scholarly journals Chemical Composition, Total Phenolic Content, and Antioxidant Activities of the Essential Oils of the Leaves and Fruit Pulp of Annona muricata L. (Soursop) from Ghana

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Joseph Nana Gyesi ◽  
Rita Opoku ◽  
Lawrence Sheringham Borquaye
Keyword(s):  
Hydrogen Peroxide ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Antioxidant Activities ◽  
Total Phenolic ◽  
Moderate Activity ◽  
Annona Muricata ◽  
Fruit Pulp ◽  
Leaf Essential Oil

Annona muricata, also called soursop, is widespread in many tropical countries, and various parts of the plant have been shown to possess very good pharmacological properties. This work evaluated the chemical composition and antioxidant activities of essential oils obtained from the fruit pulp and leaves of soursop. Essential oils were obtained via hydrodistillation and characterized by gas chromatography-mass spectrometry. Antioxidant potential was evaluated via the phosphomolybdenum, hydrogen peroxide scavenging, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays. In the leaf essential oil, a total of 31 compounds were identified with δ-cadinene (22.58%) and α-muurolene (10.64%) being the most abundant. Thirty-two compounds were identified in the fruit pulp essential oil with Ç-sitosterol (19.82%) and 2-hydroxy-1-(hydroxymethyl) ethyl ester (13.48%) being present in high amounts. Both essential oils showed very good total antioxidant capacities (49.03 gAAE/100 g and 50.88 gAAE/100 g for fruit pulp and leaf essential oils, respectively). The IC50 values from the DPPH assay were 244.8 ± 3.2 μg/mL for leaf essential oil and 512 ± 5.1 μg/mL for the fruit pulp essential oil. At 1 mg/mL, hydrogen peroxide scavenged was below 50% for both leaf and fruit pulp essential oils, indicating moderate activity. These results suggest possible application of the essential oils of Annona muricata in food preservation and processing.

scholarly journals Chemical Composition of Cinnamomum verum Leaf and Flower Essential Oils and Analysis of Their Antibacterial, Insecticidal, and Larvicidal Properties

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6303
Author(s):  
Arunaksharan Narayanankutty ◽  
Krishnaprasad Kunnath ◽  
Ahmed Alfarhan ◽  
Rajakrishnan Rajagopal ◽  
Varsha Ramesh
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Callosobruchus Maculatus ◽  
Sitophilus Oryzae ◽  
Microbial Pathogens ◽  
Traditional Medicines ◽  
Significant Toxicity ◽  
Leaf Essential Oil ◽  
Different Parts

Cinnamomum verum is widely used in traditional medicines, and the different parts of the plant, such as bark, leaves, and flowers, are used for essential oil production. The present study compared the chemical composition of the essential oil of C. verum extracted from the leaves and flowers. In addition, efficacy of these essential oils against the two common pests Sitophilus oryzae and Callosobruchus maculatus was also evaluated. The results indicated the presence of cinnamaldehyde, eugenol, caryophyllene, and linalool in these essential oils, however, at different concentrations. The leaf essential oil was found to be 10–20% more effective as a fumigant against both the pests. Likewise, the leaf essential oil found to repel these pests even at lower concentrations than that of flower essential oil of C. verum. Besides, these essential oils were also effective in controlling the growth of various gram positive and gram negative microbial pathogens and possibly a safeguard for human health. On contrary, both the essential oils were found to be safe for the application on grains, as indicated by their germination potentials. It was also observed that these essential oils do not cause any significant toxicity to guppy fishes, thus confirming their ecological safety for use as a biopesticide.

Anti-Proliferative Activity of Piper trioicum Leaf Essential Oil Based on Phytoconstituent Analysis, Molecular Docking and In Silico ADMET Approaches

2021 ◽  
Vol 25 ◽  
Author(s):  
Sudipta Jena ◽  
Asit Ray ◽  
Ambika Sahoo ◽  
Prabhat Kumar Das ◽  
Pradeep Kumar Kamila ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Cell Lines ◽  
In Silico ◽  
Proliferative Activity ◽  
In Silico Admet ◽  
Leaf Essential Oil ◽  
Ht 29

Background: The essential oils isolated from several medicinal plants are reported to have anticancer activities. Both the essential oil and extracts of many Piper species (Piperaceae) possess potential cytotoxic effect against cancer cell lines and are being used in traditional system of medicine for the treatment of cancer. There is a need to evaluate and validate the anticancer properties of essential oils extracted from other wild species of Piper. Objective: The current research was undertaken to determine the chemical composition and investigate the anti-proliferative activity of wild growing Piper trioicum leaf essential oil. The selected five major constituents were subjected to molecular docking to identify possible modes of binding against serine/threonine-protein kinase (MST3) protein Methods: The essential oil of leaf of P. trioicum was extracted by hydro distillation method and its chemical composition was carried out by GC-FID and GC-MS. The anti-proliferative activity of the essential oil was evaluated by MTT assay against normal (3T3-L1) and various cancer (HCT 116, HT-29, PC-3 and HepG2) cell lines. Molecular docking analysis was performed using AutoDock 4.2 software. The pharmacokinetic and pharmacodynamic properties of the major constituents were determined using absorption, distribution, metabolization, excretion and toxicity (ADMET) analysis. Results: The GC-MS analysis revealed the identification of 45 constituents with δ-cadinene (19.57%), germacrene-D (8.54%), β-caryophyllene (6.84%), 1-epi-cubenol (4.83%) and α-pinene (4.52%) were found to be predominant constituents in the leaf essential oil of P. trioicum. The highest cytotoxicity of essential oil was observed against HT-29 cells (IC50 value of 33.14 µg/ml). 1-epi-cubenol and δ-Cadinene exhibited low binding energy values of -6.25 and -5.92 kcal/mol, respectively. For prediction of in silico pharmacokinetic and druglike properties of the major compounds, ADMET prediction tool was also used, the results of which came within the ideal range. Conclusion: The present findings demonstrated that P. trioicum essential oil possesses significant anti-proliferative activity and could be effective against cancer treatment.

scholarly journals The Essential Oils of Rhaponticum carthamoides Hairy Roots and Roots of Soil-Grown Plants: Chemical Composition and Antimicrobial, Anti-Inflammatory, and Antioxidant Activities

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Ewa Skała ◽  
Patrícia Rijo ◽  
Catarina Garcia ◽  
Przemysław Sitarek ◽  
Danuta Kalemba ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Hairy Roots ◽  
Antioxidant Activities ◽  
Quantitative Composition ◽  
Qualitative And Quantitative ◽  
Rhaponticum Carthamoides ◽  
Sesquiterpene Hydrocarbons ◽  
Lps Treatment

The essential oils were isolated by hydrodistillation from the hairy roots (HR) and roots of soil-grown plants (SGR) of Rhaponticum carthamoides and were analyzed by GC-MS method. In the both essential oils 62 compounds were identified. The root essential oils showed the differences in the qualitative and quantitative composition. The sesquiterpene hydrocarbons (55–62%) dominated in both essential oils. The major compounds of HR essential oil were cyperene, 13-norcypera-1(5),11(12)-diene, and cadalene while aplotaxene, nardosina-1(10),11-diene, and dauca-4(11),8-diene dominated in SGR essential oil. Both essential oils showed antibacterial activity especially against Enterococcus faecalis (ATCC 29212) and Pseudomonas aeruginosa (ATCC 27853) (MIC value = 125 µg/mL). HR and SGR essential oils also decreased the expression of IL-1β, IL-6, and TNF-α and the ROS level in LPS-treatment astrocytes. This is the first report to describe the chemical composition of R. carthamoides essential oil from hairy roots, its protective effect against LPS-induced inflammation and ROS production in astrocytes, and its antimicrobial potential. The results show that R. carthamoides hairy roots may be a valuable source of the essential oil and may be an alternative to the roots of soil-grown plants.

scholarly journals Chemical Composition, Antimicrobial and Antioxidant Activities of Eugenia Dysenterica DC Essential Oil

2018 ◽  
Vol 2 (6) ◽  
pp. 410 ◽  
Author(s):  
Danielle C. S. Oliveira ◽  
Telma Mary Kaneko ◽  
Maria Cláudia Marx Young ◽  
Cynthia Murakami ◽  
Inês Cordeiro ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Native Species ◽  
Antioxidant Activities ◽  
Microdilution Method ◽  
Screening Assays ◽  
Dpph Scavenging ◽  
Bacteria And Fungi ◽  
Eugenia Dysenterica

Eugenia dysenterica DC is a native species from the Cerrado biome and can be found in several states of Brazil. This study evaluated the chemical composition, antimicrobial and antioxidant activities from the essential oils of a population collected in São Paulo state. Essential oils were obtained by conventional means, and their compositions were analyzed by GC-MS. Screening assays for antimicrobial activity were carried out by the microdilution method and the antioxidant potential was assessed by the DPPH scavenging method. The GC-MS analysis indicated that 52.63% of the essential oil is composed by oxygenated sesquiterpenes and the major compound is (-)-elema-1,3,11(13)-trien-12-ol (24.86%). The antimicrobial assay indicated MIC 42.1 µg/mL for S. aureus and MIC > 10000 µg/mL for the other tested microorganisms, Gram negative bacteria and fungi. The oil showed an IC50 of 5.4±0.632 mg/mL for in the DPPH assay. The essential oil had a different chemical composition from previous studies. The essential oil did not present a potent antioxidant activity. However, it can be considered a promising antimicrobial agent against S. aureus.

scholarly journals Chemical Composition, Antimicrobial, Antioxidant and Cytotoxic Activity of Essential Oils of Plectranthus cylindraceus and Meriandra benghalensis from Yemen

2012 ◽  
Vol 7 (8) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Nasser A. Awadh Ali ◽  
Martina Wurster ◽  
Annika Denkert ◽  
Norbert Arnold ◽  
Iman Fadail ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oils ◽  
Cytotoxic Activity ◽  
Antioxidant Activities ◽  
Antimicrobial Activities ◽  
Dilution Method ◽  
Cytotoxic Activities ◽  
Moderate Activity ◽  
Inhibition Zones ◽  
Total Oil

The chemical composition, antimicrobial, antioxidant and cytotoxic activities of the essential oils isolated from the leaves of Plectranthus cylindraceus Hoechst. ex. Benth. (EOPC) and Meriandra benghalensis (Roxb.) Benth. (EOMB) were investigated. Sixteen compounds were identified in P. cylindraceus oil representing 94.5% of the oil content with thymol (68.5%), terpinolene (5.3%), β-selinene (4.7%), β-caryophyllene (4.0%), δ-cadinol (2.1%), and ar-curcumene (1.7%) as the major compounds. In M. benghalensis oil, 12 compounds were identified, which made up 82.0% of the total oil. The most abundant constituents were camphor (43.6%), 1,8-cineole (10.7%), α-eudesmol (5.8%), caryophyllene oxide (5.8%), camphene (5.3%) and borneol (3.4%). The antimicrobial activities of both oils were evaluated against five microorganisms with the disc diffusion test, the broth micro-dilution method and a semiquantitative bioautographic test. The most sensitive microorganisms for P. cylindraceus oil were S. aureus, B. subtilis, and C. albicans with inhibition zones of 38, 42, and 43 mm and MIC values of 0.39, 0.18, and, 0.18 μL/mL, respectively. M. benghalensis oil showed weak to moderate activity against the tested microorganisms. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay was employed to study the potential antioxidant activities of both oils. The antioxidant activity of P. cylindraceus oil (IC50 34.5 μg/mL) appeared to be higher than that of M. benghalensis oil (IC50 935 μg/mL). At a concentration of 100 μg/mL, EOMB showed a stronger cytotoxic activity, with growth inhibition of 71% against HT29 tumor cells, than EOPC (18%).

A comparative analysis of bark and leaf essential oil and their chemical composition, antioxidant, anti-inflammatory, antimicrobial activities and genotoxic potential of North East Indian Cinnamomum zeylanicum Blume

2019 ◽  
Vol 09 ◽  
Author(s):  
Roktim Gogoi ◽  
Neelav Sarma ◽  
Rikraj Loying ◽  
Sudin Kumar Pandey ◽  
Twahira Begum ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Protein Denaturation ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Cinnamomum Zeylanicum ◽  
North East ◽  
Leaf Essential Oil ◽  
Anti Inflammatory

Background: Cinnamomum zeylanicum Blume bark and leaf essential oil possesses eugenol as the major component. Both the essential oil have the potential antioxidant, anti-inflammatory, antimicrobial and negligible genotoxicity. Objective: A comparative chemical composition and biological evaluation of Cinnamomum zeylanicum Blume, bark and leaf essential oils, originated from North-East India has been investigated in the present study. Methods: Gas chromatography/mass spectroscopy analysis was used to investigate the chemical composition of the essential oil samples. DPPH free radical scavenging activity, reducing power assay was used for antioxidant activity evaluation. Similarly, egg albumin denaturation assay, protease inhibitory activities were used for anti-inflammatory activity, while genotoxicity was evaluated by using Allium cepa assay. Results: The results showed that eugenol is the major component of C. zeylanicum bark (84.48%) and leaf (48.78 %) essential oil. Significant antioxidant activity were observed for both essential oils in the DPPH free radical scavenging assay (IC50= 103.2 μg/mL, bark; IC50= 234.7 μg/mL, leaf), and reducing power assay (absorbance of 1.802 nm, 0.907 nm in 48 µg/mL for bark and leaf essential oil respectively). In-vitro anti-inflammatory activity revealed strong potential of leaf essential oil (protein denaturation assay, IC50= 0.05279 μg/mL; protease inhibitory activity IC50= 3.607 μg/mL) in comparison to bark essential oil (protein denaturation assay IC50= 0.1491, protease inhibitory activity IC50= 61.06). Allium cepa root growth test, mitotic index, and chromosomal aberration test were performed to investigate the genotoxicity of C. zeylanicum bark and leaf essential oil, which resulted no toxic nature of both the essential oils. Antimicrobial activity against eight bacterial and fungal strains revealed good antimicrobial properties with the MIC value of Staphylococcus aureus at 5 μL/mL (bark), Aspergillus niger at 2.5 μL/mL (bark); Bacillus cereus at 5 μL/mL (leaf), Aspergillus niger at 2.5 μL/mL (leaf). Conclusion: Collectively, these findings indicated the strong biological potential of both essential oils, although bark essential possesses better biologically activities than the leaf essential oil and could be used in the food and beverages industries.

scholarly journals Chemical Composition, Olfactory Evaluation and Antioxidant Effects of the Leaf Essential Oil of Corymbia citriodora (Hook) from China

2007 ◽  
Vol 2 (5) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Leopold Jirovetz ◽  
Stefanie Bail ◽  
Gerhard Buchbauer ◽  
Ivanka Stoilova ◽  
Albert Krastanov ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Chemical Composition ◽  
Essential Oil ◽  
Antioxidant Activities ◽  
Oh Radicals ◽  
Leaf Essential Oil ◽  
Corymbia Citriodora ◽  
Linoleic Acid Emulsion ◽  
Oxidized Products ◽  
Antioxidant Effects

The chemical composition of a sample of lemon eucalyptus essential oil ( Corymbia citriodora) from China was determined by GC/FID and GC/MS. Citronellal (76.3%), citronellol (5.7%) and neo-isopulegol (5.5%) were the major components. The odor of the sample was evaluated as fresh, citrus-like and mildly fruity, with a pleasant woody background note. Lemon eucalyptus oil was found to exhibit antiradical activity with respect to DPPH and hydroxyl (OH•) radicals. The effect exercised on OH• radicals significantly exceeded that observed for the DPPH radical – the respective concentrations for 50% inhibition of the radicals were 0.38 μg/mL for OH• and 344.0 μg/mL for DPPH. Furthermore, the essential oil revealed antioxidant activities in a model system comprised of a linoleic acid emulsion. At a concentration of 0.1%, inhibition of conjugated dienes-formation by 59.8% was observed and the formation of secondary oxidized products of linoleic acid by 84.7%.

scholarly journals Screening of Chemical Composition, in vitro Antioxidant, α-Amylase and α-Glucosidase Inhibitory Activities of the Leaf Essential Oils of Cinnamomum wightii from Different Populations

2018 ◽  
Vol 13 (11) ◽  
pp. 1934578X1801301 ◽  
Author(s):  
Venkatraman Sriramavaratharajan ◽  
Ramar Murugan
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Slow Release ◽  
Leaf Essential Oil ◽  
Different Populations ◽  
Inhibitory Activities ◽  
The Western Ghats ◽  
Nutraceutical Products

Cnnamomum wightii is an endemic species of the Western Ghats, India and is used in Ayurveda and Siddha systems of medicine. Its bark and leaves are adulterated with commercial cinnamon in southern India. Despite its medicinal and commercial importance, the species remains underexplored. The objective of the present work was to screen the chemical composition, in vitro antioxidant, α-amylase and α-glucosidase inhibitory activities of the leaf essential oil of C. wightii collected from different populations. GC-FID and GC-MS analyses of the leaf essential oils from seven accessions enabled the identification of a total of 70 constituents, of which only 16 compounds were present in all samples. Eleven major constituents (> 5%) were identified, of which only linalool and spathulenol were present in all accessions as major constituents. Among seven accessions, essential oil from Parson's valley, Nilgiris exhibited better antioxidant activity with IC50 values of 2.552 ± 0.13 and 3.485 ± 0.09 mg/mL for ABTS and DPPH respectively. The essential oil from Korakundah, Nilgiris showed better hypoglycemic activity with IC50 values of 1.617 ± 0.02 and 1.146 ± 0.02 mg/mL for α-amylase and α-glucosidase inhibitory activities respectively. The leaf essential oils of C. wightii may be used in nutraceutical products focusing diabetes mellitus as the moderate inhibition of the metabolic enzymes has the advantage of slow release of glucose.

scholarly journals ANALYSIS OF ESSENTIAL OIL CONSTITUENTS OF THREE ANNONA SPECIES GROWING IN KERALA, INDIA

2021 ◽  
Vol 12 (5) ◽  
pp. 45-48
Author(s):  
Sonia Mol Joseph ◽  
Amala Dev A R
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Mass Spectrometry Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Spectrometry Analysis ◽  
South Indian ◽  
Germacrene D ◽  
Leaf Essential Oil ◽  
The Common

The volatile chemical composition of leaf essential oils of three Annona species (Annona cherimola, Annona muricata and Annona squamosa) from the different regions of Kerala, South Indian was determined using gas chromatography-mass spectrometry analysis. A total of 41 constituents belonging to monoterpenoids, sesquiterpenoids and diterpenoids were identified. Monoterpenes and sesquiterpenoids were the major class of volatile compounds in most of the Annona species examined. The study led to the identification of major compounds as germacrene D (23.5%), bicyclogermacrene (14.6%) and β-caryophyllene (11.7%) in A. cherimola, α-pinene (13.3%), β-caryophyllene (11.2%) and β-pinene (10.1%) in A. muricata, and β-caryophyllene (11.9%) and α-pinene (8.2%) in A. squamosa respectively. The examined essential oils showed that β-caryophyllene is the common constituent identified in all the three species and other constituents are more specific for each species under study. Present investigation reports, a comparison of essential oil compositions of three Annona species from Kerala. Results of this study prove that essential oils examined have considerable dissimilarity in chemical composition with previously reported leaf essential oil compositions from other regions. A chemotaxonomic analysis of these essential oils based on the distribution of compounds has revealed an efficient method to differentiate Annona species unambiguously.

scholarly journals Chemotypes and antibacterial activities of Inula viscosa essential oils from Algeria

2020 ◽  
Vol 21 (4) ◽  
Author(s):  
Abdelkader Ounoughi ◽  
Messaoud Ramdani ◽  
Takia Lograda ◽  
Pierre Chalard ◽  
Gilles Figueredo
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Bacterial Species ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Moderate Activity ◽  
Phytochemical Study ◽  
Aerial Parts ◽  
Total Oil

Abstract. Ounoughi A, Ramdani M, Lograda  T, Chalard P, Figueredo G. 2020. Chemotypes and antibacterial activities of Inula viscosa essential oils from Algeria. Biodiversitas 21: 1504-1517. The aim of this work is to investigate the chemical composition and the antibacterial activities of the essential oils from Inula viscosa (L.) Aiton. Samples were collected in the flowering stage, from different localities in Algeria. The aerial parts of I. viscosa were submitted to a hydro distillation. The chemical composition of the essential oil was analyzed by GC and GC/MS. The antibacterial activity of the essential oils was evaluated using the disc diffusion method against fifteen bacterial species. Fifty-eight compounds representing 98.93 ± 2.03% of the total oil was identified in I. viscosa. It was found that the chemical composition was dominated by the presence of the following major products: polygodial (19.8 ± 16.97%), phytol (12.3 ± 9.77%), fokienol (6.01 ± 3.43%), intermedeol neo (5.09 ± 2.38%), caryophyllene oxide (4.91 ± 3.03%), nerolidol-Z (4.46 ± 5.46%), nerolidol-E (4.24 ± 8.07%) and α-ionone iso methyl-E (3.72 ± 2.26%). The essential oil of I. viscosa has moderate activity against the bacteria tested. In contrast, the Escherichia coli ATCC 25922, Pseudomonon syringae ATCC 53543 and Enterococcus faecalis ATCC 49452 strains are resistant to I. viscosa essential oils. The phytochemical study of I. viscosa showed that it is rich in terpene compounds, with polygodial and phytol as major components. Three distinct chemotypes are highlighted. The (Polygodial-Intermedeol-neo-Phytol) chemotype of Salah Bey population and two chemotypes with Fokinol-polygodial and Fokinol-phytol. Moderate antibacterial activities of essential oils against the bacteria tested were found.

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