scholarly journals Application of Molecular Methods in the Identification of Ingredients in Chinese Herbal Medicines

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2728 ◽  
Author(s):  
Ke Han ◽  
Miao Wang ◽  
Lei Zhang ◽  
Chunyu Wang
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Future Development ◽  
Rapid Development ◽  
Herbal Medicines ◽  
Taxonomic Identification ◽  
Traditional Methods ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Speed And Accuracy

There are several kinds of Chinese herbal medicines originating from diverse sources. However, the rapid taxonomic identification of large quantities of Chinese herbal medicines is difficult using traditional methods, and the process of identification itself is prone to error. Therefore, the traditional methods of Chinese herbal medicine identification must meet higher standards of accuracy. With the rapid development of bioinformatics, methods relying on bioinformatics strategies offer advantages with respect to the speed and accuracy of the identification of Chinese herbal medicine ingredients. This article reviews the applicability and limitations of biochip and DNA barcoding technology in the identification of Chinese herbal medicines. Furthermore, the future development of the two technologies of interest is discussed.

scholarly journals A proposed protocol based on integrative metabonomics analysis for the rapid detection and mechanistic understanding of sulfur fumigation of Chinese herbal medicines

RSC Advances ◽  
2019 ◽  
Vol 9 (53) ◽  
pp. 31150-31161 ◽  
Author(s):  
Dai Shengyun ◽  
Wang Yuqi ◽  
Wang Fei ◽  
Mei Xiaodan ◽  
Zhang Jiayu
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Rapid Detection ◽  
Herbal Medicines ◽  
Lonicera Japonica ◽  
Current Work ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Mechanistic Understanding

In the current work, Lonicera japonica Flos (FLJ) was selected as a model Chinese herbal medicine (CHM) and a protocol was proposed for the rapid detection of sulfur-fumigated (SF) CHMs.

scholarly journals Effect of Traditional Chinese Herbal Medicine with Antiquorum Sensing Activity onPseudomonas aeruginosa

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Weihua Chu ◽  
Shuxin Zhou ◽  
Yan Jiang ◽  
Wei Zhu ◽  
Xiyi Zhuang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Cell Communication ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Traditional Chinese Herbal Medicines

Traditional Chinese herbal medicines (TCHMs) were tested for their ability of antiquorum sensing. Water extracts ofRhubarb, Fructus gardeniae, and Andrographis paniculatashow antiquorumsensing activity when usingChromobacterium violaceumCV12472 as reporter; the sub-MIC concentrations of these TCHMs were tested against AHL-dependent phenotypic expressions of PAO1. Results showed significant reduction in pyocyanin pigment, protease, elastase production, and biofilm formation in PAO1 without inhibiting the bacterial growth, revealing that the QSI by the extracts is not related to static or killing effects on the bacteria. The results indicate a potential modulation of bacterial cell-cell communication,P. aeruginosabiofilm, and virulence factors by traditional Chinese herbal medicine. This study introduces not only a new mode of action for traditional Chinese herbal medicines, but also a potential new therapeutic direction for the treatment of bacterial infections, which have QSI activity and might be important in reducing virulence and pathogenicity of pathogenic bacteria.

scholarly journals Prediction Methods of Herbal Compounds in Chinese Medicinal Herbs

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2303 ◽  
Author(s):  
Ke Han ◽  
Lei Zhang ◽  
Miao Wang ◽  
Rui Zhang ◽  
Chunyu Wang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Virtual Screening ◽  
Chinese Herbal Medicine ◽  
Screening Method ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Prediction Methods ◽  
Chinese Herbal Medicines ◽  
Advantages And Disadvantages ◽  
Chinese Herbal

Chinese herbal medicine has recently gained worldwide attention. The curative mechanism of Chinese herbal medicine is compared with that of western medicine at the molecular level. The treatment mechanism of most Chinese herbal medicines is still not clear. How do we integrate Chinese herbal medicine compounds with modern medicine? Chinese herbal medicine drug-like prediction method is particularly important. A growing number of Chinese herbal source compounds are now widely used as drug-like compound candidates. An important way for pharmaceutical companies to develop drugs is to discover potentially active compounds from related herbs in Chinese herbs. The methods for predicting the drug-like properties of Chinese herbal compounds include the virtual screening method, pharmacophore model method and machine learning method. In this paper, we focus on the prediction methods for the medicinal properties of Chinese herbal medicines. We analyze the advantages and disadvantages of the above three methods, and then introduce the specific steps of the virtual screening method. Finally, we present the prospect of the joint application of various methods.

scholarly journals Effect of Active Ingredients of Chinese Herbal Medicine on the Rejuvenation of Healthy Aging: Focus on Stem Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Chen Wang ◽  
Shuang Ling ◽  
Jin-Wen Xu
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Herbal Medicines ◽  
Stem Cell Differentiation ◽  
Chinese Herbs ◽  
Active Ingredients ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

Stem cells (SCs) are special types of cells with the ability of self-renewal and multidirectional differentiation. As the organism ages, the ability to maintain homeostasis and regeneration deteriorates and the number and activity of stem cells decline. Theoretically, the restoration of stem cells might reverse aging. However, due to their own aging, donor-derived immune rejection, and difficulties in stem cell differentiation control, a series of problems need to be solved to realize the potential for clinical application of stem cells. Chinese herbal medicine is a nature drug library which is suitable for the long-term treatment of aging-related diseases. Modern pharmacological studies have revealed that many active ingredients of Chinese herbal medicines with the effect of promoting stem cells growth and differentiation mainly belong to “reinforcing herbs.” In recent years, exploration of natural active ingredients from Chinese herbal medicines for delaying aging, improving the stem cell microenvironment, and promoting the proliferation and differentiation of endogenous stem cells has attracted substantial attention. This article will focus on active ingredients from Chinese herbs-mediated differentiation of stem cells into particular cell type, like neural cells, endothelial cells, cardiomyocytes, and osteoblasts. We will also discuss the effects of these small molecules on Wnt, Sonic Hedgehog, Notch, eNOS-cGMP, and MAP kinase signal transduction pathways, as well as reveal the role of estrogen receptor α and PPAR γ on selectively promoting or inhibiting stem cells differentiation. This review will provide new insights into the health aging strategies of active ingredients in Chinese herbal medicine in regenerative medicine.

Application of Wireless Sensor Network in the Monitoring System for Valuable Chinese Herbal Medicine Growth

2013 ◽  
Vol 475-476 ◽  
pp. 442-445
Author(s):  
Ying Li Zhu ◽  
Ling Qin Xie
Keyword(s):  
Wireless Sensor Network ◽  
Herbal Medicine ◽  
Sensor Network ◽  
Monitoring System ◽  
Chinese Herbal Medicine ◽  
Herbal Medicines ◽  
Wireless Sensor ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Artificial Cultivation

Chinese herbal medicine with no side effects can help people resist disease and keep healthy, due to predatory excavation, and heavy deforestation, the destruction ecological environment, lots of the precious Chinese herbal medicines are on the edge of exhaustion. In order to protect Chinese herbal medicines and do artificial cultivation, the paper presents a real-time monitoring system based wireless sensor network. The system gives the hardware design of wireless sensor node and software implementations. The nodes are mainly responsible for collecting and transporting the environment parameters of the Chinese herbal medicine including temperature, humidity and light intensity and so on, and send the data through the GPRS module to the remote monitoring center. The system can make the artificial cultivation of the medicines more modern, scientific and objective.

scholarly journals Chinese Herbal Medicine Versus Other Interventions in the Treatment of Type 2 Diabetes

2018 ◽  
Vol 23 ◽  
pp. 2515690X1878151 ◽  
Author(s):  
Ao Yu ◽  
David Adelson ◽  
David Mills
Keyword(s):  
Type 2 Diabetes ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Clinical Symptoms ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
The World

Diabetes affects 422 million people and directly caused 4.9 million deaths according to the global report on diabetes in 2014. Type 2 diabetes accounts for 90% of people with diabetes around the world. Chinese herbal medicine treatment for diabetes has more than 2000-year history in China. An increasing number of people around the world are trying to manage type 2 diabetes with Chinese herbal medicine. However, there is a lack of evidence to decide if Chinese herbal medicine is effective and safe when compared with other interventions for the treatment of type 2 diabetes We identified 58 randomized controlled trials involving 6637 participants with type 2 diabetes with trial periods lasting from 8 weeks to 1 year (average 12 weeks). We extracted data following a predefined hierarchy. A total of 132 different Chinese herbal medicines were examined. We included studies comparing Chinese herbal medicine with other interventions and excluded trials that did not satisfy the inclusion criteria. We evaluated primary outcomes of trials in accordance with the Cochrane Handbook for Systematic Reviews of Intervention. Fifty-six out of 58 studies reported evidence that Chinese herbal medicines were effective at controlling blood sugar, insulin resistance, and traditional Chinese medicine clinical symptoms for patients with type 2 diabetes. And outcome variables are summarized. However, the evidence is limited because of the quality of the studies. Well-designed long-term studies with large samples and multiple centers as well as standardization and quality control will be required to determine if Chinese herbal medicine treatment is effective and safe for type 2 diabetes.

scholarly journals Nephrotoxicity and Chinese Herbal Medicine

2018 ◽  
Vol 13 (10) ◽  
pp. 1605-1611 ◽  
Author(s):  
Bo Yang ◽  
Yun Xie ◽  
Maojuan Guo ◽  
Mitchell H. Rosner ◽  
Hongtao Yang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Aristolochic Acid ◽  
Herbal Medicines ◽  
Kidney Injury ◽  
Medicine Use ◽  
Chinese Herbal ◽  
Aristolochic Acids ◽  
Increase Risk ◽  
Plant Alkaloids

Chinese herbal medicine has been practiced for the prevention, treatment, and cure of diseases for thousands of years. Herbal medicine involves the use of natural compounds, which have relatively complex active ingredients with varying degrees of side effects. Some of these herbal medicines are known to cause nephrotoxicity, which can be overlooked by physicians and patients due to the belief that herbal medications are innocuous. Some of the nephrotoxic components from herbs are aristolochic acids and other plant alkaloids. In addition, anthraquinones, flavonoids, and glycosides from herbs also are known to cause kidney toxicity. The kidney manifestations of nephrotoxicity associated with herbal medicine include acute kidney injury, CKD, nephrolithiasis, rhabdomyolysis, Fanconi syndrome, and urothelial carcinoma. Several factors contribute to the nephrotoxicity of herbal medicines, including the intrinsic toxicity of herbs, incorrect processing or storage, adulteration, contamination by heavy metals, incorrect dosing, and interactions between herbal medicines and medications. The exact incidence of kidney injury due to nephrotoxic herbal medicine is not known. However, clinicians should consider herbal medicine use in patients with unexplained AKI or progressive CKD. In addition, exposure to herbal medicine containing aristolochic acid may increase risk for future uroepithelial cancers, and patients require appropriate postexposure screening.

scholarly journals Diagnosis and Management of Infected or Suspected Patients with Covid-19 a Study of 48 Cases in the UK

2022 ◽  
Vol 5 (1) ◽  
pp. 01-06
Author(s):  
Dan Jiang
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Herbal Medicines ◽  
Treatment Method ◽  
Individual Case ◽  
The Body ◽  
Critical Stage ◽  
Significant Information ◽  
Positive Effects ◽  
Chinese Herbal

Covid-19 is a pandemic infective disease, which has been erupting throughout the whole world from 2020 to 2021. There have been at the time of reviewing more than a hundred million cases (102,399,513) of infection, and more than 2 million deaths (2,217,005) in more than 200 countries; this information is taken from the Covid-19 daily situation report issued on 1st Feb 2021 by WHO. The pandemic was also declared as an outbreak of Public Health Emergency of International Concern on 30th Jan 2020 by WHO. No effective treatment model has yet been confirmed by conventional western medicine, but some herbal treatments used in China can be recognized as having positive results in Covid-19 cases. This pandemic disaster has been severely damaging to quality of life, disturbing social communication, economic development and the progress of humanity. Successful results were first reported from temporary hospitals (Fangcang Hospitals set up in arenas and exhibition spaces) in Wuhan, China, where more than 90% of patients treated with Chinese herbal medicine were prevented by transferring from the minor or milder stages of the disease to the severe or critical stage. In all of them the positive PCR became negative; herbs were involved in the rescue and treatment of severe and critical cases in ICU’s in hospitals as well. It was an important factor in how Covid-19 was controlled so quickly in China. The author recruited both confirmed and suspected Covid-19 patients through social media (WeChat, WhatsApp, Internet, message etc.) as a volunteer TCM consultant from March 2020, during the first Lockdown phase in UK. It was quickly realized that the appearance of the tongue provides special and significant information for identifying whether Covid-19 is present and shows its severity, from a TCM perspective, as the degree and type of dampness accumulated within the body. Herbal prescriptions were sent by post for patients’ treatment according to their clinical findings, virus exposure history and tongue information (from photos). Similar positive effects were found as in China, and treatment reports and results are summarized here. The author believes there are many herbal medicines that can be effective in controlling the Sars-Cov-2 virus, and that prescribing the appropriate formula to match each individual case is the key point for TCM control of Covid-19. Chinese herbal medicine is the most effective current treatment method that can prevent cases in the minor and ordinary stages from progressing to the severe or critical stage, and so can play a significant role in the decrease and cure of Covid-19.

scholarly journals Traditional Chinese Herbal Medicine for Whitening

2020 ◽  
Vol 15 (2) ◽  
pp. 1934578X2090514 ◽  
Author(s):  
Na Zhao ◽  
Xiaoming Su ◽  
Yueyang Wang ◽  
Jianguang Chen ◽  
Wenyue Zhuang
Keyword(s):  
Herbal Medicine ◽  
Biological Activities ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Skin Whitening ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Chinese Drugs ◽  
Traditional Chinese Drugs ◽  
Traditional Chinese Herbal Medicines

Melanin is the chief pigment responsible for the pigmentation of human skin. Increasing evidence indicates that traditional Chinese drugs with skin-whitening effects are attracting the attention of consumers and researchers because they are perceived to be milder, safer, and healthier than synthetic alternatives. This commentary summarizes the current research on Chinese herbal medicines that inhibit melanin and their biological activities. The findings presented in this study suggest that these traditional Chinese herbal medicines might be potential candidates for novel skin-whitening agents.

scholarly journals Chinese Herbal Medicine Meets Biological Networks of Complex Diseases: A Computational Perspective

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Shuo Gu ◽  
Jianfeng Pei
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Biological Networks ◽  
Rapid Development ◽  
Regulatory Function ◽  
Network Pharmacology ◽  
Chinese Herbal ◽  
Computational Workflow ◽  
Computational Research

With the rapid development of cheminformatics, computational biology, and systems biology, great progress has been made recently in the computational research of Chinese herbal medicine with in-depth understanding towards pharmacognosy. This paper summarized these studies in the aspects of computational methods, traditional Chinese medicine (TCM) compound databases, and TCM network pharmacology. Furthermore, we chose arachidonic acid metabolic network as a case study to demonstrate the regulatory function of herbal medicine in the treatment of inflammation at network level. Finally, a computational workflow for the network-based TCM study, derived from our previous successful applications, was proposed.

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