scholarly journals Microbial Detoxification of Dimethoate and Methomyl Residues in Aqueous Media

Water ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1117
Author(s):  
Aly Derbalah ◽  
Ahmed Massoud ◽  
Ibrahim El-Mehasseb ◽  
Moustafa Saad Allah ◽  
Mohamed S. Ahmed ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Xanthomonas Campestris ◽  
Bacterial Isolate ◽  
Aqueous Media ◽  
Potential Effect ◽  
Toxicity Tests ◽  
Contaminated Water ◽  
Histopathological Changes ◽  
Aspergillus Fumigates ◽  
Microbial Isolates

The extensive and random application of major organic pollutants, mainly pesticides, threatens ecosystems and human health. The present study was conducted to isolate and identify microorganisms from some water resources contaminated with pesticides. We investigated the ability of the identified microbes to grow in water spiked with dimethoate and methomyl. We also evaluated the potential effect of the identified microbial isolates on dimethoate and methomyl biodegradation in water. In addition, the total detoxification of dimethoate and methomyl residues in water after treatment with the most effective microbial isolates was confirmed using toxicity tests and analyzing biochemical parameters and histopathological changes in the kidney and liver of treated rats. The microbial isolates were identified as Xanthomonas campestris pv. Translucens and Aspergillus fumigates. Results showed that X. campestris pv. Translucens and A. fumigatus grow in media supplemented with dimethoate and methomyl faster than in other media without both pesticides. About 97.8% and 91.2% of dimethoate and 95% and 87.8% of methomyl (initial concentration of both 5 mg L−1) were biodegraded within 32 days of incubation with X. campestris pv. Translucens and A. fumigatus, respectively. There was no remaining toxicity in rats treated with dimethoate- and methomyl-contaminated water with respect to biochemical parameters and histopathological changes. Collectively, the identified bacterial isolate showed high potential for the complete degradation of dimethoate and methomyl residues in water.

Potential effect of pharmaceutical care to improve outcomes in patients with chronic kidney disease-mineral bone disorder in Sulaimani dialysis centers

2020 ◽  
pp. 82-94
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Pharmaceutical Care ◽  
Biochemical Parameters ◽  
Positive Impact ◽  
Potential Effect ◽  
Care Group ◽  
Mineral Bone Disorder ◽  
Bone Disorder

Objective: the present study was aimed to evaluate the role of pharmaceutical services in improving the outcome of mineral bone disorder in patients with advanced chronic kidney disease. Methodology: One hundred and twenty patients with chronic kidney disease-mineral bone disorder (CKD-MBD) screened for eligibility, seventy-six patients enrolled in the study and randomly allocated into two groups: pharmaceutical care and usual care, both groups interviewed by the pharmacist using specific questionnaire for assessing the quality of life (QoL). All the drug related problems (DRPs) including drug-drug interactions (DDIs) were recorded by the pharmacist. Blood samples were collected and utilized for analyzing the levels of vitamin D, phosphorous, calcium, albumin and parathyroid hormone at baseline and three months after. The pharmaceutical care group received all the educations about their medications and how to minimize DRPs; improve the QoL. Additionally, the pharmaceutical intervention included correcting the biochemical parameters. Results: Pharmaceutical care significantly improved patients QoL and minimized DRPs and DDIs. It was also effective in improving the biochemical parameters. Conclusion: Pharmaceutical care has a positive impact on improving the outcome of patients with CKD-MBD through attenuating DRPs, improving the biochemical parameters and the QoL.

Problems in Detoxifying Fresh Waters Polluted by Base Metal Minewaters

1971 ◽  
Vol 6 (1) ◽  
pp. 53-79
Author(s):  
Vaclav Kresta ◽  
Gerald B. Ward
Keyword(s):  
Chelating Agents ◽  
Toxicity Tests ◽  
Contaminated Water ◽  
Total Dosage ◽  
Toxic Compounds ◽  
Mining Sites ◽  
Know How ◽  
Chemical Agents ◽  
Copper And Zinc ◽  
Receiving Waters

Abstract At many mining sites process (milling) and drainage waters escape treatment and cause receiving waters to become contaminated above avoidance or even toxic levels for fish. The present know-how on chemical agents which can be used to complex with copper and zinc to form non-toxic compounds is limited to chelating agents such as NTA or EDTA. Preferential reaction with trivalent ions such as iron means that such ions must be tied up before complexation of copper and zinc can occur. As the amount of iron in contaminated water is usually two to eight times higher than that of copper and zinc, high dosages of chelating agents are usually required. In this project, the use of salts of anthranilic acid, especially calcium anthranilate, was investigated. The consumption of anthranilateions was found to be about the same as that of NTA or EDTA, i.e. four milligrams per milligram of copper or zinc. The total dosage to be applied to contaminated waters would be, however, several times lower as iron is not involved in the reactions and copper and zinc are complexed in that order. Toxicity tests to compare the efficiency and dasages of calcium anthranilate and NTA or EDTA are presently being carried out.

Aluminium Administration is Associated with Biochemical Parameters Histopathological Changes in Rat Liver

Metabolism ◽  
2021 ◽  
Vol 116 ◽  
pp. 154505
Author(s):  
Demmouche Abbassia ◽  
H. Bekhadda ◽  
A.E. Menadi ◽  
D. Ferrag ◽  
Khalloua Zine Charaf ◽  
...  
Keyword(s):  
Rat Liver ◽  
Biochemical Parameters ◽  
Histopathological Changes

Changes of biochemical parameters in blood serum rats under chronic light desynchronosis

2020 ◽  
Vol 66 (6) ◽  
pp. 450-455
Author(s):  
E.G. Batotsyrenova ◽  
E.A. Zolotoverkhaja ◽  
V.A. Kashuro ◽  
A.V. Sharabanov
Keyword(s):  
Total Protein ◽  
Biochemical Parameters ◽  
Physical Factor ◽  
Toxicity Tests ◽  
Constant Darkness ◽  
Serum Total Protein ◽  
Modified Model ◽  
Medicinal Substances ◽  
Light Mode

Ten biochemical parameters total protein, albumin, glucose, cholesterol, urea, creatinine, total bilirubin, ALT, AST, APh were determined during long-term light mode changes in serum of rats. Changing the light mode, a number of parameters revealed unreliable 24-hour rhythms. An ultradian 12-hour reliable rhythm has been for serum total protein of rats exposed to constant darkness during 1 month. The light-modified model can be used to study the effects of the chemical factor in combination with the physical factor of the external environment, as well as in preclinical toxicity tests of medicinal substances in different light modes.

scholarly journals Abamectin Induced Biochemical and Histopathological Changes in the Albino Rat, Rattus Norvegicus

2013 ◽  
Vol 53 (3) ◽  
pp. 263-270 ◽  
Author(s):  
Hany Kamal Abd-Elhady ◽  
Gamal Elsayed Abou-Elghar
Keyword(s):  
Total Protein ◽  
Biochemical Parameters ◽  
Corn Oil ◽  
Male Rats ◽  
Streptomyces Avermitilis ◽  
Sublethal Dose ◽  
Histopathological Changes ◽  
Albino Rat ◽  
Liver And Kidney ◽  
Sublethal Doses

Abstract Abamectin (Avermectin B1a), is a natural fermentation product derived from the soil bacterium Streptomyces avermitilis. Abamectin (Avermectin B1a) is widely used as an insecticide, acaricide, and anthelmintic. The present study assessed the effects of repeated subacute and subchronic exposure to the commercial formulation of abamectin (Vertemic, 1.8% EC) in albino male rats. The toxic effects of abamectin were studied. The various biochemical parameters and histopathological changes were noted. A stomach tube was used to orally administer sublethal doses of abamectin suspended in corn oil to the rats. The animals were divided into four groups. Rats of the group T1 were orally administered a sublethal dose of 30 mg/kg body weight (b.wt.) (1/10 LD50) three times a week for 30 days and the animals in group T2 were exposed to 10 mg/kg b.wt. (1/30 LD50) for 210 days, once a week. Two control groups (C1 and C2) were used in parallel studies, where animals were administered a corn oil vehicle. At the end of the study period, blood samples were collected from all groups to measure plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities, and the levels of creatinine and urea. Also, total protein and RNA contents were determined in the liver and kidney tissues. Changes in biochemical parameters were more intense in male rats from group T2 than those reported in group T1. The levels of ALT, AST, urea and creatinine were significantly elevated in rats from group T2 when compared to the control. In group T2, a significant decrease in the levels of total protein and RNA in both the liver and kidneys was observed. Fertility was also significantly reduced in male rats ingesting abamectin in group T2. The number of offspring was significantly reduced. Histopathological changes were more intense in male rats from group T2 than those from group T1. In conclusion, the results of this study demonstrate that subchronic oral administration of abamectin altered some biochemical parameters which correlated with histopathological changes

Utilization of Jackfruit Peel as a Low-Cost adsorbent for the Removal of Methylene Blue Dye from Synthetically Polluted Water

2020 ◽  
Vol 16 ◽  
Author(s):  
Mohsina Ahmed ◽  
Abu Nasar
Keyword(s):  
Methylene Blue ◽  
Low Cost ◽  
Aqueous Media ◽  
Polluted Water ◽  
Blue Dye ◽  
Batch Adsorption ◽  
Contaminated Water ◽  
Abrupt Increase ◽  
Agriculture Waste ◽  
Pseudo Second Order

Background: Due to an abrupt increase in the contamination of freshwater systems by dye-containing wastewater, there is an urgent need to find robust and greener adsorbents for the elimination of dyes from the contaminated water. As the dyes not only change the appearance of water but are also a cause of many serious problems, which can be some time mutagenic and carcinogenic. Methods: This research paper is based on the use of adsorbent made from the peel of jackfruit (POJ). The adsorbent derived from agriculture waste was low cost and efficient for the elimination of methylene blue (MB) dye from aqueous media. Batch adsorption experiments were accompanied by varying the pH of the solution, contact time, POJ dosage, and initial MB concentration. Results: It was seen that adsorption of MB onto Jackfruit peel adsorbent follows pseudo-second-order (PSO) kinetics and Langmuir isotherm with maximum biosorption capacity (qm) of 232.55 mg/g. The thermodynamic study revealed that the adsorption was spontaneous, endothermic, and associated with the rise in entropy. Conclusion: In view of the low-cost and promising adsorption efficiency, the present investigation submits that that POJ is novel and economically feasible adsorbent for the removal of MB from aqueous solutions.

scholarly journals Antimicrobial activity and acute and chronic toxicity of the essential oil of Lippia origanoides

2014 ◽  
Vol 34 (12) ◽  
pp. 1153-1161 ◽  
Author(s):  
Viviane A. Andrade ◽  
Anna C. Almeida ◽  
Dayane S. Souza ◽  
Keila G.F. Colen ◽  
Auricélio A. Macêdo ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Biochemical Parameters ◽  
Chronic Toxicity ◽  
Safety Margin ◽  
Toxic Effects ◽  
Histopathological Changes ◽  
Practical Application ◽  
E Coli ◽  
Hematological And Biochemical Parameters

Currently, there is a growing interest in medicinal plants, because of an increased demand for alternate therapies. In this study, the antimicrobial activity and toxicity of the essential oil of Lippia origanoides (L. origanoides) were investigated. The essential oil of L. origanoides was extracted by steam-dragging distillation and its constituents were identified by chromatography coupled with mass spectrometry. Among the 15 compounds identified, the most abundant were carvacrol (29.00%), o-cymene (25.57%), and thymol methyl ether (11.50%). The essential oil was studied in antimicrobial assays to determine the MIC and MBC. The results indicated that a concentration of 120μL/mL of oil was sufficient to inhibit the growth of the following microorganisms: Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923) and Salmonella cholerasuis (ATCC 10708). Acute and chronic toxic effects of orally administered oil were investigated in Wistar rats by using standard methods. Doses of 30, 60 and 120mg/kg of the essential oil did not induce significant changes in weight, behavior or hematological and biochemical parameters in the animals. There were no signs of any histopathological changes to the liver, kidneys or heart of the treated rats, suggesting that Lippia origanoides oil is non-toxic after oral administration in acute or chronic toxicity studies. The results obtained in this study show that the essential oil of L. origanoides has a high safety margin, with no detectable toxic effects in rats treated with doses to 120mg/kg. In addition, L. origanoides oil demonstrated potent antimicrobial activity against S. aureus, E. coli and S. cholerasuis. Based on these findings, this essential oil may have practical application as a veterinary antimicrobial.

Sign in / Sign up

Export Citation Format

Share Document