomé Gonçalves-Monteiro ◽  
Edgar Pinto ◽  
Sára Kalivodová ◽  
Agostinho Almeida ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Half Life ◽  
Inductively Coupled Plasma ◽  
Mammary Glands ◽  
Preclinical Pharmacokinetics ◽  
Inductively Coupled ◽  
Terminal Half Life ◽  
Plasma Mass Spectrometry ◽  
Kidney Liver

Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kinetic profiles of palladium/platinum in serum, serum ultrafiltrate and tissues (kidney, liver, brain, heart, lungs, ovaries, adipose tissue and mammary glands) were studied in healthy female Balb/c mice after a single intraperitoneal bolus injection of Pd2Spm (3 mg/kg bw) or cisplatin (3.5 mg/kg bw) between 0.5 and 48 h post-injection. Palladium in serum exhibited biphasic kinetics with a terminal half-life of 20.7 h, while the free palladium in serum ultrafiltrate showed a higher terminal half-life than platinum (35.5 versus 31.5 h). Palladium was distributed throughout most of the tissues except for the brain, with the highest values in the kidney, followed by the liver, lungs, ovaries, adipose tissue and mammary glands. The in vitro cellular accumulation was also evaluated in breast cancer cells, evidencing a passive diffusion as a mechanism of Pd2Spm’s cellular entry. This study reports, for the first time, the favorable pharmacokinetics and biodistribution of Pd2Spm, which may become a promising pharmacological agent for cancer treatment.

scholarly journals Mercury in the human thyroid gland: Potential implications for thyroid cancer, autoimmune thyroiditis, and hypothyroidism

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246748
Author(s):  
Roger Pamphlett ◽  
Philip A. Doble ◽  
David P. Bishop
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Thyroid Gland ◽  
Toxic Metals ◽  
Inductively Coupled Plasma ◽  
Human Thyroid ◽  
Follicular Cells ◽  
Inductively Coupled ◽  
Thyroid Follicular Cells ◽  
Plasma Mass Spectrometry

Objective Mercury and other toxic metals have been suggested to be involved in thyroid disorders, but the distribution and prevalence of mercury in the human thyroid gland is not known. We therefore used two elemental bio-imaging techniques to look at the distribution of mercury and other toxic metals in the thyroid glands of people over a wide range of ages. Materials and methods Formalin-fixed paraffin-embedded thyroid tissue blocks were obtained from 115 people aged 1–104 years old, with varied clinicopathological conditions, who had thyroid samples removed during forensic/coronial autopsies. Seven-micron sections from these tissue blocks were used to detect intracellular inorganic mercury using autometallography. The presence of mercury was confirmed using laser ablation-inductively coupled plasma-mass spectrometry which can detect multiple elements. Results Mercury was found on autometallography in the thyroid follicular cells of 4% of people aged 1–29 years, 9% aged 30–59 years, and 38% aged 60–104 years. Laser ablation-inductively coupled plasma-mass spectrometry confirmed the presence of mercury in samples staining with autometallography, and detected cadmium, lead, iron, nickel and silver in selected samples. Conclusions The proportion of people with mercury in their thyroid follicular cells increases with age, until it is present in over one-third of people aged 60 years and over. Other toxic metals in thyroid cells could enhance mercury toxicity. Mercury can trigger genotoxicity, autoimmune reactions, and oxidative damage, which raises the possibility that mercury could play a role in the pathogenesis of thyroid cancers, autoimmune thyroiditis, and hypothyroidism.

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