Effects of cigarette smoking on thyroid function and the prevalence of goitre, thyrotoxicosis and autoimmune thyroiditis

1991 ◽  
Vol 229 (1) ◽  
pp. 67-71 ◽  
Author(s):  
U.-B. ERICSSON ◽  
F. LINDGÄRDE
Keyword(s):  
Cigarette Smoking ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis

scholarly journals Abnormal Thyroid Function and Recurrent Pregnancy Loss

2014 ◽  
Vol 9 (1) ◽  
pp. 29-32
Author(s):  
A Shrestha ◽  
CD Chawla
Keyword(s):  
Longitudinal Study ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Disorder ◽  
Positive Message ◽  
Effect Of Treatment ◽  
Tsh Levels

Aims: The aim of our study was to observe the benefit of screening for thyroid function amongst women with recurrent pregnancy loss and effect of treatment for thyroid disorder on pregnancy outcome. Methods: This was a longitudinal study conducted from June 2012 to December 2013. One hundred and three patients with recurrent pregnancy loss without features of thyroid disorder were included. They were investigated for thyroid stimulating hormone (TSH), free tri iodothyronin (FT3), free thyroxine (FT4) levels and for auto-antibodies against thyroperoxidase (anti TPO). The patients with abnormal TSH levels were treated with thyroxine depending on the level of TSH. Results: TSH, FT3, FT4 and anti TPO levels were measured. Amongst 103 ladies, thirty-eight (36.89%) had high levels of TSH. Thirty-five (33.98%) of them underwent test for anti TPO, of which two (5.71%) had autoimmune thyroiditis. Nine (8.73%) out of 103 had high FT4 levels. Ladies with diagnosis of hypothyroidism underwent treatment and 17 (44.73%) out of 38 had conceived. Conclusions: Of 103 women with recurrent pregnancy loss, abnormal thyroid function was detected in 47. Seventeen (44.73%) of them with increased TSH level conceived after treatment with thyroxine, which gives a positive message that hypothyroidism is a treatable cause for recurrent pregnancy loss. DOI: http://dx.doi.org/10.3126/njog.v9i1.11184 NJOG 2014 Jan-Jun; 2(1):29-32

Different aetiologies in post-partum thyroiditis?

1983 ◽  
Vol 104 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Per Anders Dahlberg ◽  
Rolf Jansson
Keyword(s):  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Thyroid Dysfunction ◽  
Post Partum ◽  
Lymphocytic Infiltration ◽  
Graves Disease ◽  
Thyroid Autoantibodies ◽  
Radioiodine Uptake ◽  
Thyroid Cytology

Abstract. During a 4 year period 19 women with post-partum onset of thyroid dysfunction have been seen in our clinic. Five women had high radioiodine uptake thyrotoxicosis (Graves' disease). Twelve women had hypothyroid symptoms starting within 3–6 months of delivery. All of these women had thyroid microsomal and/or cytoplasmic autoantibodies and thyroid lymphocytic infiltration suggesting aggravation of pre-existing subclinical autoimmune thyroiditis (Hashimoto's disease). At follow-up thyroid function gradually improved in all but signs of persistent thyroid hypofunction remained in seven. Thus women developing symptomatic postpartum hypothyroidism should be followed regularly and when thyroxine treatment is commenced in the post-partum period, it has to be continued indefinitely in many cases. Two women presented with transient low radioiodine uptake thyrotoxicosis and a small painless goitre. Thyroid cytology revealed thyroiditis but they had no thyroid autoantibodies. When followed after a succeeding delivery none of these women developed post-partum thyroid dysfunction in contrast to women in the autoimmune group. Probably the aetiology of thyroid dysfunction in these 2 women was different.

Interaction between Cigarette Smoking and Iodine-intake and Their Impact on Thyroid Function

2010 ◽  
Author(s):  
Nam H. Cho ◽  
Hoon Sung Choi ◽  
Kyung Won Kim ◽  
Hyung-Lae Kim ◽  
Soo-Youn Lee ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Thyroid Function ◽  
Iodine Intake

scholarly journals Early thyroxine treatment in Down syndrome and thyroid function later in life

2017 ◽  
Vol 176 (5) ◽  
pp. 505-513 ◽  
Author(s):  
Nitash Zwaveling-Soonawala ◽  
M Emma Witteveen ◽  
Jan Pieter Marchal ◽  
Femke C C Klouwer ◽  
Nadine A Ikelaar ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Placebo Group ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Thyroid Volume ◽  
Treated Group ◽  
Set Point ◽  
Children With Down Syndrome ◽  
Thyroxine Treatment ◽  
Hpt Axis

Objective The hypothalamus–pituitary–thyroid (HPT) axis set point develops during the fetal period and first two years of life. We hypothesized that thyroxine treatment during these first two years, in the context of a randomized controlled trial (RCT) in children with Down syndrome, may have influenced the HPT axis set point and may also have influenced the development of Down syndrome-associated autoimmune thyroiditis. Methods We included 123 children with Down syndrome 8.7 years after the end of an RCT comparing thyroxine treatment vs placebo and performed thyroid function tests and thyroid ultrasound. We analyzed TSH and FT4 concentrations in the subgroup of 71 children who were currently not on thyroid medication and had no evidence of autoimmune thyroiditis. Results TSH concentrations did not differ, but FT4 was significantly higher in the thyroxine-treated group than that in the placebo group (14.1 vs 13.0 pmol/L; P = 0.02). There was an increase in anti-TPO positivity, from 1% at age 12 months to 6% at age 24 months and 25% at age 10.7 years with a greater percentage of children with anti-TPO positivity in the placebo group (32%) compared with the thyroxine-treated group (18.5%) (P = 0.12). Thyroid volume at age 10.7 years (mean: 3.4 mL; range: 0.5–7.5 mL) was significantly lower (P < 0.01) compared with reference values (5.5 mL; range: 3–9 mL) and was similar in the thyroxine and placebo group. Conclusion Thyroxine treatment during the first two years of life led to a mild increase in FT4 almost 9 years later on and may point to an interesting new mechanism influencing the maturing HPT axis set point. Furthermore, there was a trend toward less development of thyroid autoimmunity in the thyroxine treatment group, suggesting a protective effect of the early thyroxine treatment. Lastly, thyroid volume was low possibly reflecting Down-specific thyroid hypoplasia.

scholarly journals STUDY OF THE INFLUENCE OF 6-(40 -IODOPHENYL)-2,3-DIHYDRO [2,1-B] THIAZOLE AT THYROID FUNCTION MALE WHITE RATS WITH EXPERIMENTAL AUTOIMMUNE THYROIDITIS

2016 ◽  
Vol 57 (3) ◽  
pp. 43-49
Author(s):  
N. G. Malova ◽  
L. A. Sirotenko ◽  
I. V. Komarova ◽  
E. S. Anikeeva ◽  
A. V. Spiridonov ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
T Lymphocytes ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Active Compound ◽  
Biologically Active ◽  
Experimental Autoimmune Thyroiditis ◽  
White Rats ◽  
Biologically Active Compound ◽  
Experimental Autoimmune

The study of new biologically active compound PL-308 with immunomodulating properties on the thyroid function in rats with experimental autoimmune thyroiditis. It was determined that the introduction of PL-308 reduces autoimmune aggression by lowering the level of antibodies to thyroglobulin, increases the number of all subpopulations of T-lymphocytes, in particular Tsuppressors. It was observed normalization of the functional state of the thyroid gland.

scholarly journals THYROID FUNCTION OF RATS WITH EXPERIMENTAL AIT AT AN EARLY PERIOD AFTER THE INJECTION OF BIOPREPARATIONS OF CORD BLOOD

2021 ◽  
Vol 78 (4) ◽  
pp. 104-109
Author(s):  
Yuliia Kurylko ◽  
Nataliya Malova ◽  
Larisa Sirotenko
Keyword(s):  
Cord Blood ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Early Period ◽  
Male Rats ◽  
Human Thyroid ◽  
Enzyme Linked Immunosorbent Assay ◽  
Actual Problem ◽  
Autoimmune Thyroid ◽  
Biological Preparation

The development of new methods for the treatment of autoimmune thyroid disease is an actual problem of endocrinology. The aim of research was studying of the cell-free effect biological product of cord blood with immunomodulatory properties "Cryocell-Cryocord " on rats’ thyroid function with AIT simulated at an early period of the study. Simulation of autoimmune thyroiditis was carried out by immunization with a suboperatively isolated human thyroid antigen in combination completing Freund's adjuvant on 30 adult male rats weighing 130 - 150 g. Correction was carried out by parenteral ingection of the "Cryocell-Cryocord". Hormonal research (determination of the content of thyroid hormones and antibodies to thyroglobulin (TG-AT) were effected by using standard test kits for enzyme-linked immunosorbent assay at early stages after exposure (7 days, 1 month). Statistical maintained of the results was carried out using the methods of variation statistics. It was used normal distribution to unpaired Student's test to compare indicators. The difference was considered significant at p<0.05. It has been shown the biological preparation of cord blood "Cryocell - Cryocord" has a positive effect with induced autoimmune thyroiditis. It has been noted the normalizing result of the effected correction on the thyroid function of animals in the early period of the studying. It has been proved after the introduction of the biological preparation "Cryocell - Cryocord" in animals with experimental autoimmune thyroiditis observed the inhibition of the manifestations of autoimmune aggression and the normalization of the functional activity of the thyroid gland. These investigations can be the foundation for the development of a new approach to the treatment of patients.

Normobaric interval hypoxytherapy in the correction of neuroimmunoendocrine disorders in children and adolescents with autoimmune thyroiditis

2021 ◽  
Author(s):  
Z.Kh. Abazova ◽  
A.B. Ivanov ◽  
I.Kh. Borukaeva ◽  
K.Yu. Shkhagumov
Keyword(s):  
Children And Adolescents ◽  
Key Words ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Neurological Status ◽  
Training Method ◽  
Autoimmune Process ◽  
Mental Performance ◽  
Cd8 Cells ◽  
Hypoxic Training

130 children and adolescents aged 6 to 16 years with a diagnosis of autoimmune thy-roiditis (AIT) at the stage of hypothyroidism underwent a course of hypoxytherapy. The high ef-ficiency of the normobaric interval hypoxic training method in the treatment of hypothyroidism on the background of AIT is shown. An increase in the function and number of CD8+ cells after a course of hypoxytherapy prevents the progression of the autoimmune process and promotes the restoration of thyroid function, which in turn leads to positive dynamics in the neurological status of patients: improved indicators of mental performance and fine coordination of move-ments. Key words: autoimmune thyroiditis, hypothyroidism, hypoxytherapy, interval hypoxic training, neuroimmunoendocrine disorders.

Effect of Cigarette Smoking on Thyroid Function in Depressed Patients

1988 ◽  
Vol 20 (1) ◽  
pp. 12-14 ◽  
Author(s):  
Russell T. Joffe ◽  
Anthony J. Levitt
Keyword(s):  
Cigarette Smoking ◽  
Thyroid Function ◽  
Depressed Patients

scholarly journals Serum concentrations of proinflammatory cytokines in Graves' disease: effect of treatment, thyroid function, ophthalmopathy and cigarette smoking

2000 ◽  
pp. 197-202 ◽  
Author(s):  
M Salvi ◽  
M Pedrazzoni ◽  
G Girasole ◽  
N Giuliani ◽  
R Minelli ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Thyroid Function ◽  
Interleukin 1 ◽  
Antithyroid Drug ◽  
Normal Subjects ◽  
Tnf Alpha ◽  
Graves Disease ◽  
Serum Concentrations ◽  
Necrosis Factor Alpha ◽  
Disease Effect

OBJECTIVE: In the present study we have measured the concentrations of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and IL-1 receptor antagonist (IL-1Ra) in the serum of patients with Graves' disease (GD). By multivariate analysis, we have evaluated the effect of antithyroid treatment, thyroid function, the presence or absence of active thyroid-associated ophthalmopathy (TAO), the patient's smoking habits and the relation to circulating anti-thyrotropin (TSH) receptor (TRAb) and anti-thyroperoxidase antibodies (TPOAb). SUBJECTS: We studied 84 GD patients, 51 untreated and 33 receiving methimazole (MMI) therapy. Twenty-three (45%) untreated patients and 18 (54%) patients on MMI had active TAO. We also studied 67 normal subjects as controls. Thirty-one GD patients (43%) and 16 controls (36%) were smokers. RESULTS: Serum IL-6 concentrations were significantly higher in both untreated patients (P<0.001) and treated patients (P<0.006), when compared with controls. Serum sIL-6R concentrations were significantly affected by treatment (P=0.001). Serum IL-1Ra concentrations were not different in GD patients, whether treated or untreated, compared with controls. Serum IL-6 concentrations were not influenced by thyroid function and there was a significant interaction between treatment and the presence of active TAO (P=0.003). In hyperthyroid patients with active TAO serum, sIL-6R concentrations were significantly higher than in those with inactive TAO (P=0.003). In untreated GD patients there was no significant effect of thyroid function and TAO activity on the serum concentrations of TNF-alpha and IL-1 beta. Serum IL-1Ra concentrations were not affected by the presence of TAO. Smoking had no effect on serum IL-6, sIL-6R, TNF-alpha, IL-1 beta and IL-1Ra concentrations, even in the presence of an active TAO. Serum concentrations of IL-6, sIL-6R, TNF-alpha and IL-1 beta and IL-1Ra were not different in patients with and without TRAb or TPOAb, in relation to either thyroid function, TAO activity or smoking. CONCLUSIONS: Our work shows that: (i) the proinflammatory cytokine pattern in GD is greatly influenced by antithyroid drug treatment; (ii) the increased circulating IL-6/sIL-6R concentrations observed in patients with active TAO may derive from the activation of humoral reactions in sites other than the thyroid; and, (iii) cigarette smoking has no effect on serum IL-1/IL-1Ra concentrations in TAO.

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