scholarly journals Review of Oral Rabies Vaccination of Dogs and Its Application in India

Viruses ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 155
Author(s):  
Gowri Yale ◽  
Marwin Lopes ◽  
Shrikrishna Isloor ◽  
Jennifer R. Head ◽  
Stella Mazeri ◽  
...  
Keyword(s):  
Human Rabies ◽  
Global Public Health ◽  
Stray Dog ◽  
Indian State ◽  
The Usa ◽  
Public Health Institutions ◽  
Health Institutions ◽  
Vaccination Campaigns ◽  
Rabies Vaccination ◽  
High Output

Oral rabies vaccines (ORVs) have been in use to successfully control rabies in wildlife since 1978 across Europe and the USA. This review focuses on the potential and need for the use of ORVs in free-roaming dogs to control dog-transmitted rabies in India. Iterative work to improve ORVs over the past four decades has resulted in vaccines that have high safety profiles whilst generating a consistent protective immune response to the rabies virus. The available evidence for safety and efficacy of modern ORVs in dogs and the broad and outspoken support from prominent global public health institutions for their use provides confidence to national authorities considering their use in rabies-endemic regions. India is estimated to have the largest rabies burden of any country and, whilst considerable progress has been made to increase access to human rabies prophylaxis, examples of high-output mass dog vaccination campaigns to eliminate the virus at the source remain limited. Efficiently accessing a large proportion of the dog population through parenteral methods is a considerable challenge due to the large, evasive stray dog population in many settings. Existing parenteral approaches require large skilled dog-catching teams to reach these dogs, which present financial, operational and logistical limitations to achieve 70% dog vaccination coverage in urban settings in a short duration. ORV presents the potential to accelerate the development of approaches to eliminate rabies across large areas of the South Asia region. Here we review the use of ORVs in wildlife and dogs, with specific consideration of the India setting. We also present the results of a risk analysis for a hypothetical campaign using ORV for the vaccination of dogs in an Indian state.

scholarly journals Development of a Non-Meat-Based, Mass Producible and Effective Bait for Oral Vaccination of Dogs against Rabies in Goa State, India

2019 ◽  
Vol 4 (3) ◽  
pp. 118 ◽  
Author(s):  
Andrew D. Gibson ◽  
Stella Mazeri ◽  
Gowri Yale ◽  
Santosh Desai ◽  
Vilas Naik ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Scale Up ◽  
Meat Products ◽  
Target Population ◽  
Human Rabies ◽  
High Uptake ◽  
Minimum Requirements ◽  
Global Goal ◽  
Vaccination Campaigns ◽  
Rabies Vaccination

Introduction: To achieve the global goal of canine-mediated human rabies elimination by 2030 there is an urgent need to scale-up mass dog vaccination activities in regions with large dog populations that are difficult to access; a common situation in much of India. Oral rabies vaccination may enable the vaccination of free-roaming dogs that are inaccessible to parenteral vaccination, and is considered a promising complementary measure to parenteral mass dog vaccination campaigns. WHO and OIE have published detailed minimum requirements for rabies vaccines and baits to be used for this purpose, requiring that baits must not only be well-accepted by the target population but must also efficiently release the vaccine in the oral cavity. For oral rabies vaccination approaches to be successful, it is necessary to develop baits which have a high uptake by the target population, are culturally accepted and amenable to mass production. The aim of this study was to compare the interest and uptake rates of meat-based and an egg-based prototype bait constructs by free roaming dogs in Goa, India. Methods: Three teams randomly distributed two prototype baits; an egg-flavoured bait and a commercial meat dog food (gravy) flavoured bait. The outcomes of consumption were recorded and compared between baits and dog variables. Results: A total of 209 egg-bait and 195 gravy-bait distributions were recorded and analysed. No difference (p = 0.99) was found in the percentage of dogs interested in the baits when offered. However, significantly more dogs consumed the egg-bait than the gravy-bait; 77.5% versus 68.7% (p = 0.04). The release of the blue-dyed water inside the sachet in the oral cavity of the animals was significant higher in the dogs consuming an egg-bait compared to the gravy-bait (73.4% versus 56.7%, p = 0.001). Conclusions: The egg-based bait had a high uptake amongst free roaming dogs and also enabled efficient release of the vaccine in the oral cavity, whilst also avoiding culturally relevant materials of bovine or porcine meat products.

scholarly journals Epidemiology of CoViD-19 Pandemic: Recovery and mortality ratio around the globe

2020 ◽  
Vol 36 (COVID19-S4) ◽  
Author(s):  
Aziz Ullah Noor ◽  
Farhana Maqbool ◽  
Zulfiqar Ahmed Bhatti ◽  
Asmat Ullah Khan
Keyword(s):  
Mortality Rate ◽  
Human Population ◽  
Clinical Symptoms ◽  
Global Public Health ◽  
Creative Commons ◽  
Rapid Spread ◽  
Mortality Ratio ◽  
Public Health Institutions ◽  
Health Institutions ◽  
Novel Coronavirus

Coronavirus Disease 2019 (CoViD-19) is the third type of coronavirus disease after severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) that appears in human population from the past two decades. It is highly contagious and rapidly spread in the human population and compelled global public health institutions on high alert. Due to genetic similarity of this novel coronavirus 2019 with bat virus its emergence from bat to humans is possible. The virus survive in the droplets of coughing and sneezing and spread around the large areas through infected person resulting in its rapid spread among people. Clinical symptoms of CoViD-19 include fever, dry cough, dyspnea, loose stool, nausea and vomiting. The present review discuss the origin of CoViD-19, its rapid spread, mortality rate and recoveries ratio around the world. Since its origin from Wuhan, the CoViD-19 spread very rapidly all across the countries, on April 17, 2020 this disease has affected 210 countries of the globe. The data obtained showed over 2.4 million confirmed cases of CoViD-19. Higher mortality rate was found in Algeria and Belgium as 15% and 13.95%, respectively. Lower mortality rate was found in Qatar 0.17% and Singapore 0.2%. Recovery versus deceased ratio showed that recovery was 68, 59 and 35 times higher than the death in Singapore, Qatar and Thailand respectively. It is concluded that 2019-novel corona virus is a zoonotic pathogen similar to MERS and SARS. Therefore, a barrier should be maintained between and across the human, household and wild animals to avoid such pandemics. doi: https://doi.org/10.12669/pjms.36.COVID19-S4.2660 How to cite this:Noor AU, Maqbool F, Bhatti ZA, Khan AU. Epidemiology of CoViD-19 Pandemic: Recovery and mortality ratio around the globe. Pak J Med Sci. 2020;36(COVID19-S4):---------. doi: https://doi.org/10.12669/pjms.36.COVID19-S4.2660 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Cost-effectiveness of the national dog rabies prevention and control program in Mexico, 1990–2015

2021 ◽  
Vol 15 (3) ◽  
pp. e0009130
Author(s):  
Jesús Felipe González-Roldán ◽  
Eduardo A. Undurraga ◽  
Martin I. Meltzer ◽  
Charisma Atkins ◽  
Fernando Vargas-Pino ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
World Health Organization ◽  
Public Health Problem ◽  
World Health ◽  
Human Rabies ◽  
National Program ◽  
Rabies Control ◽  
Health Organization ◽  
Vaccination Campaigns ◽  
Rabies Vaccination

Background Rabies is a viral zoonosis that imposes a substantial disease and economic burden in many developing countries. Dogs are the primary source of rabies transmission; eliminating dog rabies reduces the risk of exposure in humans significantly. Through mass annual dog rabies vaccination campaigns, the national program of rabies control in Mexico progressively reduced rabies cases in dogs and humans since 1990. In 2019, the World Health Organization validated Mexico for eliminating rabies as a public health problem. Using a governmental perspective, we retrospectively assessed the economic costs, effectiveness, and cost-effectiveness of the national program of rabies control in Mexico, 1990–2015. Methodology Combining various data sources, including administrative records, national statistics, and scientific literature, we retrospectively compared the current scenario of annual dog vaccination campaigns and post-exposure prophylaxis (PEP) with a counterfactual scenario without an annual dog vaccination campaign but including PEP. The counterfactual scenario was estimated using a mathematical model of dog rabies transmission (RabiesEcon). We performed a thorough sensitivity analysis of the main results. Principal findings Results suggest that in 1990 through 2015, the national dog rabies vaccination program in Mexico prevented about 13,000 human rabies deaths, at an incremental cost (MXN 2015) of $4,700 million (USD 300 million). We estimated an average cost of $360,000 (USD 23,000) per human rabies death averted, $6,500 (USD 410) per additional year-of-life, and $3,000 (USD 190) per dog rabies death averted. Results were robust to several counterfactual scenarios, including high and low rabies transmission scenarios and various assumptions about potential costs without mass dog rabies vaccination campaigns. Conclusions Annual dog rabies vaccination campaigns have eliminated the transmission of dog-to-dog rabies and dog-mediated human rabies deaths in Mexico. According to World Health Organization standards, our results show that the national program of rabies control in Mexico has been highly cost-effective.

The necropolitics of neoliberal state response to the Covid-19 pandemic in India

Organization ◽  
2021 ◽  
pp. 135050842110201
Author(s):  
Srinath Jagannathan ◽  
Rajnish Rai
Keyword(s):  
Social Security ◽  
Indian Population ◽  
Job Security ◽  
The State ◽  
Hindu Nationalism ◽  
Life And Death ◽  
State Response ◽  
Indian State ◽  
Public Health Institutions ◽  
Health Institutions

We draw from the experience of the Covid-19 pandemic in India to outline that the neoliberal consolidation of the state is enabled by precariousness, violence, and inequality in overlapping planes of marginality. The pandemic showed the abysmal state of public health institutions in India as people experienced an erosion of dignity in both life and death. The harsh and sudden lockdown announced by the Indian state rendered workers jobless, hungry, exhausted, and on the borders of death. Instead of providing social security to workers, the state embarked on a neoliberal agenda of deregulation, weakening job security, and collective bargaining legislation. The state enacted a violent discourse of Hindu nationalism to blame Muslims for the spread of the pandemic in India to deflect attention from its abdication of responsibility in making healthcare and social security available to vulnerable segments of the Indian population. The neoliberal policy response of the state during the pandemic was embedded in the necropolitics of protecting the middle class and elite lives while directing structural violence against the working class and Muslims, making their lives disposable.

scholarly journals Bite Injuries among Vaccination Staff Participating in a Mass Canine Rabies Vaccination Campaign, Haiti 2016–2017

2021 ◽  
Author(s):  
Rudy T. Kirkhope ◽  
Andrew D. Gibson ◽  
Pierre Dilius Augustin ◽  
Kelly Crowdis ◽  
Natael Fénelon ◽  
...  
Keyword(s):  
Medical Care ◽  
Large Scale ◽  
Vaccination Campaign ◽  
Human Rabies ◽  
Control Group ◽  
Survey Analysis ◽  
Dog Bite ◽  
Increased Risk ◽  
Vaccination Campaigns ◽  
Rabies Vaccination

Elimination of dog-transmitted human rabies worldwide will require large-scale dog vaccination campaigns. However, this places participating vaccinators at increased risk. Data from the 2016–2017 Haitian mass rabies vaccination campaign was analyzed to determine dog bite incidence among vaccinators. A survey was then developed for completion by all identifiable bitten vaccinators covering demographics; experience and training; bite episode details; attitudes toward dogs and rabies; and medical care. A parallel group of unbitten vaccinators was also surveyed. Dog bite incidence was 0.03% (43/127,000) of all dogs vaccinated. The capture, vaccinate, and release method of vaccination carried a significantly higher risk of dog bite (0.35%, 6/1,739 vaccinations) than other methods (P < 0.001). Twenty-seven bitten vaccinators, and 54 control vaccinators were included in the survey analysis. No differences were found between groups in demographics, experience, or training. However, bitten vaccinators were significantly more likely than the control group to have experienced a dog bite before the study period (P < 0.001). This may be associated with a lesser appreciation of dogs, and/or a poorer ability to interpret dog behavioral signals within this group. Although 98% of the control group indicated they would seek medical care for a dog bite, only 35% of bitten vaccinators sought such care. On a yearly basis, for the Haitian campaign, a full series of postexposure rabies vaccinations for all bite victims would prove more cost-effective than preexposure vaccination of all vaccinators. These findings may prove useful for the planning and safety of future mass dog vaccination campaigns.

scholarly journals Rabies Vaccination of 6-Week-Old Puppies Born to Immunized Mothers: A Randomized Controlled Trial in a High-Mortality Population of Owned, Free-Roaming Dogs

2020 ◽  
Vol 5 (1) ◽  
pp. 45 ◽  
Author(s):  
Sintayehu Arega ◽  
Anne Conan ◽  
Claude T. Sabeta ◽  
Jan E. Crafford ◽  
Jeanette Wentzel ◽  
...  
Keyword(s):  
High Mortality ◽  
Controlled Trial ◽  
Geometric Mean ◽  
Human Rabies ◽  
Average Effect ◽  
Randomized Controlled ◽  
Causes Of Mortality ◽  
Vaccination Campaigns ◽  
Current Guidelines ◽  
Rabies Vaccination

To achieve global elimination of human rabies from dogs by 2030, evidence-based strategies for effective dog vaccination are needed. Current guidelines recommend inclusion of dogs younger than 3 months in mass rabies vaccination campaigns, although available vaccines are only recommended for use by manufacturers in older dogs, ostensibly due to concerns over interference of maternally-acquired immunity with immune response to the vaccine. Adverse effects of vaccination in this age group of dogs have also not been adequately assessed under field conditions. In a single-site, owner-blinded, randomized, placebo-controlled trial in puppies born to mothers vaccinated within the previous 18 months in a high-mortality population of owned, free-roaming dogs in South Africa, we assessed immunogenicity and effect on survival to all causes of mortality of a single dose of rabies vaccine administered at 6 weeks of age. We found that puppies did not have appreciable levels of maternally-derived antibodies at 6 weeks of age (geometric mean titer 0.065 IU/mL, 95% CI 0.061–0.069; n = 346), and that 88% (95% CI 80.7–93.3) of puppies vaccinated at 6 weeks had titers ≥0.5 IU/mL 21 days later (n = 117). Although the average effect of vaccination on survival was not statistically significant (hazard ratio [HR] 1.35, 95% CI 0.83–2.18), this effect was modified by sex (p = 0.02), with the HR in females 3.09 (95% CI 1.24–7.69) and the HR in males 0.79 (95% CI 0.41–1.53). We speculate that this effect is related to the observed survival advantage that females had over males in the unvaccinated group (HR 0.27; 95% CI 0.11–0.70), with vaccination eroding this advantage through as-yet-unknown mechanisms.

scholarly journals Acute renal pain as an adverse reaction of the rabies immunization

2009 ◽  
Vol 62 (3-4) ◽  
pp. 133-135
Author(s):  
Dusan Lalosevic
Keyword(s):  
Immune Complexes ◽  
Optimal Dose ◽  
Rabies Vaccine ◽  
Human Rabies ◽  
Low Weight ◽  
Wrong Direction ◽  
Stray Dog ◽  
Repeated Doses ◽  
Bite Wounds ◽  
Rabies Vaccination

Introduction. HRIG is the best preparate in rabies prophylaxis, and it's considered that optimal dose is 20 international units per kilogram and must not been reduced or overdosed. HRIG have to be injected infiltrative around bite wounds, and if after that remains a part of the dose, it has to be given in gluteal muscle. Application only in gluteus is vitium artis. Case report. At one patient immunized against rabies has occured acute bilateral renal pain and fever at time of immunization against rabies, and because of that vaccination must been stopped after the 3rd dose of vaccine. Patient was a 26-year-old female without significant pre-existing disease, bitten by stray dog. After the start of immunization, because the wrong direction, she received about 2.5 more amount of human rabies immunoglobuline (HRIG) then is recommended on declaration at etiquette of ampoule, and only in gluteus in quantity of 10.5 ml. Discussion. Glomerulonephritis after rabies vaccination until now was described just once by Singhal et al. in 1981. year. Acute renal pain, after rabies vaccine, which aggravated after repeated vaccine doses in our patient who received overdosed HRIG, may be explained by immunopathological mechanism, rather with formation of circulating immune complexes, their precipitation on the glomerular basement membrane and developing glomerulonephritis. Conclusion. Low weight soluble molecular immune complexes formed when antigen is in excess, as in case after repeated doses of rabies vaccine, circulate and precipitate on glomerular membrane and causes glomerulonephritis. As contribution to this explanation, is that symptoms as renal pain disappeared after interrupting vaccination protocol in our patient.

scholarly journals From hostile worlds to multiple spheres: towards a normative pragmatics of justice for the Googlization of health

2021 ◽  
Author(s):  
Tamar Sharon
Keyword(s):  
Public Health ◽  
Market Value ◽  
Theory Of Justice ◽  
Alternative Framework ◽  
Orders Of Worth ◽  
Public Health Institutions ◽  
Health Institutions ◽  
Normative Pragmatics ◽  
The Many ◽  
Critical Perspectives

AbstractThe datafication and digitalization of health and medicine has engendered a proliferation of new collaborations between public health institutions and data corporations like Google, Apple, Microsoft and Amazon. Critical perspectives on these new partnerships tend to frame them as an instance of market transgressions by tech giants into the sphere of health and medicine, in line with a “hostile worlds” doctrine that upholds that the borders between market and non-market spheres should be carefully policed. This article seeks to outline the limitations of this common framing for critically understanding the phenomenon of the Googlization of health. In particular, the mobilization of a diversity of non-market value statements in the justification work carried out by actors involved in the Googlization of health indicates the co-presence of additional worlds or spheres in this context, which are not captured by the market vs. non-market dichotomy. It then advances an alternative framework, based on a multiple-sphere ontology that draws on Boltanski and Thevenot’s orders of worth and Michael Walzer’s theory of justice, which I call a normative pragmatics of justice. This framework addresses both the normative deficit in Boltanski and Thevenot’s work and provides an important emphasis on the empirical workings of justice. Finally, I discuss why this framework is better equipped to identify and to address the many risks raised by the Googlization of health and possibly other dimensions of the digitalization and datafication of society.

scholarly journals Engaging patients: how to speak so patients want to listen

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Rubinelli
Keyword(s):  
Health Professional ◽  
Lived Experience ◽  
Health Information ◽  
Health Professionals ◽  
Health Condition ◽  
Public Health Institutions ◽  
Health Institutions ◽  
Basic Approaches ◽  
The Impact

Abstract The paternalistic approach to health professional-patient communication is often no longer successful. The main reasons for this include the fact that trust in medicine and health professionals is no longer taken for granted. In many domains, the concepts of 'expert' and 'science' are in shadow. Moreover, patients can access all sorts of health information, including information that is or seems inconsistent with the advice given by their health professionals. This talk aims to illustrate some basic approaches to communication that can enhance health professional-patient interaction. First, health professionals should consider their communication with patients as a form of persuasion. Persuasion, that does not equal manipulation, is a way to communicate that takes into consideration the knowledge, beliefs, and attitudes of interlocutors. By adopting a person-centered style, health professionals should present their advice by contextualizing it into the emotional and cognitive setting of the patients. Second, communication should consider the lived experience of patients, that is the impact that a health condition or a preventive behavior has on their quality of life and their experience of pleasure. Indeed, managing health conditions is not just applying health advice: it often demands a change in lifestyles that can negatively impact how patients live their lives. Third, health professionals should develop clear strategies to engage with information that patients find from other sources. Health professionals must ask patients if they disagree with them, and to clarify any eventual difference of opinion. The information age has positively favored a democratization of health information. Yet, it imposes that health systems care for their communication. This talk concludes by presenting main evidence from on how to reinforce hospitals, public health institutions, and health services in communication so that patients want to listen.

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