Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication
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SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent potential treatments of the corresponding disease. With respect to its essential role in the replication of viral RNA, RNA-dependent RNA polymerase (RdRp) is one of the prime targets. HeE1-2Tyr and related derivatives were originally discovered as inhibitors of the RdRp of flaviviruses. Here, we present that these pyridobenzothiazole derivatives also significantly inhibit SARS-CoV-2 RdRp, as demonstrated using both polymerase- and cell-based antiviral assays.
2005 ◽
Vol 79
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pp. 7803-7811
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2015 ◽
Vol 34
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pp. 1512-1532
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1997 ◽
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pp. 5990-5996
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Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?
2009 ◽
Vol 19
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pp. 768-774
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1999 ◽
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pp. 198-204
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2001 ◽
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