Effect of Fibre-Enriched Orange Juice on Postprandial Glycaemic Response and Satiety in Healthy Individuals: An Acute, Randomised, Placebo-Controlled, Double-Blind, Crossover Study

Background: Consumption of fibre-enriched orange juice may be an appropriate way to supplement daily fibre intake and achieve beneficial effects on metabolic health. The present study aimed to assess the short-term effects of fibre-enriched orange juice on postprandial metabolism and satiety in a healthy adult population. Methods: In this double-blind, randomised, placebo-controlled, crossover study 10 healthy subjects underwent two one-day trials in which they consumed an orange juice beverage containing 1.4 g/100 mL of citrus fibre (29.3% soluble and 41.9% insoluble) or a placebo (regular orange juice without added fibre). Postprandial glucose, insulin, gut hormones (GLP1, GIP and ghrelin), leptin and qualitative appetite/satiety assessment were measured every 15 or 30 min over the 120 min test period. Results: The fibre-enriched orange juice decreased postprandial serum glucose and circulating insulin levels at 15 min compared with the placebo. In addition, after intake of the fibre-enriched juice, a significant effect on qualitative feelings of satiety and fullness was observed at 15 and 120 min, and was accompanied by a significant decrease in GLP1 response at 15 min. No significant changes were observed in leptin, GIP and ghrelin after juice intake. Conclusions: In healthy individuals, a single acute consumption of fibre-enriched orange juice has short-term beneficial effects on postprandial glycaemia, circulating insulin levels and satiety through GLP1 secretion.

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Erratum: Bosch-Sierra, N., et al. Effect of Fibre-Enriched Orange Juice on Postprandial Glycaemic Response and Satiety in Healthy Individuals: An Acute, Randomised, Placebo-Controlled, Double-Blind, Crossover Study. Nutrients 2019, 11, 3014

Nutrients ◽

10.3390/nu13020696 ◽

2021 ◽

Vol 13 (2) ◽

pp. 696

Author(s):

Neus Bosch-Sierra ◽

Roger Marqués-Cardete ◽

Aránzazu Gurrea-Martínez ◽

Carmen Grau-Del Valle ◽

Clara Talens ◽

...

Keyword(s):

Crossover Study ◽

Orange Juice ◽

Healthy Individuals ◽

Glycaemic Response ◽

Double Blind ◽

Blind Crossover Study ◽

Double Blind Crossover Study

The authors have requested that the following changes be made to their paper [...]

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Acute and Short-term Chronic Testosterone Fluctuation Effects on Glucose Homeostasis, Insulin Sensitivity, and Adiponectin: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2013-2807 ◽

2014 ◽

Vol 99 (6) ◽

pp. E1088-E1096 ◽

Cited By ~ 14

Author(s):

Christian Høst ◽

Lars C. Gormsen ◽

David M. Hougaard ◽

Jens S. Christiansen ◽

Steen B. Pedersen ◽

...

Keyword(s):

Molecular Weight ◽

Glucose Metabolism ◽

Crossover Study ◽

High Molecular Weight ◽

Glucose Disposal ◽

Short Term ◽

High Molecular Weight Adiponectin ◽

Double Blind ◽

Double Blind Placebo ◽

Total Glucose

Context: Low levels of adiponectin and T in men have been shown to predict development of the metabolic syndrome, but the effects of T on glucose metabolism are incompletely understood and may be influenced either directly or indirectly through changes in body composition or in levels of adiponectin. Objective: The aim of the study was to test whether T exerts its effects on glucose metabolism directly or indirectly. Design, Setting, and Participants: In a randomized, double-blind, placebo-controlled, crossover study, 12 healthy young males were studied on four separate occasions. They received GnRH agonist treatment 1 month before 3 of 4 trial days to induce castrate levels of T. On trial days, T gel containing either high or low physiological T dose or placebo was applied to the body. On a fourth trial day, participants constituted their own eugonadal controls. Intervention: Each study comprised a 5-hour basal period and a 3-hour hyperinsulinemic euglycemic clamp. Main Outcome Measures: We measured the effect of acute T on peripheral glucose disposal, total adiponectin and subforms, and other indices of glucose metabolism. Results: Short-term hypogonadism was associated with increased high molecular weight adiponectin levels (P < .03) and increased oxidative glucose disposal (P = .03) but not total glucose disposal (P = .07). Acute T treatment was an independent suppressor of high molecular weight adiponectin levels (P = .04) but did not affect total glucose disposal (P = .17). Conclusions: These data show that T can act through putative fast nongenomic pathways to affect adiponectin levels in humans. The early hypogonadal state is characterized by a marked shift in fuel oxidation from lipids toward glucose, which may rely partly on buffering capabilities of adiponectin.

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Greater bioavailability of xanthophylls compared to carotenes from orange juice (high-pressure processed, pulsed electric field treated, low-temperature pasteurised, and freshly squeezed) in a crossover study in healthy individuals

Food Chemistry ◽

10.1016/j.foodchem.2021.130821 ◽

2021 ◽

pp. 130821

Author(s):

Begona Olmedilla-Alonso ◽

Fernando Granado-Lorencio ◽

Begoña de Ancos ◽

Begoña De Ancos ◽

Concepción Sánchez-Moreno ◽

...

Keyword(s):

High Pressure ◽

Low Temperature ◽

Electric Field ◽

Crossover Study ◽

Orange Juice ◽

Pulsed Electric Field ◽

Healthy Individuals

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Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study

Journal of Psychopharmacology ◽

10.1177/0269881117724406 ◽

2017 ◽

Vol 31 (10) ◽

pp. 1374-1376

Author(s):

Jack H Wilson ◽

Amy H Criss ◽

Sean A Spangler ◽

Katherine Walukevich ◽

Sandra Hewett

Keyword(s):

Young Adults ◽

Healthy Adult ◽

Adult Population ◽

Critical Role ◽

Random Order ◽

Controlled Study ◽

High Dose ◽

Short Term ◽

Double Blind ◽

Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7–10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.

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