scholarly journals Synthesis of New Naphthyl Aceto Hydrazone-Based Metal Complexes: Micellar Interactions, DNA Binding, Antimicrobial, and Cancer Inhibition Studies

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1044
Author(s):  
Fawad Ahmad ◽  
Muneera D. F. Alkahtani ◽  
Muhammad Babar Taj ◽  
Afnan M. Alnajeebi ◽  
Seraj Omar Alzahrani ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Sodium Stearate ◽  
Critical Micellar Concentration ◽  
Dna Interaction ◽  
Fungal Strains ◽  
Hela Cell Lines ◽  
Ft Ir ◽  
Free Energy Of Micellization ◽  
Inhibition Studies ◽  
Cancer Inhibition

In the present study, naphthyl acetohydrazide (HL) ligand was prepared and used for the synthesis of new six amorphous transition metal (Co(II), Ni(II), Cu(II), Zn(II), Pb(II), Cd(II)) complexes. All the compounds were characterized by elemental analysis, UV-vis, FT-IR, 1H- and 13C-NMR, and Matrix-Assisted Laser Desorption Ionization (MALDI). The solubilization study was carried out by estimating the interaction between the metal complexes with surfactants viz. sodium stearate (SS) and Cetyltrimethylammonium bromide (CTAB). UV-Visible spectroscopy was employed to determine partitioning and binding parameters, whereas electrical conductivity measurements were employed to estimate critical micellar concentration (CMC), the extent of dissociation, and free energy of micellization. The CT-DNA interaction of synthesized compounds with DNA represents the major groove binding. The synthesized ligand and metal complexes were also tested against bacterial and fungal strains and it has been observed that Cu(II) complex is active against all the strains except Candida albicans, while Cd(II) complex is active against all bacterial and fungal strains except Pseudomonas. Among all compounds, only the Pd(II) complex shows reasonable activity against cervical cancer HeLa cell lines, representing 97% inhibition.

New Ferrocene-Integrated Multifunctional Guanidine Surfactants: Synthesis, Spectroscopic Elucidation, DNA Interaction Studies, and DFT Calculations

2021 ◽  
Author(s):  
Sameen Nawaz ◽  
Faiza Asghar ◽  
Jahangeer Patujo ◽  
Saira Fatima ◽  
Babar Murtaza ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Atomic Absorption ◽  
Absorption Spectroscopy ◽  
13C Nmr ◽  
Atomic Absorption Spectroscopy ◽  
Analytical Methods ◽  
Dna Interaction ◽  
Interaction Studies ◽  
Ft Ir

Three new ferrocene-substituted aliphatic guanidines were successfully synthesized and well characterized by means of several analytical methods such as: FT-IR, 1H & 13C-NMR, Raman, atomic absorption spectroscopy (AAS), and elemental...

Catalytic properties of plate-like cadmium oxide nanoparticles in removal of sulfathiazole with anticancer activity

2018 ◽  
Vol 41 (3-4) ◽  
pp. 121-128 ◽  
Author(s):  
Leila Hoseini ◽  
Azar Bagheri
Keyword(s):  
Binding Constant ◽  
Cadmium Oxide ◽  
Reaction Times ◽  
Dna Interaction ◽  
New Drugs ◽  
Binding Modes ◽  
Hyperchromic Effect ◽  
Initial Ph ◽  
Ft Ir ◽  
Spectroscopy Studies

Abstract The study of the interaction of drugs with DNA is very exciting and significant not only for understanding the mechanism of the interaction but also for the design of new drugs. Here, we report the results of Fourier transform infrared (FT-IR) and ultraviolet (UV)-visible spectroscopy studies to determine the external binding modes of sulfathiazole (STZ), and the binding constant and stability of the STZ-DNA complex in aqueous solution. The results of absorption spectra showed that the interaction of STZ-DNA is weak because there is only a hyperchromic effect. A hyperchromic effect reflects the corresponding changes of DNA in its conformation and structure after the drug-DNA interaction has occurred. Spectroscopic evidence revealed that STZ binds DNA with an overall binding constant of K (STZ-DNA)=0.42×103 m−1. FT-IR spectroscopy showed that the complexation of STZ with DNA occurred via A-T and PO2 groups. Nano cadmium hydroxide has been synthesized using hexamine as the template at room temperature. Then, this nano cadmium hydroxide recrystallizes into nano cadmium oxide (CdO) at 400°C for 2 h. The product was characterized by using X-ray diffraction and scanning electron microscopy. The presence of drugs in aquatic media has emerged in the last decade as a new environmental risk. The other aim of this study was to investigate the degradation of the STZ antibiotic by nanosized CdO under ultraviolet irradiation. Various experimental parameters, such as initial CdO concentration, initial pH, and reaction times, were investigated. According to the results, this method has a good performance in the removal of STZ.

scholarly journals PHYSICAL CHEMICAL STUDIES OF THE SURFACTANT DILAURYLDIMETHYLAMMONIUM BROMIDE (DLDMAB): AGGREGATION AND CATALYTIC PROPERTIES

2009 ◽  
Vol 17 (17) ◽  
pp. 21-32
Author(s):  
Elizabeth Fatima de Souza ◽  
Silvia Dani ◽  
Lavinel G. IONESCU
Keyword(s):  
Thermodynamic Parameters ◽  
Catalytic Properties ◽  
Activation Parameters ◽  
Critical Micellar Concentration ◽  
Physical Chemical ◽  
Chemical Studies ◽  
Diphenyl Phosphate ◽  
C 32 ◽  
Free Energy Of Micellization ◽  
Hydrolysis Of

The micellization of dilauryldimethylammonium bromide (DLDMAB) in water was studied by using surface tension measurements. The critical micellar concentration (CMC) was determined at 25°C, 32°C and 40°C and thermodynamic parameters such as the free energy of micellization (∆G°mic), enthalpy (∆H°mic), and entropy (∆S°mic) of micellization were measured. The CMC at 25°C was 4.93 x 10-5 M and the corresponding values of the thermodynamic parameters were: ∆G°mic = -5.87 kcal/mol; ∆H°mic = -1.12 kcal/mol and ∆S°mic = +16.00 e.u. Micelles of the surfactant DLDMAB act as catalysts for the alkaline hydrolysis of p-nitrophenyl diphenyl phosphate (NPDPP) with a maximum catalytic factor of approximately 120 compared to 80 for CTAB. Typical activation parameters measured for 1.00 x 10-3 M surfactant and 0.005 M NaOH were: Ea = 9.7 kcal/mo/; ∆H°≠ = 9.1 kcal/mol; ∆G°≠ = 19.6 kcal/mol and ∆S°≠ = -33.9 e.u. The kinetic results were also analyzed in terms of the pseudo-phase ion-exchange models (PPIE) and showed that the model is applicable to describe the experimental results.

scholarly journals Synthesis and Antibacterial Studies of Novel Phosphorus Ligand 5-(2-diphenylphosphino) phenyl-1,2-dihydro-1,2,4-triazole-3-thione and its Metal Complexes with some Transition Metals

2010 ◽  
Vol 4 (2) ◽  
pp. 37-45
Author(s):  
Matheel D. Al-Sabti ◽  
Ahmed A. H. Al-Amiery ◽  
Thorria R. Marzoog ◽  
Yasmien K. Al-Majedy
Keyword(s):  
Metal Complexes ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Cadmium Complex ◽  
Gram Positive Bacteria ◽  
Visible Spectra ◽  
Number Of Microorganisms ◽  
Ft Ir ◽  
The Stability

This study involves the chemical synthesis of the novel ligand 5-(2-diphenylphosphino) phenyl-1,2-dihydro-1,2,4-triazole-3-thione (DPDTT) by the reaction of 2-diphenylphosphino benzoic acid with absolute ethanol that yield ethyl 2-diphenylphosphino benzoate and by cyclization of this compound with thiosemicarbazide, DPDTT will be produced. The chelating complexes of this ligand with Cr(III), Co(II), Ni(II), Cu(II) and Cd(II) were also prepared and studied. The new complexes were characterized by FT-IR, UV/visible spectra, and room temperature magnetic susceptibility. The stability for the prepared complexes was also measured using the density function theory and it was found that the cadmium complex is the most stable and the chromium complex is the least stable. Free ligand and its metal complexes have been tested in vitro against a number of microorganisms, like gram positive bacteria Staphylococcus aureus and gram negative bacteria E. coli, Proteus vulgaris, Pseudomonas and Klebsiella in order to assess their antimicrobial properties. All complexes showed considerable activity against all the studied bacteria.

scholarly journals Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
K. Savithri ◽  
B. C. Vasantha Kumar ◽  
H. K. Vivek ◽  
H. D. Revanasiddappa
Keyword(s):  
Metal Complexes ◽  
Antimicrobial Activities ◽  
Spectroscopic Studies ◽  
Docking Studies ◽  
Bacterial Strains ◽  
Spectral Techniques ◽  
Light Reduction ◽  
Drug Candidates ◽  
Ft Ir

A bidentate (N- and O-) imine-based ligand (L1) and its metal complexes of types [CuII(L1)2] (C1), [CuII(L1)(Phen)] (C2), [CoIII(L1)2] (C3), and [CoIII(L1)(Phen)] (C4) (L1 = 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol and phen = 1,10-phenanthroline) were synthesized as potential chemotherapeutic drug candidates. The prepared complexes were structurally characterized by spectral techniques (NMR, FT-IR, LC-MS, EPR, and electronic absorption), thermogravimetric analysis (TGA/DTA), magnetic moment, and CHNO elemental analysis. Spectroscopic studies suggested the distorted octahedral structure for all complexes. In vitro bioassay studies include binding and nuclease activities of the ligand and its complexes with target calf thymus- (CT-) DNA were carried out by employing UV-Vis, fluorescence spectroscopy, viscosity, and gel electrophoresis techniques. The extent of binding propensity was determined quantitatively by Kb and Ksv values which revealed a higher binding affinity for C2 and C4 as compared to C1 and C3. In addition, the scavenging superoxide anion free radical (O∙-2) activity of metal complexes was determined by nitroblue tetrazolium (NBT) light reduction assay. Molecular docking studies with DNA and SOD enzyme were also carried out on these compounds. The antimicrobial study has shown that all the compounds are potential antibacterial agents against Gram-negative bacterial strains and better antifungal agents with respect to standard drugs used.

Synthesis and Characterization of Zirconium Metal Complexes Derived from Benzene-1, 4-dicarboxylic acid

2020 ◽  
Vol 42 (6) ◽  
pp. 919-919
Author(s):  
Hafiz Muhammad Arshad Hafiz Muhammad Arshad ◽  
Shazia Khurshid Shazia Khurshid ◽  
Shahzad Sharif Shahzad Sharif ◽  
Muhammad Ali Muhammad Ali ◽  
Muhammad Dilshad Muhammad Dilshad ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Dicarboxylic Acid ◽  
Terephthalic Acid ◽  
Research Work ◽  
Early Developmental Stage ◽  
Practical Applications ◽  
Secondary Building Units ◽  
Ft Ir ◽  
Zirconium Metal

Amongst organo-metallic frameworks (OMFs), the metallic framework having Zirconium metal indicate fascinating structural properties and excellent stability. Such organo-metallic frameworks (OMFs) function as a potential material for practical application. Even though these particular organo-metallic frameworks are in the early developmental stage but considerable advancements have been carried out recently. We studied the characterization of zirconium-based organo-metallic frameworks. We built Zr-based OMFs by four different synthetic ways. Initially, upgraded preparation under green and commercially feasible conditions has been carried out by modifying Zr-OMFs. Zirconium based OMFs having different structures are then classified and explained based on various organic ligands and zirconium-based secondary building units. We have synthesized the zirconium metal complexes; they have been characterized on the bases of FT-IR and CHNS analyzer. FT-IR results show binding of metal with the Benzene-1, 4-dicarboxylic acid [C6H4 (COOH) 2]. Zirconium metal can bind with the organic substances for the construction of a variety of complexes. From my research work, it is concluded that zirconium metal forms a polymeric complex with terephthalic acid. In which oxygen atoms of Terephthalic acid form bridging structure with the zirconium metal. Our study based on a particular type of OMF is likely expected to present guidance for in-depth exploration of OMFs towards practical applications. It is concluded that the metal-organic frameworks (MOFs) of zirconium metal have many applications in the field of chemistry, biology and other numerous fields of science

Comprehensive GC-MS and FT-IR Profiling of Coleus zeylanicus essential oil and investigation of its anti-fungal and anti - oxidant activities

2021 ◽  
Vol 12 (1) ◽  
pp. 636-642
Author(s):  
Lakshmi M ◽  
Nandagopal S
Keyword(s):  
Antioxidant Activity ◽  
Candida Albicans ◽  
Essential Oil ◽  
Malassezia Furfur ◽  
Fungal Strains ◽  
Anti Oxidant ◽  
Ft Ir ◽  
Dpph Scavenging ◽  
Dpph Scavenging Assay ◽  
Anti Fungal

To evaluate the leaf volatile constituents of essential oil of Coleus zeylanicus and evaluate their anti-oxidant and anti-fungal activity. The Chemical composition of Coleus zeylanicus essential oil was determined using GC-MS and FT-IR analytical techniques. The antioxidant activity was evaluated using DPPH scavenging assay. The anti-fungal effect was tested against two potential pathogenic fungal strains - Candida albicans and Malassezia furfur using agar well diffusion method. The essential oil was profiled by the presence of sesquiterpene hydrocarbons 90.67% of their total composition followed by oxygenated monoterpenes and monoterpene hydrocarbons as 5.3% and 2.1% respectively. The GC-MS results showed 14 compounds from Coleus zeylanicus leaf EO representing 98.07% of the total oil composition. The major component was identified as a-Gurjunene (35.94%), a-bisabolol (10.82%) and G-selinene (4.26%). EO showed remarkable antioxidant activity values of IC50 = 59.78± 3.21µg/ml by DPPH scavenging assay. The essential oil showed interesting anti-fungal effects against two pathogenic fungal strains. The most sensible strains to Coleus zeylanicus EO was Malassezia furfur (32.00±0.50mm) compared to that of Candida albicans (15.00±1.25mm). Hence, Coleus zeylanicus EO has potential application against fungal infection and oxidative stress-related diseases. However, further investigations are necessary to isolate and investigate the action mechanism of these bioactive compounds.

Catalytic Reduction Performance of Carboxylated Alginic Acid Derivatives

2021 ◽  
Author(s):  
Raed H. Althomali ◽  
Khalid A. Alamry ◽  
Mahmoud Hussein Abdo ◽  
Shams H. Abdel-Hafez
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Alginic Acid ◽  
Catalytic Reduction ◽  
Organic Dyes ◽  
Reduction Process ◽  
Spectroscopic Techniques ◽  
Reduction Behavior ◽  
Long Time ◽  
Ft Ir

Abstract In this study, the catalytic reduction behavior of carboxylated alginic acid derivatives has been investigated against the harmful organic dyes including Methyl Orange (MO) and Congo Red (CR). Alginic acid was firstly oxidized through an easy addition of KMnO4 as an oxidizing agent. A carboxylated alginic acid (CAA) has been interacted with selected metal ions (Sn, Fe, Ni, and Zr) through coordination bonds at the value of pH = 4 to form the corresponding metal complexes namely: Sn-CAA, Fe-CAA, Ni-CAA and Zr-CAA. The consistency of the coordination was confirmed by several spectroscopic techniques including FT-IR, XRD, SEM, and EDX. The catalytic reduction of these metal ion-based products was carried out against MO and CR in the presence of NaBH4 as a reducing agent under UV irradiation. All catalysts based metal complexes showed enhanced catalytic reduction against CR compared to MO. Among all those mentioned metal complexes Sn-CAA showed the best catalytic reduction of these dyes. The time taken by the Sn-CAA for CR, and MO is 5 and 7min respectively. Ni-CAA was classified as the second efficient product against both dyes, where the reduction process took 20 and 9 min respectively. The other two catalysts took a long time for CR and MO reduction. Zr-CAA showed more than 80 % reduction of only CR dye within 20 min. Whereas, Fe-CAA did not show any significant sign of reduction against both the dyes after the same time. The order of higher catalytic reduction was illustrated as: Sn-CAA > Ni-CAA > Zr-CAA = Fe-CAA.

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