Temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethyl amino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials synthesized via RAFT polymerization and thiol-ene reaction: Potential candidates as drug delivery systems

2016 ◽  
Vol 179 ◽  
pp. 65-71 ◽  
Author(s):  
Zhenglong Yang ◽  
Xinyan Liu ◽  
Xiaoli Xu ◽  
Sai Chen ◽  
Xingyi Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hybrid Materials ◽  
Drug Delivery Systems ◽  
Raft Polymerization ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Delivery Systems ◽  
Ene Reaction ◽  
Dual Responsive ◽  
Reaction Potential ◽  
Oligomeric Silsesquioxane

scholarly journals Dual Responsive Polymersomes for Gold Nanorod and Doxorubicin Encapsulation: Nanomaterials with Potential Use as Smart Drug Delivery Systems

Polymers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 939 ◽  
Author(s):  
Melissa DiazDuarte-Rodriguez ◽  
Norma A. Cortez-Lemus ◽  
Angel Licea-Claverie ◽  
Jacob Licea-Rodriguez ◽  
Eugenio R. Méndez
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Delivery Systems ◽  
Dual Responsive ◽  
Poly Ethylene ◽  
Potential Use

In the present study, poly(ethylene glycol)-b-poly(N,N-diethylaminoethyl methacrylate) (PEG-b-PDEAEM) amphiphilic block copolymers were synthetized by reversible addition-fragmentation chain transfer (RAFT) polymerization using two different macro chain transfer agents containing PEG of 2000 and 5000 g/mol and varying the length of the PDEAEM segment. From the obtained block copolymers, polymersome type nanometric aggregates were obtained by two different techniques. By direct dispersion, particle diameters around 200 nm were obtained, while by solvent exchange using THF and water, the obtained diameters were around 100 nm. These block copolymers were used to encapsulate gold nanorods and doxorubicin (DOX) with good efficiencies to obtain nanomaterials with potential use as dual stimuli-sensitive drug delivery systems for combined anticancer therapies. Drug delivery studies showed that the release rate of DOX was accelerated when the pH was lowered from 7.4 to 5.8 and also when the systems were irradiated with a NIR laser at pH 7.4. The combination of lower pH and near infrared (NIR) irradiation resulted in higher drug release only in the case of polymersomes with lower molecular weight PEG.

scholarly journals Rational design of drug delivery systems for potential programmable drug release and improved therapeutic effect

2019 ◽  
Vol 3 (6) ◽  
pp. 1159-1167 ◽  
Author(s):  
Yuxun Ding ◽  
Jinjian Liu ◽  
Xue Li ◽  
Linlin Xu ◽  
Chang Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Therapeutic Effect ◽  
Drug Delivery Systems ◽  
Rational Design ◽  
Delivery Systems ◽  
Dual Responsive ◽  
Ph Reduction

pH-Reduction dual responsive nanocarriers (DRNs) achieve programmable release of CA4 and CDDP in cancer therapy.

Synthesis and characterization of novel dual-responsive nanogels and their application as drug delivery systems

Nanoscale ◽  
2012 ◽  
Vol 4 (8) ◽  
pp. 2694 ◽  
Author(s):  
Jinrong Peng ◽  
Tingting Qi ◽  
Jinfeng Liao ◽  
Min Fan ◽  
Feng Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Synthesis And Characterization ◽  
Dual Responsive

scholarly journals Synthesis of stimuli-sensitive copolymers by RAFT polymerization: potential candidates as drug delivery systems

2014 ◽  
Vol 17 (suppl 1) ◽  
pp. 191-196 ◽  
Author(s):  
Marli L. Tebaldi ◽  
Debora Abrantes Leal ◽  
Sergio R. Montoro ◽  
Cesar Petzhold
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Raft Polymerization ◽  
Delivery Systems ◽  
Stimuli Sensitive

“Smart” self-assembled structures: toward intelligent dual responsive drug delivery systems

2020 ◽  
Vol 8 (21) ◽  
pp. 5787-5803
Author(s):  
Mahsa Shahriari ◽  
Vladimir P. Torchilin ◽  
Seyed Mohammad Taghdisi ◽  
Khalil Abnous ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Dual Responsive ◽  
Current Review ◽  
Self Assembled ◽  
Novel Structures

In the current review, we summarized the polymer and peptide-based schizophrenic copolymers which could form micellar and vesicular (polymersome) systems providing novel structures with beneficial applications.

scholarly journals Synthesis, characterization and bioevaluation of irinotecan-collagen hybrid materials for biomedical applications as drug delivery systems in tumoral treatments

2013 ◽  
Vol 11 (12) ◽  
pp. 2134-2143 ◽  
Author(s):  
Georgeta Voicu ◽  
Ruxandra Geanaliu ◽  
Cristina Ghiţulică ◽  
Anton Ficai ◽  
Alexandru Grumezescu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hybrid Materials ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Local Treatment ◽  
Collagen Type I ◽  
Delivery Systems ◽  
Antitumoral Activity ◽  
Type I

AbstractThe purpose of the present study is the preparation and characterization of collagen/antitumor drug hybrids as drug delivery systems. Materials used for obtaining collagen-based drug delivery systems were collagen type I (Coll) as matrix and irinotecan (I) as hydrophilic active substances. After incorporation of I into Coll in differing ratios, the obtained hybrid materials (Coll/I) could be used according to our results as potential drug delivery systems in medicine for the topical (local) treatment of cancerous tissues or bone. The released amount of I varies with amount of Coll from hybrid materials: the higher, the slower the release amount of irinotecan transferred is in the first 6 hours. The in vitro citotoxicity demonstrates an antitumoral activity of the obtained hybrid materials and their potential use for biomedical applications as drug delivery systems in tumoral treatments.

scholarly journals New Biocompatible Mesoporous Silica/Polysaccharide Hybrid Materials as Possible Drug Delivery Systems

Materials ◽  
2018 ◽  
Vol 12 (1) ◽  
pp. 15 ◽  
Author(s):  
Andreea Madalina Pandele ◽  
Corina Andronescu ◽  
Adi Ghebaur ◽  
Sorina Alexandra Garea ◽  
Horia Iovu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Hybrid Materials ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
The Body ◽  
Simulated Gastric Fluid ◽  
Release Mechanism

A high number of studies support the use of mesoporous silica nanoparticles (MSN) as carriers for drug delivery systems due to its high biocompatibility both in vitro and in vivo, its large surface area, controlled pore size and, more than this, its good excretion capacity from the body. In this work we attempt to establish the optimal encapsulation parameters of benzalkonium chloride (BZC) into MSN and further study its drug release. The influence of different parameters towards the drug loading in MSN such as pH, contact time and temperature were considered. The adsorption mechanism of the drug has been determined by using the equilibrium data. The modification process was proved using several methods such as Fourier transform-infrared (FT-IR), ultraviolet-visible (UV-VIS), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). Since MSN shows a lower drug release amount due to the agglomeration tendency, in order to increase MSN dispersion and drug release amount from MSN, two common biocompatible and biodegradable polymers were used as polymer matrix in which the MSN-BZC can be dispersed. The drug release profile of the MSN-BZC and of the synthesized hybrid materials were studied both in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Polymer-MSN-BZC hybrid materials exhibit a higher drug release percent than the pure MSN-BZC when a higher dispersion is achieved. The dispersion of MSN into the hybrid materials was pointed out in scanning electron microscope (SEM) images. The release mechanism was determined using four mathematic models including first-order, Higuchi, Korsmeyer–Peppas and Weibull.

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