scholarly journals Alkaloids from some Mongolian medicinal plants

2018 ◽  
pp. 10-20
Author(s):  
Selenge D ◽  
Jamyansan Ya ◽  
Javzan S ◽  
Delegmaa M ◽  
Dumaa M ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Collaborative Work ◽  
Smooth Muscles ◽  
Molecular Structures ◽  
Phytochemical Study ◽  
Total Alkaloids ◽  
Physiologically Active Substances ◽  
Academy Of Sciences ◽  
First Time

The detailed phytochemical study of Mongolian medicinal plants started in 1973, when a Department for a study of physiologically active substances chemistry was established in the Institute of Chemistry, Mongolian Academy of Sciences. We had studied alkaloids of 30 medicinal plant species grown in Mongolia for the first time. According to the study, 320 alkaloids had been isolated and their molecular structures were identified. Among them, 34 alkaloids had been established as natural new com-pounds and all results of the investigation were published in peer-reviewed international journals. Some biological activities of total alkaloids and certain individual compounds had been studied. In accordance with phytochemical and biological activity studies, several products, the cattle weight gain preparation “Targa”, the preparation for the uterus smooth muscles contraction “Alkum”, the anti-diabetic preparation “Dentamon-10”, the expectorant “Stelleriaphytin”, the liver protective and immune-active preparation “Barbadin”, had been obtained on the basis of collaborative work and the products had been introduced in the market. Монгол орны зарим эмийн ургамлын алкалоидын судалгаа Хураангуй: 1973 онд Химийн хүрээлэнд Ургамлын физиологийн идэвхт нэгдлийн химийн тасаг байгуулагдсанаар Монгол орны эмийн ургамлын фитохимийн нарийвчилсан судалгаа хийгдэж эхэлсэн. Бид Монгол орны алкалоидот 30 зүйл эмийн ургамлын алкалоидын судалгааг анх удаа гүйцэтгэн 320 алкалоидыг ялгаж таньж тодорхойлсны дотор өмнө нь байгалаас ялгагдаж байгаагүй 34 шинэ алкалоидыг нээн илрүүлж бүтэц байгуулалтыг тогтоон олон улсын мэрэгжлийн сэтгүүлд хэвлүүлэн үр дүнг баталгаажуулсан. Бид гарган авсан нийлбэр алкалоид ба зарим цэвэр алкалоидуудын биологийн идэвхийг тодорхойлуулсны үр дүнд хамтын бүтээл болох алкалоидод суурилсан малын амьдын жин нэмэгдүүлэгч “Тарга”, савны гилгэр булчин агшаагч “Алькум” бэлдмэлүүд мал эмнэлгийн практикт; Чихрийн шижингийн эсрэг идэвхтэй “Дентамон-10”, цэр ховхлох үйлдэл бүхий “Стеллериафитин”, элэг хамгаалах, дархлаа дэмжигч “Барбадин” бэлдмэлүүд хүн эмнэлгийн практикт тус тус нэвтрэх боломж бүрдсэн. Түлхүүр үгс: хинолизидины алкалоид, изохинолины алкалоид, тропаны алкалоид, стероид алкалоид

scholarly journals Phytochemical Study of Stem and Leaf of Clausena lansium

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3124 ◽  
Author(s):  
Wenwen Peng ◽  
Xiaoxiang Fu ◽  
Yuyan Li ◽  
Zhonghua Xiong ◽  
Xugen Shi ◽  
...  
Keyword(s):  
Biological Activities ◽  
Healthcare Systems ◽  
Water Soluble ◽  
Phytochemical Analysis ◽  
Phytochemical Study ◽  
Spectroscopic Analyses ◽  
First Time ◽  
Local Healthcare ◽  
Carbazole Alkaloids ◽  
Aromatic Glycoside

Clausena lansium Lour. Skeels (Rutaceae) is widely distributed in South China and has historically been used as a traditional medicine in local healthcare systems. Although the characteristic components (carbazole alkaloids and coumarins) of C. lansium have been found to possess a wide variety of biological activities, little attention has been paid toward the other components of this plant. In the current study, phytochemical analysis of isolates from a water-soluble stem and leaf extract of C. lansium led to the identification of 12 compounds, including five aromatic glycosides, four sesquiterpene glycosides, two dihydrofuranocoumarin glycosides, and one adenosine. All compounds were isolated for the first time from the genus Clausena, including a new aromatic glycoside (1), a new dihydrofuranocoumarin glycoside (6), and two new sesquiterpene glycosides (8 and 9). The phytochemical structures of the isolates were elucidated using spectroscopic analyses including NMR and MS. The existence of these compounds demonstrates the taxonomic significance of C. lansium in the genus Clausena and suggests that some glycosides from this plant probably play a role in the anticancer activity of C. lansium to some extent.

scholarly journals Phytochemical Study and Biological Activities of Two Medicinal Plants used in Burkina Faso: Lannea velutina A. Rich (Anacardiaceae) and Ximenia americana L. (Olacaceae)

2019 ◽  
pp. 1-9 ◽  
Author(s):  
Dramane Pare ◽  
Jotham Yhi-pênê N’do ◽  
Samson Guenne ◽  
Mahamadi Nikiema ◽  
Adama Hilou
Keyword(s):  
Antimicrobial Activity ◽  
Medicinal Plants ◽  
Burkina Faso ◽  
Bacterial Infections ◽  
Biological Activities ◽  
Public Health Problem ◽  
Bacterial Strains ◽  
Phytochemical Study ◽  
Ximenia Americana ◽  
Study Laboratory

Background: Bacterial infections are at the origin of a number of serious pathologies, including meningitis, bronchopneumopathies, typhoid fever and especially diarrhea, which are still a real public health problem for the child population in developing countries. In most of these countries, people use medicinal plants for primary health care. The objective of this study was to determine the content of phenolic compounds, the antioxidant and antimicrobial activity of extracts from two plants used in traditional medicine in Burkina Faso, Lannea velutina and Ximenia americana. Place and Duration of Study: Laboratory of Biochemistry and Applied Chemistry (LABIOCA). Methods: The total phenolics and flavonoid content of the ethanolic extract extracts were determined by spectrometric assay. The DPPH and FRAP method were used to measure the antioxidant capacity of the extracts. The antibacterial potential was determined on five bacterial strains. Results: The ethanolic extracts of Lannea velutina showed the best polyphenol content with 969.67±8.23 ​​mgGAE/g extract against 753.145917±66.31 mgGAE/g extract for Ximenia americana. On the DPPH radical Ximenia americana gave the best activity with a percentage inhibition of 62.32±0.17% compared to Lannea velutina. This species also gave the best reducing activity with a reducing capacity of 3.45±0.97 mmol EAA/10 g of extract. Shigella dysenteria and Staphylococcus aureus were susceptible to Lannea velutina and Ximenia americana with inhibition diameters greater than 8 mm. Conclusion: These results showed that the extract has good antioxidant potential as well as antimicrobial activity. These extracts could be used to prevent damage from oxidative stress and infections.

scholarly journals Phytochemical study of Jurinea mongolica Maxim

2018 ◽  
pp. 53-58
Author(s):  
Dumaa M ◽  
Margit Gruner ◽  
Luebkim Tilo ◽  
Solongo T ◽  
Chunsriimyatav G ◽  
...  
Keyword(s):  
Petroleum Ether ◽  
Mass Spectrometer ◽  
2D Nmr ◽  
Molecular Structures ◽  
Phytochemical Study ◽  
Aerial Parts ◽  
First Time

There are hispidulin, quercetin-3-О-rutinoside, lupeol, taraxasterol, β-sitosterolwere isolated from the ethylacetate, n-buthanol and petroleum ether fractions of the aerial parts of Jurinea mongolica Maxim. grown in Mongolia. Molecular structures of these compounds were elucidated by using TLC, CC, IR, Mass spectrometer and 1H, 13C and 2D NMR (HSQC, HMBC, 1H-1H COSY, NOESY) methods. All of these compounds were isolated from the Mongolian J. mongolica for the first time. Монгол чоногоно (Jurinea mongolica Maxim.) ургамлын фитохимийн судалгаа Манай орны унаган ургамалд багтдаг Монгол чоногоно (Jurinea mongolica Maxim.) ургамлын газрын дээд хэсгийн этилацетат, н-бутанол, петролейний эфирийн фракцаас гиспидулин, кверцетин-3-О-рутинозид, тараксастерол, лупеол, β-ситостерол бодисыг химийн цэвэр төлөв байдлаар ялгав. Тэдгээр бодисын молекулын бүтэц байгууламжийг НУТ, масс спектрометр, хроматомасс спектроскоп, 1Н ПСР, 13С болон хоѐр хэмжээст ЦСР-ын спектроскопын аргаар таньж тодорхойлов. Судалгааны дүнд 2 фенолт нэгдэл, 2 тритерпен, 1 стеролын төрлийн бодисыг энэ зүйл ургамлаас анх удаа олсон нь шинжлэх ухааны шинэ мэдээлэл болов. Түлхүүр үгс: Монгол чоногоно, Нийлмэл цэцэгтэн, фенолт нэгдэл, тритерпен, стерол

scholarly journals Phytochemical and Biological Activity Studies of the Bhutanese Medicinal Plant Corydalis crispa

2012 ◽  
Vol 7 (5) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Phurpa Wangchuk ◽  
Paul A. Keller ◽  
Stephen G. Pyne ◽  
Thanapat Sastraruji ◽  
Malai Taweechotipatr ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Multidrug Resistant ◽  
Scientific Basis ◽  
Phytochemical Study ◽  
Nmr Data ◽  
Tnf Α ◽  
First Time ◽  
Multidrug Resistant Strain

The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for 2 and 3 provided here for the first time. Crude extracts exhibited significant anti-inflammatory (p<0.01) activity against TNF- α production in LPS activated THP-1 cells. The acetylcholinesterase inhibitory activity of compounds 2, 4 and 7 and the antiplasmodial activity of compound 5 against P. falciparum strains TM4/8.2 and K1CB1 (multidrug resistant strain) are reported here for the first time. Stylopine (4) did not show antimalarial activity against the K1CB1 strain in contrast to a previous report. This study generated a scientific basis for the use of this plant in Bhutanese traditional medicine, either individually or in combination with other medicinal ingredients to treat a broad range of disorders. This study also identified compound 5 as potential new antimalarial lead compound.

scholarly journals Phytochemical Investigation and Antioxidant Effects of Different Solvent Extracts of Pterocephalus Nestorianus Nab. Growing in Kurdistan Region-Iraq

2018 ◽  
Vol 6 (1) ◽  
pp. 21
Author(s):  
Fuad O. Abdullah ◽  
Faiq H.S. Hussain ◽  
Lucia Cucca ◽  
Giovanni Vidari
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Kurdistan Region ◽  
Oral Diseases ◽  
Phytochemical Study ◽  
Phytochemical Investigation ◽  
First Time ◽  
Antioxidant Effects

The medicinal plants have been used as a herbal tradition in Kurdistan. Most of the medicinal plants are still not investigated from a phytochemical and biological activity. Therefore, different solvent extraction carried out to study phytochemicals and antioxidant activity of Pterocephalus nestorianus Nab. Through this research, it is reported for the first time that the phytochemicals and antioxidant activity on P.  nestorianus Nab. collected at Safeen Mountain in Erbil-Iraq, which was known as a Lawa in Kurdistan. It is used against inflammation and oral diseases. The phytochemical study of four extracts (Hexane, ethyl acetate, methanol and methanol 70%) of P. nestorianus flowers, leaves and roots revealed that it contains rich phytochemical composition. C4H8O2 and CH3OH extracts of P. nestorianus showed a high radical scavenging activity compared with trihydroxy benzoic acid as a standard. The flavonoid and phenolic presence showed strong correlation with the antioxidant activity. 

scholarly journals Chemical Constituents and Biological Activities of the Aerial Parts of Cyperus rotundus (Cypereaceae)

2021 ◽  
Vol 33 (8) ◽  
pp. 1935-1940
Author(s):  
Abdoulaye Hamidou ◽  
Jean Momeni ◽  
Isaac Silvère Gade ◽  
Alfred Ngenge Tamfu ◽  
Emmanuel Talla ◽  
...  
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Cyperus Rotundus ◽  
Antidiabetic Activity ◽  
Phytochemical Study ◽  
Antioxidant Power ◽  
Aerial Parts ◽  
Ferric Reducing Antioxidant Power ◽  
First Time

The present study reports the chemical constituents, antioxidant, anticonvulsant and α-amylase activities of the aerial part of Cyperus rotundus collected in Cameroon. Phytochemical study leads to the isolation of six known compounds alongwith lupeol (1), stigmasterol (2), tetracosanoic acid (3), a mixture of β-sitosterol (4a) and stigmasterol (4b), ursolic acid (5) and saikogenin F (6). Compounds 3, 5 and 6 were isolated for the first time from this species. The structures of these compounds were determined using spectroscopic analysis including 1D and 2D NMR, mass spectrometry and comparison with the literature data. Biological activities carried out on the extracts showed that the methanol extract exhibited good antiradical scavenging activity against DPPH radical (IC50 = 2.873 μg/mL) and very good ferric reducing antioxidant power (FRAP) (IC50 = 7.535 μg/mL). It appeared that the mixture of hexane and ethyl acetate extract at the dose 100 mg/kg protected 66% of mice against convulsion induced by the pentylenetetrazol and 50% of protection when using picrotoxin at the same dose. All the extracts and compounds from this plant showed no inhibition against α-amylase related to antidiabetic activity.

scholarly journals Digital Corpora and their Applications in Semantic Studies and Lexicography

2015 ◽  
pp. 353-367
Author(s):  
Ludmila Dimitrova ◽  
Violetta Koseska–Toszewa
Keyword(s):  
Collaborative Work ◽  
Significant Part ◽  
Polish Academy ◽  
Digital Resources ◽  
Bulgarian Academy ◽  
Comparable Corpora ◽  
Academy Of Sciences ◽  
First Time ◽  
Slavic Studies

Digital Corpora and their Applications in Semantic Studies and LexicographyThe paper describes the first Bulgarian-Polish digital resources — parallel and comparable corpora, and their applications in the semantic studies and lexicography for creation of Bulgarian-Polish digital dictionary, a significant part of these bilingual resources. Some examples show how valuable the links between the bilingual aligned corpus and the digital dictionary are. The first Bulgarian-Polish digital resources are the main result of collaborative work between the Institute of Mathematics and Informatics of the Bulgarian Academy of Sciences (IMI-BAS) and the Institute of Slavic Studies of the Polish Academy of Sciences (ISS-PAS), established for the first time in 2006.

Dwindling status of Epimedium Elatum (Morren & Decne) and its geographical distribution in Kashmir Himalaya, India

2018 ◽  
pp. 47-52
Keyword(s):  
Medicinal Plant ◽  
Biological Activities ◽  
Conservation Status ◽  
Natural Populations ◽  
Culture Techniques ◽  
Kashmir Himalayas ◽  
Near Future ◽  
First Time ◽  
Tissue Culture Techniques

Epimedium elatum (Morren & Decne) of family Berberidaceace is a rare perennial medicinal plant, endemic to high altitude forests of Northwestern Himalayas in India. Ethnobotanically, it has been used as an ingredient for treatment of bone-joint disorders, impotence and kidney disorders in Kashmir Himalayas. Phytochemically, it is rich in Epimedin ABC and Icariin; all of these have been demonstrated to possess remarkable biological activities like PDE-5 inhibition (treatment of erectile dysfunction), anticancer, antiosteoporosis antioxidant and antiviral properties. The present investigation reports its traditional usage, comprehensive distribution and conservation status from twenty ecogeographical regions in Kashmir Himalayas, India. The species was reported from Gurez valley for the first time. Numerous threats like excessive grazing, deforestration, habitat fragmentation, tourism encroachment, landslides and excessive exploitation have decreased its natural populations in most of the surveyed habitats. Consequently, its existence may become threatened in near future if timely conservation steps are not taken immediately by concerned stakeholders involved in medicinal plant research. Moreover, use of plant tissue culture techniques is recommended for development of its in vitro propagation protocols. Therefore, introduction of this medicinal plant in botanical gardens, protected sites and development of monitoring programmes are needed for its immediate conservation in Northwestern Himalayas, India.

ABEL PRIZE AS THE FLAGSHIP OF WORLD MATH ADVANCES

2020 ◽  
pp. 57-71
Author(s):  
Nataliya V. Grishina ◽  
Keyword(s):  
Great Britain ◽  
Nobel Prize ◽  
Historical Background ◽  
Famous Scientist ◽  
International Authority ◽  
Academy Of Sciences ◽  
First Time

The annual prize, awarded by the Norwegian Academy of Sciences, bears the name of the famous scientist Niels-Henrik Abel and has a reputation as a Nobel Prize for mathematicians, with its size in terms of money of about $1 million. Since Alfred Nobel, in his will, determined the range of scientific areas for the payment of bonuses that did not include mathematics, the Norwegian mathematician Sofus Lee at the end of his life devoted all his efforts and his international authority to create a foundation for awarding prizes to mathematicians. He wanted to give the award the name of Niels Henrik Abel, also a Norwegian mathematician. The article presents a historical background for the formation of the Abel Prize. The winners of the main mathematical prize for all the years of its existence and their major achievements are shown. Among laureates of the Abel Prize there are outstanding scientists from 11 countries: France, Great Britain, Lebanon, USA, Hungary, Sweden, India, Belgium, Russia, Canada and Israel. Three times the prize was at once awarded to two scientists. And in 2019, for the first time ever the woman – Karen Keskalla Uhlenbeck – professor, American mathematician, became the winner of the prestigious mathematics award.

Root with Alternation of -ravn-/-rovn- (From Materials of the Academic Description of Russian Spelling)

2020 ◽  
Vol 81 (6) ◽  
pp. 90-96
Author(s):  
E. V. Arutiunova ◽  
E. V. Beshenkova ◽  
O. E. Ivanova
Keyword(s):  
Russian Language ◽  
Study Guides ◽  
Russian Academy Of Sciences ◽  
Academy Of Sciences ◽  
The Given ◽  
First Time ◽  
The Russian Language

The study investigates the rule of spelling the root -ravn-/-rovn- and is considered to be a fragment of the academic description of Russian spelling, which is currently being under investigation at the Russian Language Institute of the Russian Academy of Sciences. The authors clarify the meanings that determine the spelling of the unstressed root, supplement the lists of exceptions, denote words with meanings not corresponding to the given values-criteria, and, for the first time in linguistics, investigate the words that can be correlated with different values-criteria, that is, they have double motivation. The rule codifies the spelling of words that have double motivation and fluctuate in usus, dictionaries, study guides and reference books. Spelling recommendations for these words correspond to the current linguistic norm and were approved by the Spelling Commission of the Russian Academy of Sciences in 2019. The linguistic commentary to the rule contains the most significant etymological facts concerning the root -ravn-/-rovn- and summarises the scientific and methodological attempts to figure out the distribution of vocabulary with root -ravn-/-rovn- based on the meanings selected in the spelling rules. In the paper it is shown that the instability in spelling of various verbs with the root -ravn-/-rovn- in modern writing and dictionaries is determined by the double motivation of words, as well as contradictory recommendations and gaps in the rules.

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