Adverse reactions during chemotherapy: skin toxicity

2020 ◽  
pp. 28-64
Author(s):  
Maksim Leonidovich Maksimov ◽  
Malika Anarbekovna Ismailova
Keyword(s):  
Skin Toxicity ◽  
Chemotherapeutic Agents ◽  
Current Data ◽  
Antitumor Antibiotics ◽  
Antitumour Agents ◽  
Oncological Diseases ◽  
Dermatological Toxicity ◽  
Mechanisms Of Development ◽  
Toxic Reactions

Chemotherapy of oncological diseases is associated with high toxicity. The occurrence of various toxic reactions during the use of antitumor drugs is explained by the fact that most antitumor medicines are not strictly specific, therefore, their effect can extend not only to tumor cells, but also to normal cells, especially to tissues with rapid proliferation. All antitumour agents have skin toxicity in one form or another. However, for some chemotherapeutic agents, skin toxicity is a kind of «reflection» of certain mechanisms of drugs action, and, in most cases, the severity of dermatological reactions correlates with the effectiveness of chemotherapy. Dermatological toxicity deserves special attention, as it affects the quality of life of cancer patients and, in some cases, may require a dose reduction or even cancellation of chemotherapy. This article presents current data on the mechanisms of development of skin toxicity of routine chemotherapeutic agents, growth factor inhibitors and some antitumor antibiotics, its correction and prevention opportunities.

scholarly journals CHARACTERISTIC FEATURES OF ANEMIC SYNDROME IN ONCOLOGICAL PATIENTS

2018 ◽  
pp. 10-16
Author(s):  
T.G. Kulibaba ◽  
I.Y. Pchelin ◽  
L.A. Slepyh
Keyword(s):  
Specific Treatment ◽  
Negative Influence ◽  
Current Data ◽  
Common Complication ◽  
Safety Issues ◽  
Oncological Patients ◽  
Oncological Diseases ◽  
Characteristic Features ◽  
Review Current

Anemia is a common complication of oncological diseases that has a strong negative influence not only on the quality of life, but also on the effectiveness of specific treatment and survival rate. In the present review, current data on the pathogenesis and clinical implications of anemia in patients with malignancies are summarized. General principles underlying management of this group of patients are outlined on the basis of the results of recent clinical trials and guidelines. The safety issues related to administration of erythropoiesis-stimulating agents and vitamin B12 are discussed.

Cytoprotective Agents to Avoid Chemotherapy Induced Sideeffects on Normal Cells: A Review

2019 ◽  
Vol 19 (10) ◽  
pp. 765-781
Author(s):  
Seema Rohilla ◽  
Harish Dureja ◽  
Vinay Chawla
Keyword(s):  
Adverse Effects ◽  
Anticancer Agents ◽  
Therapeutic Index ◽  
Chemotherapeutic Agents ◽  
Vital Role ◽  
Normal Cells ◽  
Normal Tissues ◽  
Organ Specific ◽  
Delay In Treatment

Anticancer agents play a vital role in the cure of patients suffering from malignancy. Though, the chemotherapeutic agents are associated with various adverse effects which produce significant toxic symptoms in the patients. But this therapy affects both the malignant and normal cells and leads to constricted therapeutic index of antimalignant drugs which adversely impacts the quality of patients’ life. Due to these adversities, sufficient dose of drug is not delivered to patients leading to delay in treatment or improper treatment. Chemoprotective agents have been developed either to minimize or to mitigate the toxicity allied with chemotherapeutic agents. Without any concession in the therapeutic efficacy of anticancer drugs, they provide organ specific guard to normal tissues.

Psychosomatic Features, Compliance and Complementary Therapies in Rheumatoid Arthritis

2020 ◽  
Vol 16 (3) ◽  
pp. 215-223
Author(s):  
Rostislav A. Grekhov ◽  
Galina P. Suleimanova ◽  
Andrei S. Trofimenko ◽  
Liudmila N. Shilova
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Interpersonal Relationships ◽  
Behavioral Therapy ◽  
Current Data ◽  
Psychotherapeutic Interventions ◽  
And Coping ◽  
Regulation Of Emotion ◽  
The Impact

This review highlights the issue of psychosomatic conditions in rheumatoid arthritis, paying special attention to new researches and trends in this field. Emerging concepts in all the major parts of the problem are covered consecutively, from the impact of chronic musculoskeletal pain on the emotional state to disease influence over quality of life, socio-psychological, and interpersonal relationships. Chronic pain is closely related to emotional responses and coping ability, with a pronounced positive effect of psychotherapeutic interventions, family and social support on it. Psychosexual disorders, anxiety, depression also commonly coexist with rheumatoid arthritis, leading to further decrease in quality of life, low compliance, and high suicide risk. Influence of psychosomatic conditions on the overall treatment effect is usually underestimated by rheumatologists and general practitioners. Psychosomatic considerations are of great importance for up-to-date management of rheumatoid arthritis, as they strongly influence the quality of life, compliance, and thereby disease outcomes. Two major approaches of psychological rehabilitation exist, both coping with pain through the regulation of emotion and psychotherapeutic intervention, which not only helps patients in coping with the disease, but also aimed at improving the overall adaptation of the patient. It includes techniques of relaxation, cognitive-behavioral therapy, and biofeedback therapy. Current data about the efficacy of the additional correcting therapies for patients with rheumatoid arthritis, both emerging and common ones, are discussed in the review.

Cytotoxic agents and radiation therapy: mechanisms of action and clinical applications

2014 ◽  
Vol 14 (1) ◽  
pp. 63-69
Author(s):  
Amanda Marrone ◽  
William T. Tran
Keyword(s):  
Cell Cycle ◽  
Radiation Therapy ◽  
Disease Free Survival ◽  
Treatment Resistance ◽  
Mechanisms Of Action ◽  
Chemotherapeutic Agents ◽  
Cytotoxic Agents ◽  
Theoretical Frameworks ◽  
Oncological Diseases ◽  
Health Database

AbstractBackgroundThe combination of radiation therapy and chemotherapy is rooted in its ability to help achieve locoregional and systemic control, therefore increasing the overall disease-free survival of patients. Understanding the mechanistic actions of cytotoxic agents and their targets on the cell cycle, as well as the governing pharmacokinetic principles can improve treatment delivery. The adjuvant treatment setting can overcome barriers such as hypoxia and genetically driven treatment resistance.PurposeThe purpose of this review is to present theoretical frameworks behind the chemoradiation paradigm and to describe current chemoradiation practices in radiation oncology.MethodologyA review was conducted using the US National Library of Medicine, National Institutes of Health database (PubMed) using the following search keywords: chemoradiation, spatial cooperation, chemotherapeutic agents, pharmacokinetics, anti-vascular agents, tumour vasculature and tumour hypoxia.Results and conclusionsCurrent research has reported several rationales for the beneficial combination of radiation and chemotherapy to eradicate oncological diseases. Mechanisms of action and biological approaches are showing that concurrent treatments, as well as novel agents such as anti-vascular and anti-angiogenic agents may benefit improved treatment outcomes by reducing micro hypoxic environments in tumours. In addition, chemotherapy administered in tandem with radiation enhances cell-killing effects by targeting the cell cycle.

Pierwotna małopłytkowość immunologiczna u dzieci

2018 ◽  
Vol 22 (4) ◽  
Author(s):  
Anna Dusza ◽  
Michał Matysiak
Keyword(s):  
Immune Thrombocytopenia ◽  
Clinical Symptoms ◽  
Pediatric Population ◽  
Current Data ◽  
Current Investigation ◽  
Surgical Interventions ◽  
Hematological Disorders ◽  
Primary Immune Thrombocytopenia

In this article we present current investigation on primary immune thrombocytopenia in children. There are described pathomorphology, clinical symptoms, diagnosis and treatment. We also present current data from literature about genetic tests and latest data on treating options in children. Primary immune thrombocytopenia (ITP) is one of the most frequent hematological disorders in pediatric population. Although the majority of children have a self-limited and short duration of the disease. However, approximately 20-30% of those patients can develop chronic ITP, which can cause significant complications and higher mortality and reduced quality of life. Especially regarding to long-term immunosupression or surgical interventions, such like splenectomy and restrictions on daily activities to avoid trauma. Over the past decades a lot of informations has been reported about pathogenic features of ITP. Nowdays, we know that it is not only caused by increased platet destruction and decreased platet production, but also complex, multifactorial immune dysregulation, like loss of immune tolerance and generation of platelet autoantibodies. In this article we present current investigation on ITP including clinical symptoms, diagnosis, pathomorphology and latests options on treatment in children. We also present current data about genetic biomarker, such as Vanin-1 (VNN-1) which has been suggested as one of predictors of chronic disease and potentially can offer early prognosis estimation.

Constrained Shape Scaling of Trimmed NURBS Surfaces

1999 ◽  
Author(s):  
Pifu Zhang ◽  
Caiming Zhang ◽  
Fuhua (Frank) Cheng
Keyword(s):  
Data Exchange ◽  
Surface Deformation ◽  
Current Data ◽  
Free Form ◽  
Test Results ◽  
Nurbs Surface ◽  
Curvature Distribution ◽  
The Given ◽  
Boundary Curves

Abstract A method to scale and deform a trimmed NURBS surface while holding the shape and size of specific features (trimming curves) unchanged is presented. The new surface is formed by scaling the given surface according to the scaling requirement first; and then attaching the (original) features to the scaled NURBS surface at appropriate locations. The attaching process requires several geometric operations and constrained free-form surface deformation. The resulting surface has the same features as the original surface and same boundary curves as the scaled surface while reflecting the shape and curvature distribution of the scaled surface. This is achieved by minimizing a shape-preserving objective function which covers all the factors in the deformation process such as bending, stretching and spring effects. The resulting surface maintains a NURBS representation and, hence, is compatible with most of the current data-exchange standards. Test results on several car parts with trimming curves are included. The, quality of the resulting surfaces is examined using the highlight line model.

Examining the Construct Validity of the V-RQOL in Speakers Who Use Alaryngeal Voice

2014 ◽  
Vol 23 (2) ◽  
pp. 196-202 ◽  
Author(s):  
Catherine C. Bornbaum ◽  
Adam M. B. Day ◽  
Philip C. Doyle
Keyword(s):  
Factor Analysis ◽  
Construct Validity ◽  
Total Laryngectomy ◽  
Current Data ◽  
Social Emotional ◽  
Scoring Algorithm ◽  
Two Factors ◽  
Related Quality ◽  
The Voice

Purpose The construct validity of the Voice-Related Quality of Life (V-RQOL; Hogikyan & Sethuraman, 1999) measure was evaluated in a sample of 109 individuals who have undergone total laryngectomy. Method A principal components factor analysis was performed on participant responses to the 10-question V-RQOL measure. Results Factor analysis of the V-RQOL in our alaryngeal sample confirmed the presence of two factors (physical and social–emotional), which is consistent with the identified domains in the current V-RQOL. However, the current data indicate that some of the questions proposed by the original authors of the V-RQOL (Questions 7 and 9) do not align with their proposed domains in this postlaryngectomy sample. Conclusion The results indicate that some V-RQOL questions do not align with their proposed domains. Consequently, an alternative scoring algorithm may be warranted for alaryngeal populations, and the authors make suggestions for this change that are simple and efficient. Based on the findings of the present factor analysis, use of this modified scoring procedure may serve to increase the sensitivity of the V-RQOL for those who are laryngectomized and use alaryngeal methods of voice and speech. Consequently, the value and application of the V-RQOL may be expanded in the clinical setting.

National Data for Monitoring and Evaluating Racial and Ethnic Health Inequities: Where Do We Go From Here?

2006 ◽  
Vol 33 (4) ◽  
pp. 470-487 ◽  
Author(s):  
Derek M. Griffith ◽  
Ernest Moy ◽  
Thomas M. Reischl ◽  
Elizabeth Dayton
Keyword(s):  
Health Education ◽  
Monitoring And Evaluation ◽  
Public Health Education ◽  
Health Inequities ◽  
Current Data ◽  
Effective Strategies ◽  
Key Aspects ◽  
Health Agenda

The elimination of racial and ethnic health inequities has become a central focus of health education and the national health agenda. The documentation of an increasing gap in life expectancy and other health outcomes suggests the need for more effective strategies to eliminate health inequities, which can be informed by better monitoring and evaluation data. Although the sophistication and volume of health data available have increased dramatically in recent years, this article examines the quality of the current data collected to achieve the goal of eliminating racial and ethnic health inequities. This article explores several key aspects of data to inform addressing inequities including terminology, the role of data, and explanations of the problem. The authors conclude with recommendations for refining data collection to facilitate the elimination of racial and ethnic health inequities and suggest how the Society for Public Health Education can become a more central figure in our national efforts

scholarly journals Mining and processing plants: Economic trends and options of corporate governance improvement

2020 ◽  
pp. 40-44
Author(s):  
Yu. B. Vinslav ◽  
◽  
V. I. Lisov ◽  
A. N. Lunkin ◽  
D. A. Lunkin ◽  
...  
Keyword(s):  
Corporate Governance ◽  
Current Data ◽  
Staffing Level ◽  
Production Chain ◽  
Process Stage ◽  
Chain Link ◽  
Processing Plants ◽  
Economic Trends ◽  
Net Assets

The authors closely consider the economic performance behavior of Russia’s top eight mining and processing plants over the period of a few years. Sustainability of the companies and high demand for their products in the market are highlighted. An important criterion of liquidity position of mining and processing plants (MPP is English for the Russian GOK) is the change in the net assets which have on the whole grown over the period under analysis from 38,5 to 52,8 BRub, i.e., 1.37 times. After a decline in the post-crisis period (2015–2016), the index of the net assets increased by 31 % in 2018. Inventories of all GOKs increased, and the annual average values jumped 2 times (Lebedinsky GOK–2.15 times, Mikhailovsky GOK–2.3 times, Kovdor GOK and Karelski Okatysh–2.4 time, other GOKs–1.2–1.5 times). This proves stability of the liquidity positions of the test companies. A steadily growing trend was observed in buildup of the permanent assets of GOKs: this index of the test companies was 9.6 BRub in 2011 and 22.9 BRub in 2018 (a 2.4 times growth). The highest rate growth was demonstrated by the largest GOKs: Lebedinsky (2.8 times), Stoilensky (3.4 times) and Kovdor (2.1 times). At the same time, there is a downward trend in profitability of the test GOKs, which, by the authors’ opinion, dictates the corporate governance improvement. Efficiency of the corporate governance and competitive ability of a company drastically depend on: capacity of equipment in each process stage; quality of interaction between process stages; balance of capacities of process stages; high-skilled staffing level of each link in the production chain; efficiency of management; quality of information accumulation of current data on the behavior of each production chain link.

scholarly journals SOIL MANAGEMENT IN THE URBAN ENVIRONMENT: TODAY AND FUTURE

2019 ◽  
Vol 1 (1) ◽  
pp. 66-71
Author(s):  
Bogdan Stanescu ◽  
Adriana Cuciureanu
Keyword(s):  
Performance Management ◽  
Urban Environment ◽  
Urban Areas ◽  
Large Scale ◽  
Current Data ◽  
Soil Protection ◽  
The European Union ◽  
Residential Areas

The present article presents the expertise realized by the Department of Environmental Monitoring Pollution Evaluation within the INCD ECOIND, in the evaluation of the quality of urban soils in the municipality of Bucharest and the main big cities in Romania. The current data available at the level of the 27 member states of the European Union show that annually over 100,000 hectares of land are introduced into the urban environment, a direct consequence of the development of cities. There are a number of legislative obstacles to strategic soil protection measures. Moreover, at the level of the local authorities there is a conflict regarding the measures of soil protection in the long term, on the one hand, and, the accelerated economic development in the short term, on the other. European environmental experts consider that the urban development, absolutely necessary for the economic growth, requires an adequate management of the natural resources in order for the development to be done on a sustainable basis, respectively to follow a series of strategic objectives. In our country, at least in the last decade, we find on a large scale the conversion of industrial areas into commercial or residential areas. The footprint of industrial activities can be found even after long periods of time present by identifying the remnant of soil pollution or in those areas known as historically polluted (for example the town of Copsa Mica). The conclusions stemming from the assessment of pollution in urban areas over large areas, in correlation with the potential sources of pollution, underline the need to monitor the quality of soils in the urban environment, but also to apply a performance management in order to protect this natural resource in the long term.

Sign in / Sign up

Export Citation Format

Share Document