Recent Advances in Nanotechnology based Tubercular Chemotherapy

2015 ◽  
Vol 8 (3) ◽  
pp. 2979-2994
Author(s):  
Harish Dureja ◽  
Sunil Khatak
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Effective Drug ◽  
Prolonged Treatment ◽  
Multi Drug Resistance ◽  
Second Line ◽  
Drug Bioavailability ◽  
Solid Lipid

Tuberculosis (TB) is a more prevalent granulomatos bacterial infection, which remains the world’s second most common cause of death due to infections of Mycobacterium tuberculosis (M.Tuberculosis). A number of characteristics of mycobacterium makes there disease chronic and necessitate prolonged treatment. The emergence of multi-drug-resistance (MDR) stains of M.Tuberculosis makes its necessary for the development of effective combinations of either first-line or second-line drugs or discovery of new safe and effective drug molecules and also implements other modalities of treatment. A number of novel carrier-based drug delivery systems incorporating the traditional and newer anti-tubercular agents have been shown incredible promise to target the site of action, reduce dosing frequency and enhance drug bioavailability with the objective of improving patient compliance. Nanoparticulate system have unique and comparatively more effective drug delivery carriers, including liposomal-mediated drug delivery, polymeric nanoparticles/microparticles, solid lipid nanoparticles, nanosuspensions, nanoemulsions, niosomes, dendrimers, Metal/cyclodextrin inclusion complexes and other nanosystems exploiting the extraordinary properties of matter at the nanoscale. Nanoparticles shown significant improvements in diagnosis, treatment and prevention and provide the flexibility of selecting the invasive and non-invasive route of delivery for chemotherapy of tuberculosis. This manuscript have been made to highlight and overviews the present WHO estimated burden of tuberculosis globally, recent discovery of safe and effective newer anti-tubercular drug moleculesfor MDR and XDR tuberculosis, first and second line anti-tubercular drugs loaded novel nanoparticle carriers for chemotherapy and development of solid lipid nanoparticles as an alternative drug carriers for tubercular chemotherapy.  

scholarly journals Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Smart Drug Delivery Systems in the Treatment of Glioblastoma Multiforme

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 860
Author(s):  
Raneem Jnaidi ◽  
António José Almeida ◽  
Lídia M. Gonçalves
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Tumor Location ◽  
Delivery Systems ◽  
Nanostructured Lipid Carriers ◽  
Solid Lipid

Glioblastoma multiforme (GBM) is the most common and malignant type of brain tumor. In fact, tumor recurrence usually appears a few months after surgical resection and chemotherapy, mainly due to many factors that make GBM treatment a real challenge, such as tumor location, heterogeneity, presence of the blood-brain barrier (BBB), and others. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) represent the most promising carriers for therapeutics delivery into the central nervous system (CNS) owing to their inherent ability to cross the BBB. In this review, we present the main challenges in GBM treatment, a description of SLNs and NLCs and their valuable role as drug carriers in GBM treatment, and finally, a detailed description of all modification strategies that aim to change composition of SLNs and NLCs to enhance treatment outcomes. This includes modification of SLNs and NLCs to improve crossing the BBB, reduced GBM cell resistance, target GBM cells selectively minimizing side effects, and modification strategies to enhance SLNs and NLCs nose-to-brain delivery. Finally, future perspectives on their use are also be discussed, to provide insight about all strategies with SLNs and NLCs formulation that could result in drug delivery systems for GBM treatment with highly effective theraputic and minimum undesirable effects.

scholarly journals Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4781
Author(s):  
Van-An Duong ◽  
Thi-Thao-Linh Nguyen ◽  
Han-Joo Maeng
Keyword(s):  
Drug Delivery ◽  
Process Parameters ◽  
Solid Lipid Nanoparticles ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Nanostructured Lipid Carriers ◽  
Solvent Injection ◽  
Injection Method ◽  
Solid Lipid ◽  
Injection Process

Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as potential drug delivery systems for various applications that are produced from physiological, biodegradable, and biocompatible lipids. The methods used to produce SLNs and NLCs have been well investigated and reviewed, but solvent injection method provides an alternative means of preparing these drug carriers. The advantages of solvent injection method include a fast production process, easiness of handling, and applicability in many laboratories without requirement of complicated instruments. The effects of formulations and process parameters of this method on the characteristics of the produced SLNs and NLCs have been investigated in several studies. This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method. We summarize recent development in SLNs and NLCs production using this technique. In addition, the effects of solvent injection process parameters on SLNs and NLCs characteristics are discussed.

scholarly journals Solid Lipid Nanoparticles: A Brief Review

2021 ◽  
pp. 368-385
Author(s):  
Amol Giri ◽  
Aijaz Sheikh ◽  
P R Tathe ◽  
G R Sitaphale ◽  
K R Biyani
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Surfactant Solution ◽  
Lipid Nanoparticles ◽  
Drug Bioavailability ◽  
New Approach ◽  
Pharmaceutical Ingredients ◽  
Advantages And Disadvantages ◽  
Solid Lipid ◽  
Novel Drug

In this present review this new approach of solid lipid Nanoparticles (SLNs) is discussed in terms of their aims, advantages, and disadvantages, methods of preparation, characterization and special features. In the state of developments in the research and development of new drug delivery systems have been made in Last decade by resolving various disorders, such as Low Drug Bioavailability and unpredictable gastric emptying era. Most of the active pharmaceutical ingredients are under poor bioavailability and also their solubility. By using the nanotechnology to overcome this problems of novel drug delivery system. The main advantage of nanotechnology i.e. solid lipid Nanoparticles increases the bioavailability and elimination biological half-life of the drugs. Solid lipid Nanoparticles are spherical lipid particles ranging in size from 1 to 1000 nm and are dispersed in water or in aqueous surfactant solution.

Expanding opportunities in treatment of leukemia by solid lipid nanoparticles

2020 ◽  
Vol 17 ◽  
Author(s):  
Prarthna Yadav ◽  
Harshita Mishra ◽  
Manju Nagpal ◽  
Geeta Aggarwal
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Multi Drug Resistance ◽  
Solid Lipid ◽  
Nano Drug Delivery ◽  
Toxicity Of Drugs ◽  
Severe Type

Background: Leukemia is a severe type of blood cancer that involves an abnormal proliferation of blood-forming cells. Its conventional treatment faces many challenges, including resistance, lack of specificity and high unwanted toxicity of drugs. Nano drug delivery systems help in overcoming these challenges by delivering the drug to the target site actively or passively. Solid lipid nanoparticles are gaining popularity because they reduce unwanted toxicity, are biocompatible, increase bioavailability and are versatile in terms of incorporated agents (hydrophilic as well as lipophilic drugs, genes, enzymes, etc.). Purpose: The aim of this review is to discuss recent advancements in anti-leukemic therapy utilizing Solid lipid nanoparticles (SLNs) as successful carriers in enhancing efficiency of the treatment and bioavailability of the incorporated drug along with overcoming multi drug resistance. Methods: This review represents the existing literature on the applications of SLNs in anti-leukemic therapy. A qualitative literature review has been done for this purpose. We performed keyword research in popular databases such as Google Scholar, Wiley, Elsevier, Scopus, Google patent and PubMed. Only articles published in English and from reputed journals from specific fields were considered. Benchmark studies having major importance from 2000 to 2020 were selected to follow the progress in the field across the globe. Results: This article improves the understanding of role of SLNs in treatment of leukemia. Traditional anti-leukemic therapy involves many challenges, including resistance, lack of specificity and high unwanted toxicity of drugs. SLNs are emerging as a better alternative to conventional delivery systems as they can reduce unwanted toxicity, are biocompatible, and can provide active as well as passive molecular targeting. Conclusion: SLNs provide several advantages in drug delivery for leukemia including enhancement of efficiency and bioavailability and reduction of toxicity by virtue of their small size, lipid core, non-dependency on organic solvents and versality in terms of incorporated drugs.

scholarly journals Solid Lipid Nanoparticles (SLN): Method, Characterization and Applications

2012 ◽  
Vol 1 (11) ◽  
pp. 384-393 ◽  
Author(s):  
Akanksha Garud ◽  
Deepti Singh ◽  
Navneet Garud
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Clinical Medicine ◽  
Drug Carriers ◽  
Pharmaceutical Journal ◽  
Lipid Nanoparticles ◽  
Conventional Chemotherapy ◽  
Solid Lipid ◽  
Potential Applications ◽  
Alternative Routes

Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Proteins and antigens intended for therapeutic purposes may be incorporated or adsorbed onto SLN, and further administered by parenteral routes or be alternative routes such as oral, nasal and pulmonary. The obstacles associated with conventional chemotherapy may be partially overcome by encapsulating them as SLN. The present review focuses on the utility of SLN in terms of their advantages, production methodology, characterization and applications. If properly investigated, SLNs may open new vistas in therapy of complex diseases.DOI: http://dx.doi.org/10.3329/icpj.v1i11.12065 International Current Pharmaceutical Journal 2012, 1(11): 384-393

Challenges in oral drug delivery and applications of lipid nanoparticles as potent oral drug carriers for managing cardiovascular risk factors

2020 ◽  
Vol 21 ◽  
Author(s):  
Neslihan Üstündağ Okur ◽  
Panoraia I. Siafaka ◽  
Evren Homan Gökçe
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Risk ◽  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Oral Drug Delivery ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Nanostructured Lipid Carriers ◽  
Oral Drug ◽  
Solid Lipid

Background: The oral application of drugs is the most popular route through which the systemic effect can be achieved. Nevertheless, oral administration is limited by difficulties related to physicochemical properties of the drug molecule, including low aqueous solubility, instability, low permeability, and rapid metabolism, all of which result in low and irregular oral bioavailability. Objective: The enhancement of oral bioavailability of drug molecules with such properties could lead to extreme complications in drug preparations. Oral lipid based nanoparticles seems to possess extensive advantages due to their ability to increase the solubility, simplifying intestinal absorption and decrease or eradicate the effect of food on the absorption of low soluble, lipophilic drugs and therefore improving the oral bioavailability. Method: The present review provides a summary of the general theory of lipid based nanoparticles, their preparation methods as well as their oral applications. Moreover, the oral drug delivery challenges are discussed. Results: According to this review, the most frequent types of lipid-based nanoparticle, the solid lipid nanoparticles and nanostructured lipid carriers are potent oral carriers due to their ability to penetrate the oral drug adsorption barriers. Moreover, such lipid nanoparticles can be beneficial drug carriers against cardiovascular risk disorders as diabetes, hypertension etc. Conclusion: In this review, the most current and promising studies involving Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as oral drug carriers are reported aiming to assist researchers who focus their research on lipid based nanoparticles.

scholarly journals SOLID LIPID NANOPARTICLES (SLNs) AS NANO DRUG DELIVERY CARRIERS: PREPARATION, CHARACTERIZATION AND APPLICATION

2019 ◽  
pp. 1-9
Author(s):  
MONA QUSHAWY ◽  
ALI NASR
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Colloidal Particles ◽  
Drug Carrier ◽  
Physical Stability ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Colloidal Dispersion ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Over the last few years, there has been a significant consideration of solid lipid nanoparticles (SLNs) as an alternative method to other colloidal dispersion methods for drug delivery. Special consideration has been given to the use of SLNs as a drug carrier in recent years. SLNs are aqueous dispersions in which the colloidal particles consist of solid lipids that are biodegradable. As a result of their physical stability, the protection of the entrapped drug from decomposition, the provision of controlled drug release, and the exceptional acceptability, SLNs have several advantages over other drug carriers. This article focuses on the techniques of SLNs preparation and characterization, the effect of formulation variables on SLNs properties, the routes of administration, and the pharmaceutical applications. The data used for this review was collected by searching on Google Scholar and PubMed using the following keywords during the period from 2010 to date.

Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

2009 ◽  
Vol 1 (1) ◽  
Author(s):  
Pravin Patil ◽  
Anil Sharma ◽  
Subhash Dadarwal ◽  
Vijay Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Rotation Speed ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Brain Penetration ◽  
Solid Lipid ◽  
Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

Solid Lipid Nanoparticles: A Promising Drug Delivery Technology

2009 ◽  
Vol 2 (2) ◽  
pp. 509-516
Author(s):  
S. Pragati ◽  
S. Kuldeep ◽  
S. Ashok ◽  
M. Satheesh
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Large Scale ◽  
Colloidal Particles ◽  
Scale Up ◽  
Lipid Nanoparticles ◽  
Scale Production ◽  
Research Activity ◽  
New Approach ◽  
Solid Lipid

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.

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