Combined Endoscopic and Intraoral Approach or Intraoral Alone in Surgical Management of Odontogenic Sinusitis

The physiological behavior of paranasal sinuses depends on the potency of the ostiomeatal complex and on normal mucociliary function. The interruption of this delicate equilibrium can lead to pathological conditions such as sinusitis. Anywhere between 10% and over 25% of cases of maxillary sinusitis have an odontogenic origin, such as: dental infection; alveolar dental trauma; or iatrogenic causes, such as extractions, endodontic therapies, maxillary osteotomies or placement of endosseous implants. The resolution of sinus pathology is related to the resolution of odontogenic pathology. Aim: to evaluate the therapeutic efficacy of a combined oral and endoscopic approach in the treatment of chronic odontogenic sinusitis vs. oral dental management through a case control study. Materials and Methods: all patients showing signs and symptoms of odontogenic sinusitis with obliteration (appreciable radiopacity in CT) of unilateral maxillary sinus between January 2018 and September 2019 at Padua University Hospital were enrolled in this retrospective study. The exclusion criteria were: maxillary sinusitis without odontogenic origin, or resolution with a systemic antibiotic therapy; and presence of anatomical abnormalities that promote the onset of rhinosinusitis. The patients were divided into two groups: one group was treated with a combined surgical approach under general anesthesia (Functional Endoscopic Sinus Surgery-FESS and simultaneous closure of oroantral communication with Bichat’s fat pad advancement); while the other group was treated only with an intraoral approach under local anesthesia and conscious sedation (closure of oroantral communication with Bichat’s fat pad advancement). The variable “success of the surgical procedure” in the two groups was compared by a Student test (with p < 0.05). Results: among the patients enrolled, 10 patients (aged between 42 and 70) made up the case group and the other 10 patients (aged between 51 and 74) constituted the control group. There was no statistically significant difference in success between the two groups (p < 0.025). Conclusions: according to this case study, an exclusive annotation invasive intraoral approach seemed to be comparable to the transoral endoscopic combined method. However, during diagnosis it is necessary and fundamental to distinguish between odontogenic and rhinogenic sinusitis in order for the resolution of odontogenic sinusitis to be achieved.

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Optimization of postoperative management of patients undergoing functional endoscopic sinus surgery

OTORHINOLARYNGOLOGY 2-3(2) 2019 - OTORHINOLARYNGOLOGY ◽

10.37219/2528-8253-2018-1-26 ◽

2018 ◽

pp. 26-31

Author(s):

Sergey Bezshapochny ◽

Andrey Loburets ◽

Valery Loburets

Keyword(s):

Nasal Cavity ◽

Postoperative Period ◽

Sodium Hyaluronate ◽

Sinus Surgery ◽

Control Group ◽

Nasal Breathing ◽

Traditional Therapy ◽

Significant Difference ◽

Water Salt ◽

Experimental Group

Topicality: The result of surgical treatment depends largely on the chosen method of management of the postoperative period, the main purpose of which is to reduce the effects of surgical trauma. Despite the wide variety of drugs for local and systemic use, the question of pharmacotherapy of the operated sinus remains open to this day. The main properties that a modern drug should possess are safety and high clinical efficacy. Aim: to study the clinical efficacy of topical application of a complex preparation based on a saline solution containing sodium hyaluronate and dexpanthenol in patients with chronic sinusitis after functional endoscopic sinus surgery (FESS). Materials and Methods: Clinical and laboratory studies were conducted on 47 patients with chronic rhinosinusitis who underwent surgery using the FESS technique. Patients were divided into 2 groups according to the principle of the postoperative period. Patients of research group (n=21), except for traditional therapy, was used locally NASOMER (a preparation based on a water-salt solution containing sodium hyaluronate and dexpanthenol); to the control group (n=26) patients entered, in the postoperative period received traditional therapy. Traditional therapy included a toilet of the nasal cavity, the use of short-course topical decongestants, irrigation of the nasal cavity with water-salt solutions. Criteria of clinical effectiveness: data of endoscopy of the nasal cavity, rhinomanometry, activity of the mucociliary transport system. The effectiveness of functional research methods in the postoperative period was determined on the 7th and 14th day of treatment. Results: On the 3rd day of the study, an increase in the swelling of the nasal cavity was observed in patients of both clinical groups, correlated with difficulty in nasal breathing. On the 7th day, a decrease in edema was observed in patients of both groups, but in the experimental group, the index of nasal breathing, according to rhinomanometry, was significantly (p<0.05) different from the control group, and was respectively 1.54±0.14 and 2.04±0.19 kPa/l*s. On the 14th day of the study, no significant difference was observed between these indicators. When studying the activity of the ciliated epithelium of the mucous membrane of the nasal cavity, it was proved that patients of the experimental group on day 7 after surgery showed a statistically significant difference in this indicator compared to the control group (17.8±1.0 and 22.7±2.1 min. respectively). Conclusions: The use of NASOMER after surgical intervention in patients with chronic rhinosinusitis contributes to more effective treatment compared with traditional therapy, as evidenced by the rapid recovery of the main functional parameters according to active posterior rhinomanometry and mucociliary clearance. Based on the results of the studies performed, the use of NASOMER for pharmacotherapy in the postoperative period is recommended for patients who have undergone rhinosurgical interventions with the aim of reducing the period of postoperative rehabilitation as an effective anti-inflammatory and wound-healing agent.

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The clinical efficacy of arthroscopic therapy with knee infrapatellar fat pad cell concentrates in treating knee cartilage lesion: a prospective, randomized, and controlled study

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-021-02224-9 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Yiqin Zhou ◽

Haobo Li ◽

Dong Xiang ◽

Jiahua Shao ◽

Qiwei Fu ◽

...

Keyword(s):

Clinical Efficacy ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Knee Arthroscopy ◽

Infrapatellar Fat Pad ◽

Control Group ◽

Knee Cartilage ◽

Fat Pad ◽

Group 12 ◽

Significant Difference

Abstract Introduction To evaluate the clinical efficacy of arthroscopic therapy with infrapatellar fat pad cell concentrates in treating knee cartilage lesions, we conducted a prospective randomized single-blind clinical study of controlled method. Methods Sixty cases from Shanghai Changzheng Hospital from April 2018 to December 2019 were chosen and randomly divided into 2 groups equally. Patients in the experiment group were treated through knee arthroscopy with knee infrapatellar fat pad cell concentrates containing mesenchymal stromal cells, while patients in the control group were treated through regular knee arthroscopic therapy. VAS and WOMAC scores were assessed at pre-operation, and 6 weeks, 12 weeks, 6 months, and 12 months after intervention. MORCART scores were assessed at pre-operation and 12 months after intervention. Results Twenty-nine cases in the experiment group and 28 cases in the control group were followed up. No significant difference in VAS, WOMAC, and MOCART scores were found between the two groups before surgery (P > 0.05). The WOMAC total and WOMAC function scores of the experiment group were significantly lower than those of the control group 6 months and 12 months after surgery (P < 0.05). The VAS rest and VAS motion scores of the experiment group were found significantly lower than those of the control group 12 months after surgery (P < 0.05). The MOCART scores of the experiment group were found significantly higher compared with the control group 12 months after surgery (P < 0.05). No significant difference in WOMAC stiffness scores were found between the two groups. Conclusions The short-term results of our study are encouraging and demonstrate that knee arthroscopy with infrapatellar fat pad cell concentrates containing mesenchymal stromal cells is safe and provides assistance in reducing pain and improving function in patients with knee cartilage lesions. Trial registration ChiCTR1800015379. Registered on 27 March 2018, http://www.chictr.org.cn/showproj.aspx?proj=25901.

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Corneal Biomechanical Parameters and Central Corneal Thickness in Glaucoma Patients, Glaucoma Suspects, and a Healthy Population

Journal of Clinical Medicine ◽

10.3390/jcm10122637 ◽

2021 ◽

Vol 10 (12) ◽

pp. 2637

Author(s):

Mª. Ángeles del Buey-Sayas ◽

Elena Lanchares-Sancho ◽

Pilar Campins-Falcó ◽

María Dolores Pinazo-Durán ◽

Cristina Peris-Martínez

Keyword(s):

Central Corneal Thickness ◽

Corneal Thickness ◽

Mean Difference ◽

The Other ◽

Control Group ◽

Healthy Population ◽

Diagnostic Categories ◽

Significant Difference ◽

Biomechanical Parameters ◽

The Mean

Purpose: To evaluate and compare corneal hysteresis (CH), corneal resistance factor (CRF), and central corneal thickness (CCT), measurements were taken between a healthy population (controls), patients diagnosed with glaucoma (DG), and glaucoma suspect patients due to ocular hypertension (OHT), family history of glaucoma (FHG), or glaucoma-like optic discs (GLD). Additionally, Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated IOP (IOPcc) were compared between the different groups of patients. Methods: In this prospective analytical-observational study, a total of 1065 patients (one eye of each) were recruited to undergo Ocular Response Analyzer (ORA) testing, ultrasound pachymetry, and clinical examination. Corneal biomechanical parameters (CH, CRF), CCT, IOPg, and IOPcc were measured in the control group (n = 574) and the other groups: DG (n = 147), FHG (n = 78), GLD (n = 90), and OHT (n = 176). We performed a variance analysis (ANOVA) for all the dependent variables according to the different diagnostic categories with multiple comparisons to identify the differences between the diagnostic categories, deeming p < 0.05 as statistically significant. Results: The mean CH in the DG group (9.69 mmHg) was significantly lower compared to controls (10.75 mmHg; mean difference 1.05, p < 0.001), FHG (10.70 mmHg; mean difference 1.00, p < 0.05), GLD (10.63 mmHg; mean difference 0.93, p < 0.05) and OHT (10.54 mmHg; mean difference 0.84, p < 0.05). No glaucoma suspects (FHG, GLD, OHT groups) presented significant differences between themselves and the control group (p = 1.00). No statistically significant differences were found in the mean CRF between DG (11.18 mmHg) and the control group (10.75 mmHg; mean difference 0.42, p = 0.40). The FHG and OHT groups showed significantly higher mean CRF values (12.32 and 12.41 mmHg, respectively) than the DG group (11.18 mmHg), with mean differences of 1.13 (p < 0.05) and 1.22 (p < 0.001), respectively. No statistically significant differences were found in CCT in the analysis between DG (562 μ) and the other groups (control = 556 μ, FHG = 576 μ, GLD = 569 μ, OHT = 570 μ). The means of IOPg and IOPcc values were higher in the DG patient and suspect groups than in the control group, with statistically significant differences in all groups (p < 0.001). Conclusion: This study presents corneal biomechanical values (CH, CRF), CCT, IOPg, and IOPcc for diagnosed glaucoma patients, three suspected glaucoma groups, and a healthy population, using the ORA. Mean CH values were markedly lower in the DG group (diagnosed with glaucoma damage) compared to the other groups. No significant difference was found in CCT between the DG and control groups. Unexpectedly, CRF showed higher values in all groups than in the control group, but the difference was only statistically significant in the suspect groups (FHG, GLD, and OHT), not in the DG group.

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The Effect of Geogebra on Students’ Conceptual and Procedural Knowledge: The Case of Applications of Derivative

Higher Education Studies ◽

10.5539/hes.v7n2p67 ◽

2017 ◽

Vol 7 (2) ◽

pp. 67 ◽

Cited By ~ 2

Author(s):

Mehmet Fatih Ocal

Keyword(s):

Conceptual Knowledge ◽

Teaching And Learning ◽

Procedural Knowledge ◽

Dynamic Geometry ◽

The Other ◽

Control Group ◽

Other Hand ◽

Significant Difference ◽

Before And After ◽

Post Test

Integrating the properties of computer algebra systems and dynamic geometry environments, Geogebra became an effective and powerful tool for teaching and learning mathematics. One of the reasons that teachers use Geogebra in mathematics classrooms is to make students learn mathematics meaningfully and conceptually. From this perspective, the purpose of this study was to investigate whether instruction with Geogebra has effect on students’ achievements regarding their conceptual and procedural knowledge on the applications of derivative subject. This study adopted the quantitative approach with pre-test post-test control group true experimental design. The participants were composed of two calculus classrooms involving 31 and 24 students, respectively. The experimental group with 31 students received instruction with Geogebra while the control group received traditional instruction in learning the applications of derivative. Independent samples t-test was used in the analysis of the data gathered from students’ responses to Applications of Derivative Test which was subjected to them before and after teaching processes. The findings indicated that instruction with Geogebra had positive effect on students’ scores regarding conceptual knowledge and their overall scores. On the other hand, there was no significant difference between experimental and control group students’ scores regarding procedural knowledge. It could be concluded that students in both groups were focused on procedural knowledge to be successful in learning calculus subjects including applications of derivative in both groups. On the other hand, instruction with Geogebra supported students’ learning these subjects meaningfully and conceptually.

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Tratamento de fístula bucosinusal após exodontia com corpo adiposo da bochecha e retalho vestibular em paciente diabético: relato de caso

ARCHIVES OF HEALTH INVESTIGATION ◽

10.21270/archi.v9i3.4801 ◽

2020 ◽

Vol 9 (3) ◽

Author(s):

Rodrigo Capalbo-Silva ◽

Hiskell Francine Fernandes e Oliveira ◽

Henrique Hadad ◽

Bruno Coelho Mendes ◽

Breno dos Reis Fernandes ◽

...

Keyword(s):

Advancement Flap ◽

Rational Approach ◽

Collagen Membrane ◽

Fat Pad ◽

Buccal Fat Pad ◽

Posterior Teeth ◽

Oroantral Fistula ◽

Surgical Options ◽

Odontogenic Sinusitis ◽

Oroantral Communication

A comunicação bucosinusal trata-se da comunicação não natural da cavidade bucal com o seio maxilar, estando muitas vezes relacionada a extração dos dentes superiores posteriores. A literatura apresenta diversas opções de tratamento para esses casos, entre eles o fechamento com o retalho pediculado com o corpo adiposo bucal. O objetivo deste trabalho foi relatar um caso de fístula bucosinusal em paciente diabético, discutindo alternativas cirúrgicas correlacionadas com problema sistêmico do paciente e características locais do defeito. Paciente do sexo masculino, 55 anos de idade, com histórico de dez dias de exodontia do elemento 27, com queixa de passagem de ar ao meio bucal através do sítio cirúrgico. Com base nos exames, o diagnóstico definitivo foi de comunicação bucosinusal, sendo estipulado o tratamento cirúrgico para o fechamento da comunicação através de duas camadas com o corpo adiposo da bochecha seguido do retalho vestibular. No acompanhamento de 8 meses e meio o paciente não apresenta queixas e pode-se observar o fechamento completo da comunicação bucosinusal. O retalho pediculado do corpo adiposo bucal seguido do retalho vestibular mostrou-se efetivo no tratamento da fístula bucosinusal em paciente diabético controlado.Descritores: Fístula Bucoantral; Cirurgia Bucal; Diabetes Mellitus.ReferênciasLozano-Carrascal N, Salomó-Coll O, Gehrke SA, Calvo-Guirado JL, Hernández-Alfaro F, Gargallo-Albiol J. Radiological evaluation of maxillary sinus anatomy: A cross-sectional study of 300 patients. Ann Anat. 2017;214:1-8.Jang JK, Kwak SW, Ha JH, Kim HC. Anatomical relationship of maxillary posterior teeth with the sinus floor and buccal cortex. J Oral Rehabil. 2017;44(8):617-25. Khandelwal P, Hajira N. Management of Oro-antral Communication and Fistula: Various Surgical Options. World J Plast Surg. 2017;6(1):3-8.Parvini P, Obreja K, Begic A, et al. Decision-making in closure of oroantral communication and fistula. Int J Implant Dent. 2019;5(1):13.Lin PT, Bukachevsky R, Blake M. Management of odontogenic sinusitis with persistent oro-antral fistula. Ear Nose Throat J. 1991;70(8):488-90.Al-Juboori MJ, Al-Attas MA, Magno Filho LC. Treatment of chronic oroantral fistula with platelet-rich fibrin clot and collagen membrane: a case report. Clin Cosmet Investig Dent. 2018; 10:245-49.Kiran Kumar Krishanappa S, Eachempati P, Kumbargere Nagraj S, Shetty NY, Moe S, Aggarwal H et al. Interventions for treating oro-antral communications and fistulae due to dental procedures. Cochrane Database Syst Rev. 2018;8(8):CD011784. Darr A, Jolly K, Martin T, Monaghan A, Grime P, Isles M et al. Three-layered technique to repair an oroantral fistula using a posterior-pedicled inferior turbinate, buccal fat pad, and buccal mucosal advancement flap. Br J Oral Maxillofac Surg. 2018;56(7):638-39.Parvini P, Obreja K, Sader R, Becker J, Schwarz F, Salti L. Surgical options in oroantral fistula management: a narrative review. Int J Implant Dent. 2018;4(1):40. Lin PT, Bukachevsky R, Blake M. Management of odontogenic sinusitis with persistent oro-antral fistula. Ear Nose Throat J. 1991;70(8):488-90.Borgonovo AE, Berardinelli FV, Favale M, Maiorana C. Surgical options in oroantral fistula treatment. Open Dent J. 2012;6:94-8.Ribeiro FS, de Toledo CT, Aleixo MR, Durigan MC, Silva WC, Bueno SK et al. Treatment of Oroantral Communication Using the Lateral Palatal Sliding Flap Technique. Case Rep Med. 2015;2015:730623.Erdoğan O, Esen E, Ustün Y. Bony palatal necrosis in a diabetic patient secondary to palatal rotational flap. J Diabetes Complications. 2005;19(6):364-67.Tideman H, Bosanquet A, Scott J. Use of the buccal fat pad as a pedicled graft. J Oral Maxillofac Surg. 1986;44(6):435-40.Yang S, Jee YJ, Ryu DM. Reconstruction of large oroantral defects using a pedicled buccal fat pad. Maxillofac Plast Reconstr Surg. 2018; 40(1):7.Raldi FV, Sardinha SCS, Albergaria-Barbosa JR. Fechamento de comunicação bucossinusal usando enxerto pediculado com corpo adiposo bucal. BCI. 2000;7(25):60-3.Poeschl PW, Baumann A, Russmueller G, Poeschl E, Klug C, Ewers R. Closure of oroantral communications with Bichat's buccal fat pad. J Oral Maxillofac Surg. 2009;67(7):1460-66.Batra H, Jindal G, Kaur S. Evaluation of different treatment modalities for closure of oro-antral communications and formulation of a rational approach. J Maxillofac Oral Surg. 2010;9(1):13-8. Weinstock RJ, Nikoyan L, Dym H. Composite three-layer closure of oral antral communication with 10 months follow-up-a case study. J Oral Maxillofac Surg. 2014;72(2):266.e1-266.e2667.Candamourty R, Jain MK, Sankar K, Babu MR. Double-layered closure of oroantral fistula using buccal fat pad and buccal advancement flap. J Nat Sci Biol Med. 2012;3(2):203-5.

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The Effect of the round house strategy on the achievement of physical concepts at the ninth grade in Jordan: فاعلية استراتيجية البيت الدائري في إكساب المفاهيم الفيزيائية لطالبات الصف التاسع في الأردن

المجلة العربية للعلوم ونشر الأبحاث مجلة العلوم التربوية والنفسية ◽

10.26389/ajsrp.r280719 ◽

2020 ◽

Vol 4 (1) ◽

Author(s):

Rida Ali Alsous

Keyword(s):

Secondary School ◽

Ninth Grade ◽

The Other ◽

Control Group ◽

Average Performance ◽

Significant Difference ◽

Post Test ◽

Experimental Group

The aim of the study was to clear-out the effect of the round house strategy on the achievement of physical concepts at the ninth grade. The study consisted of (48) students at the Jufa Secondary School for girls for the second semester 2018/2019, distributed randomly to two divisions in the same school, one of which was experimental and the other experimental. This study found that there was a statistically significant difference in the post-test in the students' acquisition of physical concepts at (α = 0.05) between the average performance of the experimental group studied using the circular house strategy and obtained an average of (19.70), and the control group studied in the usual way and obtained Average (14.63), in favor of the experimental group. In light of these results, the researcher recommended using the circular house strategy because of its importance in gaining physical concepts among students. In light of these results, the researcher recommended using the round house strategy and its role in acquiring physical concepts in demand

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Effect of Educational Games on Self-concept Levels of Inclusive Students Studying in Secondary Schools

Journal of Education and Training Studies ◽

10.11114/jets.v6i10.3365 ◽

2018 ◽

Vol 6 (10) ◽

pp. 183

Author(s):

Serhat Üstündağ ◽

Gülsen Özcan

Keyword(s):

Secondary Schools ◽

Peer Relationships ◽

Repeated Measures ◽

Educational Games ◽

The Other ◽

Self Concept ◽

Control Group ◽

Spring Semester ◽

Significant Difference ◽

Experimental Group

This research examines the effect of educational games on self-concept levels of inclusive students enrolled in secondary schools. The research was conducted in two secondary schools in Golbasi district of Ankara, the capital of Turkey, in the spring semester of 2015 - 2016 academic year. The research employed semi-experimental design with pretest and posttest control group. Of a total of 24 students, 12 (4 girls, 8 boys) were included in the experimental group and the other 12 (6 girls, 6 boys) were included in the control group. Educational games program, an independent variable of the research, was applied for 11 weeks, 2 lessons per week. The program that did not include educational games was applied to the control group. Self-concept Scale (SCS) was used to collect data in the research. Independent group t test was used for data analysis, and for single-factor repeated measures, two-factor ANOVA test was used. The significance level was determined to be 0.05. At the end of this research, a significant difference was found in favor of the students in the experimental group in terms of physical competence, physical appearance, peer relationships and general self-concept dimensions of the self-concept scale. On the other hand, there was not any significant difference in favor of both groups in terms of the dimension of relations with parents of the scale.

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The effect of hydroalcoholic extract of Cannabis Sativa on appetite hormone in rat

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2014-0006 ◽

2014 ◽

Vol 11 (4) ◽

Cited By ~ 4

Author(s):

Mohsen Mazidi ◽

Sara Baghban Taraghdari ◽

Peyman Rezaee ◽

Maryam Kamgar ◽

Mohammad Reza Jomezadeh ◽

...

Keyword(s):

Energy Intake ◽

Cannabis Sativa ◽

The Other ◽

Vehicle Group ◽

Control Group ◽

Hydroalcoholic Extract ◽

Significant Difference ◽

Orexigenic Peptide ◽

Male Wistar Rats ◽

Total Ghrelin

Abstract: Ghrelin is an orexigenic peptide which is secreted from stomach.: Thirty male Wistar rats were randomly divided into five groups. Two control groups were selected, the first group received 0.5 mL water per day (vehicle group) and another group did not receive anything (control group). The other three groups were treated daily with 50, 100 or 150 mg/kg of C. sativa for 7 days, respectively. Daily energy intake of the rats was calculated for 10 days prior to the> intervention and for the 7 day intervention. To investigate changes in plasma ghrelin as a potential mechanism, an orexigenic dose (150 mg/kg) of: There was no significant difference in energy intake between control and vehicle groups. Treatment with 100 and 150 mg/kg of the extract significantly increased energy intake vs the other groups (p<0.05). Total ghrelin levels were significantly elevated in the: This study showed that

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Use of Platelet-Rich Fibrin Associated with Xenograft in Critical Bone Defects: Histomorphometric Study in Rabbits

Symmetry ◽

10.3390/sym11101293 ◽

2019 ◽

Vol 11 (10) ◽

pp. 1293

Author(s):

Paulo Wilson Maia ◽

Marcelo Lucchesi Teixeira ◽

Luís Guilherme Scavone de Macedo ◽

Antonio Carlos Aloise ◽

Celio Amaral Passos Junior ◽

...

Keyword(s):

Bone Formation ◽

Saline Solution ◽

Healing Process ◽

Test Group ◽

The Other ◽

Control Group ◽

Collagen Membrane ◽

Platelet Rich Fibrin ◽

Histomorphometric Study ◽

Significant Difference

Platelet-rich fibrin (PRF) is an autologous material used to improve bone regeneration when associated with bone grafts. It affects tissue angiogenesis, increasing the healing process and, theoretically, presenting potential to increase bone neoformation. The aim of this study was to verify, histomorphometrically, the effects of the association of PRF to a xenograft. Twelve adult white New Zealand rabbits were randomly assigned into two groups containing six animals each. After general anesthesia of the animals, two critical defects of 12 mm were created in the rabbit calvaria, one on each side of the sagittal line. Each defect was filled with the following biomaterials: in the control group (CG), xenograft hydrated with saline solution filling one defect and xenograft hydrated with saline solution covered with collagen membrane on the other side; in the test group (TG), xenograft associated with PRF filling the defect of one side and xenograft associated with PRF covered with collagen membrane on the other side. After eight weeks the animals were euthanized and a histomorphometric analysis was performed. The results showed that in the sites that were covered with collagen membrane, there was no statistically significant difference for all the analyzed parameters. However, when comparing the groups without membrane coverage, a statistically significant difference could be observed for the vital mineralized tissue (VMT) and nonmineralized tissue (NMT) parameters, with more VMT in the test group and more NMT in the control group. Regarding the intragroup comparison, the use of the membrane coverage presented significant outcomes in both groups. Therefore, in this experimental model, PRF did not affect the levels of bone formation when a membrane coverage technique was used. However, higher levels of bone formation were observed in the test group when membrane coverage was not used.

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Evaluation of the concentration of malondialdehyde and nitrite in patients with sickle cell anemia treated or not with hydroxyurea

Einstein (São Paulo) ◽

10.1590/s1679-45082010ao1731 ◽

2010 ◽

Vol 8 (4) ◽

pp. 414-418 ◽

Cited By ~ 6

Author(s):

Darcielle Bruna Dias Elias ◽

Rivelilson Mendes de Freitas ◽

Romélia Pinheiro Gonçalves ◽

Hemerson Yuri Ferreira Magalhães ◽

Jacqueline Holanda de Sousa ◽

...

Keyword(s):

Sickle Cell ◽

Sickle Cell Anemia ◽

Serum Levels ◽

The Other ◽

Control Group ◽

Clinical Variables ◽

Short Period ◽

Significant Difference ◽

Group 2 ◽

Group 1

ABSTRACT Objective: To determine the serum levels of malondialdehyde and nitrite in patients with sickle cell anemia treated or not with hydroxyurea in outpatient's setting. Methods: Of the 65 patients with sickle cell anemia selected for the study, 51 were not treated with hydroxyurea (Group 1), 14 made chronic use of hydroxyurea (Group 2) and 20 individuals had no hemoglobinopathies (Control Group). Results: The Control Group had a lower and more homogeneous concentration of malondialdehyde levels as compared to the other groups. The results of Groups 1 and 2 showed increased values of malondialdehyde levels when compared to the Control Group. Considering the values of Groups 1 and 2, there were no significant changes in the malondialdehyde levels. There was no significant difference in the serum levels of nitrite between the groups. Group 2 presented a statistically significant correlation between serum malondialdehyde levels and the clinical variables investigated. In turn, Group 1 showed correlation only with occurrence of three or more vaso-occlusive crises. There was no correlation between nitrite levels and the clinical variables. Conclusion: The results revealed that during the pathogenesis of sickle cell anemia, an increase in lipid peroxidation was observed. On the other hand, no changes in oxidative parameters were detected during treatment with hydroxyurea, probably due to the short period of treatment of the patients studied.

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