scholarly journals The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1019 ◽  
Author(s):  
Jane Fletcher ◽  
Sheldon C. Cooper ◽  
Subrata Ghosh ◽  
Martin Hewison
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bowel Disease ◽  
Active Form ◽  
Vitamin D Supplementation ◽  
Gastrointestinal Microbiota ◽  
Beneficial Effects ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Low Serum

Vitamin D has been linked to human health benefits that extend far beyond its established actions on calcium homeostasis and bone metabolism. One of the most well studied facets of extra-skeletal vitamin D is its activity as an immuno-modulator, in particular its potent anti-inflammatory effects. As a consequence, vitamin D deficiency has been associated with inflammatory diseases including inflammatory bowel disease (IBD). Low serum levels of the major circulating form of vitamin D, 25-hydroxyvitamin D (25-OH-D) are significantly more prevalent in patients with IBD, particularly in the winter and spring months when UV-induced synthesis of vitamin D is lower. Dietary malabsorption of vitamin D may also contribute to low serum 25(OH)D in IBD. The benefits of supplementation with vitamin D for IBD patients are still unclear, and improved vitamin D status may help to prevent the onset of IBD as well as ameliorating disease severity. Beneficial effects of vitamin D in IBD are supported by pre-clinical studies, notably with mouse models, where the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25-(OH)2D) has been shown to regulate gastrointestinal microbiota function, and promote anti-inflammatory, tolerogenic immune responses. The current narrative review aims to summarise the different strands of data linking vitamin D and IBD, whilst also outlining the possible beneficial effects of vitamin D supplementation in managing IBD in humans.

scholarly journals Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Qingdong Guan ◽  
Jiguo Zhang
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Inflammatory Cytokines ◽  
Bowel Disease ◽  
Intestinal Inflammation ◽  
Beneficial Effects ◽  
Recent Advances ◽  
Inflammatory Bowel ◽  
Inflammation Targeting ◽  
Anti Inflammatory

Cytokines play an important role in the immunopathogenesis of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, where they drive and regulate multiple aspects of intestinal inflammation. The imbalance between proinflammatory and anti-inflammatory cytokines that occurs in IBD results in disease progression and tissue damage and limits the resolution of inflammation. Targeting cytokines have been novel strategies in the treatment of IBD. Recent studies show the beneficial effects of anticytokine treatments to IBD patients, and multiple novel cytokines are found to be involved in the pathogenesis of IBD. In this review, we will discuss the recent advances of novel biologics in clinics and clinical trials, and novel proinflammatory and anti-inflammatory cytokines found in IBD with focusing on IL-12 family and IL-1 family members as well as their relevance to the potential therapy of IBD.

scholarly journals Managing vitamin D deficiency in inflammatory bowel disease

2019 ◽  
Vol 10 (4) ◽  
pp. 394-400 ◽  
Author(s):  
Ole Haagen Nielsen ◽  
Thomas Irgens Hansen ◽  
John Mark Gubatan ◽  
Kim Bak Jensen ◽  
Lars Rejnmark
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Therapeutic Strategy ◽  
Critical Role ◽  
Vitamin D Supplementation ◽  
Disease Outcomes ◽  
Immunological Effects ◽  
Inflammatory Bowel

Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.

scholarly journals Vitamin D and Inflammatory Bowel Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
Marco Ardesia ◽  
Guido Ferlazzo ◽  
Walter Fries
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin D Receptor ◽  
Bowel Disease ◽  
Vitamin D Levels ◽  
Inflammatory Bowel ◽  
Low Serum

Vitamin D deficiency has been recognized as an environmental risk factor for Crohn’s disease since the early 80s. Initially, this finding was correlated with metabolic bone disease. Low serum 25-hydroxyvitamin D levels have been repeatedly reported in inflammatory bowel diseases together with a relationship between vitamin D status and disease activity. Subsequently, low serum vitamin D levels have been reported in various immune-related diseases pointing to an immunoregulatory role. Indeed, vitamin D and its receptor (VDR) are known to interact with different players of the immune homeostasis by controlling cell proliferation, antigen receptor signalling, and intestinal barrier function. Moreover, 1,25-dihydroxyvitamin D is implicated in NOD2-mediated expression of defensin-β2, the latter known to play a crucial role in the pathogenesis of Crohn’s disease (IBD1 gene), and several genetic variants of the vitamin D receptor have been identified as Crohn’s disease candidate susceptibility genes. From animal models we have learned that deletion of the VDR gene was associated with a more severe disease. There is a growing body of evidence concerning the therapeutic role of vitamin D/synthetic vitamin D receptor agonists in clinical and experimental models of inflammatory bowel disease far beyond the role of calcium homeostasis and bone metabolism.

scholarly journals Vitamin D supplementation dose needs to be higher in patients with inflammatory bowel disease: interventional study

2019 ◽  
Vol 65 (7-8) ◽  
pp. 470-474
Author(s):  
Vladimír Kojecký ◽  
Jan Matouš ◽  
Zdena Zádorová ◽  
Martin Gřiva ◽  
Bohuslav Kianička ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bowel Disease ◽  
Vitamin D Supplementation ◽  
Interventional Study ◽  
Inflammatory Bowel

Effects of oral Vitamin D supplementation on inflammatory bowel disease: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yiwen Guo ◽  
Tao Zhang ◽  
Yandan Wang ◽  
Ruijie Liu ◽  
Ming Chang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bowel Disease ◽  
Effective Properties ◽  
Meta Analysis ◽  
Critical Role ◽  
Vitamin D Supplementation ◽  
Oral Vitamin ◽  
Inflammatory Bowel

Vitamin D (VitD) is a fat-soluble micronutrient that plays a critical role in inflammatory bowel disease (IBD). Although the effective properties of VitD in anti-inflammatory and immune moderation were reviewed,...

Evaluation of a 12-week targeted vitamin D supplementation regimen in patients with active inflammatory bowel disease

2018 ◽  
Vol 37 (4) ◽  
pp. 1375-1382 ◽  
Author(s):  
Mayur Garg ◽  
Ourania Rosella ◽  
Gennaro Rosella ◽  
Yunqiu Wu ◽  
John S. Lubel ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Bowel Disease ◽  
Vitamin D Supplementation ◽  
Active Inflammatory Bowel Disease ◽  
Inflammatory Bowel
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