scholarly journals Classification of Diffuse Glioma Subtype from Clinical-Grade Pathological Images Using Deep Transfer Learning

Sensors ◽  
2021 ◽  
Vol 21 (10) ◽  
pp. 3500
Author(s):  
Sanghyuk Im ◽  
Jonghwan Hyeon ◽  
Eunyoung Rha ◽  
Janghyeon Lee ◽  
Hojin Choi ◽  
...  
Keyword(s):  
Deep Learning ◽  
Transfer Learning ◽  
Genetic Alterations ◽  
Response To Therapy ◽  
Classification Model ◽  
World Health ◽  
Diffuse Glioma ◽  
Integrated Diagnosis ◽  
Diffuse Gliomas

Diffuse gliomas are the most common primary brain tumors and they vary considerably in their morphology, location, genetic alterations, and response to therapy. In 2016, the World Health Organization (WHO) provided new guidelines for making an integrated diagnosis that incorporates both morphologic and molecular features to diffuse gliomas. In this study, we demonstrate how deep learning approaches can be used for an automatic classification of glioma subtypes and grading using whole-slide images that were obtained from routine clinical practice. A deep transfer learning method using the ResNet50V2 model was trained to classify subtypes and grades of diffuse gliomas according to the WHO’s new 2016 classification. The balanced accuracy of the diffuse glioma subtype classification model with majority voting was 0.8727. These results highlight an emerging role of deep learning in the future practice of pathologic diagnosis.

scholarly journals Design of Accurate Classification of COVID-19 Disease in X-Ray Images Using Deep Learning Approach

2021 ◽  
Vol 2 (2) ◽  
pp. 132-148
Author(s):  
Joy Iong-Zong Chen
Keyword(s):  
Transfer Learning ◽  
Research Work ◽  
Well Being ◽  
Classification Model ◽  
Classification Method ◽  
World Health ◽  
Detection Methods ◽  
X Rays ◽  
X Ray

COVID-19 appears to be having a devastating influence on world health and well-being. Moreover, the COVID-19 confirmed cases have recently increased to over 10 million worldwide. As the number of verified cases increase, it is more important to monitor and classify healthy and infected people in a timely and accurate manner. Many existing detection methods have failed to detect viral patterns. Henceforth, by using COVID-19 thoracic x-rays and the histogram-oriented gradients (HOG) feature extraction methodology; this research work has created an accurate classification method for performing a reliable detection of COVID-19 viral patterns. Further, the proposed classification model provides good results by leveraging accurate classification of COVID-19 disease based on the medical images. Besides, the performance of our proposed CNN classification method for medical imaging has been assessed based on different edge-based neural networks. Whenever there is an increasing number of a class in the training network, the accuracy of tertiary classification with CNN will be decreasing. Moreover, the analysis of 10 fold cross-validation with confusion metrics can also take place in our research work to detect various diseases caused due to lung infection such as Pneumonia corona virus-positive or negative. The proposed CNN model has been trained and tested with a public X-ray dataset, which is recently published for tertiary and normal classification purposes. For the instance transfer learning, the proposed model has achieved 85% accuracy of tertiary classification that includes normal, COVID-19 positive and Pneumonia. The proposed algorithm obtains good classification accuracy during binary classification procedure integrated with the transfer learning method.

scholarly journals Molecular Classification of Diffuse Gliomas

2020 ◽  
Vol 47 (4) ◽  
pp. 464-473
Author(s):  
Navya Kalidindi ◽  
Rosemarylin Or ◽  
Sam Babak ◽  
Warren Mason
Keyword(s):  
Dna Methylation ◽  
Molecular Markers ◽  
World Health ◽  
Low Grade ◽  
Diffuse Glioma ◽  
Isocitrate Dehydrogenase 1 ◽  
Anaplastic Gliomas ◽  
Diffuse Gliomas ◽  
The Impact

ABSTRACT:Technological advances in the field of molecular genetics have improved the ability to classify brain tumors into subgroups with distinct clinical features and important therapeutic implications. The World Health Organization’s newest update on classification of gliomas (2016) incorporated isocitrate dehydrogenase 1 and 2 mutations, ATRX loss, 1p/19q codeletion status, and TP53 mutations to allow for improved classification of glioblastomas, low-grade and anaplastic gliomas. This paper reviews current advances in the understanding of diffuse glioma classification and the impact of molecular markers and DNA methylation studies on survival of patients with these tumors. We also discuss whether the classification and grading of diffuse gliomas should be based on histological findings, molecular markers, or DNA methylation subgroups in future iterations of the classification system.

scholarly journals Deep Learning Technology for Weld Defects Classification Based on Transfer Learning and Activation Features

2020 ◽  
Vol 2020 ◽  
pp. 1-16
Author(s):  
Chiraz Ajmi ◽  
Juan Zapata ◽  
Sabra Elferchichi ◽  
Abderrahmen Zaafouri ◽  
Kaouther Laabidi
Keyword(s):  
Deep Learning ◽  
Transfer Learning ◽  
Data Augmentation ◽  
Fine Tuning ◽  
Classification Model ◽  
Learning Technology ◽  
X Ray ◽  
Weld Defects ◽  
Defects Classification

Weld defects detection using X-ray images is an effective method of nondestructive testing. Conventionally, this work is based on qualified human experts, although it requires their personal intervention for the extraction and classification of heterogeneity. Many approaches have been done using machine learning (ML) and image processing tools to solve those tasks. Although the detection and classification have been enhanced with regard to the problems of low contrast and poor quality, their result is still unsatisfying. Unlike the previous research based on ML, this paper proposes a novel classification method based on deep learning network. In this work, an original approach based on the use of the pretrained network AlexNet architecture aims at the classification of the shortcomings of welds and the increase of the correct recognition in our dataset. Transfer learning is used as methodology with the pretrained AlexNet model. For deep learning applications, a large amount of X-ray images is required, but there are few datasets of pipeline welding defects. For this, we have enhanced our dataset focusing on two types of defects and augmented using data augmentation (random image transformations over data such as translation and reflection). Finally, a fine-tuning technique is applied to classify the welding images and is compared to the deep convolutional activation features (DCFA) and several pretrained DCNN models, namely, VGG-16, VGG-19, ResNet50, ResNet101, and GoogLeNet. The main objective of this work is to explore the capacity of AlexNet and different pretrained architecture with transfer learning for the classification of X-ray images. The accuracy achieved with our model is thoroughly presented. The experimental results obtained on the weld dataset with our proposed model are validated using GDXray database. The results obtained also in the validation test set are compared to the others offered by DCNN models, which show a best performance in less time. This can be seen as evidence of the strength of our proposed classification model.

scholarly journals Effectiveness of transfer learning for enhancing tumor classification with a convolutional neural network on frozen sections

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Young-Gon Kim ◽  
Sungchul Kim ◽  
Cristina Eunbee Cho ◽  
In Hye Song ◽  
Hee Jin Lee ◽  
...  
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Transfer Learning ◽  
Frozen Section ◽  
Medical Center ◽  
External Validation ◽  
Model Performance ◽  
Classification Model ◽  
Training Dataset

AbstractFast and accurate confirmation of metastasis on the frozen tissue section of intraoperative sentinel lymph node biopsy is an essential tool for critical surgical decisions. However, accurate diagnosis by pathologists is difficult within the time limitations. Training a robust and accurate deep learning model is also difficult owing to the limited number of frozen datasets with high quality labels. To overcome these issues, we validated the effectiveness of transfer learning from CAMELYON16 to improve performance of the convolutional neural network (CNN)-based classification model on our frozen dataset (N = 297) from Asan Medical Center (AMC). Among the 297 whole slide images (WSIs), 157 and 40 WSIs were used to train deep learning models with different dataset ratios at 2, 4, 8, 20, 40, and 100%. The remaining, i.e., 100 WSIs, were used to validate model performance in terms of patch- and slide-level classification. An additional 228 WSIs from Seoul National University Bundang Hospital (SNUBH) were used as an external validation. Three initial weights, i.e., scratch-based (random initialization), ImageNet-based, and CAMELYON16-based models were used to validate their effectiveness in external validation. In the patch-level classification results on the AMC dataset, CAMELYON16-based models trained with a small dataset (up to 40%, i.e., 62 WSIs) showed a significantly higher area under the curve (AUC) of 0.929 than those of the scratch- and ImageNet-based models at 0.897 and 0.919, respectively, while CAMELYON16-based and ImageNet-based models trained with 100% of the training dataset showed comparable AUCs at 0.944 and 0.943, respectively. For the external validation, CAMELYON16-based models showed higher AUCs than those of the scratch- and ImageNet-based models. Model performance for slide feasibility of the transfer learning to enhance model performance was validated in the case of frozen section datasets with limited numbers.

scholarly journals Uncertainty-Aware Deep Learning-Based Cardiac Arrhythmias Classification Model of Electrocardiogram Signals

Computers ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 82
Author(s):  
Ahmad O. Aseeri
Keyword(s):  
Deep Learning ◽  
Cardiac Arrhythmias ◽  
Large Scale ◽  
Clinical Decision Making ◽  
Probabilistic Approach ◽  
Classification Model ◽  
Gating Mechanism ◽  
Uncertainty Estimates ◽  
Wide Range

Deep Learning-based methods have emerged to be one of the most effective and practical solutions in a wide range of medical problems, including the diagnosis of cardiac arrhythmias. A critical step to a precocious diagnosis in many heart dysfunctions diseases starts with the accurate detection and classification of cardiac arrhythmias, which can be achieved via electrocardiograms (ECGs). Motivated by the desire to enhance conventional clinical methods in diagnosing cardiac arrhythmias, we introduce an uncertainty-aware deep learning-based predictive model design for accurate large-scale classification of cardiac arrhythmias successfully trained and evaluated using three benchmark medical datasets. In addition, considering that the quantification of uncertainty estimates is vital for clinical decision-making, our method incorporates a probabilistic approach to capture the model’s uncertainty using a Bayesian-based approximation method without introducing additional parameters or significant changes to the network’s architecture. Although many arrhythmias classification solutions with various ECG feature engineering techniques have been reported in the literature, the introduced AI-based probabilistic-enabled method in this paper outperforms the results of existing methods in outstanding multiclass classification results that manifest F1 scores of 98.62% and 96.73% with (MIT-BIH) dataset of 20 annotations, and 99.23% and 96.94% with (INCART) dataset of eight annotations, and 97.25% and 96.73% with (BIDMC) dataset of six annotations, for the deep ensemble and probabilistic mode, respectively. We demonstrate our method’s high-performing and statistical reliability results in numerical experiments on the language modeling using the gating mechanism of Recurrent Neural Networks.

Tobacco Leaf Grading Based on Deep Convolutional Neural Networks and Machine Vision

2021 ◽  
Vol 65 (1) ◽  
pp. 11-22
Author(s):  
Mengyao Lu ◽  
Shuwen Jiang ◽  
Cong Wang ◽  
Dong Chen ◽  
Tian’en Chen
Keyword(s):  
Neural Networks ◽  
Deep Learning ◽  
Transfer Learning ◽  
Convolutional Neural Networks ◽  
Classification Accuracy ◽  
Classification Model ◽  
List Type ◽  
Tobacco Leaves ◽  
Tobacco Leaf ◽  
Grading Model

HighlightsA classification model for the front and back sides of tobacco leaves was developed for application in industry.A tobacco leaf grading method that combines a CNN with double-branch integration was proposed.The A-ResNet network was proposed and compared with other classic CNN networks.The grading accuracy of eight different grades was 91.30% and the testing time was 82.180 ms, showing a relatively high classification accuracy and efficiency.Abstract. Flue-cured tobacco leaf grading is a key step in the production and processing of Chinese-style cigarette raw materials, directly affecting cigarette blend and quality stability. At present, manual grading of tobacco leaves is dominant in China, resulting in unsatisfactory grading quality and consuming considerable material and financial resources. In this study, for fast, accurate, and non-destructive tobacco leaf grading, 2,791 flue-cured tobacco leaves of eight different grades in south Anhui Province, China, were chosen as the study sample, and a tobacco leaf grading method that combines convolutional neural networks and double-branch integration was proposed. First, a classification model for the front and back sides of tobacco leaves was trained by transfer learning. Second, two processing methods (equal-scaled resizing and cropping) were used to obtain global images and local patches from the front sides of tobacco leaves. A global image-based tobacco leaf grading model was then developed using the proposed A-ResNet-65 network, and a local patch-based tobacco leaf grading model was developed using the ResNet-34 network. These two networks were compared with classic deep learning networks, such as VGGNet, GoogLeNet-V3, and ResNet. Finally, the grading results of the two grading models were integrated to realize tobacco leaf grading. The tobacco leaf classification accuracy of the final model, for eight different grades, was 91.30%, and grading of a single tobacco leaf required 82.180 ms. The proposed method achieved a relatively high grading accuracy and efficiency. It provides a method for industrial implementation of the tobacco leaf grading and offers a new approach for the quality grading of other agricultural products. Keywords: Convolutional neural network, Deep learning, Image classification, Transfer learning, Tobacco leaf grading

scholarly journals Deep Learning Based Depthwise Separable Model For Effective Diagnosis And Classification of Lung Ct Images

2019 ◽  
Vol 9 (1) ◽  
pp. 1808-1819 ◽  
Keyword(s):  
Lung Cancer ◽  
Feature Extraction ◽  
Deep Learning ◽  
Noise Removal ◽  
Ct Images ◽  
Classification Model ◽  
Diagnosis And Classification ◽  
Effective Diagnosis ◽  
Lung Ct

Lung cancer is a serious illness which leads to increased mortality rate globally. The identification of lung cancer at the beginning stage is the probable method of improving the survival rate of the patients. Generally, Computed Tomography (CT) scan is applied for finding the location of the tumor and determines the stage of cancer. Existing works has presented an effective diagnosis classification model for CT lung images. This paper designs an effective diagnosis and classification model for CT lung images. The presented model involves different stages namely pre-processing, segmentation, feature extraction and classification. The initial stage includes an adaptive histogram based equalization (AHE) model for image enhancement and bilateral filtering (BF) model for noise removal. The pre-processed images are fed into the second stage of watershed segmentation model for effectively segment the images. Then, a deep learning based Xception model is applied for prominent feature extraction and the classification takes place by the use of logistic regression (LR) classifier. A comprehensive simulation is carried out to ensure the effective classification of the lung CT images using a benchmark dataset. The outcome implied the outstanding performance of the presented model on the applied test images.

scholarly journals Attention-Guided Digital Adversarial Patches on Visual Detection

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Dapeng Lang ◽  
Deyun Chen ◽  
Ran Shi ◽  
Yongjun He
Keyword(s):  
Deep Learning ◽  
Learning Model ◽  
Detection Algorithm ◽  
Classification Model ◽  
Practical Application ◽  
Single Target ◽  
Attachment Mechanism ◽  
Human Eyes ◽  
Deep Learning Model

Deep learning has been widely used in the field of image classification and image recognition and achieved positive practical results. However, in recent years, a number of studies have found that the accuracy of deep learning model based on classification greatly drops when making only subtle changes to the original examples, thus realizing the attack on the deep learning model. The main methods are as follows: adjust the pixels of attack examples invisible to human eyes and induce deep learning model to make the wrong classification; by adding an adversarial patch on the detection target, guide and deceive the classification model to make it misclassification. Therefore, these methods have strong randomness and are of very limited use in practical application. Different from the previous perturbation to traffic signs, our paper proposes a method that is able to successfully hide and misclassify vehicles in complex contexts. This method takes into account the complex real scenarios and can perturb with the pictures taken by a camera and mobile phone so that the detector based on deep learning model cannot detect the vehicle or misclassification. In order to improve the robustness, the position and size of the adversarial patch are adjusted according to different detection models by introducing the attachment mechanism. Through the test of different detectors, the patch generated in the single target detection algorithm can also attack other detectors and do well in transferability. Based on the experimental part of this paper, the proposed algorithm is able to significantly lower the accuracy of the detector. Affected by the real world, such as distance, light, angles, resolution, etc., the false classification of the target is realized by reducing the confidence level and background of the target, which greatly perturbs the detection results of the target detector. In COCO Dataset 2017, it reveals that the success rate of this algorithm reaches 88.7%.

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