scholarly journals Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 105
Author(s):  
Eliza Rocha Gomes ◽  
Marina Santiago Franco
Keyword(s):  
Management Strategy ◽  
State Of The Art ◽  
Significant Proportion ◽  
Abscopal Effect ◽  
Tumor Site ◽  
Disease Management Strategy ◽  
Assisted Delivery ◽  
The World ◽  
Multiple Molecules ◽  
Trigger Molecule

Cancer is responsible for a significant proportion of death all over the world. Therefore, strategies to improve its treatment are highly desired. The use of nanocarriers to deliver anticancer treatments has been extensively investigated and improved since the approval of the first liposomal formulation for cancer treatment in 1995. Radiotherapy (RT) is present in the disease management strategy of around 50% of cancer patients. In the present review, we bring the state-of-the-art information on the combination of nanocarrier-assisted delivery of molecules and RT. We start with formulations designed to encapsulate single or multiple molecules that, once delivered to the tumor site, act directly on the cells to improve the effects of RT. Then, we describe formulations designed to modulate the tumor microenvironment by delivering oxygen or to boost the abscopal effect. Finally, we present how RT can be employed to trigger molecule delivery from nanocarriers or to modulate the EPR effect.

scholarly journals D-Penicillamine: The State of the Art in Humans and in Dogs from a Pharmacological and Regulatory Perspective

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 648
Author(s):  
Michela Pugliese ◽  
Vito Biondi ◽  
Enrico Gugliandolo ◽  
Patrizia Licata ◽  
Alessio Filippo Peritore ◽  
...  
Keyword(s):  
Veterinary Medicine ◽  
State Of The Art ◽  
European Medicines Agency ◽  
Therapeutic Goals ◽  
First Choice ◽  
Regulatory Perspective ◽  
The World ◽  
United States Food ◽  
States Food ◽  
Food And Drugs Administration

Chelant agents are the mainstay of treatment in copper-associated hepatitis in humans, where D-penicillamine is the chelant agent of first choice. In veterinary medicine, the use of D-penicillamine has increased with the recent recognition of copper-associated hepatopathies that occur in several breeds of dogs. Although the different regulatory authorities in the world (United States Food and Drugs Administration—U.S. FDA, European Medicines Agency—EMEA, etc.) do not approve D-penicillamine for use in dogs, it has been used to treat copper-associated hepatitis in dogs since the 1970s, and is prescribed legally by veterinarians as an extra-label drug to treat this disease and alleviate suffering. The present study aims to: (a) address the pharmacological features; (b) outline the clinical scenario underlying the increased interest in D-penicillamine by overviewing the evolution of its main therapeutic goals in humans and dogs; and finally, (c) provide a discussion on its use and prescription in veterinary medicine from a regulatory perspective.

scholarly journals Multi-Task Learning Using Task Dependencies for Face Attributes Prediction

2019 ◽  
Vol 9 (12) ◽  
pp. 2535
Author(s):  
Di Fan ◽  
Hyunwoo Kim ◽  
Jummo Kim ◽  
Yunhui Liu ◽  
Qiang Huang
Keyword(s):  
Human Computer Interaction ◽  
Video Surveillance ◽  
State Of The Art ◽  
Learning Task ◽  
Face Verification ◽  
Task Learning ◽  
The World ◽  
In The Wild ◽  
And Gender ◽  
Learning Architectures

Face attributes prediction has an increasing amount of applications in human–computer interaction, face verification and video surveillance. Various studies show that dependencies exist in face attributes. Multi-task learning architecture can build a synergy among the correlated tasks by parameter sharing in the shared layers. However, the dependencies between the tasks have been ignored in the task-specific layers of most multi-task learning architectures. Thus, how to further boost the performance of individual tasks by using task dependencies among face attributes is quite challenging. In this paper, we propose a multi-task learning using task dependencies architecture for face attributes prediction and evaluate the performance with the tasks of smile and gender prediction. The designed attention modules in task-specific layers of our proposed architecture are used for learning task-dependent disentangled representations. The experimental results demonstrate the effectiveness of our proposed network by comparing with the traditional multi-task learning architecture and the state-of-the-art methods on Faces of the world (FotW) and Labeled faces in the wild-a (LFWA) datasets.

Management Concept of Modern Distance and Open University: Taking Consideration to Social Responsibilities and Operating Performance

2011 ◽  
Vol 268-270 ◽  
pp. 1613-1618
Author(s):  
Fan Li ◽  
Fei Wang
Keyword(s):  
Social Responsibility ◽  
Economic Benefit ◽  
Management Strategy ◽  
Operating Performance ◽  
Management Model ◽  
Open University ◽  
Social Responsibilities ◽  
The World ◽  
Management Concept ◽  
Development Tendency

Paying more attention to economic benefit but less to social responsibility is a problem faced by many Radio & TV universities in China. As the most successful distance education university in the world, the Open University of UK provides much experience on management model. Favorable benefit and well development tendency are gotten by hammering at shouldering community responsibilities and winning public praise with quality. The management strategy of it would make contributions to the development of China’s Radio & TV universities.

Rose Fitzgerald Kennedy bridge over the River Barrow. Design and Construction of a long span extrados bridge

2021 ◽  
Author(s):  
Marcos Sanchez Sanchez ◽  
John Iliff
Keyword(s):  
State Of The Art ◽  
Single Plane ◽  
Robust Approach ◽  
Analysis Techniques ◽  
Long Span ◽  
The World ◽  
Art Analysis ◽  
Concrete Deck ◽  
Design And Construction

<p>This paper describes the key elements from early planning to completion of a new bridge over the River Barrow which is part of the New Ross bypass in the south of Ireland. The structure has a total length of 887m, with a span arrangement of 36-45-95-230-230-95-70-50-36m. The two central twin spans are the longest of its kind in the world (extrados with a full concrete deck). The bridge carries a dual carriageway with a cable arrangement consisting of a single plane of cables located in the central axis of the deck. The design and construction focused in providing a structure with long term durability, resilience, and a robust approach to design scenarios using the Eurocodes and state of the art analysis techniques, including extreme events such as fire and ship impact<i>.</i></p>

Appreciating Rapid Technology Integration in Creating Value in Enterprises

2014 ◽  
Vol 12 (1) ◽  
pp. 53-75 ◽  
Author(s):  
Mambo G. Mupepi ◽  
Sylvia C. Mupepi
Keyword(s):  
Knowledge Creation ◽  
Significant Proportion ◽  
Social Economy ◽  
Primary Objective ◽  
Social Enterprises ◽  
Use Of Technology ◽  
Wide Range ◽  
The World ◽  
Skilled Personnel ◽  
Increase Productivity

The primary objective of this paper is about innovation within specific social organization which compacts with the division of labor, knowledge creation, and the use of technology such as e-enterprise in social economy aimed at improving productivity. A significant proportion of the world's economy is organized to make profits not only for investors but to sustain the employment of many disadvantaged people throughout the world. It includes cooperative organizations, foundations and many other social enterprises that provide a wide range of products and services across the globe and generate sustainable employment. Productivity tends to increase when the job is divided into manageable portions and then performed by adequately skilled personnel. In order to succeed in an environment in which other businesses fiercely compete along with social enterprises it is imperative to take into account innovative systems such as e-enterprise to leverage competition and increase productivity.

Sir Charles Parsons and Electrical Power Generation—a Turbine Designer's Perspective

1994 ◽  
Vol 208 (3) ◽  
pp. 159-176 ◽  
Author(s):  
J R Bolter
Keyword(s):  
Power Generation ◽  
Steam Turbine ◽  
Gas Turbine ◽  
Electrical Power Generation ◽  
Analytical Methods ◽  
State Of The Art ◽  
Electrical Power ◽  
Turbine Generator ◽  
Current State ◽  
The World

Sir Charles Parsons died some three years after the author was born. In this paper the author looks back at the pioneering work of Parsons in the field of power generation. It shows how he was able to increase output of the steam turbine generator from 7.5 kW in 1884 to 50000 kW in 1930 while increasing efficiency from 1.6 to 36 per cent, and relates these achievements to the current state of the art. Blading design, rotor construction and other aspects of turbine engineering are considered. The conclusion is that Parsons and his associates charted the course which manufacturers and utilities throughout the world have continued to follow, although increasingly sophisticated design and analytical methods have succeeded the intuitive approach of Parsons. His constant search for improved efficiency was and is highly relevant to today's concern for the environment. Finally, although it did not become a practical proposition in his lifetime, the paper reviews Parsons' vision of, and continuing interest in, the gas turbine, first mentioned in his 1884 patents.

scholarly journals Turbulence and Flow–Sediment Interactions in Open-Channel Flows

Water ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3169
Author(s):  
Roberto Gaudio
Keyword(s):  
Open Channel ◽  
Field Experiments ◽  
State Of The Art ◽  
Channel Flows ◽  
Special Issue ◽  
Panoramic View ◽  
Open Channel Flows ◽  
River Hydraulics ◽  
The World ◽  
Computing Skills

The main focus of this Special Issue of Water is the state-of-the-art and recent research on turbulence and flow–sediment interactions in open-channel flows. Our knowledge of river hydraulics is becoming deeper and deeper, thanks to both laboratory/field experiments related to the characteristics of turbulence and their link to the erosion, transport, deposition, and local scouring phenomena. Collaboration among engineers, physicists, and other experts is increasing and furnishing new inter/multidisciplinary perspectives to the research in river hydraulics and fluid mechanics. At the same time, the development of both sophisticated laboratory instrumentation and computing skills is giving rise to excellent experimental–numerical comparative studies. Thus, this Special Issue, with ten papers by researchers from many institutions around the world, aims at offering a modern panoramic view on all the above aspects to the vast audience of river researchers.

scholarly journals Meta-Transfer Learning Driven Tensor-Shot Detector for the Autonomous Localization and Recognition of Concealed Baggage Threats

Sensors ◽  
2020 ◽  
Vol 20 (22) ◽  
pp. 6450
Author(s):  
Taimur Hassan ◽  
Muhammad Shafay ◽  
Samet Akçay ◽  
Salman Khan ◽  
Mohammed Bennamoun ◽  
...  
Keyword(s):  
Transfer Learning ◽  
State Of The Art ◽  
Autonomous Systems ◽  
Aviation Security ◽  
Dual Energy ◽  
Average Precision ◽  
X Ray ◽  
Shot Classification ◽  
Object Proposals ◽  
The World

Screening baggage against potential threats has become one of the prime aviation security concerns all over the world, where manual detection of prohibited items is a time-consuming and hectic process. Many researchers have developed autonomous systems to recognize baggage threats using security X-ray scans. However, all of these frameworks are vulnerable against screening cluttered and concealed contraband items. Furthermore, to the best of our knowledge, no framework possesses the capacity to recognize baggage threats across multiple scanner specifications without an explicit retraining process. To overcome this, we present a novel meta-transfer learning-driven tensor-shot detector that decomposes the candidate scan into dual-energy tensors and employs a meta-one-shot classification backbone to recognize and localize the cluttered baggage threats. In addition, the proposed detection framework can be well-generalized to multiple scanner specifications due to its capacity to generate object proposals from the unified tensor maps rather than diversified raw scans. We have rigorously evaluated the proposed tensor-shot detector on the publicly available SIXray and GDXray datasets (containing a cumulative of 1,067,381 grayscale and colored baggage X-ray scans). On the SIXray dataset, the proposed framework achieved a mean average precision (mAP) of 0.6457, and on the GDXray dataset, it achieved the precision and F1 score of 0.9441 and 0.9598, respectively. Furthermore, it outperforms state-of-the-art frameworks by 8.03% in terms of mAP, 1.49% in terms of precision, and 0.573% in terms of F1 on the SIXray and GDXray dataset, respectively.

scholarly journals Management of Stress: From the Perspectives of the Natural Theory Philosophers

2020 ◽  
Vol 2 (2) ◽  
pp. 69-74
Author(s):  
Ncha Gabriel Bubu
Keyword(s):  
Content Analysis ◽  
Stress Management ◽  
Management Strategy ◽  
The World ◽  
Poor Management

The phenomenon of stress among humans, has become a disturbing one and a source of worry and sorrow for millions of people all over the world. This, in most cases, has resulted in deaths, strokes and paralysis, and if these occur with individuals that are bread winners in families, the consequences could be devastating as members of such families who are dependent on the bread winners would be put into untold hardship which could result in further stress related problems. One important cause of this phenomenon is poor management of stress and the lack of a suitable stress management strategy. This paper examines this phenomenon and argues that the natural theorist approach could be therapeutic. The method adopted is expository and content analysis.

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