Abstract P033: Relationship Between Adiponectin Level and Metabolic Syndrome after Weight Loss in Patients with Abdominal Obesity

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Aelita Berezina ◽  
Olga Belyaeva ◽  
Olga Berkovich ◽  
Elena Baranova ◽  
Tatyina Karonova
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Abdominal Obesity ◽  
Metabolic Disorders ◽  
Intervention Program ◽  
Adiponectin Level ◽  
The Metabolic Syndrome ◽  
Outpatient Intervention ◽  
Before And After ◽  
The Relationship

Objective: to investigate the relationship between adiponectin level and metabolic syndrome (MS) after weight loss in patients with abdominal obesity (AO). Method: A 3-year randomized lifestyle intervention trial performed in 153 patients with AO, age 43,2±0,8 yrs, BMI 32,1±1,9 kg/m 2 . 74 patients keep hypocaloric diet (gr.1), 79 patients keep diet and performed aerobic exercise (gr.2). Adiponectin concentration, body mass (BM), waist circumference (WC), body fat (BF), BMI, the levels of BP, glucose, insulin, HOMA-IR, TC, HDL-C, LDL-C, TG, CRP were measured before and after a 3-years outpatient intervention program. Results. 100% patients with AO had some metabolic disorders and 38% had MS before the treatment. The adiponectin levels and others parameters didn’t differ between the groups before intervention (p>0,05). In 3 years 53 (71,6%) and 58 (73,4%) patients from 1 and 2 groups reduced weight. The rate of improving BM, BMI, BF, WC, HDL-C, TG and insulin was grater in patients gr.2 (p<0,05). The favorable dynamics of MS (MS didn’t appeared at the end of study or didn’t registered in patients who had it before) didn’t differ between the groups 1 and 2 (81,1% and 91,4%, p>0,05). The increasing of adiponectin level occurred more often in patients gr.2, than gr.1 (93,1% and 58,5%, p=0,001, respectively). Adiponectin level increased only in patients gr.2 (18,0±1,1mcg/ml and 23,8±1,3 mcg/ml, p= [[Unable to Display Character: &#1088;]]=0,0001), didn’t changed in gr.1 (p>0,05). It was established that in patients with combination of weight loss and increasing of adiponectin level favorable dynamics of MS occurred more often than in patients who lost weight without increasing of adiponectin level (91,7% and 69,2%, p=0,0001). In patients with favorable dynamics of MS increasing of adiponectin level had met more often, than in patients with unfavorable dynamics of MS (MS continued or appeared) (88,6% and 11,4%, p=0,0001). Increasing of adiponectin level associated with positive dynamics of the MS - OR=9,1 (4,0-20,6). Conclusion. Combination of weight loss and increasing of adiponectin level associated with favorable dynamics of the metabolic syndrome.

scholarly journals Appetite Control Might not Be Improved after Weight Loss in Adolescents with Obesity, Despite Non-Persistent Metabolic Syndrome

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3885
Author(s):  
Valérie Julian ◽  
Laurie Isacco ◽  
Marwa Khammassi ◽  
Alicia Fillon ◽  
Maud Miguet ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Body Composition ◽  
Energy Intake ◽  
Weight Loss Intervention ◽  
Appetite Control ◽  
Post Intervention ◽  
The Metabolic Syndrome ◽  
Daily Energy ◽  
Before And After

The aim of this study was to evaluate the effect of a multidisciplinary weight loss intervention on energy intake and appetite sensations in adolescents with obesity, depending on the initial diagnosis or persistence of the metabolic syndrome. Ninety-two adolescents with obesity (12–15 years) followed a 16-week multidisciplinary weight loss intervention. Anthropometric and body composition characteristics, metabolic profile, ad libitum daily energy intake, and appetite sensations were assessed before and after the intervention. The presence of metabolic syndrome (MS) was determined at baseline (MS vs. non-MS) and after the program (persistent vs. non-persistent). While the intervention was effective in inducing weight loss (body weight T0: 87.1 ± 14.9 vs. T1: 81.2 ± 13.0 kg; p < 0.001) and body composition improvements in both adolescents with and without MS, energy intake (p = 0.07), hunger (p = 0.008), and prospective food consumption (p = 0.03) increased, while fullness decreased (p = 0.04) in both groups. Energy intake and appetite were not improved in non-persistent MS after the program and remained significantly higher among non-persistent adolescents compared with initially non-MS adolescents. To conclude, appetite control seems impaired in obese adolescents, irrespective of being affected by MS or not, whereas the treatment of MS in this population might fail to effectively preclude the adolescents from potential post-intervention compensatory food intake and subsequent weight regain.

scholarly journals The Relationship Between Leisure-Time Physical Activity and the Metabolic Syndrome: An Examination of NHANES III, 1988-1994

2005 ◽  
Vol 2 (4) ◽  
pp. 470-487 ◽  
Author(s):  
Katrina D. DuBose ◽  
Cheryl L. Addy ◽  
Barbara E. Ainsworth ◽  
Gregory A. Hand ◽  
J. Larry Durstine
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Smoking Status ◽  
Nhanes Iii ◽  
The Metabolic Syndrome ◽  
Low Hdl ◽  
The Relationship

Background:This study was performed to determine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome (MS) in 16,681 adults (43 ± 0.44 y) enrolled in NHANES III.Methods:LTPA was classified as regularly active (≥ 5 d/wk moderate and/or ≥ 3 d/wk vigorous), irregularly active (some LTPA), or inactive (no LTPA). The MS was positive with three or more conditions: 1) abdominal obesity, 2) low HDL-C, 3) hypertriglyceridemia, 4) elevated blood pressure, or 5) elevated glucose. Logistic regression examined the relationship between LTPA and the MS, adjusting for age, race, smoking status, and educational attainment stratified by gender.Results:In men only, irregular activity and inactivity was related to an increase in the MS (irregular: OR = 1.52 95% CI 1.11, 1.23; inactive: OR = 1.60, 95% CI 1.18, 1.98; test for trend P = 0.004). Inactivity increased the odds for abdominal obesity (P < 0.05).Conclusions:LTPA levels might influence the development of MS and abdominal obesity.

scholarly journals The Relationship Between Metabolic Syndrome with Incidence of Stroke

2016 ◽  
Vol 4 (1) ◽  
pp. 25
Author(s):  
Fila Fatmisua Chrisna ◽  
Santi Martini
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Significant Relationship ◽  
Fasting Glucose ◽  
Hdl Cholesterol ◽  
Glucose Levels ◽  
The Third ◽  
The Metabolic Syndrome ◽  
The Relationship

Stroke is one of non-communicable diseases and affected by many risk factors. Some stroke risk factors have in common with the metabolic syndrome criteria, such as abdominal obesity, glucose intolerance, decreased HDL cholesterol, elevated triglyceride levels, and insulin resistance. The goals to analyze the relationship between the metabolic syndrome with the incidence of stroke. This research is analytic by using case-control design. The case groups were hospitalized patients of stroke and undergoing inpatient in dr. M. Soewandhie Surabaya. The case groups were 32 peoples and control group 32 peoples were selected at random. The variables studied were age, sex, metabolic syndrome, the first criteria, the second criteria of metabolic syndrome, and the third criteria of metabolic syndrome. The results showed that the majority of stroke patients in the age range 51-75 years (78%). Results of Chi-Square test indicates a significant relationship between the metabolic syndrome criteria first (abdominal obesity, triglycerides, and HDL cholesterol levels) p = 0,01 OR = 6,82 (95% CI = 1,23 to 68,17 ) and the second criteria of metabolic syndrome (HDL cholesterol, blood pressure, and fasting glucose levels) p= 0,007 OR = 5,80 (95% CI = 1,30 to 35,15) with the incidence of stroke. While for the third criteria of metabolic syndrome (fasting glucose levels, abdominal obesity, triglyceride  levels) there was no significant relationship to the incidence of stroke. It is expected for people, especially over the age of 35 years can do a lipid profile and circle abdominal measurements to detect of   metabolic syndrome and the risk of stroke.Keywords: Metabolic Syndrome, Stroke, Abdominal Obesity, Triglyceride, HDL

scholarly journals The Relationship Between Metabolic Syndrome with Incidence of Stroke

2016 ◽  
Vol 4 (1) ◽  
pp. 25
Author(s):  
Fila Fatmisua Chrisna ◽  
Santi Martini
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Significant Relationship ◽  
Fasting Glucose ◽  
Hdl Cholesterol ◽  
Glucose Levels ◽  
The Third ◽  
The Metabolic Syndrome ◽  
The Relationship

ABSTRACT Stroke is one of non-communicable diseases and affected by many risk factors. Some stroke risk factors have in common with the metabolic syndrome criteria, such as abdominal obesity, glucose intolerance, decreased HDL cholesterol, elevated triglyceride levels, and insulin resistance. The goals to analyze the relationship between the metabolic syndrome with the incidence of stroke. This research is analytic by using case-control design. The case groups were hospitalized patients of stroke and undergoing inpatient in dr. M. Soewandhie Surabaya. The case groups were 32 peoples and control group 32 peoples were selected at random. The variables studied were age, sex, metabolic syndrome, the first criteria, the second criteria of metabolic syndrome, and the third criteria of metabolic syndrome. The results showed that the majority of stroke patients in the age range 51-75 years (78%). Results of Chi-Square test indicates a significant relationship between the metabolic syndrome criteria first (abdominal obesity, triglycerides, and HDL cholesterol levels) p = 0,01 OR = 6,82 (95% CI = 1,23 to 68,17 ) and the second criteria of metabolic syndrome (HDL cholesterol, blood pressure, and fasting glucose levels) p= 0,007 OR = 5,80 (95% CI = 1,30 to 35,15) with the incidence of stroke. While for the third criteria of metabolic syndrome (fasting glucose levels, abdominal obesity, triglyceride  levels) there was no significant relationship to the incidence of stroke. It is expected for people, especially over the age of 35 years can do a lipid profile and circle abdominal measurements to detect of   metabolic syndrome and the risk of stroke. Keywords: Metabolic Syndrome, Stroke, Abdominal Obesity, Triglyceride, HDL

scholarly journals Multiplexed Analysis of Biomarkers Related to Obesity and the Metabolic Syndrome in Human Plasma, Using the Luminex-100 System

2005 ◽  
Vol 51 (7) ◽  
pp. 1102-1109 ◽  
Author(s):  
Mine Y Liu ◽  
Antonios M Xydakis ◽  
Ron C Hoogeveen ◽  
Peter H Jones ◽  
E O’Brian Smith ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Plasma Concentrations ◽  
Correlation Coefficients ◽  
Assay Sensitivity ◽  
C Peptide ◽  
Monocyte Chemoattractant Protein 1 ◽  
The Metabolic Syndrome ◽  
Tnf Α ◽  
Before And After

Abstract Background: The complex pathology of disease has sparked the development of novel protein expression profiling techniques that require validation in clinical settings. This study focuses on multiplexed analyses of adipocytokines and biomarkers linked to the metabolic syndrome, diabetes, and cardiovascular disease. Methods: Multiplexed immunoassays using fluorescent microspheres and the Luminex-100 system were performed on plasma from 80 obese patients (40 with the metabolic syndrome) before and after 6–8 weeks of diet-induced weight loss. Leptin, insulin, C-peptide, monocyte chemoattractant protein-1 (MCP-1), eotaxin, interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and IL-6 concentrations measured with multiplex panels from 3 different manufacturers were compared with results from commercial ELISAs. Detection limits and between- and within-run imprecision were determined for each analyte. Bland–Altman analysis was used to determine agreement between multiplexed immunoassays and ELISAs. Results: Correlation between the Luminex multiplexed assays and ELISAs was good for leptin (Linco), insulin (Linco), MCP-1 (Biosource and Upstate), and eotaxin (Biosource) with correlation coefficients of 0.711–0.895; fair for eotaxin (Upstate) and C-peptide (Linco) with correlation coefficients of 0.496–0.582; and poor for TNF-α, IL-8, and IL-6 (Linco, Biosource, Upstate, and R&D) with correlation coefficients of −0.107 to 0.318. Within- and between-run imprecision values for the multiplex method were generally &lt;15%. Relative changes in plasma leptin and insulin concentrations after diet-induced weight loss were similar whether assessed by multiplex assay or ELISA. Conclusion: Although this technology appears useful in clinical research studies, low assay sensitivity and poor correlations with conventional ELISA methods for some analytes with very low plasma concentrations should be considered when using the Luminex platform in clinical studies.

scholarly journals Components of the Metabolic Syndrome and the Main Manifestations of Metabolic Disorders in School Children

2019 ◽  
Vol 5 (11) ◽  
pp. 79-84 ◽  
Author(s):  
E. Alymbayev ◽  
B. Ongoeva ◽  
G. Kozhonazarova
Keyword(s):  
Metabolic Syndrome ◽  
At Risk ◽  
Abdominal Obesity ◽  
School Children ◽  
Metabolic Disorders ◽  
Critical Values ◽  
Children At Risk ◽  
The Metabolic Syndrome

The article presents data from a survey of 217 children with various manifestations of metabolic disorders. This study made it possible to identify children at risk of developing atherogenic diseases whose abdominal obesity has not yet reached critical values.

scholarly journals Association of Serum Adiponectin Levels with Metabolic Syndrome Risk Factors in Malay Adults

2017 ◽  
Vol 1 (1) ◽  
pp. 17
Author(s):  
Nur Firdaus Isa ◽  
Laila Ruwaida Mohd Zainuddin ◽  
Wan Manan Wan Muda ◽  
Hamid Jan B. Jan Mohamed
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Adiponectin Level ◽  
Hdl Cholesterol ◽  
Serum Adiponectin ◽  
Biochemical Tests ◽  
The Metabolic Syndrome ◽  
Overnight Fasting ◽  
Serum Adiponectin Concentration ◽  
The Relationship

Introduction: This study aimed to investigate the relationship between serum adiponectin and metabolic syndrome in adults living in rural Malaysia.Methods: A total of 299 Malay adults (men=124; women = 175) with a mean age 48.8 (11.7) years were recruited. Measurements for waist circumference and blood pressure were taken before drawing an overnight fasting blood samples. Biochemical tests for triglycerides, HDL cholesterol, glucose and serum adiponectin concentration were measured.Results: Our results show that the adiponectin level in the subjects with metabolic syndrome was significantly lower than those without metabolic syndrome (p < 0.05). Among the metabolic syndrome risk factors, adiponectin level was significantly associated with hypertriglyceridemia and reduced HDL cholesterol (p < 0.001).Conclusion: The outcome from this study which highlights the association of hypoadiponectinemia with risk factors of metabolic syndrome in Malay adults, suggests that the reduced level of adiponectin may play a pivotal role in the development of metabolic syndrome in this ethnic group.

Study Upon the Serum Level of Uric Acid and the Metabolic Syndrome Components

2019 ◽  
Vol 70 (3) ◽  
pp. 1062-1066
Author(s):  
Maria Rada ◽  
Delia Berceanu-Vaduva ◽  
Milan Velimirovici ◽  
Simona Dragan ◽  
Daniel Duda-Seiman ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Level ◽  
Abdominal Obesity ◽  
Cardiometabolic Risk ◽  
Serum Levels ◽  
Mean Value ◽  
The Metabolic Syndrome ◽  
Direct Association ◽  
Metabolic Syndrome Components

The serum level of uric acid (UA) appears to be associated with a variety of cardiometabolic risk factors; however, direct association with the metabolic syndrome (MetS) remains controversial. The aim of this study is to investigate the association between serum levels of UA and the components that define MetS, differentiated by gender. 262 patients were enrolled (132 women and 130 men); mean value of the age: 58.7�16 year. Hyperuricemia was considered when the level of serum UA �7mg/dL in men, and � 6mg/dL in women; MetS was defined according to the IDF criteria. The prevalence of MetS in the studied group was 35.11% and the prevalence of hyperuricemia was 16.79%. Men with hyperuricemia had the highest prevalence of abdominal obesity (87.5% vs. 66.32%, p [0.001) and hypertriglyceridemia (65.62% vs. 45.91%, p [ 0.001) versus men with normal level of serum UA. Women with hyperuricemia also had a significantly higher incidence of abdominal obesity (75% vs. 57.51%, p [0.001), hypertriglyceridemia (58.33% vs. 38.33%, p [0.001), decreased HDL (50% vs. 33.33%, p [0.001) and hyperglycemia (66.66% versus 50%, p [0.001) compared to those with normal levels of serum UA. The majority of men with hyperuricemia have more than 4 of the MetS components. Hyperuricemia had a higher prevalence in patients with MetS, it may be considered as a causal factor of MetS. Elevated levels of serum uric acid were significantly more associated with the increasing number of MetS components. Early detection and treatment of hyperuricemia is essential for preventing the metabolic syndrome and its complications.

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