scholarly journals A Supramolecular Photosensitizer System Based on Nano-Cu/ZIF-8 Capped with Water-Soluble Pillar[6]arene and Methylene Blue Host–Guest Complexations

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3878
Author(s):  
Chenhao Hu ◽  
Yueyuan Yu ◽  
Shuang Chao ◽  
Huidan Zhu ◽  
Yuxin Pei ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Combination Therapy ◽  
Fenton Reaction ◽  
Water Soluble ◽  
Low Oxygen ◽  
Non Invasive ◽  
Anti Cancer

Photodynamic therapy (PDT) as a safe, non-invasive modality for cancer therapy, in which the low oxygen and high glutathione in the tumor microenvironment reduces therapeutic efficiency. In order to overcome these problems, we prepared a supramolecular photosensitive system of O2-Cu/ZIF-8@ZIF-8@WP6–MB (OCZWM), which was loaded with oxygen to increase the oxygen concentration in the tumor microenvironment, and the Cu2+ in the system reacted with glutathione (GSH) to reduce the GSH concentration to generate Cu+. It is worth noting that the generated Cu+ can produce the Fenton reaction, thus realizing the combination therapy of PDT and chemodynamic therapy (CDT) to achieve the purpose of significantly improving the anti-cancer efficiency.

Double pH-sensitive Nanotheranostics of Polypeptide Nanoparticle-Encapsulated BODIPY with Both NIR Activated Fluorescence and Enhanced Photodynamic Therapy

2021 ◽  
Author(s):  
Huiping Dang ◽  
Quan Cheng ◽  
Youliang Tian ◽  
Changchang Teng ◽  
Kai Xie ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Intelligent Systems ◽  
Ph Sensitive ◽  
Nir Fluorescence

To achieve accurate fluorescence imaging-guided cancer therapy, intelligent systems with specific responsiveness to the tumor microenvironment need to be designed. Here, we have achieved both enhanced NIR fluorescence and photodynamic...

A HMCuS@MnO2 nanocomplex responsive to multiple tumor environmental clues for photoacoustic/fluorescence/magnetic resonance trimodal imaging-guided and enhanced photothermal/photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (23) ◽  
pp. 12508-12521 ◽  
Author(s):  
Qian Li ◽  
Junjie Ren ◽  
Qiubing Chen ◽  
Weiwei Liu ◽  
Zhigang Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Magnetic Resonance ◽  
Tumor Microenvironment ◽  
Combination Therapy ◽  
Surface Functionalization ◽  
Multiple Tumor

Surface functionalization of HMCuS NPs with MnO2 as a gatekeeper of encapsulated Ce6 for tumor microenvironment responsive and imaging-guided combination therapy.

An efficient delivery of photosensitizers and hypoxic prodrugs for a tumor combination therapy by membrane camouflage nanoparticles

2020 ◽  
Vol 8 (14) ◽  
pp. 2876-2886 ◽  
Author(s):  
Hanjie Wang ◽  
Chaonan Zhang ◽  
Yingying Zhang ◽  
Ran Tian ◽  
Guohui Cheng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Invasive Cancer ◽  
Non Invasive ◽  
Efficient Delivery

Photodynamic therapy (PDT) is an oxygen-dependent, non-invasive cancer treatment.

scholarly journals MicroRNA-Based Combinatorial Cancer Therapy: Effects of MicroRNAs on the Efficacy of Anti-Cancer Therapies

Cells ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 29 ◽  
Author(s):  
Hyun Ah Seo ◽  
Sokviseth Moeng ◽  
Seokmin Sim ◽  
Hyo Jeong Kuh ◽  
Soo Young Choi ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Therapeutic Resistance ◽  
Cancer Therapies ◽  
Anti Cancer ◽  
Different Types ◽  
Therapeutic Responses

The susceptibility of cancer cells to different types of treatments can be restricted by intrinsic and acquired therapeutic resistance, leading to the failure of cancer regression and remission. To overcome this problem, a combination therapy has been proposed as a fundamental strategy to improve therapeutic responses; however, resistance is still unavoidable. MicroRNA (miRNAs) are associated with cancer therapeutic resistance. The modulation of dysregulated miRNA levels through miRNA-based therapy comprising a replacement or inhibition approach has been proposed to sensitize cancer cells to other anti-cancer therapies. The combination of miRNA-based therapy with other anti-cancer therapies (miRNA-based combinatorial cancer therapy) is attractive, due to the ability of miRNAs to target multiple genes associated with the signaling pathways controlling therapeutic resistance. In this article, we present an overview of recent findings on the role of therapeutic resistance-related miRNAs in different types of cancer. We review the feasibility of utilizing dysregulated miRNAs in cancer cells and extracellular vesicles as potential candidates for miRNA-based combinatorial cancer therapy. We also discuss innate properties of miRNAs that need to be considered for more effective combinatorial cancer therapy.

A photo and tumor microenvironment activated nano-enzyme with enhanced ROS generation and hypoxia relief for efficient cancer therapy

2021 ◽  
Vol 9 (39) ◽  
pp. 8253-8262
Author(s):  
Yali Chen ◽  
Yujun Cai ◽  
Xingsu Yu ◽  
Hong Xiao ◽  
Haozhe He ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Therapy Strategies

Reactive oxygen species (ROS) mediated tumor therapy strategies have exhibited great prospects and attracted increasing attention, among which photodynamic therapy (PDT) has been well-established.

Microneedle-mediated delivery of MIL-100(Fe) as a tumor microenvironment-responsive biodegradable nanoplatform for O2 evolving chemophototherapy

2021 ◽  
Author(s):  
Sulan Luo ◽  
Yiting Zhao ◽  
Kewei Pan ◽  
Yixian Zhou ◽  
Guilan Quan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Antitumor Efficacy ◽  
Oxygen Level ◽  
Low Oxygen ◽  
Physiological Conditions

Low oxygen level in tumors significantly reduces antitumor efficacy of photodynamic therapy (PDT). Provision of O2 and monomeric hydrophobic photosensitizers (PSs) under physiological conditions would greatly help to shrink malignant...

scholarly journals Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy

2012 ◽  
Vol 5 (3) ◽  
pp. 211-223 ◽  
Author(s):  
Bingxue Shang ◽  
Gaochuan Zhang ◽  
Yanyan Pan ◽  
Quansheng Zhou
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Malignant Tumor ◽  
Anti Cancer ◽  
Key Features

scholarly journals Photodynamic Therapy and Hyperthermia in Combination Treatment—Neglected Forces in the Fight against Cancer

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1147
Author(s):  
Aleksandra Bienia ◽  
Olga Wiecheć-Cudak ◽  
Aleksandra Anna Murzyn ◽  
Martyna Krzykawska-Serda
Keyword(s):  
Photodynamic Therapy ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Combination Treatment ◽  
Therapeutic Agent ◽  
Diagnostic Methods ◽  
Cancer Therapies ◽  
Treatment Side Effects ◽  
Anti Cancer

Cancer is one of the leading causes of death in humans. Despite the progress in cancer treatment, and an increase in the effectiveness of diagnostic methods, cancer is still highly lethal and very difficult to treat in many cases. Combination therapy, in the context of cancer treatment, seems to be a promising option that may allow minimizing treatment side effects and may have a significant impact on the cure. It may also increase the effectiveness of anti-cancer therapies. Moreover, combination treatment can significantly increase delivery of drugs to cancerous tissues. Photodynamic therapy and hyperthermia seem to be ideal examples that prove the effectiveness of combination therapy. These two kinds of therapy can kill cancer cells through different mechanisms and activate various signaling pathways. Both PDT and hyperthermia play significant roles in the perfusion of a tumor and the network of blood vessels wrapped around it. The main goal of combination therapy is to combine separate mechanisms of action that will make cancer cells more sensitive to a given therapeutic agent. Such an approach in treatment may contribute toward increasing its effectiveness, optimizing the cancer treatment process in the future.

Nanodrug with Dual-Sensitivity to Tumor Microenvironment for Immuno-Sonodynamic Anti-Cancer Therapy

Biomaterials ◽  
2021 ◽  
pp. 120636
Author(s):  
Jinsheng Huang ◽  
Zecong Xiao ◽  
Yongcheng An ◽  
Shisong Han ◽  
Wei Wu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Anti Cancer
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