scholarly journals Effect of Propolis Paste and Mouthwash Formulation on Healing after Teeth Extraction in Periodontal Disease

Plants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1603
Author(s):  
Maria Jesús Lisbona-González ◽  
Esther Muñoz-Soto ◽  
Cristina Lisbona-González ◽  
Marta Vallecillo-Rivas ◽  
Javier Diaz-Castro ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Periodontal Disease ◽  
Healing Process ◽  
Mutans Streptococci ◽  
Viable Alternative ◽  
Dental Surgery ◽  
Bacterial Proliferation ◽  
Socket Healing ◽  
Tooth Extractions ◽  
Teeth Extraction

This study investigated the antimicrobial effects of a mouthwash containing propolis and the effect of a propolis paste formulation on dental healing after teeth extraction in patients with periodontal disease. In the mouthwash experience, the population comprised 40 patients, which were divided as follows: the control mouthwash, 0.2% chlorhexidine (v/v) mouthwash, 2% (w/v) propolis mouthwash, and propolis + chlorhexidine mouthwash. The study of the propolis paste comprised a population of 60 patients with periodontal disease, and a total of 120 symmetric tooth extractions were performed. Propolis showed antimicrobial activity by itself, and especially with the chlorhexidine association. Three days after surgery in the teeth treated with control paste, only 13.4% had completely healed; however, with propolis paste, in 90% of the periodontal sockets, healing was complete. In addition, a reduction in Mutans Streptococci and Lactobacilli cfu was observed with propolis, and especially with the association of chlorhexidine + propolis. Propolis mouthwash reduced bacterial proliferation, especially in association with chlorhexidine. Propolis paste is a viable alternative for socket healing after dental extraction. The knowledge gained from these findings will provide a foundation for similar propolis therapies in order to improve the healing process after dental surgery.

scholarly journals Dental extraction in patients with HIV/AIDS: report of two cases

RSBO ◽  
2019 ◽  
Vol 16 (1) ◽  
pp. 51-06
Author(s):  
Mariane Cristina Sloniak ◽  
Sara Regina Barancelli Todero ◽  
Luciana Aparecida Lyra ◽  
Elenara Beatriz Fontana ◽  
Paulo Sérgio Batista ◽  
...  
Keyword(s):  
Oral Health ◽  
Periodontal Disease ◽  
Hiv Infection ◽  
Dental Treatment ◽  
Treatment Plan ◽  
Healing Process ◽  
Special Treatment ◽  
Individual Treatment ◽  
Dental Surgery ◽  
First Case

The oral health of patients with HIV infection is often compromised by caries and periodontal disease. Thus, many patients need to undergo oral surgical procedures. Case report: This article describes two cases of patients with HIV infection who had undergone exodontia due to prosthetic indications. Both patients had been hospitalized for treatment of respiratory complications from HIV infection and were referred for dental treatment. In the first case, the adult patient had generally good oral health. However, the treatment plan for the installation of a removable prosthesis required the removal of tooth 38 since it was fairly inclined to the mesial. The second patient had poor oral conditions due to advanced periodontal disease. Thus, all upper arch teeth were removed in a single session followed by the installation of an immediate total prosthesis. No postoperative complications were recorded and the healing process occurred without incident for both patients. Dental treatment of patients with asymptomatic HIV infection does not differ from that performed for any other patient in practice. Nevertheless, patients in advanced stages of disease may require special treatment and an individual treatment plan must be developed for even routine procedures. Conclusion: The dental care of these individuals often requires more rigorous clinical follow-up for maintaining oral health. The performance of dental surgery in patients with HIV infection does not require technical modifications, but does require a complete anamnesis.

scholarly journals Dental extraction in patients with HIV/AIDS: report of two cases

RSBO ◽  
2019 ◽  
Vol 16 (1) ◽  
pp. 51
Author(s):  
Mariane Cristina Sloniak ◽  
Sara Regina Barancelli Todero ◽  
Luciana Aparecida Lyra ◽  
Elenara Beatriz Fontana ◽  
Paulo Sérgio Batista ◽  
...  
Keyword(s):  
Oral Health ◽  
Periodontal Disease ◽  
Hiv Infection ◽  
Dental Treatment ◽  
Treatment Plan ◽  
Healing Process ◽  
Special Treatment ◽  
Individual Treatment ◽  
Dental Surgery ◽  
First Case

Introduction and objective: The oral health of patients with HIV infection is often compromised by caries and periodontal disease. Thus, many patients need to undergo oral surgical procedures. Case report: This article describes two cases of patients with HIV infection who had undergone exodontia due to prosthetic indications. Both patients had been hospitalized for treatment of respiratory complications from HIV infection and were referred for dental treatment. In the first case, the adult patient had generally good oral health. However, the treatment plan for the installation of a removable prosthesis required the removal of tooth 38 since it was fairly inclined to the mesial. The second patient had poor oral conditions due to advanced periodontal disease. Thus, all upper arch teeth were removed in a single session followed by the installationof an immediate total prosthesis. No postoperative complications were recorded and the healing process occurred without incident for both patients. Dental treatment of patients with asymptomatic HIV infection does not differ from that performed for any other patient in practice. Nevertheless, patients in advanced stages of disease may require special treatment and an individual treatment plan must be developed for even routine procedures. Conclusion: The dental careof these individuals often requires more rigorous clinical follow-up for maintaining oral health. The performance of dental surgery in patients with HIV infection does not require technical modifications, but does require a complete anamnesis.

The Capacity of a Specific Anti-Streptococcus Mutans Monoclonal Antibodies Test to Identify the Diabetic Patients with Increased Risk of Periodontal Disease

2017 ◽  
Vol 68 (11) ◽  
pp. 2556-2559
Author(s):  
Mona Ionas ◽  
Sebastian Ioan Cernusca Mitariu ◽  
Adela Dancila ◽  
Tiberiu Horatiu Ionas ◽  
Raluca Monica Comaneanu ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Periodontal Disease ◽  
Streptococcus Mutans ◽  
Mutans Streptococci ◽  
Diabetic Patients ◽  
A Value ◽  
Salivary Level ◽  
Increased Risk ◽  
The Status

By means of a specific anti-Streptococcus mutans monoclonal antibodies test we want to identify the diabetic patients which have an increased risk to develop the periodontal disease. The highest percentage, of 88.1% of all patients included in this study represents the subjects with a level greater than 500,000 cfu / mL of streptococcus mutans. The Kruskal-Wallis test reveals a value of p = 0.283 resulted from the status of diabetes in patients and the level of streptococcus mutans in saliva. In conclusion, the status of diabetes in patients seems not to influence the salivary level of mutans streptococci determined with the method used in our study.

scholarly journals Reasons for Tooth Extractions and Related Risk Factors in Adult Patients: A Cohort Study

2020 ◽  
Vol 17 (7) ◽  
pp. 2575
Author(s):  
Pier Carmine Passarelli ◽  
Stefano Pagnoni ◽  
Giovan Battista Piccirillo ◽  
Viviana Desantis ◽  
Michele Benegiamo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Periodontal Disease ◽  
Smoking Habit ◽  
Extraction Process ◽  
Adult Patients ◽  
Diabetic Patients ◽  
Related Risk ◽  
Potential Risk Factors ◽  
Practice Methods ◽  
Tooth Extractions

Background: The aim of this study was to evaluate oral status, the reasons for tooth extractions and related risk factors in adult patients attending a hospital dental practice. Methods: 120 consecutive patients ranging from 23 to 91 years in age (mean age of 63.3 ± 15.8) having a total of 554 teeth extracted were included. Surveys about general health status were conducted and potential risk factors such as smoking, diabetes and age were investigated. Results: a total of 1795 teeth were missing after extraction procedures and the mean number of remaining teeth after the extraction process was 16.8 ± 9.1 per patient. Caries (52.2%) was the most common reason for extraction along with periodontal disease (35.7%). Males were more prone to extractions, with 394 of the teeth extracted out of the total of 554 (71.1%). Male sex (β = 2.89; 95% CI 1.26, 4.53; p = 0.001) and smoking habit (β = 2.95; 95% CI 1.12, 4.79; p = 0.002) were related to a higher number of teeth extracted. Age (β = −0.24; 95% CI −0.31, −0.16; p < 0.001) and diabetes (β = −4.47; 95% CI −7.61, −1.33; p = 0.006) were related to a higher number of missing teeth at evaluation time. Moreover, periodontal disease was more common as a reason of extraction among diabetic patients than among non-diabetic ones (p = 0.04). Conclusions: caries and periodontal disease were the most common causes of extraction in a relatively old study population: further screening strategies might be required for the early interception of caries and periodontal disease.

scholarly journals Analysing the effectiveness of topical bleeding care following tooth extraction in patients receiving dual antiplatelet therapy-retrospective observational study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bogumił Lewandowski ◽  
Aleksander Myszka ◽  
Małgorzata Migut ◽  
Ewelina Czenczek-Lewandowska ◽  
Robert Brodowski
Keyword(s):  
Antiplatelet Therapy ◽  
Tooth Extraction ◽  
Dual Antiplatelet Therapy ◽  
Clinical Problem ◽  
Dental Surgery ◽  
Coronary Syndrome ◽  
Secondary Bleeding ◽  
Tooth Removal ◽  
Tooth Extractions ◽  
Retrospective Examination

Abstract Background Patients using antiplatelet drugs following infarctions, acute coronary syndrome or stroke pose a significant clinical problem if it is necessary to perform surgery, including dental surgery, since they are at risk of prolonged or secondary post-extraction bleeding. Discontinuation of this therapy is associated with a high risk of serious thromboembolic complications. The purpose of this study was to assess the effectiveness of TachoSil fibrin-collagen patches in stopping and preventing of secondary post-extraction bleeding in patients undergoing chronic antiplatelet therapy. Methods The study was conducted through retrospective examination of the medical records of 153 patients using chronic antiplatelet therapy and those qualified for tooth extraction. The largest group comprised 74 patients using aspirin and clopidogrel as dual platelet antiaggregation therapy; in this group 75 tooth extractions were carried out. In all of the patients TachoSil fibrin-collagen patches and stiches were applied to the wounds resulting from tooth removal. Results Following tooth extraction, primary bleeding was stopped in all the patients and their wounds closed via coagulation within 20–30 min. In eight cases, accounting for 4.9% of the patients, secondary bleeding occurred and was successfully stopped only by applying a pressure dressing soaked in tranexamic acid. Secondary bleeding occurred in three patients on the second day and in five patients on the third day following tooth removal. Conclusion Topical application of TachoSil patches following tooth removal in patients using single or dual antiplatelet therapy effectively stopped bleeding and prevented secondary bleeding after tooth extraction.

Effect of CBX7 deficiency on the socket healing after tooth extractions

2018 ◽  
Vol 37 (4) ◽  
pp. 584-593 ◽  
Author(s):  
Fei Jiang ◽  
Xiaohan Yang ◽  
Xin Meng ◽  
Zhixuan Zhou ◽  
Ning Chen
Keyword(s):  
Socket Healing ◽  
Tooth Extractions

scholarly journals Concentrated Growth Factors vs. Leukocyte-and-Platelet-Rich Fibrin for Enhancing Postextraction Socket Healing. A Longitudinal Comparative Study

2020 ◽  
Vol 10 (22) ◽  
pp. 8256
Author(s):  
Marco Mozzati ◽  
Giorgia Gallesio ◽  
Margherita Tumedei ◽  
Massimo Del Fabbro
Keyword(s):  
Growth Factors ◽  
Oral Surgery ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Significant Difference ◽  
Postoperative Symptoms ◽  
Concentrated Growth Factors ◽  
Socket Healing ◽  
And Control ◽  
Tooth Extractions

Platelet concentrates (PCs) have been used for over 20 years in dentistry, as an adjunct to oral surgery procedures, to improve hard and soft tissue healing and control postoperative symptoms. Among various PCs, Leukocyte and Platelet-Rich Fibrin (L-PRF) has become very popular due to its excellent cost-effectiveness ratio, and to the simple preparation protocol, but comparative clinical studies with other PCs are lacking. The aim of this split-mouth cohort study was to evaluate the effect of Concentrated Growth Factors (CGF), a recently introduced PC, as compared to L-PRF for enhancing post-extraction socket healing. Methods: Patients in need of bilateral tooth extractions were included. Each side was treated with either CGF or L-PRF. Pain, socket closure and healing index were the main outcomes. Results: Forty-five patients (24 women), aged 60.52 ± 11.75 years (range 37–87 years) were treated. No significant difference in outcomes was found, except for Pain at day 1 (p < 0.001) and socket closure in the vestibulo-palatal/lingual dimension at day 7 post-extraction (p = 0.04), both in favor of CGF. Conclusions: based on the present results, CGF proved to be as effective and safe as L-PRF, representing a valid alternative option for improving alveolar socket healing and reducing postoperative discomfort.

scholarly journals Aliskiren Attenuates the Inflammatory Response and Wound Healing Process in Diabetic Mice With Periodontal Disease

2019 ◽  
Vol 10 ◽  
Author(s):  
Sandra Helena Penha Oliveira ◽  
Victor Gustavo Balera Brito ◽  
Sabrina Cruz Tfaile Frasnelli ◽  
Bianca da Silva Ribeiro ◽  
Milena Nunes Ferreira ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Periodontal Disease ◽  
Healing Process ◽  
Wound Healing Process ◽  
Diabetic Mice

scholarly journals Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication

2016 ◽  
Vol 60 (6) ◽  
pp. 3276-3282 ◽  
Author(s):  
Tyler D. P. Goralski ◽  
Kalyan K. Dewan ◽  
John N. Alumasa ◽  
Victoria Avanzato ◽  
David E. Place ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Francisella Tularensis ◽  
Ex Vivo ◽  
Eukaryotic Cells ◽  
Content Type ◽  
Antibiotic Development ◽  
Bacterial Proliferation ◽  
Virulent Strains ◽  
Arrest Growth

Bacteria require at least one pathway to rescue ribosomes stalled at the ends of mRNAs. The primary pathway for ribosome rescue istrans-translation, which is conserved in >99% of sequenced bacterial genomes. Some species also have backup systems, such as ArfA or ArfB, which can rescue ribosomes in the absence of sufficienttrans-translation activity. Small-molecule inhibitors of ribosome rescue have broad-spectrum antimicrobial activity against bacteria grown in liquid culture. These compounds were tested against the tier 1 select agentFrancisella tularensisto determine if they can limit bacterial proliferation during infection of eukaryotic cells. The inhibitors KKL-10 and KKL-40 exhibited exceptional antimicrobial activity against both attenuated and fully virulent strains ofF. tularensisin vitroand duringex vivoinfection. Addition of KKL-10 or KKL-40 to macrophages or liver cells at any time after infection byF. tularensisprevented further bacterial proliferation. When macrophages were stimulated with the proinflammatory cytokine gamma interferon before being infected byF. tularensis, addition of KKL-10 or KKL-40 reduced intracellular bacteria by >99%, indicating that the combination of cytokine-induced stress and a nonfunctional ribosome rescue pathway is fatal toF. tularensis. Neither KKL-10 nor KKL-40 was cytotoxic to eukaryotic cells in culture. These results demonstrate that ribosome rescue is required forF. tularensisgrowth at all stages of its infection cycle and suggest that KKL-10 and KKL-40 are good lead compounds for antibiotic development.

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