scholarly journals Exploring the Chemical Diversity of Algerian Plants: Three New Pentacyclic Triterpenoids from Launaea acanthoclada Roots

Molecules ◽  
2017 ◽  
Vol 23 (1) ◽  
pp. 80 ◽  
Author(s):  
Nabila Zergainoh ◽  
Maria Ciavatta ◽  
Marianna Carbone ◽  
Fatma Bitam ◽  
Mohamed Aberkane ◽  
...  
Keyword(s):  
Chemical Diversity ◽  
Pentacyclic Triterpenoids

scholarly journals Saponin Composition Analysis of the Aerial Part of Panax Bipinnatifidus Seem. Collected in Sa Pa, Lao Cai

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Dang Thi Ngan ◽  
Bui Thi Thanh Van ◽  
Tran Thi Ngoc Ha ◽  
Nong My Hoa ◽  
Cao Thi Phuong Thao ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Aerial Part ◽  
Chemical Diversity ◽  
Composition Analysis ◽  
Viet Nam ◽  
Anticancer Activities ◽  
Pentacyclic Triterpenoids ◽  
Chromatographic Techniques ◽  
Lao Cai ◽  
Stem Leaf

Panax bipinnatifidus Seem. is a precious medicinal plant belonging to the Araliaceae family. This study qualitatively analyzed saponins of the stem, leaf and rhizome of P. bipinnatifidus by HPLC. Subsequently, by using chromatographic techniques, a major saponin from the leaf of P.bipinnatifidius Seem. was isolated. On the basis of NMR and MS spectroscopic data as well as comparison with those reported in the literature, the isolated saponin’s structure was identified as stipuleanoside R2. To the best our knowledge, this is the first report of saponin from the aerial part of P. bipinnatifidius Seem. Keywords Panax bipinnatifidus, Araliaceae, Stipuleanosid R2, HPLC.. [1] Nguyễn Văn Tập, Các loài thuộc chi Panax L. ở Việt Nam, Tạp chí Dược liệu. 10(3) (2005) 71-76. [2] Nguyễn Văn Tập, Phạm Thanh Huyền, Kết quả nghiên cứu về phân bố, sinh thái sâm vũ diệp và Tam thất hoang ở Việt Nam, Tạp chí Dược liệu. 11(5) (2006) 177-180. [3] Nguyen Huu Tung, Tran Hong Quang, Nguyen Thị Thanh Ngan, Chau Van Minh, Bui Kim Anh, Pham Quoc Long, Nguyen Manh Cuong, Young Ho Kim, Oleanolic triterpenesaponins from the roots of Panax bipinnatifidus, Chem Pharm Bull (Tokyo). 59(11) (2011) 1417-1420. [4] Đỗ Văn Hào, Nguyễn Thị Huệ, Nguyễn Thị Thu Thủy, Đặng Thị Ngần, Đào Thị Hồng Bích, Nguyễn Thị Hoàng Anh, Dương Thị Ly Hương, Nguyễn Hữu Tùng, Thành phần hóa học của phân đoạn ethyl acetat từ rễ cây sâm vũ diệp (Panax bipinnatifidus Seem.) thu hái ở Sa Pa, Lào Cai, Tạp chí Khoa học ĐHQGHN - Khoa học Y Dược. 33(2) (2017) 50-55. [5] Nguyễn Thị Thu Thủy, Nguyễn Thị Huệ, Đặng Thị Thùy, Nguyễn Thị Hoàng Anh, Dương Thị Phượng, Phạm Thị Tuyết Nhung, Hà Vân Oanh, Dương Thị Ly Hương, Nguyễn Hữu Tùng, Thành phần saponin của thân rễ sâm vũ diệp thu hái ở Sa Pa, Lào Cai, Tạp chí Dược liệu. 23(2) (2018) 82-88.[6] Wen-zhi Yang, Ying Hu, Wan-ying Wu, Min Ye, De-an Guo, Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity, Phytochemistry. 106 (2014) 7-14. [7] Shashi B. Mahato, Asish P. Kundu, 13C NMR spectra of pentacyclic triterpenoids - a complication and some salient features, Phytochemistry. 37 (1994) 1517-1575. [8] Pawan K. Agrawal, NMR spectroscopy in the structural elucidation of oligossacharides and glycosides, Phytochemistry. 31 (1992) 1307-1330. [9] Chun Liang, Yan Ding, Huu Tung Nguyen, Jeong-Ah Kim, Hye-Jin Boo, Hee-Kyoung Kang, Mahn Cuong Nguyen, Young Ho Kim, Oleanane –type triterpenoids from Panax stipuleannatus and their anticancer activities, Bioorg Med Chem Lett. 20 (2010) 7110-7115.  

What can phylogeny tell us about chemical diversity?

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
N Rønsted ◽  
GI Stafford ◽  
AW Meerow ◽  
G Petersen ◽  
J Van Staden ◽  
...  
Keyword(s):  
Chemical Diversity

High throughput screening to investigate Brazilian Cerrado biome plant extract bank chemical diversity

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
LS Espindola ◽  
RG Dusi ◽  
KR Gustafson ◽  
J McMahon ◽  
JA Beutler
Keyword(s):  
High Throughput ◽  
Plant Extract ◽  
High Throughput Screening ◽  
Chemical Diversity ◽  
Brazilian Cerrado ◽  
Cerrado Biome

Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain

2020 ◽  
Author(s):  
Luke Adams ◽  
Lorna E. Wilkinson-White ◽  
Menachem J. Gunzburg ◽  
Stephen J. Headey ◽  
Martin J. Scanlon ◽  
...  
Keyword(s):  
Binding Site ◽  
Systematic Approach ◽  
Structural Information ◽  
Peptide Binding ◽  
Chemical Diversity ◽  
Chemical Probes ◽  
Protein Targets ◽  
Structure Activity ◽  
Peptide Binding Site ◽  
Selection Of

The development of low-affinity fragment hits into higher affinity leads is a major hurdle in fragment-based drug design. Here we demonstrate an approach for the Rapid Elaboration of Fragments into Leads (REFiL) applying an integrated workflow that provides a systematic approach to generate higher-affinity binders without the need for structural information. The workflow involves the selection of commercial analogues of fragment hits to generate preliminary structure-activity relationships. This is followed by parallel microscale chemistry using chemoinformatically designed reagent libraries to rapidly explore chemical diversity. Upon completion of a fragment screen against Bromodomain-3 extra terminal (BRD3-ET) domain we applied the REFiL workflow, which allowed us to develop a series of tetrahydrocarbazole ligands that bind to the peptide binding site of BRD3-ET. With REFiL we were able to rapidly improve binding affinity >30-fold. The REFiL workflow can be applied readily to a broad range of protein targets without the need of a structure, allowing the efficient evolution of low-affinity fragments into higher affinity leads and chemical probes.<br>

Oxazole-Based Compounds As Anticancer Agents

2020 ◽  
Vol 26 (41) ◽  
pp. 7337-7371 ◽  
Author(s):  
Maria A. Chiacchio ◽  
Giuseppe Lanza ◽  
Ugo Chiacchio ◽  
Salvatore V. Giofrè ◽  
Roberto Romeo ◽  
...  
Keyword(s):  
Cancer Research ◽  
Drug Discovery ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Chemical Diversity ◽  
Biologically Active ◽  
New Drugs ◽  
The Core ◽  
Anti Cancer ◽  
Biologically Active Derivatives

: Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the newly discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.

New Applications of Oleanolic Acid and its Derivatives as Cardioprotective Agents: A Review of their Therapeutic Perspectives

2019 ◽  
Vol 25 (35) ◽  
pp. 3740-3750 ◽  
Author(s):  
Ning Sun ◽  
Dongli Li ◽  
Xiaoqing Chen ◽  
Panpan Wu ◽  
Yu-Jing Lu ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Liver Diseases ◽  
Therapeutic Agent ◽  
Heart Diseases ◽  
Pentacyclic Triterpenoids ◽  
Hepatic Drug ◽  
Approved Drugs ◽  
New Applications ◽  
Functional Mechanisms ◽  
Potent Therapeutic Agent

Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five approved drugs derived from pentacyclic triterpenoids, including oleanolic acid (liver diseases), asiaticoside (wound healing), glycyrrhizinate (liver diseases), isoglycyrrhizinate (liver disease) and sodium aescinate (hydrocephalus). To understand more about the bioactivity and functional mechanisms of oleanolic acid, it can be developed as a potent therapeutic agent, in particular, for the prevention and treatment of heart diseases that are the leading cause of death for people worldwide. The primary aim of this mini-review is to summarize the new applications of oleanolic acid and its derivatives as cardioprotective agents reported in recent years and to highlight their therapeutic perspectives in cardiovascular diseases.

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