Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

Medical implant use is associated with a risk of infection caused by bacteria on their surface. Implants with a surface that has both bone growth-promoting properties and antibacterial properties are of interest in orthopedics. In the current study, we fabricated a bioactive coating of hydroxyapatite nanoparticles on polyether ether ketone (PEEK) using the sonocoating method. The sonocoating method creates a layer by immersing the object in a suspension of nanoparticles in water and applying a high-power ultrasound. We show that the simple layer fabrication method results in a well-adhering layer with a thickness of 219 nm to 764 nm. Dropping cefuroxime sodium salt (Cef) antibiotic on the coated substrate creates a layer with a drug release effect and antibacterial activity against Staphylococcus aureus. We achieved a concentration of up to 1 mg of drug per cm2 of the coated substrate. In drug release tests, an initial burst was observed within 24 h, accompanied by a linear stable release effect. The drug-loaded implants exhibited sufficient activity against S. aureus for 24 and 168 h. Thus, the simple method we present here produces a biocompatible coating that can be soaked with antibiotics for antibacterial properties and can be used for a range of medical implants.

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Strong Antibacterial Properties of Cotton Fabrics Coated with Ceria Nanoparticles under High-Power Ultrasound

Nanomaterials ◽

10.3390/nano11102704 ◽

2021 ◽

Vol 11 (10) ◽

pp. 2704

Author(s):

Anna V. Abramova ◽

Vladimir O. Abramov ◽

Igor S. Fedulov ◽

Alexander E. Baranchikov ◽

Daniil A. Kozlov ◽

...

Keyword(s):

High Power ◽

Antibacterial Properties ◽

Antimicrobial Properties ◽

Healthcare Sector ◽

Power Ultrasound ◽

E Coli ◽

Advantages And Disadvantages ◽

High Power Ultrasound ◽

Low Toxicity ◽

High Level

Flexible materials, such as fabric, paper and plastic, with nanoscale particles that possess antimicrobial properties have a significant potential for the use in the healthcare sector and many other areas. The development of new antimicrobial coating formulations is an urgent topic, as such materials could reduce the risk of infection in hospitals and everyday life. To select the optimal composition, a comprehensive analysis that takes into account all the advantages and disadvantages in each specific case must be performed. In this study, we obtained an antimicrobial textile with a 100% suppression of E. coli on its surface. These CeO2 nanocoatings exhibit low toxicity, are easy to manufacture and have a high level of antimicrobial properties even at very low CeO2 concentrations. High-power ultrasonic treatment was used to coat the surface of cotton fabric with CeO2 nanoparticles.

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An ultrasonic technology for production of antibacterial nanomaterials and their coating on textiles

Beilstein Journal of Nanotechnology ◽

10.3762/bjnano.5.62 ◽

2014 ◽

Vol 5 ◽

pp. 532-536 ◽

Cited By ~ 9

Author(s):

Anna V Abramova ◽

Vladimir O Abramov ◽

Aharon Gedanken ◽

Ilana Perelshtein ◽

Vadim M Bayazitov

Keyword(s):

Zno Nanoparticles ◽

Antibacterial Properties ◽

Ultrasonic Waves ◽

Simultaneous Application ◽

Power Ultrasound ◽

E Coli ◽

High Power Ultrasound ◽

Ultrasonic Technology ◽

Electrical Discharge In Water ◽

Very High

A method for the production of antibacterial ZnO nanoparticles has been developed. The technique combines passing an electric current with simultaneous application of ultrasonic waves. By using high-power ultrasound a cavitation zone is created between two zinc electrodes. This leads to the possibility to create a spatial electrical discharge in water. Creation of such discharge leads to the depletion of the electrodes and the formation of ZnO nanoparticles, which demonstrate antibacterial properties. At the end of this reaction the suspension of ZnO nanoparticles is transported to a specially developed ultrasonic reactor, in which the nanoparticles are deposited on the textile. The nanoparticles are embedded into the fibres by the cavitation jets, which are formed by asymmetrically collapsing bubbles in the presence of a solid surface and are directed towards the surface of textile at very high velocities. Fabrics coated with ZnO nanoparticles by using the developed method showed good antibacterial activity against E. coli.

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Encapsulation of Capacitive Micromachined Ultrasonic Transducers (CMUTs) for the Acoustic Communication between Medical Implants

Sensors ◽

10.3390/s21020421 ◽

2021 ◽

Vol 21 (2) ◽

pp. 421

Author(s):

Jorge Oevermann ◽

Peter Weber ◽

Steffen H. Tretbar

Keyword(s):

Data Security ◽

Ultrasonic Transducers ◽

Surrounding Tissue ◽

Center Frequency ◽

Medical Implants ◽

Research Groups ◽

Capacitive Micromachined Ultrasonic Transducers ◽

Polyether Ether Ketone ◽

High Bandwidth ◽

Ether Ketone

The aim of this work was to extend conventional medical implants by the possibility of communication between them. For reasons of data security and transmitting distances, this communication should be realized using ultrasound, which is generated and detected by capacitive micromachined ultrasonic transducers (CMUTs). These offer the advantage of an inherent high bandwidth and a high integration capability. To protect the surrounding tissue, it has to be encapsulated. In contrast to previous results of other research groups dealing with the encapsulation of CMUTs, the goal here is to integrate the CMUT into the housing of a medical implant. In this work, CMUTs were designed and fabricated for a center frequency of 2 MHz in water and experimentally tested on their characteristics for operation behind layers of Polyether ether ketone (PEEK) and titanium, two typical materials for the housings of medical implants. It could be shown that with silicone as a coupling layer it is possible to operate a CMUT behind the housing of an implant. Although it changes the characteristics of the CMUT, the setup is found to be well suited for communication between two transducers over a distance of at least 8 cm.

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Synthesis and Characterization of Nano-Sized 4-Aminosalicylic Acid–Sulfamethazine Cocrystals

Pharmaceutics ◽

10.3390/pharmaceutics13020277 ◽

2021 ◽

Vol 13 (2) ◽

pp. 277 ◽

Cited By ~ 1

Author(s):

Ala’ Salem ◽

Anna Takácsi-Nagy ◽

Sándor Nagy ◽

Alexandra Hagymási ◽

Fruzsina Gősi ◽

...

Keyword(s):

High Power ◽

Active Pharmaceutical Ingredient ◽

Polymorphic Form ◽

Degree Of Crystallinity ◽

Dissolution Enhancement ◽

Aminosalicylic Acid ◽

Nano Technology ◽

Power Ultrasound ◽

High Power Ultrasound ◽

High Degree

Drug–drug cocrystals are formulated to produce combined medication, not just to modulate active pharmaceutical ingredient (API) properties. Nano-crystals adjust the pharmacokinetic properties and enhance the dissolution of APIs. Nano-cocrystals seem to enhance API properties by combining the benefits of both technologies. Despite the promising opportunities of nano-sized cocrystals, the research at the interface of nano-technology and cocrystals has, however, been described to be in its infancy. In this study, high-pressure homogenization (HPH) and high-power ultrasound were used to prepare nano-sized cocrystals of 4-aminosalysilic acid and sulfamethazine in order to establish differences between the two methods in terms of cocrystal size, morphology, polymorphic form, and dissolution rate enhancement. It was found that both methods resulted in the formation of form I cocrystals with a high degree of crystallinity. HPH yielded nano-sized cocrystals, while those prepared by high-power ultrasound were in the micro-size range. Furthermore, HPH produced smaller-size cocrystals with a narrow size distribution when a higher pressure was used. Cocrystals appeared to be needle-like when prepared by HPH compared to those prepared by high-power ultrasound, which had a different morphology. The highest dissolution enhancement was observed in cocrystals prepared by HPH; however, both micro- and nano-sized cocrystals enhanced the dissolution of sulfamethazine.

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