scholarly journals Effects of Essential Oils and Some Constituents from Ingredients of Anti-Cellulite Herbal Compress on 3T3-L1 Adipocytes and Rat Aortae

2021 ◽  
Vol 14 (3) ◽  
pp. 253
Author(s):  
Ngamrayu Ngamdokmai ◽  
Tamkeen Urooj Paracha ◽  
Neti Waranuch ◽  
Krongkarn Chootip ◽  
Wudtichai Wisuitiprot ◽  
...  
Keyword(s):  
Essential Oils ◽  
Lipid Accumulation ◽  
Vascular System ◽  
Chemical Constituents ◽  
Rat Aorta ◽  
Water Extracts ◽  
System A ◽  
Vasodilatory Effect ◽  
Mixed Oil ◽  
Isolated Rat

Cellulite is associated with a complex array of adipocytes under the skin and vascular system. A herbal compress that was previously developed was proven to have an anti-cellulite effect in healthy volunteers within 2 weeks of treatment. However, its mechanism and ingredients responsible for reducing cellulite were not known. The purpose of this study was to investigate the activity of eight essential oils in, and two water extracts from, the ingredients of the herbal compress together with nine monoterpenoid constituents on the 3T3-L1 adipocytes. The vasodilatory effect on rat aortae was also studied. The adipocytes were induced by dexamethasone, 3-isobutyl-1-methylxanthine and insulin. At all concentrations tested, all essential oils, water extracts and their monoterpenoid constituents significantly inhibited lipid accumulation activity (p < 0.05) and decreased the amount of triglycerides when compared to untreated cells (p < 0.01). In addition, our results showed that the mixed oil distilled from the herbal compress mixed ingredients could relax the isolated rat aorta (EC50 = 14.74 ± 2.65 µg/mL). In conclusion, all essential oils, extracts and chemical constituents tested showed effects on adipogenesis inhibition and lipolysis induction on the cultured adipocytes with the mixed oil demonstrating vasorelaxation activity, all of which might be the mechanisms of the anti-cellulite effects of the herbal compress.

Effects of liposome-entrapped adenosine in the isolated rat aorta

1993 ◽  
Vol 250 (3) ◽  
pp. 489-492 ◽  
Author(s):  
Eugen Brailoiu ◽  
Dragomir N. Serban ◽  
Sebastian Slatineanu ◽  
Catalin M. Filipeanu ◽  
Bogdan C. Petrescu ◽  
...  
Keyword(s):  
Rat Aorta ◽  
Isolated Rat

Human plasma-derived material with clonidine displacing substance (CDS)-like properties contracts the isolated rat aorta

1991 ◽  
Vol 11 (6) ◽  
pp. 343-351 ◽  
Author(s):  
Dennis Synetos ◽  
Vangelis G. Manolopoulos ◽  
Daphne Atlas ◽  
Eva Pipili-Synetos
Keyword(s):  
Human Plasma ◽  
Rat Aorta ◽  
Isolated Rat

Acetylcholine-induced endothelium-dependent vascular smooth muscle relaxation in nitroglycerin-tolerant isolated rat aorta

1991 ◽  
Vol 6 (3) ◽  
pp. 175-180 ◽  
Author(s):  
Atsushi Namiki ◽  
Jo Aikawa ◽  
Masao Moroi ◽  
Kiyoshi Machii ◽  
Nobuharu Akatsuka
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Relaxation ◽  
Rat Aorta ◽  
Smooth Muscle Relaxation ◽  
Vascular Smooth Muscle Relaxation ◽  
Isolated Rat

Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent

2011 ◽  
Vol 89 (7) ◽  
pp. 467-476 ◽  
Author(s):  
Ji Seok Baik ◽  
Ju-Tae Sohn ◽  
Seong-Ho Ok ◽  
Jae-Gak Kim ◽  
Hui-Jin Sung ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Smooth Muscle ◽  
Calcium Influx ◽  
Rat Aorta ◽  
Isometric Tension ◽  
Guanosine Monophosphate ◽  
Response Curves ◽  
Calcium Dependent ◽  
Isolated Rat

Levobupivacaine is a long-acting local anesthetic that intrinsically produces vasoconstriction in isolated vessels. The goals of this study were to investigate the calcium-dependent mechanism underlying levobupivacaine-induced contraction of isolated rat aorta in vitro and to elucidate the pathway responsible for the endothelium-dependent attenuation of levobupivacaine-induced contraction. Isolated rat aortic rings were suspended to record isometric tension. Cumulative levobupivacaine concentration–response curves were generated in either the presence or absence of the antagonists verapamil, nifedipine, SKF-96365, 2-aminoethoxydiphenylborate, Gd3+, NW-nitro-l-arginine methyl ester (L-NAME), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), and methylene blue, either alone or in combination. Verapamil, nifedipine, SKF-96365, 2-aminoethoxydiphenylborate, low calcium concentrations, and calcium-free Krebs solution attenuated levobupivacaine-induced contraction. Gd3+ had no effect on levobupivacaine-induced contraction. Levobupivacaine increased intracellular calcium levels in vascular smooth muscle cells. L-NAME, ODQ, and methylene blue increased levobupivacaine-induced contraction in endothelium-intact aorta. SKF-96365 attenuated calcium-induced contraction in a previously calcium-free isotonic depolarizing solution containing 100 mmol/L KCl. Levobupivacaine-induced contraction of rat aortic smooth muscle is mediated primarily by calcium influx from the extracellular space mainly via voltage-operated calcium channels and, in part, by inositol 1,4,5-trisphosphate receptor-mediated release of calcium from the sarcoplasmic reticulum. The nitric oxide – cyclic guanosine monophosphate pathway is involved in the endothelium-dependent attenuation of levobupivacaine-induced contraction.

scholarly journals Comparison of chemical constituents and antimicrobial activities of three essential oils from three different brands' clove samples collected from Gulf region

2014 ◽  
Vol 4 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Mohammad Amzad Hossain ◽  
Saliha Rashid AL Harbi ◽  
Afaf Mohammed Weli ◽  
Qasim Al-Riyami ◽  
Jamal Nasser Al-Sabahi
Keyword(s):  
Essential Oils ◽  
Chemical Constituents ◽  
Antimicrobial Activities ◽  
Gulf Region

Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus

2021 ◽  
Vol 20 ◽  
Author(s):  
Paula Alexandra Postu ◽  
Adrian Tiron ◽  
Crina Elena Tiron ◽  
Dragoș Lucian Gorgan ◽  
Marius Mihasan ◽  
...  
Keyword(s):  
Essential Oils ◽  
Dna Fragmentation ◽  
Rat Model ◽  
Pinus Halepensis ◽  
Chemical Constituents ◽  
Gene Expressions ◽  
Bdnf Expression ◽  
Neuroprotective Effects ◽  
Positive Effects ◽  
Cognitive Improvement

Background: The conifer species Pinus halepensis (Pinaceae) and Tetraclinis articulata (Cupressaceae) are widely used in traditional medicine due to their health beneficial properties. Objective: This study aimed to investigate the mechanisms by which P. halepensis and T. articulata essential oils (1% and 3%) could exhibit neuroprotective effects in an Alzheimer's disease (AD) rat model, induced by intracerebroventricular (i.c.v.) administration of amyloid beta1-42 (Aβ1-42). Method: The essential oils were administered by inhalation to the AD rat model, once daily, for 21 days. DNA fragmentation was assessed through Cell Death Detection ELISA kit. Brain-derived neurotrophic factor (BDNF), activity-regulated cytoskeleton-associated protein (ARC) and interleukin-1β (IL-1β) gene expressions were determined by RT-qPCR analysis, while BDNF and ARC protein expressions were assessed using immunohistochemistry technique. Results: Our data showed that both essential oils substantially attenuated memory impairments, with P. halepensis mainly stimulating ARC expression and T. articulata mostly enhancing BDNF expression. Also, the inhalation of essential oils reduced IL-1β expression and induced positive effects against DNA fragmentation associated with Aβ1-42-induced toxicity, further contributing to the cognitive improvement in the rats with AD-like model. Conclusion: Our findings provide further evidence that these essential oils and their chemical constituents could be natural agents of therapeutic interest against Aβ1-42-induced neurotoxicity.

scholarly journals Constituents of Peel and Leaf Essential Oils of Citrus Medica L

2009 ◽  
Vol 1 (2) ◽  
pp. 387-392 ◽  
Author(s):  
M. N. I. Bhuiyan ◽  
J. Begum ◽  
P. K. Sardar ◽  
M. S. Rahman
Keyword(s):  
Gas Chromatography ◽  
Essential Oil ◽  
Essential Oils ◽  
Mass Spectroscopy ◽  
Chemical Constituents ◽  
Citrus Medica ◽  
Leaf Oil ◽  
Gas Chromatography Mass Spectroscopy ◽  
Total Oil ◽  
Peel Oil

The chemical constituents of leaf and peel essential oil of Citrus medica L. were analysed by gas chromatography mass spectroscopy (GC-MS). Nineteen components accounting for 99.9% of the oil were identified in leaf oil. The major constituents are erucylamide (28.43%), limonene (18.36%) and citral (12.95%). The peel oil contains forty three components accounting for 99.8% of the total oil and the major components are isolimonene (39.37%), citral (23.12%) and limonene (21.78%). Keywords: Citrus medica; Essential oils; GC-MS; Erucylamide; Isolimonene. © 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.DOI: 10.3329/jsr.v1i2.1760   

Effects of Diazoxide on KCl‐ and Norepinephrine‐Induced Contraction in Isolated Rat Aorta

1994 ◽  
Vol 83 (6) ◽  
pp. 838-841 ◽  
Author(s):  
T. Nakai
Keyword(s):  
Rat Aorta ◽  
Isolated Rat

scholarly journals Protein kinase C (PKC) activities in cytoplasmic and particulate membrane fractions of isolated rat aorta

1995 ◽  
Vol 67 ◽  
pp. 185
Author(s):  
Yukisato Ishida ◽  
Asami Seino
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Aorta ◽  
Kinase C ◽  
Isolated Rat

Laboratory cage studies on the efficacy of some medicinal plant essential oils for controlling varroosis in Apis mellifera (Hym.: Apidae)

2016 ◽  
Vol 21 (10) ◽  
pp. 1681
Author(s):  
Vahid Ghasemi ◽  
Saeid Moharramipour ◽  
Gholam Hossein Tahmasbi
Keyword(s):  
Apis Mellifera ◽  
Essential Oils ◽  
Honey Bee ◽  
Exposure Time ◽  
Chemical Constituents ◽  
Integrated Control ◽  
Eucalyptus Camaldulensis ◽  
Safe Alternative ◽  
Plant Essential Oils ◽  
Mite Mortality

Varroosis is a disease of Apis mellifera L. caused by the mite Varroa destructor Anderson and Trueman. Essential oils and their chemical constituents offer a safe alternative to synthetic acaricides for the control of this mite in bee hives. The present study was conducted to evaluate anti-parasitic activity of essential oils from Thymus kotschyanus Bioss & Hohen., Mentha longifolia L., Eucalyptus camaldulensis Dehnh., and Ferula gummosa L. at concentrations of 1, 2.5, 4, and 5.5 µl/l air for 5 and 10 h. Findings indicated that mite mortality increased as oils concentration and exposure time increased. T. kotschyanus oil at 5.5 µl/l air caused a mite mortality rate of 54.4% and 84.43% after 5 and 10 h fumigation, respectively. At the same concentration and exposure time, the honey bee mortality was 0% and 7.2%, respectively. Application of M. longifolia and E. camaldulensis oils at 5.5 µl/l air resulted in 65.53% and 71.06% mortality in Varroa mites and 10.13% and 12% mortality in honey bees after 10 h exposure. Despite moderate acaricidal activity of F. gummosa oil against Varroa mite (49.69%), it was highly toxic to honey bee (30%). Also, GC/MS analysis of the oils showed that carvacrol (47.99%) and thymol (30.61%) in T. kotschyanus oil, piperitenone (36.86%), piperitenone oxide (27.53%),Cispiperitone epoxide (22.21%), and pulegone (8.38%) in M. longifoliaoil, 1,8-cineol (74.7%) and α-pinene (8.35%) in E. camaldulensis oil, and β-pinene (87.29%) in F. gummosa oil were the main chemical constituents. Collectively, our results led to a conclusion that T. kotschyanus, M. longifolia, and E. camaldulensis oils have enough potential to play an important role in integrated control programs of varroosis in apiaries. 

Sign in / Sign up

Export Citation Format

Share Document