scholarly journals Double-Layer Fatty Acid Nanoparticles as a Multiplatform for Diagnostics and Therapy

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 205
Author(s):  
María Salvador ◽  
José Luis Marqués-Fernández ◽  
José Carlos Martínez-García ◽  
Dino Fiorani ◽  
Paolo Arosio ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Double Layer ◽  
Colloidal Stability ◽  
Superparamagnetic Iron Oxide ◽  
Magnetic Hyperthermia ◽  
Polymeric Coating ◽  
Resonance Imaging ◽  
Good Surface ◽  
Acid Sample

Today, public health is one of the most important challenges in society. Cancer is the leading cause of death, so early diagnosis and localized treatments that minimize side effects are a priority. Magnetic nanoparticles have shown great potential as magnetic resonance imaging contrast agents, detection tags for in vitro biosensing, and mediators of heating in magnetic hyperthermia. One of the critical characteristics of nanoparticles to adjust to the biomedical needs of each application is their polymeric coating. Fatty acid coatings are known to contribute to colloidal stability and good surface crystalline quality. While monolayer coatings make the particles hydrophobic, a fatty acid double-layer renders them hydrophilic, and therefore suitable for use in body fluids. In addition, they provide the particles with functional chemical groups that allow their bioconjugation. This work analyzes three types of self-assembled bilayer fatty acid coatings of superparamagnetic iron oxide nanoparticles: oleic, lauric, and myristic acids. We characterize the particles magnetically and structurally and study their potential for resonance imaging, magnetic hyperthermia, and labeling for biosensing in lateral flow immunoassays. We found that the myristic acid sample reported a large r2 relaxivity, superior to existing iron-based commercial agents. For magnetic hyperthermia, a significant specific absorption rate value was obtained for the oleic sample. Finally, the lauric acid sample showed promising results for nanolabeling.

scholarly journals A Tailor-Made Protocol to Synthesize Yolk-Shell Graphene-Based Magnetic Nanoparticles for Nanomedicine

2018 ◽  
Vol 4 (4) ◽  
pp. 55 ◽  
Author(s):  
Raquel Rodrigues ◽  
Giovanni Baldi ◽  
Saer Doumett ◽  
Juan Gallo ◽  
Manuel Bañobre-López ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Colloidal Stability ◽  
Superparamagnetic Iron Oxide ◽  
In Vitro Tests ◽  
Chemotherapeutic Drug ◽  
On Demand ◽  
Superparamagnetic Behaviour ◽  
Ph Conditions

A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-demand drug nanocarrier systems for drug delivery, exhibiting the following features: good colloidal stability, good loading capacity of the chemotherapeutic drug doxorubicin, high pH-controlled release of the encapsulated drug (targeting tumour acidic pH conditions), superparamagnetic behaviour and biocompatibility. Due to their combined properties (i.e., physicochemical, magnetic, and biocompatibility), GbMNPs show high potentiality to be combined with other biomedical techniques, such as magnetic hyperthermia, which can represent an enhancement in the treatment of cancer.

scholarly journals In vivo magnetic resonance imaging tracking of C6 glioma cells labeled with superparamagnetic iron oxide nanoparticles

2012 ◽  
Vol 10 (2) ◽  
pp. 164-170 ◽  
Author(s):  
Javier Bustamante Mamani ◽  
Jackeline Moraes Malheiros ◽  
Ellison Fernando Cardoso ◽  
Alberto Tannús ◽  
Paulo Henrique Silveira ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Tumor Growth ◽  
Prussian Blue ◽  
Superparamagnetic Iron Oxide ◽  
C6 Glioma Cells ◽  
C6 Cells ◽  
Resonance Imaging

OBJECTIVE: The aim of the current study was to monitor the migration of superparamagnetic iron oxide nanoparticle (SPION)-labeled C6 cells, which were used to induce glioblastoma tumor growth in an animal model, over time using magnetic resonance imaging (MRI), with the goal of aiding in tumor prognosis and therapy. METHODS: Two groups of male Wistar rats were used for the tumor induction model. In the first group (n=3), the tumors were induced via the injection of SPION-labeled C6 cells. In the second group (n=3), the tumors were induced via the injection of unlabeled C6 cells. Prussian Blue staining was performed to analyze the SPION distribution within the C6 cells in vitro. Tumor-inducing C6 cells were injected into the right frontal cortex, and subsequent tumor monitoring and SPION detection were performed using T2- and T2*-weighted MRI at a 2T field strength. In addition, cancerous tissue was histologically analyzed after performing the MRI studies. RESULTS: The in vitro qualitative evaluation demonstrated adequate distribution and satisfactory cell labeling of the SPIONs. At 14 or 21 days after C6 injection, a SPION-induced T2- and T2*-weighted MRI signal reduction was observed within the lesion located in the left frontal lobe on parasagittal topography. Moreover, histological staining of the tumor tissue with Prussian Blue revealed a broad distribution of SPIONs within the C6 cells. CONCLUSION: MRI analyses exhibit potential for monitoring the tumor growth of C6 cells efficiently labeled with SPIONs.

Superparamagnetic Iron Oxide Nanoarticles for Biomedical Applications: a focus on PVA as a coating

2003 ◽  
Vol 789 ◽  
Author(s):  
M. Chastellain ◽  
A. Petri ◽  
H. Hofmann
Keyword(s):  
Iron Oxide ◽  
Biomedical Applications ◽  
Large Scale ◽  
Colloidal Stability ◽  
Superparamagnetic Iron Oxide ◽  
Narrow Size Distribution ◽  
Water Based ◽  
Co Precipitation

ABSTRACTNanoscaled particles showing a superparamagnetic behavior have been intensively studied these past years for biomedical applications and water-based ferrofluids turned out to be promising candidates for various in vivo as well as in vitro applications. Nevertheless, the lack of well-defined particles remains an important problem. One of the major challenges is still the large-scale synthesis of particles with a narrow size distribution. In this work iron oxide nanoparticles are obtained by classical co-precipitation in a water-based medium and are subsequently coated with polyvinyl alcohol. The thus obtained ferrofluids are studied and a focus is made on their colloidal stability.

scholarly journals A Hybrid System for Magnetic Hyperthermia and Drug Delivery: SPION Functionalized by Curcumin Conjugate

Materials ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 2388 ◽  
Author(s):  
Dorota Lachowicz ◽  
Agnieszka Kaczyńska ◽  
Roma Wirecka ◽  
Angelika Kmita ◽  
Wojciech Szczerba ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Thin Layer ◽  
Hybrid System ◽  
Active Agent ◽  
Superparamagnetic Iron Oxide ◽  
Magnetic Hyperthermia ◽  
Water Soluble ◽  
Cancer Therapies ◽  
Ca 50

Cancer is among the leading causes of death worldwide, thus there is a constant demand for new solutions, which may increase the effectiveness of anti-cancer therapies. We have designed and successfully obtained a novel, bifunctional, hybrid system composed of colloidally stabilized superparamagnetic iron oxide nanoparticles (SPION) and curcumin containing water-soluble conjugate with potential application in anticancer hyperthermia and as nanocarriers of curcumin. The obtained nanoparticulate system was thoroughly studied in respect to the size, morphology, surface charge, magnetic properties as well as some biological functions. The results revealed that the obtained nanoparticles, ca. 50 nm in diameter, were the agglomerates of primary particles with the magnetic, iron oxide cores of ca. 13 nm, separated by a thin layer of the applied cationic derivative of chitosan. These agglomerates were further coated with a thin layer of the sodium alginate conjugate of curcumin and the presence of both polymers was confirmed using thermogravimetry. The system was also proven to be applicable in magnetic hyperthermia induced by the oscillating magnetic field. A high specific absorption rate (SAR) of 280 [W/g] was registered. The nanoparticles were shown to be effectively uptaken by model cells. They were found also to be nontoxic in the therapeutically relevant concentration in in vitro studies. The obtained results indicate the high application potential of the new hybrid system in combination of magnetic hyperthermia with delivery of curcumin active agent.

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