scholarly journals Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4047
Author(s):  
Mustafa Sait Gönen ◽  
Merve Alaylıoğlu ◽  
Emre Durcan ◽  
Yusuf Özdemir ◽  
Serdar Şahin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Clinical Outcomes ◽  
Treatment Protocol ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Vitamin D Metabolism ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
Vitamin D3 Supplementation

Background: We aimed to establish an acute treatment protocol to increase serum vitamin D, evaluate the effectiveness of vitamin D3 supplementation, and reveal the potential mechanisms in COVID-19. Methods: We retrospectively analyzed the data of 867 COVID-19 cases. Then, a prospective study was conducted, including 23 healthy individuals and 210 cases. A total of 163 cases had vitamin D supplementation, and 95 were followed for 14 days. Clinical outcomes, routine blood biomarkers, serum levels of vitamin D metabolism, and action mechanism-related parameters were evaluated. Results: Our treatment protocol increased the serum 25OHD levels significantly to above 30 ng/mL within two weeks. COVID-19 cases (no comorbidities, no vitamin D treatment, 25OHD <30 ng/mL) had 1.9-fold increased risk of having hospitalization longer than 8 days compared with the cases with comorbidities and vitamin D treatment. Having vitamin D treatment decreased the mortality rate by 2.14 times. The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1. Conclusions: Vitamin D treatment shortened hospital stay and decreased mortality in COVID-19 cases, even in the existence of comorbidities. Vitamin D supplementation is effective on various target parameters; therefore, it is essential for COVID-19 treatment.

Serum Vitamin D: Correlates of Baseline Concentration and Response to Supplementation in VITAL-DKD

2021 ◽  
Author(s):  
Cora M Best ◽  
Leila R Zelnick ◽  
Kenneth E Thummel ◽  
Simon Hsu ◽  
Christine Limonte ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Parent Compound ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Total Serum ◽  
P Value ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D3 Supplementation

Abstract Context The effect of daily vitamin D supplementation on the serum concentration of vitamin D (the parent compound) may offer insight into vitamin D disposition. Objective To assess the total serum vitamin D response to vitamin D3 supplementation and whether it varies according to participant characteristics. To compare results with corresponding results for total serum 25-hydroxyvitamin D (25(OH)D), which is used clinically and measured in supplementation trials. Design Exploratory study within a randomized trial. Intervention 2,000 International Units of vitamin D3 per day (or matching placebo). Setting Community-based. Participants 161 adults (mean ± SD age 70 ± 6 years; 66% males) with type 2 diabetes. Main Outcome Measures Changes in total serum vitamin D and total serum 25(OH)D concentrations from baseline to year 2. Results At baseline, there was a positive, nonlinear relation between total serum vitamin D and total serum 25(OH)D concentrations. Adjusted effects of supplementation were a 29.2 (95% CI: 24.3, 34.1) nmol/L increase in serum vitamin D and a 33.4 (95% CI: 27.7, 39.2) nmol/L increase in serum 25(OH)D. Among those with baseline 25(OH)D &lt; 50 compared with ≥ 50 nmol/L, the serum vitamin D response to supplementation was attenuated (15.7 vs 31.2 nmol/L; interaction p-value = 0.02), whereas the serum 25(OH)D response was augmented (47.9 vs 30.7 nmol/L; interaction p-value = 0.05). Conclusions Vitamin D3 supplementation increases total serum vitamin D and 25(OH)D concentrations with variation according to baseline 25(OH)D, which suggests that 25-hydroxylation of vitamin D3 is more efficient when serum 25(OH)D concentration is low.

scholarly journals Vitamin D Deficiency in South Sharqiya in Oman and its Impact in ENT Patients- A Retrospective Study

2016 ◽  
Vol 24 (3) ◽  
pp. 122-128
Author(s):  
Hasan Abdul Cader Segana ◽  
Reghunandanan Nair ◽  
Fahim Ahmed Shah
Keyword(s):  
Vitamin D ◽  
Retrospective Study ◽  
Vitamin D Deficiency ◽  
Clinical Manifestations ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Socioeconomic Background ◽  
Vitamin D Metabolism ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Introduction Vitamin D deficiency has multitude of causes and can present with varying clinical manifestations. Studies show that it can lead on to recurrent respiratory infections, ear infections and deafness. Vitamin D also has immunomodulant action. Here we discuss the varying features concerning an Otolaryngologist in general as far as Vitamin D metabolism is concerned. Materials and Methods This retrospective study was performed on 800 patients 152 males and 648 females of different socioeconomic background at secondary level regional referral hospital under Ministry of Health in Sultanate of Oman. The patients attending the outpatient clinic with various complaints and not responding to conventional treatment were advised for assessment of vitamin D [25 (OH) D] level in blood. The patients were evaluated with general history, blood samples of serum calcium, phosphate, alkaline phosphatase and serum vitamin D level were measured by the most standardized laboratory of the country. Results Out of 800 patients, 275 cases had Vitamin D levels below 20 ng/ml and 167 patients had values greater than 30 ng/ml in serum.81% patients with vitamin D deficiency were females.56.25% patients were between third and sixth decade. Otolaryngologic manifestations were acute and recurrent URTI (n=352) 44%. 7% of the patients presented with recurrent ear infection (otitis externa). The rest of them presented to a lesser extent with deafness, otosclerosis. Discussion Vitamin D deficiency has been reported worldwide as one of the commonest deficiency diseases. It can lead to autoimmune dysfunctions, Beta cell dysfunction in pancreas, Multiple sclerosis, recurrent chest infections and congestive cardiac failure. Studies have shown the involvement of cochlea with sensorineural hearing loss and otosclerosis. Conclusion Vitamin D deficiency has multi system implications as patients presenting with different signs and symptoms. Mass level screening and vitamin D supplementation should be planned to decrease its varied and multidimensional ill effects on health. Adequate vitamin D supplementation and sensible sunlight exposure to reach optimal vitamin D status are among the front line factors of prophylaxis for spectrum of disorders.

Vitamin D and breast cancer

2014 ◽  
Vol 155 (28) ◽  
pp. 1091-1096 ◽  
Author(s):  
Tamás Nagykálnai ◽  
László Landherr ◽  
András Csaba Nagy
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Tumor Suppressor Genes ◽  
Active Form ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Scientific Publications ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The active form of vitamin D, in conjunction with his own receptor, affect a multitude of biological processes in the cell (inter alia it influences the expression of oncogenes and tumor suppressor genes). There is an increasing volume of scientific publications examining the relationships between serum vitamin D levels, vitamin D supplementation and malignant diseases. Some articles suggest inverse relationship between the low serum levels of vitamin D and the breast cancer risk and mortality, whilst other publications do not support this view. Thus the present opinion is conflicted. Vitamin D can exert a beneficial influence on the symptoms and outcomes of a large number of ailments, but its role in affecting cancer is still not completely clear. Orv. Hetil., 2014, 155(28), 1091–1096.

scholarly journals Role of vitamin D supplementation in asthma and seasonal allergic rhinitis in eastern India

2017 ◽  
Vol 8 (3) ◽  
pp. 26-29 ◽  
Author(s):  
Manuprita Sharma ◽  
Anindita Banerjee ◽  
Vineet Kumar Khemka ◽  
Ravela Malathi ◽  
Sukanta Sen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Serum Samples ◽  
Major Health Problem ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Asthma Patients

Background: Allergic rhinitis (AR) known to be a common type of chronic rhinitis which affects 10-20% of the general population while asthma is another major health problem and leading cause of morbidity in the worldwide. Vitamin D, a steroid hormone known for its important role in immunological effects has a role in AR and asthma.Aims and Objectives: The aim of our study was to assess the serum vitamin D levels in patients with asthma and seasonal AR pre-treatment or post treatment with oral vitamin D supplementation (cholecalciferol – 1000 IU) and to study the pathogenesis of the disease.Materials and Methods: The study included 66 AR and asthma patients and 46 control subjects.Fasting serum samples of control and AR subjects were analyzed for routine biochemical parameters immediately after collection while aliquots of the samples were also stored at - 200 C for the assay of 25-hydroxyvitamin D by ELISA.Results: Serum vitamin D levels were found to be significantly lower in AR and asthma patients compared with controls (p < 0.0001). On receiving vitamin D supplementation (cholecalciferol – 1000 IU) we found an increase in vitamin D serum levels in AR and asthma patients as compared to controls (p < 0.0001).Conclusion: Supplementation of vitamin D may be beneficial in the prevention of the pathogenesis of AR and asthma.Asian Journal of Medical Sciences Vol.8(3) 2017 26-29

scholarly journals A review of vitamin D supplementation as disease-modifying therapy

2018 ◽  
Vol 24 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Thomas Jack Shoemaker ◽  
Ellen M Mowry
Keyword(s):  
Vitamin D ◽  
Demyelinating Disease ◽  
Severe Disease ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Meaningful Improvement ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
The Central Nervous System ◽  
Disease Modifying

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) and a major contributor to disability of young adults in western countries. MS prevalence is highest in areas with low vitamin D. Vitamin D is a fat-soluble compound with numerous physiologic responses, including immune regulation. An increasing volume of work suggests that lower levels of serum vitamin D are associated with an increased risk of MS and a more severe disease course. With the suggestion of a role in MS disease activity, increasing attention is being paid to the potential of using vitamin D as an add-on therapy to established MS disease-modifying therapies. Several preliminary studies have reported results which have shown some promise, but none has yet provided significant evidence of a clinically meaningful improvement. We review our recommendations for off-label supplementation in the context of these findings.

scholarly journals Vitamin D Supplementation does not Effect Adiposity in Healthy Adults

2017 ◽  
Vol 1 (2) ◽  
pp. 101
Author(s):  
Zujaja-Tul-Noor Hamid Mehmood ◽  
Dimitrios Papandreou
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Epidemiological Data ◽  
Serum Levels ◽  
Vitamin D Supplementation ◽  
Hip Circumference ◽  
Related Factors ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
24 Hour Recall

Introduction: Vitamin D is crucial for skeletal and extraskeletal health outcomes as Vitamin D binding receptors are located through out body, and epidemiological data supports its link with many conditions. Data on vitamin D levels and especially Vitamin D supplementation in U.A.E. is essentially inadequate.Design: Subjects (n=20) in this 1 month prospective study were given 2000 IU of daily Vitamin D without any special dietary or physical activity changes. Anthropometrics (weight, waist circumference, hip circumference), Vitamin D/ Calcium food frequency questionnaire and 24 –Hour recall were collected.Results: Mean age of subjects was 28.7 years, and baseline mean serum Vitamin D level of 17.5 ng/mL ±6.47. It increased Vitamin D serum levels by a mean of 6.76 ng/mL. Hip Circumference also reduced statistically significantly by moderate 2% (p 0.03 ±0.59),Conclusion: Vitamin D supplementation moderate dose daily can be pivotal in acquiring health benefits and reducing adiposity related factors. However, this surely calls for further investigation for longer period.

scholarly journals Evaluation of Serum Vitamin D Levels in Adolescents with Pubertal Gynecomastia

Breast Care ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. 333-337 ◽  
Author(s):  
Melis Pehlivantürk Kızılkan ◽  
Sinem Akgül ◽  
Filiz Akbıyık ◽  
Orhan Derman ◽  
Nuray Kanbur
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Mammary Tissue ◽  
Control Group ◽  
Contributing Factors ◽  
Vitamin D Metabolism ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Pubertal Gynecomastia

Background: Since vitamin D has an inhibitory function on ductal morphogenesis of the pubertal mammary gland, it may have a role in the development of gynecomastia. The aim of this study was to determine the effect of vitamin D deficiency on the development of pubertal gynecomastia. Methods: Serum 25-hydroxyvitamin D (25D) levels in 50 adolescents with pubertal gynecomastia and 54 healthy controls between the ages of 11 and 17 years were compared. Results: Mean 25D level was 14.03 ± 6.38 (5.0-32.5) ng/ml in the pubertal gynecomastia group and 15.19 ± 6.49 (5.0-33.2) ng/ml in the control group (p = 0.361). According to the vitamin D status classification of the American Academy of Pediatrics, 66% of the pubertal gynecomastia group was found to be deficient and 14% were insufficient. In the control group these values were 53.7% and 29.6%, respectively (p = 0.158). Conclusion: From our results we hypothesize that, rather than low serum levels of 25D, a dysregulation of the vitamin D signal pathway, vitamin D metabolism or vitamin D storage within the mammary tissue might be the contributing factors to the development of gynecomastia.

scholarly journals Is Low Serum Vitamin D Associated with Early Dental Implant Failure? A Retrospective Evaluation on 1625 Implants Placed in 822 Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Francesco Mangano ◽  
Carmen Mortellaro ◽  
Natale Mangano ◽  
Carlo Mangano
Keyword(s):  
Vitamin D ◽  
Dental Implant ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Implant Failure ◽  
Smoking History ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
Early Failures ◽  
Low Serum

Aim. To investigate whether there is a correlation between early dental implant failure and low serum levels of vitamin D.Methods. All patients treated with dental implants in a single centre, in the period 2003–2015, were considered for enrollment in this study. The main outcome was early implant failure. The influence of patient-related variables on implant survival was calculated using the Chi-square test.Results. 822 patients treated with 1625 implants were selected for this study; 27 early failures (3.2%) were recorded. There was no link between gender, age, smoking, history of periodontitis, and an increased incidence of early failures. Statistical analysis reported 9 early failures (2.2%) in patients with serum levels of vitamin D > 30 ng/mL, 16 early failures (3.9%) in patients with levels between 10 and 30 ng/mL, and 2 early failures (9.0%) in patients with levels <10 ng/mL. Although there was an increasing trend in the incidence of early implant failures with the worsening of vitamin D deficiency, the difference between these 3 groups was not statistically significant (P=0.15).Conclusions. This study failed in proving an effective link between low serum levels of vitamin D and an increased risk of early implant failure. Further studies are needed to investigate this topic.

scholarly journals Prevalence of vitamin D deficiency and effect of vitamin D supplementation on feto-maternal outcome in tertiary care centre

2018 ◽  
Vol 7 (12) ◽  
pp. 4912
Author(s):  
Munmun Yadav ◽  
Mahendra Kumar Verma ◽  
Mohan Bairwa ◽  
Govardhan Meena ◽  
Lata Rajoria
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Risk Of Preeclampsia

Background: Vitamin D deficiency is widely prevalent throughout the world. Pregnant women, neonates and infants form most vulnerable groups for vitamin D deficiency. Hypovitaminosis D in pregnancy has been reported to cause various fetomaternal effect, i.e. increased risk of preeclampsia (PE), gestational diabetes mellitus (GDM), caesarean section, hypocalcemia, subclinical myopathy, neonatal tetany, hyperbilirubinemia congenital rickets and infantile rickets, etc. Only few Indian studies are available in this regard. The objectives are to find prevalence of vitamin D deficiency in pregnant women and to evaluate the effect of supplementation with cholecalciferol in improving vitamin D levels in pregnant women and evaluate its correlation with feto-maternal outcome.Methods: A prospective observational was conducted on 120 Pregnant women on their first visit to hospital irrespective of gestational age were offered the test and on the basis of inclusion and exclusion criteria are included in study and vitamin D level was done to know the prevalence of vitamin D deficiency. Apart from routine obstetrical investigation, serum vitamin D (total) level was estimated. All results were recorded and analyzed statically.Results: Out of 120 patients 101 (84.1%) were found to be vitamin D deficient. Mean age of vitamin D deficient group was 28.31±3.86 and sufficient group was 26.37±2.83.81 (67.5%) were vegetarian and 39 (32.5%) were nonvegetarian.75 (92.59%) vegetarian and 26 (66.66%) non-vegetarian found to be vitamin D deficient. (p<0.05). Vitamin D supplementation has been observed to reduce risk of preeclampsia. (p<0.05) and vitamin D sufficiency associated with reduced risk of low birth weight babies.Conclusions: Vitamin D supplementation reduces risk of maternal comorbidities and helps improve neonatal outcomes.

scholarly journals Genetic Polymorphisms of Vitamin D Metabolism Genes and Serum Level of Vitamin D in Colorectal Cancer

2017 ◽  
Vol 32 (4) ◽  
pp. 441-446 ◽  
Author(s):  
Veronica Marques Vidigal ◽  
Pedro Nazareth Aguiar ◽  
Tiago Donizetti Silva ◽  
Juliana de Oliveira ◽  
Célia Aparecida Marques Pimenta ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Active Form ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Active Vitamin ◽  
Vitamin D Metabolism ◽  
Serum Vitamin D ◽  
Active Vitamin D ◽  
Vitamin D Levels

Background The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients. Methods One hundred fifty-two CRC patients and 321 controls were included. DNA was extracted from peripheral blood. Polymorphisms of BsmI and ApaI were identified by PCR-RFLP. Those of CYP24A1 (rs6013897, rs158552 and rs17217119) and CYP27B1 (rs10877012) were determined by gene sequencing. Results The median serum levels of circulating vitamin D were not different between CRC patients and controls; however, the percentage of those with deficient vitamin D was higher in patients with cancer. The active form of the vitamin D was higher in CRC patients. VDR, CYP27B1 and CYP24A1 polymorphic genotypes had no influence on serum levels of circulating vitamin D. The correlation between circulating and active vitamin D forms was lower among patients with CRC, regardless of the presence or absence of any genetic polymorphism. The mean serum levels of active vitamin D were higher among patients with polymorphic genotype variants of Apa1 or Bsm1. Conclusions CRC patients had a higher frequence of insufficient vitamin D and a higher concentration of active vitamin D. These concentration were higher between patients with polymorphic genotypes variants of ApaI and BsmI, CYP24A1 and CYP27B1. Polymorphic genotypes cause a lower correlation between the forms of vitamin D.

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