Dual Responsive Polymersomes for Gold Nanorod and Doxorubicin Encapsulation: Nanomaterials with Potential Use as Smart Drug Delivery Systems

In the present study, poly(ethylene glycol)-b-poly(N,N-diethylaminoethyl methacrylate) (PEG-b-PDEAEM) amphiphilic block copolymers were synthetized by reversible addition-fragmentation chain transfer (RAFT) polymerization using two different macro chain transfer agents containing PEG of 2000 and 5000 g/mol and varying the length of the PDEAEM segment. From the obtained block copolymers, polymersome type nanometric aggregates were obtained by two different techniques. By direct dispersion, particle diameters around 200 nm were obtained, while by solvent exchange using THF and water, the obtained diameters were around 100 nm. These block copolymers were used to encapsulate gold nanorods and doxorubicin (DOX) with good efficiencies to obtain nanomaterials with potential use as dual stimuli-sensitive drug delivery systems for combined anticancer therapies. Drug delivery studies showed that the release rate of DOX was accelerated when the pH was lowered from 7.4 to 5.8 and also when the systems were irradiated with a NIR laser at pH 7.4. The combination of lower pH and near infrared (NIR) irradiation resulted in higher drug release only in the case of polymersomes with lower molecular weight PEG.

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Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction: Potential candidates as drug delivery systems

Materials Chemistry and Physics ◽

10.1016/j.matchemphys.2016.05.010 ◽

2016 ◽

Vol 179 ◽

pp. 65-71 ◽

Cited By ~ 14

Author(s):

Zhenglong Yang ◽

Xinyan Liu ◽

Xiaoli Xu ◽

Sai Chen ◽

Xingyi Zhu ◽

...

Keyword(s):

Drug Delivery ◽

Hybrid Materials ◽

Drug Delivery Systems ◽

Raft Polymerization ◽

Polyhedral Oligomeric Silsesquioxane ◽

Delivery Systems ◽

Ene Reaction ◽

Dual Responsive ◽

Reaction Potential ◽

Oligomeric Silsesquioxane

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Gold nanorods coated with a thermo-responsive poly(ethylene glycol)-b-poly(N-vinylcaprolactam) corona as drug delivery systems for remotely near infrared-triggered release

Polymer Chemistry ◽

10.1039/c3py01057k ◽

2014 ◽

Vol 5 (3) ◽

pp. 799-813 ◽

Cited By ~ 47

Author(s):

Ji Liu ◽

Christophe Detrembleur ◽

Marie-Claire De Pauw-Gillet ◽

Stéphane Mornet ◽

Etienne Duguet ◽

...

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Gold Nanorods ◽

Drug Delivery Systems ◽

Near Infrared ◽

Delivery Systems ◽

Poly Ethylene Glycol ◽

Triggered Release ◽

Poly Ethylene

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All-Atom Molecular Dynamics Study of a Spherical Micelle Composed of N-Acetylated Poly(ethylene glycol)−Poly(γ-benzyll-glutamate) Block Copolymers: A Potential Carrier of Drug Delivery Systems for Cancer

The Journal of Physical Chemistry B ◽

10.1021/jp906155z ◽

2009 ◽

Vol 113 (46) ◽

pp. 15181-15188 ◽

Cited By ~ 29

Author(s):

Hiroshi Kuramochi ◽

Yoshimichi Andoh ◽

Noriyuki Yoshii ◽

Susumu Okazaki

Keyword(s):

Drug Delivery ◽

Molecular Dynamics ◽

Block Copolymers ◽

Ethylene Glycol ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Poly Ethylene Glycol ◽

Spherical Micelle ◽

Poly Ethylene

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Tri-Block Copolymers Obtained by RAFT Polymerization: A Promising Material for Drug-Delivery Systems

Materials Science Forum ◽

10.4028/www.scientific.net/msf.636-637.76 ◽

2010 ◽

Vol 636-637 ◽

pp. 76-81 ◽

Cited By ~ 11

Author(s):

M.L.D.S. Tebaldi ◽

T.C. Chaparro ◽

A.M. Santos

Keyword(s):

Drug Delivery ◽

Block Copolymer ◽

Block Copolymers ◽

1H Nmr ◽

Drug Delivery Systems ◽

Chain Transfer ◽

Raft Polymerization ◽

Gel Permeation Chromatography ◽

Partial Hydrolysis ◽

Gel Permeation

Tri-block copolymer with pH- and thermo-responsive consisting of poly(t-butylacrylate) and poly(vinylcaprolactam), (PtBA/PVCL) were prepared by RAFT polymerization and characterized by gel permeation chromatography (GPC) and 1H NMR. PtBA and PVCL were used as macro chain-transfer agents (MCTA) to synthesize PtBA-b-PVCL-b-PtBA and/or PVCL-b-PtBA-b-PVCL, which after partial hydrolysis led to amphiphilic tri-block copolymers P(tBA-co-AA)-b-PVCL-b-P(tBA-co-AA) and/or PVCL-b-P(tBA-co-AA)-b-PVCL.

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Facile Construction of i-Motif DNA-Conjugated Gold Nanostars as Near-Infrared and pH Dual-Responsive Targeted Drug Delivery Systems for Combined Cancer Therapy

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.9b01159 ◽

2020 ◽

Vol 17 (4) ◽

pp. 1127-1138 ◽

Cited By ~ 1

Author(s):

Dandan Miao ◽

Yanyan Yu ◽

Yong Chen ◽

Yin Liu ◽

Gaoxing Su

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Drug Delivery Systems ◽

Near Infrared ◽

Delivery Systems ◽

Gold Nanostars ◽

Dual Responsive ◽

Targeted Drug ◽

Targeted Drug Delivery Systems

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Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer

Drug Delivery Letters ◽

10.2174/2210303108666181109120710 ◽

2019 ◽

Vol 9 (1) ◽

pp. 2-14

Author(s):

Sahil Kumar ◽

Bandna Sharma ◽

Kiran Thakur ◽

Tilak R. Bhardwaj ◽

Deo N. Prasad ◽

...

Keyword(s):

Drug Delivery ◽

Colon Cancer ◽

Hyaluronic Acid ◽

Targeted Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Near Ir ◽

Targeted Drug ◽

Poly Ethylene ◽

Novel Drug

Background: Many efforts have been explored in the last decade to treat colon cancer but nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery to colon cancer cells. Objective: In this review, we attempt to highlight recent advancements in the development of novel drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)– Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil etc. Conclusion: These novel drug delivery systems have been determined to be more efficacious in terms of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced anticancer activity.

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