scholarly journals Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness

Viruses ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2276
Author(s):  
Joshua Yi Yeo ◽  
Samuel Ken-En Gan
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Resistance Mechanisms ◽  
Human Infection ◽  
World Health ◽  
Influenza A Viruses ◽  
Host Proteins ◽  
Astrakhan Oblast ◽  
Health Organization ◽  
Wild Waterfowl

2014 marked the first emergence of avian influenza A(H5N8) in Jeonbuk Province, South Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak, it spread to domestic poultry and wild waterfowl shorebirds, leading to the first human infection in Astrakhan Oblast, Russia. Despite being clinically asymptomatic and without direct human-to-human transmission, the World Health Organization stressed the need for continued risk assessment given the nature of Influenza to reassort and generate novel strains. Given its promiscuity and easy cross to humans, the urgency to understand the mechanisms of possible species jumping to avert disastrous pandemics is increasing. Addressing the epidemiology of H5N8, its mechanisms of species jumping and its implications, mutational and reassortment libraries can potentially be built, allowing them to be tested on various models complemented with deep-sequencing and automation. With knowledge on mutational patterns, cellular pathways, drug resistance mechanisms and effects of host proteins, we can be better prepared against H5N8 and other influenza A viruses.

scholarly journals Peering Into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness

2021 ◽  
Author(s):  
Joshua Yi Yeo ◽  
Samuel Ken-En Gan
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
World Health Organisation ◽  
Resistance Mechanisms ◽  
Human Infection ◽  
World Health ◽  
Influenza A Viruses ◽  
Host Proteins ◽  
Astrakhan Oblast ◽  
Wild Waterfowl

2014 marked the first emergence of avian influenza A(H5N8) in Jeonbuk Province, South Korea, which then quickly spread worldwide. In the midst of the 2020-21 H5N8 outbreak, it spread to domestic poultry and wild waterfowl shorebirds, leading to the first human infection in Astrakhan Oblast, Russia. Despite being clinically asymptomatic and without direct human-to-human transmission, the World Health Organisation stressed the need for continued risk assessment given the nature of Influenza to reassort and generate novel strains. Given its promiscuity and spread to humans, the urgency to understand the mechanisms of possible species jumping to avert disastrous pandemics is increasing. Addressing the epidemiology of H5N8 and its mechanisms of species jumping and its implications, mutational and reassortment libraries can potentially be built, allowing them to be tested on various models complemented with deep-sequencing and automation. With the knowledge on mutational patterns, cellular pathways, drug resistance mechanisms and effects of host proteins can allow better preparedness against H5N8 and other influenza A viruses.

Avian Influenza Human Infections at the Human-Animal Interface

2020 ◽  
Vol 222 (4) ◽  
pp. 528-537 ◽  
Author(s):  
Damien A M Philippon ◽  
Peng Wu ◽  
Benjamin J Cowling ◽  
Eric H Y Lau
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Control Strategies ◽  
Influenza Pandemic ◽  
World Health ◽  
Emerging Pathogens ◽  
Influenza A Viruses ◽  
Dead Bird ◽  
Risk Of Death ◽  
Human Infections

Abstract Background Avian influenza A viruses (AIVs) are among the most concerning emerging and re-emerging pathogens because of the potential risk for causing an influenza pandemic with catastrophic impact. The recent increase in domestic animals and poultry worldwide was followed by an increase of human AIV outbreaks reported. Methods We reviewed the epidemiology of human infections with AIV from the literature including reports from the World Health Organization, extracting information on virus subtype, time, location, age, sex, outcome, and exposure. Results We described the characteristics of more than 2500 laboratory-confirmed human infections with AIVs. Human infections with H5N1 and H7N9 were more frequently reported than other subtypes. Risk of death was highest among reported cases infected with H5N1, H5N6, H7N9, and H10N8 infections. Older people and males tended to have a lower risk of infection with most AIV subtypes, except for H7N9. Visiting live poultry markets was mostly reported by H7N9, H5N6, and H10N8 cases, while exposure to sick or dead bird was mostly reported by H5N1, H7N2, H7N3, H7N4, H7N7, and H10N7 cases. Conclusions Understanding the profile of human cases of different AIV subtypes would guide control strategies. Continued monitoring of human infections with AIVs is essential for pandemic preparedness.

Phylogenetic, molecular and drug-sensitivity analysis of HA and NA genes of human H3N2 influenza A viruses in Guangdong, China, 2007–2011

2012 ◽  
Vol 141 (5) ◽  
pp. 1061-1069 ◽  
Author(s):  
P. HUANG ◽  
L.-J. LIANG ◽  
N.-M. HOU ◽  
X. ZHANG ◽  
W.-Z. SU ◽  
...  
Keyword(s):  
Influenza A ◽  
Haemagglutination Inhibition ◽  
World Health ◽  
Public Health Issue ◽  
Influenza A Viruses ◽  
Receptor Binding Site ◽  
H3n2 Influenza ◽  
Health Organization ◽  
Influenza Outbreaks ◽  
Ha1 Gene

SUMMARYAnnual H3N2 subtype influenza outbreaks in Guangdong, China are a severe public health issue and require ongoing monitoring of emerging viral variants. The variation and evolution of haemagglutinin (HA) and neuraminidase (NA) genes of influenza isolates from Guangdong during 2007–2011 and others from GenBank were analysed using Lasergene 7.1 and MEGA 5.05, and serological analysis of antigens was determined by haemagglutination inhibition (HI). Susceptibility to antiviral drugs was correlated with genetic mutations. Phylogenetic analysis and alignment of HA and NA genes were performed on 18 Guangdong isolates and 26 global reference strains. The non-synonymous (dN) evolutionary rate of HA1 was 3·13 times that of HA2. Compared with the A/Perth/16/2009 vaccine HA gene, homologies of Guangdong isolates were between 98·8–99·7% and 98·0–98·4% in 2009 and 2010, respectively. Amino-acid substitutions were found in five epitopes of HA1 from Guangdong isolates between 2007 and 2011, especially in epitopes B (N160K) and D (K174R/N). The K189E/N/Q and T228A mutations in the receptor-binding site (RBS) occurred in the 2010 strains, which affected the antigenicity of HA1. The antigenicity of the epidemic H3N2 isolates in 2010 was somewhat different from that of A/Perth/16/2009. The Guangdong H3N2 isolates were determined to be oseltamivir-resistant with IC50 of 0·396±0·085 nmol/l (n=17) and zanamivir-resistant with IC50 of 0·477±0·149 nmol/l (n=18). Variations were present in epitopes B and D, two sites in the RBS and two glycosylation sites in the Guangdong H3N2 HA1 gene. The majority of the Guangdong H3N2 isolates were sensitive to oseltamivir and zanamivir. Compared to the World Health Organization 2012 vaccine strains, Guangdong H3N2 strains varied genetically and antigenically to some degree.

scholarly journals Complete Coding Sequences of One H9 and Three H7 Low-Pathogenic Influenza Viruses Circulating in Wild Birds in Belgium, 2009 to 2012

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Steven Van Borm ◽  
Toon Rosseel ◽  
Sylvie Marché ◽  
Mieke Steensels ◽  
Didier Vangeluwe ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Illumina Sequencing ◽  
Viral Genome ◽  
Influenza A ◽  
Wild Bird ◽  
Influenza Viruses ◽  
Influenza A Viruses ◽  
Bird Population ◽  
Coding Sequences ◽  
Wild Waterfowl

The complete coding sequences of four avian influenza A viruses (two H7N7, one H7N1, and one H9N2) circulating in wild waterfowl in Belgium from 2009 to 2012 were determined using Illumina sequencing. All viral genome segments represent viruses circulating in the Eurasian wild bird population.

scholarly journals WHO investigate possible human-to-human transmission of H5N1 in Thailand, amid calls for major investment to combat avian influenza

2004 ◽  
Vol 8 (40) ◽  
Author(s):  
Keyword(s):  
Avian Influenza ◽  
World Health Organization ◽  
Influenza A ◽  
World Health ◽  
H5n1 Infection ◽  
Family Cluster ◽  
The World ◽  
Health Organization

Two new human cases of avian influenza A(H5N1) infection in Thailand have been confirmed by the World Health Organization. The two cases were in a 26 year old woman who has died, and her 32 year old sister who has been admitted to hospital. They are part of a family cluster being investigated to determine whether human-to-human transmission has occurred.

scholarly journals Novel Swine Infl uenza AH1N1 and the Phase Six Pandemic

2010 ◽  
Vol 49 (179) ◽  
Author(s):  
M Khadka
Keyword(s):  
Public Health ◽  
Influenza A ◽  
Swine Influenza ◽  
Antigenic Drift ◽  
World Health ◽  
Health Concern ◽  
Influenza A Viruses ◽  
Influenza A H1n1 ◽  
H1n1 Strain ◽  
Health Organization

The family Orthomyxoviridae consists of Influenza A virus which is negative sense single stranded virus. The genome of the virus is segmented and possesses a peculiar trait of genetic reassortment. The influenza virus on its envelop consists of the antigenic glycoprotein like haemagglutinin (HA) and neuraminidase (NA). The changes in those glycoprotein components due to antigenic shift and antigenic drift leads to the development of new strain of Influenza A viruses. Now the novel swine influenza A/H1N1 strain has been detected from different parts of the world which is causing pandemic. World Health Organization has declared the pandemic phase six and more than 60 countries have reported the cases of novel influenza A/H1N1 strain including Nepal. As the disease is spreading world wide, it is a major public health concern for all the countries. And especially the developing countries like Nepal should immediately respond to the situation and should be well prepared to combat the disease before the disease spreads to enough population. Keywords: pandemic, public health, reassortment, swine influenza A/H1N1.

scholarly journals Airborne Transmission of Avian Origin H9N2 Influenza A Viruses

2021 ◽  
Author(s):  
C. Joaquín Cáceres ◽  
Daniela S. Rajao ◽  
Daniel R. Perez
Keyword(s):  
Influenza A ◽  
Mammalian Species ◽  
World Health ◽  
Interspecies Transmission ◽  
Influenza A Viruses ◽  
Highly Pathogenic ◽  
Zoonotic Infections ◽  
The World ◽  
Avian Origin ◽  
Health Organization

Influenza A viruses (IAV) are widespread viruses affecting avian and mammalian species worldwide. Outbreaks of IAV in poultry are usually associated with substantial morbidity and mortality, significantly affecting the poultry industry and food security. IAVs from avian species can be transmitted to mammals including humans and, thus, they are of inherent pandemic concern. Most of the efforts to understand the pathogenicity and transmission of avian origin IAVs have been focused on H5 and H7 subtypes due to their highly pathogenic phenotype in poultry. However, IAV of the H9 subtype that circulate endemically in poultry flocks in some regions of the world have also been associated with cases of zoonotic infections. As a result, the World Health Organization includes avian origin H9N2 IAV among the top in the list of IAVs of pandemic concern. In this review, we discuss the interspecies transmission of H9N2 between avian and mammalian species and the molecular factors that are thought relevant for this spillover. Additionally, we discuss factors that have been associated with the ability of these viruses to transmit through the respiratory route in mammalian species.

scholarly journals Influenza at the animal–human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1)

2014 ◽  
Vol 19 (18) ◽  
Author(s):  
G S Freidl ◽  
A Meijer ◽  
E de Bruin ◽  
M de Nardi ◽  
O Munoz ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Influenza A ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Human Infection ◽  
Influenza Viruses ◽  
Diagnostic Methods ◽  
World Health ◽  
Review Of The Literature

Factors that trigger human infection with animal influenza virus progressing into a pandemic are poorly understood. Within a project developing an evidence-based risk assessment framework for influenza viruses in animals, we conducted a review of the literature for evidence of human infection with animal influenza viruses by diagnostic methods used. The review covering Medline, Embase, SciSearch and CabAbstracts yielded 6,955 articles, of which we retained 89; for influenza A(H5N1) and A(H7N9), the official case counts of the World Health Organization were used. An additional 30 studies were included by scanning the reference lists. Here, we present the findings for confirmed infections with virological evidence. We found reports of 1,419 naturally infected human cases, of which 648 were associated with avian influenza virus (AIV) A(H5N1), 375 with other AIV subtypes, and 396 with swine influenza virus (SIV). Human cases naturally infected with AIV spanned haemagglutinin subtypes H5, H6, H7, H9 and H10. SIV cases were associated with endemic SIV of H1 and H3 subtype descending from North American and Eurasian SIV lineages and various reassortants thereof. Direct exposure to birds or swine was the most likely source of infection for the cases with available information on exposure.

A Pandemic Avian Influenza Mathematical Model

2009 ◽  
pp. 798-808
Author(s):  
Mohamed Derouich
Keyword(s):  
Mathematical Model ◽  
Stability Analysis ◽  
Avian Influenza ◽  
Influenza A ◽  
Human Infection ◽  
Influenza Viruses ◽  
Human Influenza ◽  
Influenza A Viruses ◽  
The World ◽  
Pandemic Avian Influenza

Throughout the world, seasonal outbreaks of influenza affect millions of people, killing about 500,000 individuals every year. Human influenza viruses are classified into 3 serotypes: A, B, and C. Only influenza A viruses can infect and multiply in avian species. During the last decades, important avian influenza epidemics have occurred and so far, the epidemics among birds have been transmitted to humans; but the most feared problem is the risk of pandemics that may be caused by person-to person transmission. The present mathematical model deals with the dynamics of human infection by avian influenza both in birds and in humans. Stability analysis is carried out and the behaviour of the disease is illustrated by simulation with different parameters values.

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