scholarly journals Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches

Polymers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1539
Author(s):  
Stavroula G. Nanaki ◽  
Sophia Andrianidou ◽  
Panagiotis Barmpalexis ◽  
Evi Christodoulou ◽  
Dimitrios N. Bikiaris

In the present study, the preparation of controlled-released leflunomide (LFD)-loaded skin patches was evaluated, utilizing the combination of chitosan (CS) nanoparticles (NPs) incorporated into suitable poly(l-lactic acid) (PLLA) or poly(lactic-co-glycolic acid) (PLGA) polyester matrices. Initially, LFD-loaded CS NPs of ~600 nm and a smooth surface were prepared, while strong inter-molecular interactions between the drug and the CS were unraveled. In the following step, the prepared LFD-loaded CS NPs were incorporated into PLLA or PLGA, and thin-film patches were prepared via spin-coating. Analysis of the prepared films showed that the incorporation of the drug-loaded CS NPs resulted in a significant increase in the drug’s release rate and extent as compared to neat LFD-loaded polyester patches (i.e., prepared without the use of CS NPs). In-depth analysis of the prepared formulations showed that the amorphization of the drug within the matrix and the increased wetting properties of the prepared CS NPs were responsible for the improved thin-film patch characteristics.

Author(s):  
C.B. Carter ◽  
A.M. Donald ◽  
S.L. Sass

Using thin-film gold bicrystals with the boundary plane parallel to the foil surface, it has been shown(l,2) that networks of grain boundary dislocations can act as diffraction gratings and give rise to subsidiary reflections close to the matrix reflections in electron diffraction patterns. Recently several groups of workers(3-5) have shown that inclined boundaries in polycrystalline specimens also produce extra reflections which may be due to the periodic nature of the boundaries. In general grain boundaries in polycrystalline specimens will be steeply inclined to the foil surface and additional reflections due to wave matching at the boundary(6) will also be present. The diffraction technique has the potential for providing detailed information on the structure of inclined boundaries (see, for example (5)), especially for the case where the image contains no useful information. In order to provide a firm basis for this technique, the geometry of the diffraction effects expected from inclined boundaries and the influence of these effects on the appearance of images will be examined.


2021 ◽  
Vol 46 (24) ◽  
pp. 12961-12980
Author(s):  
Amanda Chen ◽  
Wen-Fan Chen ◽  
Tina Majidi ◽  
Bernadette Pudadera ◽  
Armand Atanacio ◽  
...  

2014 ◽  
Vol 602-603 ◽  
pp. 902-905
Author(s):  
Yong Jun Shen ◽  
Chuan Bin Wang ◽  
Ling Li ◽  
Qiang Shen ◽  
Lian Meng Zhang

Sr-doped lanthanum manganite (La1-xSrxMnO3) is characteristic of thermochromic, which can act as a smart thermal control material used in the variable-emittance devices. In the present study, La1-xSrxMnO3 thin films were prepared on MgO(100) substrates by pulsed laser deposition, and the effect of Sr-doping (x = 0 ~ 0.4) on the structure and infrared emissivity was investigated. Single-phased La1-xSrxMnO3 films with (100)-orientation were obtained, which showed a dense texture with smooth surface. The ratio of Mn4+/Mn3+ in the films was increased with increasing Sr doping, leading to the enhancement in double-exchange interaction and electrical conductivity. As a result, the phase transition from metal to insulator was observed with the increasing of test temperature. For the La0.8Sr0.2MnO3 thin film, a large value of emittance (De = 0.28) was obtained, indicating good variable-emittance by appropriate Sr doping.


1997 ◽  
Vol 36 (Part 1, No. 11) ◽  
pp. 7041-7047 ◽  
Author(s):  
Toshio Yada ◽  
Taro Maejima ◽  
Masaru Aoki

2011 ◽  
Vol 13 ◽  
pp. 87-92 ◽  
Author(s):  
M.S.P Sarah ◽  
F.S. Zahid ◽  
M.Z. Musa ◽  
U.M. Noor ◽  
Z. Shaameri ◽  
...  

The photoconductivity of a nanocomposite MEH-PPV:TiO2 thin film is investigated. The nanocomposite MEH-PPV:TiO2 thin film was deposited on a glass substrate by spin coating technique. The composition of the TiO2 powder was varied from 5 wt% to 20 wt% (with 5 wt% interval). The concentration of the MEH-PPV is given by 1 mg/1 ml. The current voltage characteristics were measured in dark and under illumination. The photoconductivity showed increment in value as the composition of the TiO2 is raised in the polymer based solution. The absorption showed augmentation as the amount of TiO2 is increased. The escalation of the current voltage is then supported by the results of surface morphology.


2015 ◽  
Vol 413 ◽  
pp. 1-4 ◽  
Author(s):  
C.Y. Fong ◽  
S.S. Ng ◽  
F.K. Yam ◽  
H. Abu Hassan ◽  
Z. Hassan

2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
Mohammad Hossein Habibi ◽  
Mohammad Khaledi Sardashti

Glass plate-supported nanostructure ZnO thin films were deposited by sol-gel spin coating. Films were preheated at275∘Cfor 10 minutes and annealed at 350, 450, and550∘Cfor 80 minutes. The ZnO thin films were transparent ca 80–90% in visible range and revealed that absorption edges at about 370 nm. Thec-axis orientation improves and the grain size increases which was indicated by an increase in intensity of the (002) peak at34.4∘in XRD corresponding to the hexagonal ZnO crystal. The photocatalytic degradation of X6G an anionic monoazo dye, in aqueous solutions, was investigated and the effects of some operational parameters such as the number of layer and reusability of ZnO nanostructure thin film were examined. The results showed that the five-layer coated glass surfaces have a very high photocatalytic performance.


2013 ◽  
Vol 184 ◽  
pp. 1-4 ◽  
Author(s):  
Hao Chang ◽  
Pengyue Wang ◽  
Haidong Li ◽  
Jidong Zhang ◽  
Donghang Yan

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