scholarly journals The Development of BTK Inhibitors: A Five-Year Update

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7411
Author(s):  
Bruno Tasso ◽  
Andrea Spallarossa ◽  
Eleonora Russo ◽  
Chiara Brullo
Keyword(s):  
Clinical Investigation ◽  
Autoimmune Disorders ◽  
Point Of View ◽  
Chemical Diversity ◽  
The Past ◽  
Irreversible Inhibitors ◽  
Important Target ◽  
Term Administration ◽  
Btk Inhibitors

Bruton’s tyrosine kinase (BTK) represented, in the past ten years, an important target for the development of new therapeutic agents that could be useful for cancer and autoimmune disorders. To date, five compounds, able to block BTK in an irreversible manner, have been launched in the market, whereas many reversible BTK inhibitors (BTKIs), with reduced side effects that are more useful for long-term administration in autoimmune disorders, are under clinical investigation. Despite the presence in the literature of many articles and reviews, studies on BTK function and BTKIs are of great interest for pharmaceutical companies as well as academia. This review is focused on compounds that have appeared in the literature from 2017 that are able to block BTK in an irreversible or reversible manner; also, new promising tunable irreversible inhibitors, as well as PROTAC molecules, have been reported. This summary could improve the knowledge of the chemical diversity of BTKIs and provide information for future studies, particularly from the medicinal chemistry point of view. Data reported here are collected from different databases (Scifinder, Web of Science, Scopus, Google Scholar, and Pubmed) using “BTK” and “BTK inhibitors” as keywords.

The J. C. Richardson Lecture: Prospects for Canadian Medical Neurology

1975 ◽  
Vol 2 (2) ◽  
pp. 101-107 ◽  
Author(s):  
D.W. Baxter
Keyword(s):  
Clinical Investigation ◽  
Postgraduate Education ◽  
High Standard ◽  
Undergraduate Curriculum ◽  
Influential Factors ◽  
Work Patterns ◽  
Consultation Service ◽  
The Past ◽  
Fundamental Research

In 1975, medical neurology is a well established, viable, growing specialty in Canada. There are now almost 250 neurologists scattered across the country, congregated largely in the hospitals associated with our 16 medical schools. Neurology is a major component of the undergraduate curriculum in each of these schools, and the majority of schools are approved for postgraduate training in our specialty. The Royal College has certified an average of 18 new neurologists each year for the past five years. In our hospitals we work closely with our internist and neurosurgical colleagues and we receive the support of highly competent teams of neuropathologists, clinical electrophysiologists and neuroradiologists. We believe that we provide a generally high standard of consultation service to our medical and surgical colleagues. We accept direct responsibility for patients suffering from a host of acute neurological problems, but we accept long term responsibility for very few. We do a great deal of teaching at both the undergraduate and graduate levels. In fact, the major role which neurology plays in undergraduate curricula, and the stimulus of postgraduate education, probably have been the two most influential factors shaping the number, work patterns and distribution of Canadian neurologists. Many of us are engaged in clinical investigation, but relatively few medical neurologists in Canada make fundamental research contributions.

scholarly journals Viral infections in wheezing disorders

2018 ◽  
Vol 27 (147) ◽  
pp. 170133 ◽  
Author(s):  
Peter Le Souëf
Keyword(s):  
Viral Infections ◽  
Immunoglobulin E ◽  
Antibody Therapy ◽  
Interferon Β ◽  
The Past ◽  
Immune System Function ◽  
Term Administration ◽  
Syncytial Virus ◽  
Bacterial Lysates

Over the past year, studies into virus-induced wheeze in children have shifted towards investigations that examine the mechanisms by which respiratory viruses cause wheeze and an increase in studies examining the effects of novel interventions to reduce wheezing exacerbations. Studies on rhinovirus species (RV)-C infection have found that this is associated with a decrease in expression of CDHR3, the cellular receptor specific for this virus, and a decrease in interferon-β expression, both of which are likely to favour RV-C infection. Recent clinical trials in children have found a decrease in wheezing exacerbations with both anti-respiratory syncytial virus antibody and anti-immunoglobulin E antibody therapy, and a clinical trial of prednisolone in children with their first RV-induced wheeze showed that only those with an RV viral count >7000 copies·mL−1responded. Further studies on the effects of bacterial lysates on immune system function continue to support the potential of this approach to reduce virus-induced wheezing exacerbations in children. These studies and many previous investigations into immunomodulation using bacterial lysates have led to the funding and commencement of a large study in which long-term administration of a bacterial lysate in young children will be assessed for its ability to prevent asthma.

Ivan Petrović, Photographer, Archivist and Artist: Interview with Ivan Petrović

2017 ◽  
pp. 4-9
Author(s):  
Miha Colner ◽  
Ivan Petrović
Keyword(s):  
Point Of View ◽  
Artistic Expression ◽  
Film Production ◽  
Theoretical Point ◽  
Artistic Practice ◽  
Photographic Image ◽  
The Past ◽  
Archival Work

Ivan Petrović (1973) has been working in the fields of photography and art for twenty years as a researcher, creator and collector. Since 1997, he has been creating and publishing photographic projects that reflect the spirit of space and time in which they are created, while in his works he uses both documentary approaches as well as research principles. In 2011, together with photographer Mihail Vasiljević, he founded a para-institution, the Centre for Photography (CEF). Despite lacking its own premises, infrastructure or funds for performing its activities, the institution deals with the search, preservation, collection and analysis of local photographic materials from recent history. In the past ten years, Petrović also moved his artistic practice beyond mere artistic expression, since he addresses the phenomena of photography from an analytical-theoretical point of view. His interest lies in the nature of the photographic image and its role in society and historiography. In this spirit, long-term projects such as Documents (1997–2008), Images (2002–), Portfolio Belgrade (2015–) and the latest film production were created. The interview with Ivan Petrović took place on 1 September 2017 in Belgrade. The main themes were the role of photography in the dominant history, the boundary between one’s own practice and archival work, photography as an art and the likes. Keywords: collection, documentary, photography's role, preservation, research

Different German Perspectives on Spanish Politics in the 1670s: The Reaction of Vienna and Berlin on the Coup of Juan José de Austria in the Year 1677

2019 ◽  
Vol 23 (4) ◽  
pp. 367-385
Author(s):  
Ondřej Stolička
Keyword(s):  
Seventeenth Century ◽  
Central Europe ◽  
Important Change ◽  
Point Of View ◽  
The Past ◽  
New Situation

Abstract The past thirty years has brought an important change into the scholarship of the period of the last Habsburgs on the Spanish throne. Named after the book by Christopher Storrs, the long-term paradigm of the decline of the Spanish monarchy in the last half of the seventeenth century has been reestablished, however, the research of the relationships between the Spanish Habsburgs and Central Europe in the last quarter of the seventeenth century has yet to be to be considered. This study presents a more complex perception of the coup led by Juan José of Austria in the year 1677 and discovers an important perception of the situation from the point of view of the Emperor Leopold I and the Elector of Brandenburg Frederick William. The new Spanish government, as well, enacted shifts in their politics which could endanger their positions, however both accepted the new situation differently.

scholarly journals Civilizing the Other: Beauty, Intimate Labor, and Affective Encounters in Berlin’s Brazilian Waxing Studios

Cadernos Pagu ◽  
2021 ◽  
Author(s):  
Maria Lidola
Keyword(s):  
Service Providers ◽  
Point Of View ◽  
The Other ◽  
Hair Removal ◽  
Ethnographic Research ◽  
Beauty Salon ◽  
The Past ◽  
Brazilian Method

Abstract Over the past 15 years, waxing (hair removal) studios have emerged in central Berlin and grown rapidly in number. Specializing in the “Brazilian method,” this beauty salon sector has increasingly been occupied by Brazilian migrants. In addition to being a simple hair removal service, I argue that the intimate work carried out in these salons encompasses an educational and even civilizing effort from the point of view of Brazilian depiladoras: The intimacy of their work allows for affective encounters in which Brazilian women are not seen merely as service providers. They embody the specialist in a form of beauty and femininity that is desired by German clients. Appropriating these rare moments of intimacy, Brazilian depiladoras act as educators not only for a more hygienic and more feminine corporeality but also for a more humanized sociality with the “other.” Based on long-term ethnographic research in Berlin, I discuss both the agency of beauty work and its limits within the coloniality of feminized and ethnicized labor.

scholarly journals TRENDS OF DIVERSIFICATION OF POWER CARRIERS OF MACHINE UNITS

2021 ◽  
pp. 88-96
Author(s):  
Irina Gunko
Keyword(s):  
Energy Use ◽  
Point Of View ◽  
Exhaust Gas ◽  
Hydrogen Fuel ◽  
The Past ◽  
New Methods ◽  
Policy Goals ◽  
Alcohol Fuels ◽  
Free Transport

From the point of view of environmental protection, the development of vehicles and their drives is determined in the future by the constant tightening of exhaust gas requirements. In addition, measures to reduce fuel consumption and CO2 emissions are increasingly influencing the concept of vehicle and drive optimization. Since most of the world's energy consumption is taken by transport, mainly cars, manufacturers are often faced with the need to develop and implement new, increasingly energy efficient and environmentally friendly energy methods - for example, the use of unconventional fuels, including: alcohol fuels (ethanol and methanol), biodiesel, Fischer's fluid -Tropsch, hydrogen fuel. So, the long-term guaranteed supply of transport energy, together with sound fuel management, ensures the medium and long-term diversification of energy for its production, especially, including alternative and renewable energy. Much has happened over the past decade, although policy goals remain unchanged for many countries improving energy security and limiting greenhouse gas emissions may be more important than ever. And, unprecedentedly, energy use in transportation is at the heart of these issues. New methods are needed to free transport from its persistent dependence on oil and take a new path. But technology has made interesting progress, and this progress will continue in the coming years, creating new opportunities to achieve these goals. Unsurprisingly, interest in biofuels and their production has skyrocketed over the past decade. Global production of total ethanol doubled between 1990 and 2021. In some regions, especially in Europe, the use of biofuels for diesel engines has also increased significantly in recent years. Perhaps most importantly, countries around the world are now seriously considering increasing the production and use of biofuels, and many countries have formulated policies to ensure this growth.

The efficacy and safety of long-term administration of alpha-interferon and lamivudine in patients with chronic hepatitits B

2001 ◽  
Vol 120 (5) ◽  
pp. A572-A572
Author(s):  
F JABOLI ◽  
E RODA ◽  
C FABBRI ◽  
S MARCHETTO ◽  
F FERRARA ◽  
...  
Keyword(s):  
Alpha Interferon ◽  
Efficacy And Safety ◽  
Term Administration

Chelovek.RU/Человек.RU

Chelovek RU ◽  
2020 ◽  
pp. 18-53
Author(s):  
Sergei Avanesov ◽  
Keyword(s):  
Family History ◽  
Great Distance ◽  
Point Of View ◽  
The Past ◽  
Russian Philosopher ◽  
True Meaning ◽  
The Future ◽  
Pavel Florensky ◽  
The Moment

Abstract. The article analyzes the autobiography of the famous Russian philosopher, theologian and scientist Pavel Florensky, as well as those of his texts that retain traces of memories. According to Florensky, the personal biography is based on family history and continues in children. He addresses his own biography to his children. Memories based on diary entries are designed as a memory diary, that is, as material for future memories. The past becomes actual in autobiography, turns into a kind of present. The past, from the point of view of its realization in the present, gains meaning and significance. The au-thor is active in relation to his own past, transforming it from a collection of disparate facts into a se-quence of events. A person can only see the true meaning of such events from a great distance. Therefore, the philosopher remembers not so much the circumstances of his life as the inner impressions of the en-counter with reality. The most powerful personality-forming experiences are associated with childhood. Even the moment of birth can decisively affect the character of a person and the range of his interests. The foundations of a person's worldview are laid precisely in childhood. Florensky not only writes mem-oirs about himself, but also tries to analyze the problems of time and memory. A person is immersed in time, but he is able to move into the past through memory and into the future through faith. An autobi-ography can never be written to the end because its author lives on. However, reaching the depths of life, he is able to build his path in such a way that at the end of this path he will unite with the fullness of time, with eternity.

Selective statistical estimates of multi-year monthly concentrations of biogenous pollution of small rivers of the Northwest zone of the Russian Federation

2020 ◽  
pp. 9-13
Author(s):  
Sergey Kovalenko
Keyword(s):  
Statistical Processing ◽  
Point Of View ◽  
Small Rivers ◽  
Statistical Parameters ◽  
Monthly Data ◽  
Statistical Estimates ◽  
Scientific Task ◽  
The Russian Federation ◽  
Agricultural Areas

The management of surface watercourses is an urgent scientific task. The article presents the results of statistical processing of long-term monthly data of field observations of hydrological and hydrochemical parameters along the Upper Yerga small river in the Vologda region. Sampling estimates of statistical parameters are obtained, autocorrelation and correlation analyzes are performed. The limiting periods from the point of view of pollution for water receivers receiving wastewater from drained agricultural areas are identified.

Portuguese Sardines - from the ritual to the brand

2017 ◽  
Vol 5 (2) ◽  
pp. 109-120
Author(s):  
Cecília Avelino Barbosa
Keyword(s):  
Social Construction ◽  
Place Branding ◽  
Symbolic Capital ◽  
City Council ◽  
Point Of View ◽  
City Branding ◽  
The Past ◽  
Behavioral Expression ◽  
The City ◽  
City Identity

Place branding is a network of associations in the consumer’s mind, based on the visual, verbal, and behavioral expression of a place. Food can be an important tool to summarize it as it is part of the culture of a city and its symbolic capital. Food is imaginary, a ritual and a social construction. This paper aims to explore a ritual that has turned into one of the brands of Lisbon in the past few years. The fresh sardines barbecued out of doors, during Saint Anthony’s festival, has become a symbol that can be found on t-shirts, magnets and all kinds of souvenirs. Over the year, tourists can buy sardine shaped objects in very cheap stores to luxurious shops. There is even a whole boutique dedicated to the fish: “The Fantastic World of Portuguese Sardines” and an annual competition promoted by the city council to choose the five most emblematic designs of sardines. In order to analyze the Sardine phenomenon from a city branding point of view, the objective of this paper is to comprehend what associations are made by foreigners when they are outside of Lisbon. As a methodological procedure five design sardines, were used of last year to questioning to which city they relate them in interviews carried in Madrid, Lyon, Rome and London. Upon completion of the analysis, the results of the city branding strategy adopted by the city council to promote the sardines as the official symbol of Lisbon is seen as a Folkmarketing action. The effects are positive, but still quite local. On the other hand, significant participation of the Lisbon´s dwellers in the Sardine Contest was observed, which seems to be a good way to promote the city identity and pride in their best ambassador: the citizens.

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