scholarly journals Biological Applications of Thiocarbohydrazones and Their Metal Complexes: A Perspective Review

2019 ◽  
Vol 13 (1) ◽  
pp. 4 ◽  
Author(s):  
Carmela Bonaccorso ◽  
Tiziano Marzo ◽  
Diego La Mendola
Keyword(s):  
Coordination Chemistry ◽  
Metal Complexes ◽  
Metal Binding ◽  
Structural Diversity ◽  
Binding Modes ◽  
Main Research ◽  
Research Areas ◽  
Wide Range ◽  
Clinical Drugs ◽  
Sulfur Donor Ligands

Although organic compounds account for more than 99% of currently approved clinical drugs, the established clinical use of cisplatin in cancer or auranofin in rheumatoid arthritis have paved the way to several research initiatives to identify metal-based drugs for a wide range of human diseases. Nitrogen and sulfur donor ligands, characterized by different binding motifs, have been the subject in recent years of one of the main research areas in coordination chemistry. Among the nitrogen/sulfur compounds, very little is known about thiocarbohydrazones (TCH), the higher homologues of the well-known thiosemicarbazones (TSC), and their metal complexes. The extra hydrazine moiety provides the ligands of variable metal binding modes, structural diversity and promising biological implications. The interesting coordination chemistry of TCH has mainly been focused on symmetric derivatives, which are relatively simple to synthesize while few examples of asymmetric ligands have been reported. This informative review on TCHs and their metal complexes will be helpful for improving the design of metal-based pharmaceuticals for applications ranging from anticancer to antinfective therapy.

Unravelling the versatile metal binding modes of adenine: Looking at the molecular recognition patterns of deaza- and aza-adenines in mixed ligand metal complexes

2013 ◽  
Vol 257 (19-20) ◽  
pp. 2814-2838 ◽  
Author(s):  
Alicia Domínguez-Martín ◽  
María del Pilar Brandi-Blanco ◽  
Antonio Matilla-Hernández ◽  
Hanan El Bakkali ◽  
Valeria Marina Nurchi ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Metal Complexes ◽  
Metal Binding ◽  
Mixed Ligand ◽  
Binding Modes

Biotechnology of oil production. Principles and application

2017 ◽  
Author(s):  
Nariman Ismailov
Keyword(s):  
Human Activity ◽  
Oil Production ◽  
Oil Field ◽  
General Idea ◽  
Field Development ◽  
Main Research ◽  
Research Areas ◽  
Oil Field Development ◽  
Wide Range

The importance of biotechnology in various areas of human activity has become increasingly obvious in recent years. This determines the interest that, in our opinion, this book represents. It is aimed primarily at specialists engaged in the development of biotechnologies, as well as oil practitioners. The purpose of this book is to give the most complete, in — depth understanding of what oil production biotechnology is. However, it would be frivolous to say that this book exhaustively covers this topic. It is intended to arouse the interest of researchers and practitioners to this problem and give a General idea about it. This is essentially only the basis of some of the main research areas that can be attributed to the field of oil production biotechnologies, as well as an assessment of the principles that are the basis for the development of such technologies. At the same time, we believe that this book can be a good introduction to most of the main problems of oil production biotechnology. The book is intended not only for oil practitioners and specialists in the field of microbial biotechnologies, but also for a wide range of readers. It will be very useful for a student, an engineer specializing in the field of biotechnology of oil field development, as well as scientists to read this book.

Research on physico-chemical properties of sugars and sugar crystallization at the University of Chemistry and Technology in Prague

2020 ◽  
pp. 294-298
Author(s):  
Z. Bubnik ◽  
P. Kadlec ◽  
E. Sarka ◽  
V. Pour ◽  
A. Hinkova ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Main Research ◽  
Research Areas ◽  
Research Activities ◽  
Physico Chemical ◽  
Wide Range ◽  
The University ◽  
Physical And Chemical ◽  
Kinetics Of ◽  
And Chemical Properties

This paper represents a summary of most important research activities in sucrose crystallization, in which the Department of Carbohydrates and Cereals, part of the University of Chemistry and Technology (UCT) Prague, has been involved over the last 25 years. A wide range of these projects has been carried out in cooperation with other research institutes, universities and industrial partners. These activities can be divided into four main research areas that are interconnected and support each other. – Physical and chemical properties of sucrose and sugar solutions; – Growth kinetics of sugar crystals in pure and technical sugar solutions; – Simulation and mathematical modeling of new processes and technologies; – Experimental work for industry and cooperation with industrial partners.

scholarly journals Azoligands as Bridged in Macrocyclic Dinickel Complexes

2010 ◽  
Vol 5 (1) ◽  
pp. 7-23
Author(s):  
Vasile Lozan
Keyword(s):  
Coordination Chemistry ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
X Ray ◽  
X Ray Crystallography ◽  
Coordination Site ◽  
Wide Range

The coordination chemistry of dinickel macrocyclic hexaamine-dithiophenolate complexes of Robson-type with azoligands is presented in this microreview. All complexes have been characterised by IR-,UV/Visspectroscopy, and X-ray crystallography. The bioctahedral transition metal complexes of the type [(L6)Ni2(μ-L')]+ exhibit a rich coordination chemistry since the active coordination site L' is accessible for a wide range of exogenous coligands.

scholarly journals Workshop on Extreme Physics

2011 ◽  
Vol 7 (S285) ◽  
pp. 270-270
Author(s):  
Carole Mundell ◽  
Mark Sullivan
Keyword(s):  
Gamma Ray ◽  
Electromagnetic Spectrum ◽  
Audience Participation ◽  
Relativistic Jets ◽  
Main Research ◽  
Future Technology ◽  
Research Areas ◽  
Wide Range ◽  
Theoretical Predictions

SummaryNever before has there been such a wealth of versatile ground- and space-based facilities with which to detect variable emission across the electromagnetic spectrum and beyond, to non-EM signals such as neutrinos and gravitational waves, to probe the most extreme phenomena in the Universe. The variable sky is already providing a wealth of new and surprising observations of phenomena such as GRBs, SNe and AGN that are pushing current theories beyond the state of the art. Multi-messenger follow-up will soon become de rigeur, and upcoming radio and optical all-sky transient surveys will revolutionise the study of the transient Universe. In addition to the technical and data challenges presented by such surveys, a major new challenge will be the interpretation of the wealth of available data and the identification of the underlying physics of new classes of variable (and potentially exotic) objects. Theoretical predictions will be vital for interpreting these future transient discoveries.The goal of this workshop was to bring together theorists and observers in order to identify unexplored synergies across three main research areas of extreme physics: gamma-ray bursts, supernovæ and, more generically, relativistic jets. It aimed to discuss key outstanding questions in these rapidly moving fields, such as the composition and acceleration of GRB and AGN jets, GRB progenitors and central engines, the origin of the wide range of observed variability time-scales in GRB prompt and after-glow light curves and related cosmological applications, the physics of the newly-discovered ultra-luminous SN-like optical transients—as well as to speculate on what we might hope to discover with future technology.The workshop absorbed two 90-minute sessions, selecting 3 main science topics (Relativistic Jets, GRBs and SNe) which it organised as structured discussions driven by a series of short but provocative questions. The final session featured a panel-led debate but with full audience participation.

Structural diversity in coordination chemistry of tridentate and tetradentate polyphosphines of Group 6 to 10 transition metal complexes

2003 ◽  
Vol 236 (1-2) ◽  
pp. 143-206 ◽  
Author(s):  
Jean-Cyrille Hierso ◽  
Régine Amardeil ◽  
Emmanuelle Bentabet ◽  
Roland Broussier ◽  
Bernard Gautheron ◽  
...  
Keyword(s):  
Coordination Chemistry ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Structural Diversity ◽  
Group 6

Social exchange processes, health behaviour, and health behaviour change

2008 ◽  
Vol 16 (3) ◽  
pp. 131-134
Author(s):  
Urte Scholz ◽  
Rainer Hornung
Keyword(s):  
Social Exchange ◽  
Health Behaviour ◽  
Psychological Research ◽  
Smoking Behaviour ◽  
Self Report ◽  
Long Term Effects ◽  
Main Research ◽  
Research Areas ◽  
Exchange Processes ◽  
Multi Method Approach

Abstract. The main research areas of the Social and Health Psychology group at the Department of Psychology at the University of Zurich, Switzerland, are introduced. Exemplarily, three currently ongoing projects are described. The project ”Dyadic exchange processes in couples facing dementia” examines social exchanges in couples with the husband suffering from dementia and is based on Equity Theory. This project applies a multi-method approach by combining self-report with observational data. The ”Swiss Tobacco Monitoring System” (TMS) is a representative survey on smoking behaviour in Switzerland. Besides its survey character, the Swiss TMS also allows for testing psychological research questions on smoking with a representative sample. The project, ”Theory-based planning interventions for changing nutrition behaviour in overweight individuals”, elaborates on the concept of planning. More specifically, it is tested whether there is a critical amount of repetitions of a planning intervention (e.g., three or nine times) in order to ensure long-term effects.

Borders, Conflicts and Bargaining in Federations and Communities of Governments

2009 ◽  
pp. 83-99
Author(s):  
A. Libman
Keyword(s):  
Economic Policy ◽  
Public Authority ◽  
Modern World ◽  
Main Research ◽  
Research Areas ◽  
Nation States ◽  
Distribution Of Power

Economic policy in the modern world can be treated as an outcome of interaction of multiple territorial centers of public authority: nation-states, subnational and supranational jurisdictions. In the last decades economics has increased its attention to the factors which influence the distribution of power among jurisdictions. The paper surveys two main research areas in this literature: economics of conflicts and theory of endogenous decentralization. It discusses the basic models of both approaches and their modifications applied in the literature as well as factors of conflict formation and bargaining over devolution.

Fine-Tuning Electronic Properties of Luminescent Pt(II) Complexes via Vertex-Differentiated Coordination of Sterically Invariant Carborane-Based Ligands

2018 ◽  
Author(s):  
Kent O. Kirlikovali ◽  
Jonathan C. Axtell ◽  
Kierstyn Anderson ◽  
Peter I. Djurovich ◽  
Arnold L. Rheingold ◽  
...  
Keyword(s):  
Coordination Chemistry ◽  
Metal Complexes ◽  
Electronic Properties ◽  
Fine Tuning ◽  
Fine Tune

We report the synthesis of two isomeric Pt(II) complexes ligated by doubly deprotonated 1,1′-bis(<i>o</i>-carborane) (<b>bc</b>). This work provides a potential route to fine-tune the electronic properties of luminescent metal complexes by virtue of vertex-differentiated coordination chemistry of carborane-based ligands.

Approach in improving potency and selectivity of kinase inhibitors: Allosteric kinase inhibitors

2020 ◽  
Vol 21 ◽  
Author(s):  
Shangfei Wei ◽  
Tianming Zhao ◽  
Jie Wang ◽  
Xin Zhai
Keyword(s):  
Protein Interactions ◽  
Kinase Inhibitors ◽  
Binding Modes ◽  
Allosteric Inhibitors ◽  
Wide Range ◽  
Allosteric Sites ◽  
Protein Functions ◽  
Regulate Protein

: Allostery is an efficient and particular regulatory mechanism to regulate protein functions. Different from conserved orthosteric sites, allosteric sites have distinctive functional mechanism to form the complex regulatory network. In drug discovery, kinase inhibitors targeting the allosteric pockets have received extensive attention for the advantages of high selectivity and low toxicity. The approval of trametinib as the first allosteric inhibitor validated that allosteric inhibitors could be used as effective therapeutic drugs for treatment of diseases. To date, a wide range of allosteric inhibitors have been identified. In this perspective, we outline different binding modes and potential advantages of allosteric inhibitors. In the meantime, the research processes of typical and novel allosteric inhibitors are described briefly in terms of structureactivity relationships, ligand-protein interactions and in vitro and in vivo activity. Additionally, challenges as well as opportunities are presented.

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