scholarly journals Toxoplasma gondii Infection and Suicidal Behavior in People with Alcohol Consumption

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 734
Author(s):  
Cosme Alvarado-Esquivel ◽  
Sergio Estrada-Martínez ◽  
Alma Rosa Pérez-Álamos ◽  
Isabel Beristain-García ◽  
Ángel Osvaldo Alvarado-Félix ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Toxoplasma Gondii ◽  
Alcohol Consumption ◽  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Igg Antibodies ◽  
Igm Antibodies ◽  
Immunosorbent Assays ◽  
Toxoplasma Gondii Infection

We determined the association between T. gondii infection and suicidal behavior in people with alcohol consumption. One-thousand four-hundred and twenty-three people with alcohol consumption were screened for suicidal behavior and tested for anti-T. gondii IgG and IgM antibodies using commercially available enzyme-linked immunosorbent assays. Anti-T. gondii IgG antibodies were found in 34 of 224 (15.2%) individuals with suicidal ideation and in 118 (9.8%) of 1199 individuals without suicidal ideation (OR: 1.63; 95% CI: 1.08–2.47; p = 0.01). Seropositivity to T. gondii was associated with suicidal ideation in women (OR: 2.24; 95% CI: 1.33–3.78; p = 0.001) and in individuals aged ≤30 years (OR: 2.68; 95% CI: 1.22–5.87; p = 0.01) and >50 years (OR: 2.85; 95% CI: 1.19–6.77; p = 0.01). Anti-T. gondii IgG antibodies were found in 17 of 136 (12.5%) individuals with suicide attempts and in 135 (10.5%) of 1287 individuals without suicide attempts (OR: 1.21; 95% CI: 0.71–2.08; p = 0.47). Seroprevalence of T. gondii infection was associated with suicide attempts in women (OR: 1.88; 95% CI: 0.99–3.55; p = 0.04). No association between anti-T. gondii IgM and suicidal ideation or suicide attempts was found. Results suggest that T. gondii infection is associated with suicidal behavior in people with alcohol consumption.

scholarly journals Seroepidemiology of Toxoplasma gondii infection in people with alcohol consumption in Durango, Mexico

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245701
Author(s):  
Sergio Estrada-Martinez ◽  
Alma Rosa Pérez-Álamos ◽  
Melina Ibarra-Segovia ◽  
Isabel Beristaín-Garcia ◽  
Agar Ramos-Nevárez ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Toxoplasma Gondii ◽  
Alcohol Consumption ◽  
Bivariate Analysis ◽  
History Of Surgery ◽  
Igg Antibodies ◽  
Serum Samples ◽  
Igm Antibodies ◽  
History Of ◽  
Toxoplasma Gondii Infection

The seroepidemiology of infection with Toxoplasma gondii (T. gondii) in alcohol consumers is largely undeveloped. In light of this, we sought to determine the seroprevalence of T. gondii infection in alcohol consumers in Durango, Mexico, and the association of T. gondii seroprevalence with characteristics of the population studied. Anti-T. gondii IgG and IgM antibodies were searched in sera of participants using commercially available enzyme immunoassays. Bivariate and logistic regression analyses were then used to determine the association between T. gondii infection and the characteristics of the population studied. Of the 1544 people studied (mean age: 39.4±14.0 years), 173 (11.2%) tested positive for anti-T. gondii IgG antibodies. We were able to test 167 of the 173 anti-T. gondii IgG positive sera for anti-T. gondii IgM antibodies. Fifty-five (32.9%) of these 167 serum samples were positive for anti-T. gondii IgM antibodies. Bivariate analysis showed that visual impairment, history of surgery, and hepatitis were negatively associated with T. gondii IgG seropositivity (P<0.05). In women, seropositivity to T. gondii was positively associated with a history of pregnancy (P<0.05). Logistic regression analysis showed that T. gondii seropositivity was associated with the variables consumption of armadillo meat (OR = 2.33; 95% CI: 1.04–5.22; P = 0.03), and the use of latrines for elimination of excretes (OR = 2.27; 95% CI: 1.07–4.80; P = 0.03); and high (>150 IU/ml) anti-T. gondii IgG antibodies were associated with consumption of both armadillo meat (OR = 2.25; 95% CI: 1.01–5.02; P = 0.04) and crowding at home (OR = 1.63; 95% CI: 1.02–2.61; P = 0.03). We found a distinct T. gondii seroprevalence in people with alcohol consumption from those previously found in population groups in the region. This is the first study that illustrates the association between high anti-T. gondii antibodies and crowding in Mexico, and the second study on the association between T. gondii infection and consumption of armadillo meat and the use of latrines in this country. We conclude that epidemiology of T. gondii infection in people with alcohol consumption deserves further investigation.

scholarly journals Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 677
Author(s):  
Cosme Alvarado-Esquivel ◽  
Sergio Estrada-Martínez ◽  
Agar Ramos-Nevárez ◽  
Alma Rosa Pérez-Álamos ◽  
Isabel Beristain-García ◽  
...  
Keyword(s):  
Primary Care ◽  
Health Care ◽  
Suicidal Ideation ◽  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Igg Antibodies ◽  
Primary Care Clinics ◽  
Health Care Clinics ◽  
Primary Health ◽  
History Of

This study aimed to determine the association between suicidal behavior and T. gondii seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against T. gondii were found in 37 (12.1%) out of 306 individuals with a history of suicidal ideation and in 134 (7.7%) of 1739 individuals without this history (OR: 1.64; 95% CI: 1.11–2.42; p = 0.01). Seropositivity to T. gondii was associated with suicidal ideation in women (OR: 1.56; 95% CI: 1.01–2.42; p = 0.03) and individuals aged ≤30 years (OR: 3.25; 95% CI: 1.53–6.88; p = 0.001). No association between the rates of high (>150 IU/mL) levels of anti-T. gondii IgG antibodies and suicidal ideation or suicide attempts was found. IgG antibodies against T. gondii were found in 22 of 185 (11.9%) individuals with a history of suicide attempts and in 149 (8.0%) of 1860 individuals without this history (OR: 1.54; 95% CI: 0.96–2.49; p = 0.06). The seroprevalence of T. gondii infection was associated with suicide attempts in individuals aged 31–50 years (OR: 2.01; 95% CI: 1.09–3.71; p = 0.02), and with more than three suicide attempts (OR: 4.02; 95% CI: 1.34–12.03; p = 0.008). Our results indicate that T. gondii exposure is associated with suicidal behavior among patients attending primary care clinics.

Sero-molecular evaluation of Toxoplasma gondii infection among HIV-positive patients

2019 ◽  
Vol 113 (12) ◽  
pp. 771-775 ◽  
Author(s):  
Ehsan Ahmadpour ◽  
Reza Pishkarie-Asl ◽  
Adel Spotin ◽  
Hossein Samadi Kafil ◽  
Hasan Didarlu ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Mortality Rate ◽  
Hiv Positive ◽  
Igg Antibodies ◽  
Rt Pcr ◽  
Igg Antibody ◽  
Cross Sectional ◽  
Igm Antibodies ◽  
Northwest Iran ◽  
Toxoplasma Gondii Infection

Abstract Background Toxoplasmosis is one of the most common comorbidities in HIV-positive patients with CD4+ T lymphocytes below 200 cells/μl. Early diagnosis and treatment of toxoplasmosis reduces the mortality rate in HIV-positive people. The aim of this study was to estimate the seroprevalence of Toxoplasma gondii infection in HIV-positive patients in northwest Iran using serological and molecular methods. Methods This prospective cross-sectional study included 124 HIV-positive outpatients and was conducted from January to May 2016. Anti-T. gondii IgM and IgG antibodies were detected from sera samples by chemiluminescence, while buffy coat samples were analyzed by RT-PCR for DNA detection. Patients’ socioepidemiological data were collected. Results Using chemiluminescence, 47/124 samples (37.9%) were positive for anti-Toxoplasma IgG antibodies, 2/124 samples (1.62%) were positive for IgM antibodies while 2/124 samples (1.62%) contained both IgM and IgG. There were no IgM-positive or IgG-negative patients. RT-PCR revealed four (3.22%) positive samples. On the basis of the results, a statistically significant relationship was found between anti-Toxoplasma IgG antibody seropositivity and residence (p=0.012). Conclusions The study showed a relatively low seroprevalence of anti-T. gondii IgG and IgM antibodies in HIV-positive patients in northwest Iran, while the prevalence was much higher in other regions of Iran. However, regular screening for T. gondii antibodies and early initiation of therapy are very important to decrease the mortality rate in HIV-positive patients.

A probe in the connection between inflammation, cognition and suicide

2018 ◽  
Vol 32 (4) ◽  
pp. 482-488 ◽  
Author(s):  
Ricardo Cáceda ◽  
W Sue T Griffin ◽  
Pedro L Delgado
Keyword(s):  
Suicidal Ideation ◽  
Suicidal Behavior ◽  
Linear Models ◽  
Suicide Attempts ◽  
Limited Data ◽  
Physical Pain ◽  
Reactive Protein ◽  
Depressed Patients ◽  
Downstream Effects ◽  
Suicidal Patients

Background: Increased inflammation is linked to suicide risk. However, it is unclear whether increased inflammation drives suicidal crises or is a trait associated with lifetime suicidal behavior. Limited data exist on the sources of increased inflammation observed in suicidal patients and on its downstream effects. Aims: To examine factors associated with inflammation and with suicidal ideation severity in acutely suicidal depressed patients. Methods: Fifty-two adult depressed patients of both sexes hospitalized for severe suicidal ideation were characterized for suicidality, depression, anxiety, medical comorbidity, psychological and physical pain, impulsivity, verbal fluency, C-reactive protein (CRP) and interleukin (IL) 6. Two generalized linear models were performed with either CRP or suicidal ideation severity as dependent variables. Results: CRP levels were positively associated with age, body mass index (BMI), IL6, current physical pain and number of lifetime suicide attempts. Suicidal ideation severity was not significantly correlated with either CRP or IL6. Suicidal ideation severity was positively associated with female sex, presence of an anxiety disorder, current physical pain, number of lifetime suicide attempts and with delay discounting for medium and large losses. Conclusions: Increased inflammation is not associated with acute suicidal risk, but seems to represent a trait associated with lifetime suicidal behavior.

scholarly journals Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Pengshuo Wang ◽  
Ran Zhang ◽  
Xiaowei Jiang ◽  
Shengnan Wei ◽  
Fei Wang ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Mood Disorders ◽  
Gray Matter ◽  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Gray Matter Volume ◽  
Middle Frontal Gyrus ◽  
Left And Right ◽  
Magnetic Resonance Imaging Mri ◽  
Post Hoc

Abstract Background Mood disorders are severe mental disorders related to increased suicidal behavior. Finding neural features for suicidal behavior, including suicide attempts (SAs) and suicidal ideation (SI), in mood disorders may be helpful in preventing suicidal behavior. Methods Subjects consisted of 70 patients with mood disorders and suicidal behavior, 128 patients with mood disorders without suicidal behavior (mood disorders control, MC), and 145 health control (HC) individuals. All participants underwent structural magnetic resonance imaging (MRI). We used voxel-based morphometry (VBM) techniques to examine gray matter volumes (GMVs). Results Significant differences were found in GMVs of the left and right middle frontal gyrus among the patients with mood disorders and suicidal behavior, MC, and HC. Post hoc comparisons showed significant differences in the GMVs of the above regions across all three groups (P < 0.01): HC > MC > mood disorders with suicidal behavior. However, there were no significant differences in the GMVs of the left and right middle frontal gyrus between the mood disorders with SI and mood disorders with SAs groups. Conclusions These findings provide evidence that abnormal regional GMV in the middle frontal gyrus is associated with suicidal behavior in mood disorders. Further investigation is warranted to determine whether the GMV alterations in mood disorders with SI are different from these in mood disorders with SAs.

Interoceptive deficits, non-suicidal self-injury, and suicide risk: a multi-sample study of indirect effects

2019 ◽  
Vol 49 (16) ◽  
pp. 2789-2800 ◽  
Author(s):  
Christopher R. Hagan ◽  
Megan L. Rogers ◽  
Amy M. Brausch ◽  
Jennifer J. Muehlenkamp ◽  
Thomas E. Joiner
Keyword(s):  
Suicidal Ideation ◽  
Suicidal Behavior ◽  
Indirect Effect ◽  
Indirect Effects ◽  
Suicide Ideation ◽  
Suicide Attempts ◽  
Pain Tolerance ◽  
Self Report ◽  
Self Injury ◽  
Two Samples

AbstractBackgroundInteroceptive deficits (ID) have been associated with non-suicidal self-injury (NSSI) and suicidal behavior in multiple studies. Many of these studies are limited in scope, and have not fully examined possible mechanisms explaining how ID affect suicidal behavior.MethodsThis study assesses how self-reported ID relate to suicide ideation and attempts in six distinct and geographically diverse samples of adults (n = 2706) and one sample of adolescents (n = 436). Participants responded to a variety of self-report questionnaires and interviews.ResultsContrary to our hypothesis, self-reported ID were only associated with suicidal ideation in two samples, one of which was the adolescent sample. Largely consistent with our predictions, self-reported ID exhibited an indirect effect on suicide attempts through versatility of NSSI in four of the five adult samples tested. Finally, the indirect effects of self-reported ID on suicide attempts through NSSI versatility did not act indirectly through behaviorally assessed pain tolerance.ConclusionsWe found that, in adults, self-reported ID are not associated with suicidal ideation, but are connected with a history of suicide attempts, through an indirect effect via NSSI. Our findings also indicate that the mechanism of action leading from self-reported ID to suicidal behavior may differ between adolescents and adults, and relate to suicidal behavior independent of pain tolerance. Clinical implications and future directions are discussed.

Serodiagnosis of recently acquired Toxoplasma gondii infection in pregnant women using enzyme-linked immunosorbent assays with a recombinant dense granule GRA6 protein

2008 ◽  
Vol 61 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Majid Golkar ◽  
Kayhan Azadmanesh ◽  
Ghader Khalili ◽  
Baharak Khoshkholgh-Sima ◽  
Jalal Babaie ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Dense Granule ◽  
Immunosorbent Assays ◽  
Toxoplasma Gondii Infection

Investigation of anti-Toxoplasma gondii antibodies in patients with neoplasia

2004 ◽  
Vol 53 (12) ◽  
pp. 1183-1186 ◽  
Author(s):  
Süleyman Yazar ◽  
Ozan Yaman ◽  
Bülent Eser ◽  
Fevzi Altuntaş ◽  
Fatih Kurnaz ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Patient Group ◽  
Healthy Controls ◽  
Igg Antibodies ◽  
Human Igg ◽  
Igm Antibodies ◽  
Significant Difference

This study aimed to determine the prevalence of anti-Toxoplasma gondii antibodies in patients with neoplasia. One hundred and eight patients with neoplasia and 108 healthy controls were studied for the presence of anti-T. gondii antibodies using a micro ELISA and peroxidase-labelled anti-human IgG (rabbit) and IgM (goat). Anti-T. gondii IgG antibodies were detected in 68 (63.0 %) patients and in 21 (19.4 %) of the controls, which was a statistically significant difference. In addition, anti- T. gondii IgM antibodies were detected in seven (6.5 %) patients and in one (0.9 %) control. A high percentage of positivity for Toxoplasma antibodies in patients with neoplasia was detected. Therefore, parasitological surveys of this patient group should be periodically performed.

Toxoplasma gondii Infection and Suicide Attempts

2013 ◽  
Vol 201 (11) ◽  
pp. 948-952 ◽  
Author(s):  
Cosme Alvarado-Esquivel ◽  
Luis Francisco Sánchez-Anguiano ◽  
Carlos Alberto Arnaud-Gil ◽  
Julio César López-Longoria ◽  
Luis Fernando Molina-Espinoza ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Suicide Attempts ◽  
Toxoplasma Gondii Infection

Evaluation of Suicidal Behaviour in a General Psychiatric Consultation

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
C. Silva ◽  
I. Gil ◽  
M.A. Mateus ◽  
Ó. Nogueiro
Keyword(s):  
Suicidal Ideation ◽  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Age Group ◽  
Psychiatric Consultation ◽  
Process Data ◽  
Systematic Screening ◽  
High Prevalence ◽  
History Of ◽  
Religious Aspects

Several studies have been conducted to establish a profile of the suicidal/parasuicidal patient. Also several factors have been identified as possibly influencing the suicidal rates, including the religious practices.Objectives:Characterize the profile of suicidal behavior in a sample of patients followed in a general psychiatric consultation.Methods:It was done an analytical observational study of a random sample of 100 patients followed in a general psychiatric consultation. A survey was conducted with the collection of socio-economic, religious aspects and clinical data, and it was consulted the patient"s clinical process. Data analysis was done in Excel 2003.Results:The sample was consisted mostly by women (74%), being the most representative age group between 40 and 50 years (27%), mostly married (61%), 24% had 2 children and 65% lived in the rural area. The clinical diagnosis (ICD-9) was in 46% of cases, neurotic depression. 52% consider themselves religious not practitioners, being 90% catholics. History of suicide attempts/parasuicide occurred in 32% of patients, in the form of drug intoxication (31%) or with another method (11%). Most of the individuals said to have already thought about suicide at least once in their lifetime (74%). Only 8% had current suicidal ideation. Family history of suicide occurred in 27%, particularly in first degree family members, mainly by drowning (7%) and hanging (7%).Conclusions:Our results suggest that exists a high prevalence of suicidal behavior in this patients. For that reason, it should be done a systematic screening for suicidal ideation in this risk population.

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