scholarly journals Associations of Lifestyle Factors with Osteopenia and Osteoporosis in Polish Patients with Inflammatory Bowel Disease

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1863
Author(s):  
Anna Maria Rychter ◽  
Alicja Ewa Ratajczak ◽  
Aleksandra Szymczak-Tomczak ◽  
Michał Michalak ◽  
Piotr Eder ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Alcohol Consumption ◽  
Bowel Disease ◽  
Study Group ◽  
Mineral Density ◽  
Reduced Physical Activity ◽  
Inflammatory Bowel ◽  
Made In

Reduced physical activity (PA), smoking, and coffee and alcohol drinking constitute risk factors of osteoporosis in patients with inflammatory bowel disease (IBD). The aim of the study was to measure the bone mineral density (BMD) and frequency of osteopenia and osteoporosis in patients with IBD and their correlation with PA, smoking, coffee, and alcohol. The study group consisted of 208 patients with IBD-103 with Crohn’s disease (CD), 105 suffering from ulcerative colitis (UC). Densitometric measurements were performed using the DXA. All patients completed a questionnaire concerning PA, smoking, and coffee and alcohol consumption. The prevalence of osteopenia and osteoporosis (L2–L4) in the IBD group was 48.1%; in the CD group, it amounted to 48.6%, and in the UC group, the prevalence was equal to 33.3%. Patients with CD who were diagnosed with osteopenia and osteoporosis demonstrated reduced PA compared to patients with a normal BMD who exercised regularly (p = 0.0335). A similar observation was made in the group of women with IBD. Women with a normal BMD exercised significantly more often than women suffering from osteopenia and osteoporosis (p = 0.0146). However, no differences in BMD were observed with regard to coffee use, alcohol consumption, or smoking. Thus, since the incidence of osteoporosis in IBD patients is high, it may be dependent on PA.

Risk Factors for Low Bone Density in Inflammatory Bowel Disease: Use of Glucocorticoids, Low Body Mass Index, and Smoking

2019 ◽  
Vol 37 (4) ◽  
pp. 284-290 ◽  
Author(s):  
Razi Even Dar ◽  
Yoav Mazor ◽  
Amir Karban ◽  
Sofia Ish-Shalom ◽  
Elena Segal
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Inflammatory Bowel Disease ◽  
Bone Density ◽  
Body Mass ◽  
Bowel Disease ◽  
Mineral Density ◽  
Low Bone Density ◽  
Low Body Mass Index ◽  
Inflammatory Bowel

Background: Inflammatory bowel disease (IBD) patients are reported to have lower bone density compared to healthy controls. There is limited consensus regarding factors affecting bone density among these patients. Our aim, therefore, was to determine clinical and genetic variables that contribute to lower bone mineral density (BMD) in IBD patients. Methods: A cross-sectional study of IBD patients treated in a tertiary referral center was performed. Epidemiological and clinical data were collected, and genetic testing for the common mutations in Nucleotide-binding Oligomerization Domain-containing protein (NOD)2 was performed. We examined correlations between the different variables and BMD in the total hip, femoral neck, and lumbar spine. Results: Eighty-nine patients (49% males, 67 Crohn’s disease [CD]) participated in the study. 42Forty-two (63%) of the CD and 13 (59%) of the ulcerative colitis patients met the criteria for osteoporosis/osteopenia. Factors associated with lower Z scores were low body mass index (BMI; r = –0.307, p = 0.005), use of glucocorticoids (likelihood ratio [LR] 5.1, p = 0.028), and a trend for male gender (LR = 3.4, p = 0.079). Among CD patients, low bone density showed borderline significance for association with gastrointestinal surgery (LR = 4.1, p = 0.07) and smoking (LR = 3.58, p = 0.06). Low levels of 25OHD were not associated with low BMD, nor were mutations in NOD2. No increased rate of fractures was seen among patients with osteopenia or osteoporosis. Conclusion: In addition to the generally accepted risk factors for osteoporosis (glucocorticoids, low BMI, smoking), male IBD patients had a trend toward lower BMD. Carrying a mutaticon in NOD2 did not confer a risk for bone loss.

scholarly journals LOW BONE MINERAL DENSITY IN INFLAMMATORY BOWEL DISEASE—A STUDY OF THE PREVALENCE AND RISK FACTORS

2003 ◽  
Vol 98 ◽  
pp. S257-S258
Author(s):  
Lawrence W. Comerford ◽  
Stephen J. Bickston ◽  
Kristen Arseneau ◽  
Meredith Gross ◽  
Viktor Bovbjerg ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Inflammatory Bowel Disease ◽  
Bone Mineral ◽  
Bowel Disease ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
Inflammatory Bowel

scholarly journals Bone Mineral Density and Bone Remodeling in Tunisian Patients with Inflammatory Bowel Disease

2019 ◽  
Vol 13 (1) ◽  
pp. 22-29
Author(s):  
Samar Ben Jemaa ◽  
Lassaad Chtourou ◽  
Rim Akrout ◽  
Khansa Chaabouni ◽  
Tarek Chaabouni ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Inflammatory Bowel Disease ◽  
Bone Remodeling ◽  
Bone Mineral ◽  
Bowel Disease ◽  
Healthy Controls ◽  
Mineral Density ◽  
High Prevalence ◽  
Inflammatory Bowel

Background:A high prevalence of osteopenia and osteoporosis is observed in patients with Inflammatory Bowel Disease (IBD).Objective:The aim of our study was to investigate the prevalence of bone loss, bone remodeling and risk factors in Tunisian patient with IBD.Patients and Methods:The study included 40 patients with IBD and 32 age- and sex-matched healthy controls subjects. All participants underwent bone densitometry by dual energy X-ray absorptiometry at the femoral neck and lumbar spine. Serum levels of 25-hydroxy vitamin D (25(OH)D), parathyroid hormone (PTH), osteocalcin(OC), and urinary degradation products of C-terminal telopeptide of type I collagen (CTXI) were measured in all participants to assess the bone metabolism status.Results:Twelve (30%) patients were normal, 32.5% were osteopenic and 37.5% were osteoporotic. Osteoporosis was more frequent in IBD patients than controls (p=0.0001). Age and inflammation were associated with low bone mineral density (BMD). Mean calcium, phosphorus and alkaline phosphatase levels were similar in both groups. Median 25(OH) D levels were significantly lower in IBD patients compared with controls (p=0.0001). Median urinary CTXI levels were significantly higher in IBD patients compared with healthy controls (p=0.007). No significant differences between IBD patients and controls concerning the median serum OC and PTH levels were found.Conclusion:In our study, there is a high prevalence of low BMD in IBD patients and an increase in bone resorption without a change of bone formation. Low BMI and hypovitaminoses D were identified as risk factors for low BMD.

P115 RELATIONS BETWEEN DISEASE STATUS AND BODY COMPOSITION IN PEDIATRIC INFLAMMATORY BOWEL DISEASE

2020 ◽  
Vol 26 (Supplement_1) ◽  
pp. S18-S19
Author(s):  
Saurabh Talathi ◽  
Pooja Nagaraj ◽  
Traci Jester ◽  
Jeanine Maclin ◽  
Taylor Knight ◽  
...  
Keyword(s):  
Physical Activity ◽  
Inflammatory Bowel Disease ◽  
Body Composition ◽  
Bowel Disease ◽  
Active Group ◽  
Lower Percentage ◽  
Physician Global Assessment ◽  
Healthy Controls ◽  
Mineral Density ◽  
Inflammatory Bowel

Abstract Objective To evaluate the effect of remission status on physical activity, and body composition in pediatric patients with inflammatory bowel disease (PIBD) and healthy peers. Methods Single center cohort study including 54 PIBD patients and 33 healthy peers. During initial study visit, a brief demographic questionnaire, physical activity questionnaire completed by participants and instructions on recording dietary intake were given. Physicians completed the Physician Global Assessment (PGA) for disease severity. Medical chart abstraction done to obtain disease variables of interest. DEXA scan completed one week later to obtain information on body composition. Variables of interest were compared between the three groups (IBD-Remission, IBD-Active and healthy controls) using an ANOVA or Chi square test as appropriate. Results IBD patients were older than controls, reported lower quality of life (73.9 vs 80.9) and engaged in less MVPA (195.4 versus 361.1). IBD-Active group had a significantly lower lean body mass, bone mineral density and time spent in MVPA compared to IBD-Remission group and healthy controls. IBD-Remission group had a significantly lower percentage of biologic use (55% vs 87%) and comorbidities (26% vs 44%) compared to IBD-active group. IBD-remission group also had a lower fat mass percentage. Discussion In this study, we report significantly favorable LBM, BMD, and time spent in MVPA in patients with IBD in remission compared to those not in remission with the former demonstrating a body composition resembling to that of healthy peers. While an improvement in BMD was observed with remission, the scores were still lower than controls.

Tu1805 - Clinical and Genetic Risk Factors for Decreased Bone Mineral Density in Japanese Patients with Inflammatory Bowel Disease

2018 ◽  
Vol 154 (6) ◽  
pp. S-1024-S-1025
Author(s):  
Naonobu Yokoyama ◽  
Takeo Naito ◽  
Yoichi Kakuta ◽  
Motoyuki Onodera ◽  
Rintaro Moroi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Inflammatory Bowel Disease ◽  
Bone Mineral ◽  
Bowel Disease ◽  
Genetic Risk ◽  
Japanese Patients ◽  
Genetic Risk Factors ◽  
Mineral Density ◽  
Inflammatory Bowel

Incidence, Risk Factors and Evaluation of Osteoporosis in Patients With Inflammatory Bowel Disease: A Danish Population-Based Inception Cohort With 10 Years of Follow-Up

2020 ◽  
Vol 14 (7) ◽  
pp. 904-914 ◽  
Author(s):  
Bobby Lo ◽  
Jakob Præst Holm ◽  
Marianne Kajbæk Vester-Andersen ◽  
Flemming Bendtsen ◽  
Ida Vind ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
At Risk ◽  
Bowel Disease ◽  
Population Based ◽  
Control Population ◽  
Inception Cohort ◽  
Mineral Density ◽  
Inflammatory Bowel

Abstract Background Patients with inflammatory bowel disease [IBD] including Crohn’s disease [CD] and ulcerative colitis [UC] are at risk of developing metabolic bone disease. The aims here were to investigate the screening strategy, incidence and risk factors of osteoporosis in a prospective population-based inception cohort. Method Between 2003 and 2004 all incident patients diagnosed with CD and UC in a well-defined Copenhagen area were included and followed until 2015. Data were compared with a control population [at a ratio of 1:20]. Regression models were performed with several covariates. The sensitivity of the Danish registries for osteoporosis was also assessed. Results A total of 513 patients were included [213 CD, 300 UC]. Overall, 338 (66%, CD: 164 [77%], UC: 174 [58%], p < 0.001] patients received ≥ 500 mg corticosteroid within a year, resulting in 781 patient-years at risk of osteoporosis. Of those, only 83 [10.6%] patient-years were followed by a dual-energy X-ray absorptiometry scan within the same or the following 2 years. Overall, 73 [14.2%] IBD patients (CD: 31 [14.6%], UC: 42 [14%]) and 680 [6.6%, p < 0.001] controls were diagnosed with osteoporosis during follow-up. The risk of osteoporosis was increased compared to the control population (odds ratio: CD: 2.9 [95% confidence interval: 2.0–4.1], UC: 2.8 [2.1–3.9]). Conclusion In this population-based inception cohort, the incidence of osteoporosis was significantly higher compared to a control population. Measurement of bone mineral density is infrequent, especially in patients at high risk of developing osteoporosis. These results demonstrate the need of further awareness of the risk of osteoporosis among IBD patients, and prospective population-based studies are warranted.

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