scholarly journals Phytochemical Study of Stem and Leaf of Clausena lansium

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3124 ◽  
Author(s):  
Wenwen Peng ◽  
Xiaoxiang Fu ◽  
Yuyan Li ◽  
Zhonghua Xiong ◽  
Xugen Shi ◽  
...  
Keyword(s):  
Biological Activities ◽  
Healthcare Systems ◽  
Water Soluble ◽  
Phytochemical Analysis ◽  
Phytochemical Study ◽  
Spectroscopic Analyses ◽  
First Time ◽  
Local Healthcare ◽  
Carbazole Alkaloids ◽  
Aromatic Glycoside

Clausena lansium Lour. Skeels (Rutaceae) is widely distributed in South China and has historically been used as a traditional medicine in local healthcare systems. Although the characteristic components (carbazole alkaloids and coumarins) of C. lansium have been found to possess a wide variety of biological activities, little attention has been paid toward the other components of this plant. In the current study, phytochemical analysis of isolates from a water-soluble stem and leaf extract of C. lansium led to the identification of 12 compounds, including five aromatic glycosides, four sesquiterpene glycosides, two dihydrofuranocoumarin glycosides, and one adenosine. All compounds were isolated for the first time from the genus Clausena, including a new aromatic glycoside (1), a new dihydrofuranocoumarin glycoside (6), and two new sesquiterpene glycosides (8 and 9). The phytochemical structures of the isolates were elucidated using spectroscopic analyses including NMR and MS. The existence of these compounds demonstrates the taxonomic significance of C. lansium in the genus Clausena and suggests that some glycosides from this plant probably play a role in the anticancer activity of C. lansium to some extent.

scholarly journals Phytochemical Study of Aerial Parts of Leea asiatica

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1733 ◽  
Author(s):  
Hyun Woo Kil ◽  
Taewoong Rho ◽  
Kee Dong Yoon
Keyword(s):  
2D Nmr ◽  
Healthcare Systems ◽  
Phytochemical Analysis ◽  
Phytochemical Study ◽  
Aerial Parts ◽  
Spectroscopic Analyses ◽  
Antioxidative Effects ◽  
Phenolic Glucoside ◽  
Phytochemical Constituents ◽  
Local Healthcare

Leea asiatica (L.) Ridsdale (Leeaceae) is found in tropical and subtropical countries and has historically been used as a traditional medicine in local healthcare systems. Although L. asiatica extracts have been found to possess anthelmintic and antioxidant-related nephroprotective and hepatoprotective effects, little attention has been paid toward the investigation of phytochemical constituents of this plant. In the current study, phytochemical analysis of isolates from L. asiatica led to the identification of 24 compounds, including a novel phenolic glucoside, seven triterpenoids, eight flavonoids, two phenolic glycosides, four diglycosidic compounds, and two miscellaneous compounds. The phytochemical structures of the isolates from L. asiatica were elucidated using spectroscopic analyses including 1D- and 2D-NMR and ESI-Q-TOF-MS. The presence of triterpenoids and flavonoids supports the evidence for anthelmintic and antioxidative effects of L. asiatica.

scholarly journals A PHYTOCHEMICAL STUDY ON EUPATORIUM GLANDULOSUM

2019 ◽  
pp. 77-80
Author(s):  
SILPA M ◽  
SURESH JOGHEE ◽  
HAMSALAKSHMI
Keyword(s):  
Ethyl Acetate ◽  
Water Soluble ◽  
Phytochemical Analysis ◽  
Flavonoid Content ◽  
Plant Materials ◽  
Phytochemical Study ◽  
Aerial Parts ◽  
Standard Procedures ◽  
Soxhlet Method ◽  
Alcohol Ethyl

Objective: Eupatorium glandulosum is a useful medicinal plant belongs to the family Asteraceae. It is traditionally used to treat various diseases such as wound healing, antioxidant, and antiproliferative. The present study was aimed to investigate the physicochemical and phytochemical properties of various extracts of aerial parts of E. glandulosum. Methods: The E. glandulosum plant materials were extracted using the solvents alcohol, ethyl acetate, and chloroform by Soxhlet method. The extracts were screened for physiochemical constants, preliminary phytochemical analysis for carbohydrates, glycosides, alkaloids, flavonoids, phenols, tannins, and saponins. The quantitative phytochemical analysis was carried out for total flavonoid and total phenols using standard procedures. Results: The physiochemical constituents such as total ash, acid-insoluble ash, and water-soluble ash were found to be 14.25% (w/w), 5% (w/w), and 7.30% (w/w), respectively. The preliminary phytochemical screening confirmed the presence of carbohydrates, glycosides, alkaloids, flavonoids, phenols, tannins, and saponins. The flavonoid content of the plant extracts was found to be in the descending order ethyl acetate ˃alcohol ˃chloroform and the phenolic content was found to be alcohol ˃ethyl acetate ˃chloroform. Conclusion: The result showed the presence of phytochemical constituents and higher values of phenolic and flavonoid content make the plant useful for the formulation of the different drugs for human uses for treating various diseases.

scholarly journals Rindera graeca (Boraginaceae) Phytochemical Profile and Biological Activities

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3625
Author(s):  
Christos Ganos ◽  
Nektarios Aligiannis ◽  
Ioanna Chinou ◽  
Nikolaos Naziris ◽  
Maria Chountoulesi ◽  
...  
Keyword(s):  
Free Radical ◽  
Biological Activities ◽  
Biological Membrane ◽  
3D Structure ◽  
Total Phenolic ◽  
Phytochemical Analysis ◽  
Endemic Plant ◽  
Aerial Parts ◽  
Potential Applications ◽  
First Time

Rindera graeca is a Greek endemic plant of the Boraginaceae family which has never been studied before. Consequently, this study attempted to phytochemically examine the aerial parts of this species. Nine phenolic secondary metabolites were identified, consisting of seven caffeic acid derivatives and two flavonol glucosides, namely rutin and quercetin-3-rutinoside-7-rhamnoside. These flavonoids, together with rosmarinic acid, were isolated via column chromatography and structurally determined through spectral analysis. Quercetin-3-rutinoside-7-rhamnoside is an unusual triglycoside, which is identified for the first time in Rindera genus and among Boraginaceae plants. This metabolite was further examined with thermal analysis and its 3D structure was simulated, revealing some intriguing information on its interaction with biological membrane models, which might have potential applications in microcirculation-related conditions. R. graeca was also analyzed for its pyrrolizidine alkaloids content, and it was found to contain echinatine together with echinatine N-oxide and rinderine N-oxide. Additionally, the total phenolic and flavonoid contents of R. graeca methanol extract were determined, along with free radical inhibition assays. High total phenolic content and almost complete inhibition at experimental doses at the free radical assays indicate a potent antioxidant profile for this plant. Overall, through phytochemical analysis and biological activity assays, insight was gained on an endemic Greek species of the little-studied Rindera genus, while its potential for further applications has been assessed.

scholarly journals Phytochemical analysis and antioxidant activity of different plant parts of Pellacalyx axillaris

2019 ◽  
Vol 15 (3) ◽  
pp. 394-397
Author(s):  
Najwa Ahmad Kuthi ◽  
Norazah Basar
Keyword(s):  
Antioxidant Activity ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Bark Extract ◽  
Phytochemical Analysis ◽  
Phytochemical Study ◽  
Antioxidant Power ◽  
Plant Parts ◽  
Crude Extracts ◽  
Radical Scavenging Assay

Pellacalyx axillaris or locally known as ‘membuloh’ is a mangrove species belonging to the Rhizophoraceae family. Till date, there has been only one phytochemical study found on this particular plant species and that without any documentation on its biological activities. Therefore, the present work aimed to reveal the phytoconstituents and the antioxidant activity of different crude extracts from different plant parts of P. axillaris. Experimentally, three organic solvents of different polarities i.e. n-hexane, ethyl acetate and methanol were used to prepare the crude extracts from the dried leaves, twigs and barks of P. axillaris. The preliminary phytochemical screening of this species indicated the presence of terpenoids, phenolic compounds, tannins, flavonoids, alkaloids, anthraquinone glycosides and carbohydrates. The in vitro antioxidant activity of the species evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assay, and ferric reducing antioxidant power (FRAP) suggested that the methanolic bark extract contained potential source of natural antioxidants. Further research into isolation of antioxidant compounds from this species is highly recommended.

scholarly journals VALIDATION OF TRIBAL CLAIMS ON MORINGA OLEIFERA LAM. USING PHYTOCHEMICAL ANALYSIS

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Getsial Sabatini Wallace J ◽  
S. Naveen Kumar ◽  
V. Negasta Smila ◽  
T. Nivitha ◽  
Stalin Nithaniyal ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Future Research ◽  
Phytochemical Analysis ◽  
Traditional Use ◽  
Phytochemical Study ◽  
Medicinal Uses ◽  
Pharmacological Significance ◽  
History Of

Moringa is a medicinally important genus that has long history of traditional use as a remedy to cure wounds and various ailments such as colds, diabetes, digestive problems etc. In addition, the species is consumed as a source of nutritive food and used as vegetables worldwide. The genus consists of 13 species that have been cultivated throughout Asia and Africa for their multiple purpose use value. The current study is aimed to validate the traditional medicinal uses of Moringa oleifera, provide scientific insights on the phytochemistry, biological activities and thereby correlating its therapeutic potential for future prospects. Analysis of phytochemical profile showed the presence of the major important bioactive compounds (saponin, tannin, flavonoids, phenolics, and reducing sugar) that were assessed in aqueous, methanolic aqueous and acetone-aqueous extracts following standard procedures. This study provides the foundation to explore the tribal medicinal use complemented with the scientific evaluation. Our study reinforce further phytochemical study with advanced technologies for future research opportunities of this species as it is an interesting plant containing commercially important active compounds that enable to determine pharmacological significance, and socio-economic potential.

scholarly journals Screening of Lemon Balm Extracts for Anti-Aflatoxigenic, Antioxidant and Other Biological Activities

2019 ◽  
Author(s):  
Efstathia Skotti ◽  
Nefeli Sophia Sotiropoulou ◽  
Iliada Lappa ◽  
Maria Kaiafa ◽  
Dimitrios Tsitsigiannis ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Aspergillus Flavus ◽  
Biological Activities ◽  
Fungal Growth ◽  
Aflatoxin Production ◽  
Water Soluble ◽  
Phytochemical Analysis ◽  
Growth Enhancement ◽  
Mycelium Growth ◽  
Lemon Balm

Lemon balm extracts by dry plant material of Melissa officinalis were tested against their efficacy against for different fungal species Alternaria alternata, Fusarium oxysporum, Aspergillus flavus and Beauveria bassiana. The aqueous phase of the extract was evaluated for antioxidant, antifungal and also anti-aflatoxigenic activity. A synergism evaluation was also performed concerning, the small quantity of lemon balm polar essential oil compounds extracted into the infusion and the water soluble compounds in the extract. The experiments were conducted in solid cultures and the growth inhibition was demonstrated by measuring mycelial diameter. Additionally, the effect on conidia production was also demonstrated. Lemon balm was also used for in situ test on Pistachia vera seed against Aspergillus flavus growth and aflatoxin production. Results revealed enhancement of fungal growth by lemon balm extracts however total inhibition of aflatoxins production on Pistachia vera seeds was observed, and both actions were tried to attributed to volatile and water soluble compounds identified based on GC/MS, HPLC/DAD and LC/MS, and the observed antioxidant activity. Volatile and water - soluble compounds found to be in absolute synergism in mycelium growth enhancement and the observed anti-aflatoxigenic activity addressed to the high antioxidant activity observed and synergistic action between the other water soluble phenolic compounds identified in the extract. The findings of this study underline the high biological active potential of lemon balm extracts under various screening test since for the first time full phytochemical analysis of lemon balm extracts.

scholarly journals Bioactive Capnosanes and Cembranes from the Soft Coral Klyxum flaccidum

Marine Drugs ◽  
2019 ◽  
Vol 17 (8) ◽  
pp. 461
Author(s):  
Tseng ◽  
Ahmed ◽  
Huang ◽  
Tsai ◽  
Tai ◽  
...  
Keyword(s):  
Superoxide Anion ◽  
Spectroscopic Data ◽  
Cytochalasin B ◽  
Soft Coral ◽  
Biological Activities ◽  
Human Neutrophils ◽  
Data Comparison ◽  
Spectroscopic Analyses ◽  
New Compounds ◽  
First Time

Two new capnosane-based diterpenoids, flaccidenol A (1) and 7-epi-pavidolide D (2), two new cembranoids, flaccidodioxide (3) and flaccidodiol (4), and three known compounds 5 to 7 were characterized from the marine soft coral Klyxum flaccidum, collected off the coast of the island of Pratas. The structures of the new compounds were determined by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and spectroscopic data comparison with related structures. The rare capnosane diterpenoids were isolated herein from the genus Klyxum for the first time. The cytotoxicity of compounds 1 to 7 against the proliferation of a limited panel of cancer cell lines was assayed. The isolated diterpenoids also exhibited anti-inflammatory activity through suppression of superoxide anion generation and elastase release in the N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-stimulated human neutrophils. Furthermore, 1 and 7 also exhibited cytotoxicity toward the tested cancer cells, and 7 could effectively inhibit elastase release. It is worth noting that the biological activities of 7 are reported for the first time in this paper.

scholarly journals WATER-SOLUBLE COMPONENTS OF Ancistrocladus cochinchinensis

2017 ◽  
Vol 55 (6) ◽  
pp. 683
Author(s):  
Le Quynh Lien ◽  
Hoang Le Tuan Anh ◽  
Nguyen Thi Cuc ◽  
Tran My Linh ◽  
Vu Huong Giang ◽  
...  
Keyword(s):  
Soluble Fraction ◽  
2D Nmr ◽  
Phenolic Glycosides ◽  
Water Soluble ◽  
Ginsenoside Rg1 ◽  
Water Soluble Fraction ◽  
Spectroscopic Analyses ◽  
First Time ◽  
Soluble Components

Using various chromatography methods, a saponin, ginsenoside Rg1 (1), and three phenolic glycosides, tortoside A (2), phlorizin (3), and 4-hydroxy-2-methoxyphenyl-6-O-syringyl-b-D-glucopyranoside (4) were isolated from the water-soluble fraction of Ancistrocladus cochinchinensis. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analyses and comparison with those reported in the literature. Compound 1 was reported from A. cochinchinensis for the first time.

scholarly journals Phytochemical and Biological Activity Studies of the Bhutanese Medicinal Plant Corydalis crispa

2012 ◽  
Vol 7 (5) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Phurpa Wangchuk ◽  
Paul A. Keller ◽  
Stephen G. Pyne ◽  
Thanapat Sastraruji ◽  
Malai Taweechotipatr ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Multidrug Resistant ◽  
Scientific Basis ◽  
Phytochemical Study ◽  
Nmr Data ◽  
Tnf Α ◽  
First Time ◽  
Multidrug Resistant Strain

The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for 2 and 3 provided here for the first time. Crude extracts exhibited significant anti-inflammatory (p<0.01) activity against TNF- α production in LPS activated THP-1 cells. The acetylcholinesterase inhibitory activity of compounds 2, 4 and 7 and the antiplasmodial activity of compound 5 against P. falciparum strains TM4/8.2 and K1CB1 (multidrug resistant strain) are reported here for the first time. Stylopine (4) did not show antimalarial activity against the K1CB1 strain in contrast to a previous report. This study generated a scientific basis for the use of this plant in Bhutanese traditional medicine, either individually or in combination with other medicinal ingredients to treat a broad range of disorders. This study also identified compound 5 as potential new antimalarial lead compound.

scholarly journals Alkaloids from some Mongolian medicinal plants

2018 ◽  
pp. 10-20
Author(s):  
Selenge D ◽  
Jamyansan Ya ◽  
Javzan S ◽  
Delegmaa M ◽  
Dumaa M ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Collaborative Work ◽  
Smooth Muscles ◽  
Molecular Structures ◽  
Phytochemical Study ◽  
Total Alkaloids ◽  
Physiologically Active Substances ◽  
Academy Of Sciences ◽  
First Time

The detailed phytochemical study of Mongolian medicinal plants started in 1973, when a Department for a study of physiologically active substances chemistry was established in the Institute of Chemistry, Mongolian Academy of Sciences. We had studied alkaloids of 30 medicinal plant species grown in Mongolia for the first time. According to the study, 320 alkaloids had been isolated and their molecular structures were identified. Among them, 34 alkaloids had been established as natural new com-pounds and all results of the investigation were published in peer-reviewed international journals. Some biological activities of total alkaloids and certain individual compounds had been studied. In accordance with phytochemical and biological activity studies, several products, the cattle weight gain preparation “Targa”, the preparation for the uterus smooth muscles contraction “Alkum”, the anti-diabetic preparation “Dentamon-10”, the expectorant “Stelleriaphytin”, the liver protective and immune-active preparation “Barbadin”, had been obtained on the basis of collaborative work and the products had been introduced in the market. Монгол орны зарим эмийн ургамлын алкалоидын судалгаа Хураангуй: 1973 онд Химийн хүрээлэнд Ургамлын физиологийн идэвхт нэгдлийн химийн тасаг байгуулагдсанаар Монгол орны эмийн ургамлын фитохимийн нарийвчилсан судалгаа хийгдэж эхэлсэн. Бид Монгол орны алкалоидот 30 зүйл эмийн ургамлын алкалоидын судалгааг анх удаа гүйцэтгэн 320 алкалоидыг ялгаж таньж тодорхойлсны дотор өмнө нь байгалаас ялгагдаж байгаагүй 34 шинэ алкалоидыг нээн илрүүлж бүтэц байгуулалтыг тогтоон олон улсын мэрэгжлийн сэтгүүлд хэвлүүлэн үр дүнг баталгаажуулсан. Бид гарган авсан нийлбэр алкалоид ба зарим цэвэр алкалоидуудын биологийн идэвхийг тодорхойлуулсны үр дүнд хамтын бүтээл болох алкалоидод суурилсан малын амьдын жин нэмэгдүүлэгч “Тарга”, савны гилгэр булчин агшаагч “Алькум” бэлдмэлүүд мал эмнэлгийн практикт; Чихрийн шижингийн эсрэг идэвхтэй “Дентамон-10”, цэр ховхлох үйлдэл бүхий “Стеллериафитин”, элэг хамгаалах, дархлаа дэмжигч “Барбадин” бэлдмэлүүд хүн эмнэлгийн практикт тус тус нэвтрэх боломж бүрдсэн. Түлхүүр үгс: хинолизидины алкалоид, изохинолины алкалоид, тропаны алкалоид, стероид алкалоид

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