scholarly journals Identification of peri-prostatic neurovascular fibers before and after radical prostatectomy by means of diffusion tensor imaging (DTI) with clinical correlations: initial experience

2019 ◽  
pp. 35-41
Author(s):  
SALVATORE SIRACUSANO ◽  
ANTONIO B. PORCARO ◽  
ALESSANDRO TAFURI ◽  
RENATO TALAMINI ◽  
ADAM J. CYBULSKI
Keyword(s):  
Diffusion Tensor Imaging ◽  
Radical Prostatectomy ◽  
Diffusion Tensor ◽  
Morphological Changes ◽  
Short Form ◽  
International Consultation ◽  
Significant Difference ◽  
Before And After ◽  
Spearman Test ◽  
Diffusion Tensor Imaging Dti

Aim: To evaluate if Diffusion Tensor Imaging (DTI) is able to detect morphological changes of peri-prostatic neurovascular fibers (PNF) before and after robot-assisted radical prostatectomy (RARP) and if these changes are related to urinary incontinence (UI) and erectile dysfunction (ED). Materials and methods: From October 2014 and August 2017 26 patients with biopsy-proven prostate cancer underwent prostatic multi-parametric magnetic resonance imaging (mp-MRI) including DTI sequencing before and six months after, RARP. Images were analyzed by placing six regions of interest (ROI) respectively at the base, mid-gland and apex, one for each side, to obtain tractography reconstruction of the PNF. Patients were asked to complete an International Consultation Incontinence Questionnaire – Short Form (ICIQ-SF) and International Index of Erectile Function (IIEF-5) questionnaires before RARP and 6 months postoperatively. Fractional anisotropy (FA), number (N) and length (L) of PNF before and after RARP were compared by means of Student's t-test; Spearman test was used to evaluate the correlation between DTI parameters and questionnaires scores. We observed a significant difference in N values before and after RARP (p<0.001) and a negative correlation between IIEF-5 score and post-operative FA values at both the right (rho=-0.42; p= 0.0456) and left (rho=- 0.66; p=0.0006) base of the prostate. DTI with tractography of PNF is able to detect quantitative changes in N, L and FA values in PNF after RARP. In particular we observed an inverse correlation between FA of PNF and ED at 6 months after RARP. Further investigations are needed to confirm this trend.

Visualization of peri-prostatic neurovascular fibers before and after radical prostatectomy by means of diffusion tensor imaging (DTI) with clinical correlations: preliminary report

2019 ◽  
Vol 14 (2) ◽  
pp. 357-363
Author(s):  
Salvatore Siracusano ◽  
Antonio B. Porcaro ◽  
Alessandro Tafuri ◽  
Marco Pirozzi ◽  
Adam Cybulski ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Radical Prostatectomy ◽  
Preliminary Report ◽  
Diffusion Tensor ◽  
Before And After ◽  
Clinical Correlations ◽  
Diffusion Tensor Imaging Dti

Assessment of the corticospinal tract alterations before and after resection of brainstem lesions using Diffusion Tensor Imaging (DTI) and tractography at 3T

2011 ◽  
Vol 77 (3) ◽  
pp. 383-391 ◽  
Author(s):  
Ilhami Kovanlikaya ◽  
Zeynep Firat ◽  
Arzu Kovanlikaya ◽  
Aziz M. Uluğ ◽  
M. Mutlu Cihangiroglu ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Corticospinal Tract ◽  
Diffusion Tensor ◽  
Brainstem Lesions ◽  
Before And After ◽  
Diffusion Tensor Imaging Dti

scholarly journals Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma

2021 ◽  
Author(s):  
Dilek Hacer Çeşme ◽  
Alpay Alkan ◽  
Mehmet Ali Gültekin ◽  
Lütfullah Sarı ◽  
Gökberk Alkan ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Tumor Volume ◽  
Diffusion Tensor ◽  
Gamma Knife Radiosurgery ◽  
Response To Treatment ◽  
Auditory Pathways ◽  
Significant Difference ◽  
Before And After ◽  
Adc Values ◽  
The Relationship

Objective: To investigate changes in DTI (Diffusion Tensor Imaging) parameters in brainstem subcortical auditory pathways after Gamma Knife Radiosurgery (GKR) in patients with intracanalicular vestibular schwannoma (ICVS) and to analyze the relationship between tumor volume and ADC (apparent diffusion coefficient) and FA (fractional anisotropy) values. Method: Seventeen patients with ICVS were evaluated before and after GKR. ADC and FA values of the lateral lemniscus (LL) and inferior colliculus (IC) and tumor volume were calculated. Patients who responded to GKR were classified as Group 1 and those who did not respond adequately as Group 2. The relationship between ADC and FA values and changes in tumor volume were analyzed. Results: Tumor volume significantly decreased after GKR. ADC values obtained from the tumor increased after GKR (p: 0.002). There was no significant difference in LL and IC before and after GKR in terms of FA and ADC values (n: 17). There was a positive correlation between response to treatment and contralateral LL ADC values after GKR (p=0.005, r: 0.652). There was a negative correlation between contralateral IC FA values after GKR and response to treatment (p=0.017, r: -0.568). There was a significant difference between Groups 1 and 2 in regards to contralateral LL ADC (p=0.03) and IC FA values (p=0.017). Conclusion: Since the cochlear nerve and subcortical auditory pathways have low regeneration potential after nerve damage, ADC and FA changes in LL and IC may be explained with the presence of intracanalicular tumors prior to GKR. Since GKR does not cause additional damage to the subcortical auditory pathways at the brainstem level, we think that GKR is a noninvasive treatment method that can be used safely in patients with ICVS.

scholarly journals Changes in Diffuse Tensor Imaging and Therapeutic Effect of Repetitive Transcranial Magnetic Stimulation in Traumatic Brain Injury with Central Pain

2020 ◽  
Vol 10 (12) ◽  
pp. 929
Author(s):  
Dong-Ha Kang ◽  
Gi-Wook Kim
Keyword(s):  
Traumatic Brain Injury ◽  
Neuropathic Pain ◽  
Diffusion Tensor Imaging ◽  
Magnetic Stimulation ◽  
Diffusion Tensor ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Central Pain ◽  
Spinothalamic Tract ◽  
Before And After ◽  
Diffusion Tensor Imaging Dti

Post-trauma chronic pain characterized by central pain is a symptom following traumatic brain injury (TBI). Studies on the effect of repetitive transcranial magnetic stimulation (rTMS) on central pain and the association between central pain and spinothalamic tract (STT) have been reported, but few studies have examined the effect of rTMS in patients with mild TBI with central pain through changes in diffusion tensor imaging (DTI)-based metrics of STT before and after rTMS. This case series aimed to investigate the therapeutic effect of rTMS in TBI with central pain and the changes in diffusion tensor imaging (DTI)-based metrics of the spinothalamic tract (STT) before and after rTMS. This study included four patients who complained of severe pain in the left or right side of the body below the neck area after a car accident. We performed numeric rating scale (NRS), bedside sensory examination, electrodiagnostic study, and DTI-based metrics of the STT before and after rTMS. According to the guidelines of the diagnosis and grading for neuropathic pain, all patients had neuropathic pain corresponding to “probable grade.” In all patients, rTMS was applied to the contralateral M1 cortex on the more painful side. There were no medication changes and other interventions during the rTMS. After rTMS, NRS decreased, bed sensory testing improved, and DTI-based STT metrics increased in all patients compared to before rTMS.

scholarly journals Male Urinary Incontinence

2016 ◽  
Vol 10 (6) ◽  
pp. NP127-NP135 ◽  
Author(s):  
Marcos E. Fernández-Cuadros ◽  
Javier Nieto-Blasco ◽  
Antonia Geanini-Yagüez ◽  
Daniel Ciprián-Nieto ◽  
Bárbara Padilla-Fernández ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Urinary Incontinence ◽  
Radical Prostatectomy ◽  
Abdominal Surgery ◽  
Short Form ◽  
Life Measure ◽  
International Consultation ◽  
Before And After ◽  
Male Urinary Incontinence

The aim of the current study was to determine the demographic characteristics and risk factors associated with male urinary incontinence (UI) and to assess the effectiveness and the effect on the quality-of-life of a pelvic floor muscle training (PFMT) protocol with electromyography-biofeedback (EMG-BFB) with surface electrodes. A prospective, quasi-experimental before-and-after study with a sample of 61 men out of 372 patients referred to the Pelvic Floor Unit from October 2005 to June 2012 was performed. The protocol consisted of 20 sessions of EMG-BFB supervised by a physiotherapist twice a week. The session durations were 30 minutes (118 work/rest cycles of pelvic muscles). Work lasted 3 seconds and rest 7 seconds. Patients were given standards of conduct and questionnaires (International Consultation on Incontinence–Short Form and Incontinence Quality-of-Life Measure) at the beginning and at the end of the treatment. The average age was 64.85 ± 14.34 years; 44.3% ( n = 27) had benign prostatic hypertrophy, 41.9% ( n = 25) had prostate malignant neoplasm, 86.9% ( n = 53) had undergone prostatectomy, 16.4% ( n = 10) had undergone abdominal surgery. Abdominal surgery and radical prostatectomy were significantly associated with UI ( p < .05). Stress urinary incontinence was the most common type of UI (86.67%), followed by mixed urinary incontinence (8.33%) and urge urinary incontinence (5%). A significant improvement ( p < .05) in both International Consultation on Incontinence–Short Form and Incontinence Quality-of-Life Measure questionnaires was observed when making comparisons regarding the results before and after the EMG-BFB treatment protocol. These results support that male UI is significantly associated with urological and abdominal surgery (including radical prostatectomy) and that EMG-BFB for PFMT improves incontinence and quality of life (social embarrassment, limiting behavior, and psychosocial impact) in the three types of UI on an overall basis.

scholarly journals Free-water diffusion tensor imaging detects occult periependymal abnormality in the AQP4-IgG-seropositive neuromyelitis optica spectrum disorder

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Minchul Kim ◽  
Kyu Sung Choi ◽  
Ryoo Chang Hyun ◽  
Inpyeong Hwang ◽  
Tae Jin Yun ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Free Water ◽  
White Matter Injury ◽  
Radial Diffusivity ◽  
Post Hoc Analysis ◽  
Significant Difference ◽  
Dependent Variables ◽  
Post Hoc ◽  
Diffusion Tensor Imaging Dti

AbstractTo compare free-water corrected diffusion tensor imaging (DTI) measures in the normal-appearing periependymal area between AQP4-IgG-seropositive NMOSD and multiple sclerosis (MS) to investigate occult pathophysiology. This prospective study included 44 patients (mean age, 39.52 ± 11.90 years; 14 men) with AQP4-IgG-seropositive NMOSD (n = 20) and MS (n = 24) who underwent DTI between April 2014 and April 2020. Based on free-water corrected DTI measures obtained from normal-appearing periependymal voxels of (1) lateral ventricles and (2) the 3rd and 4th ventricles as dependent variables, MANCOVA was conducted to compare the two groups, using clinical variables as covariates. A significant difference was found between AQP4-IgG-seropositive NMOSD and MS in the 3rd and 4th periependymal voxels (λ = 0.462, P = 0.001). Fractional anisotropy, axial diffusivity was significantly decreased and radial diffusivity was increased in AQP4-IgG-seropositive NMOSD in post-hoc analysis, compared with MS (F = 27.616, P < 0.001, F = 7.336, P = 0.011, and F = 5.800, P = 0.022, respectively). Free-water corrected DTI measures differ in the periependymal area surrounding the diencephalon and brain stem/cerebellum between MS and NMOSD, which may suggest occult white matter injury in areas with distribution of AQP-4 in NMOSD.

Evaluation of periprostatic neurovascular bundles before and after RARP by means of diffusion tensor imaging (DTI): Initial experience

2019 ◽  
Vol 18 (1) ◽  
pp. e2058
Author(s):  
S. Siracusano ◽  
A.B. Porcaro ◽  
M. Pirozzi ◽  
A. Tafuri ◽  
G. Cacciamani ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Initial Experience ◽  
Before And After ◽  
Neurovascular Bundles ◽  
Diffusion Tensor Imaging Dti

Treatment of Severe Urinary Incontinence following Radical Prostatectomy: Experience with Bioceram as a Bulking Agent

2019 ◽  
Author(s):  
Mohsen Ayati ◽  
Erfan Amini ◽  
Mohammad Reza Nowroozi ◽  
Seyed Ali Momeni ◽  
Solmaz Ohadian Moghadam ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Radical Prostatectomy ◽  
Short Form ◽  
Bulking Agent ◽  
External Beam Radiation ◽  
Severe Stress ◽  
Beam Radiation ◽  
International Consultation ◽  
Before And After

Background: To evaluate the efficacy of Bioceram injection in men with severe stress urinary incontinence following radical prostatectomy. Methods: A total of 18 patients underwent retrograde injection of Bioceram for severe stress urinary incontinence following radical prostatectomy. Evaluation by pad test, international consultation on the Incontinence Questionnaire - Short Form (ICIQ-SF) and American Urology Association Symptom Score - Quality of Life (AUASS-QOL) was performed before and after injection therapy. Patients were considered cured if they were using no pads or only one safety pad per day. Results: Of 18 patients, 14 had received postoperative external beam radiation therapy. Furthermore, 5 patients required transurethral incision due to simultaneous stricture of the urethrovesical anastomosis. The baseline daily pad count changed from a mean of 6.1± 0.8 to 5.3 ± 1.7 (p = 0.010). None of the patients were cured and only 3 patients showed signs of improvement following injection. Conclusion: In patients with severe urinary incontinence, treatment with bulking agent injection is associated with modest efficacy.

scholarly journals Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Cinzia Femiano ◽  
Francesca Trojsi ◽  
Giuseppina Caiazzo ◽  
Mattia Siciliano ◽  
Carla Passaniti ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Anterior Cingulate ◽  
Behavioral Impairment ◽  
Brain Areas ◽  
Significant Difference ◽  
Als Patients ◽  
Lateral Sclerosis ◽  
Diffusion Tensor Imaging Dti

Apathy is recognized as the most common behavioral change in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disorder. Particularly, apathy has been reported to be associated with poor ALS prognosis. However, the brain microstructural correlates of this behavioral symptom, reported as the most common in ALS, have not been completely elucidated. Using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS), here we aimed to quantify the correlation between brain microstructural damage and apathy scores in the early stages of ALS. Twenty-one consecutive ALS patients, in King’s clinical stage 1 or 2, and 19 age- and sex-matched healthy controls (HCs) underwent magnetic resonance imaging and neuropsychological examination. Between-group comparisons did not show any significant difference on cognitive and behavioral variables. When compared to HCs, ALS patients exhibited a decreased fractional anisotropy (FA) [p<.05, threshold-free cluster enhancement (TFCE) corrected] in the corpus callosum and in bilateral anterior cingulate cortices. Self-rated Apathy Evaluation Scale (AES) scores and self-rated apathy T-scores of the Frontal Systems Behavior (FrSBe) scale were found inversely correlated to FA measures (p<.05, TFCE corrected) in widespread white matter (WM) areas, including several associative fiber tracts in the frontal, temporal, and parietal lobes. These results point towards an early microstructural degeneration of brain areas biologically involved in cognition and behavior regulation in ALS. Moreover, the significant correlations between apathy and DTI measures in several brain areas may suggest that subtle WM changes may be associated with mild behavioral symptoms in ALS even in the absence of overt cognitive and behavioral impairment.

scholarly journals Lack of association between the ICIQ-SF questionnaire and the urodynamic diagnosis in men with post radical prostatectomy incontinence

2013 ◽  
Vol 28 (suppl 1) ◽  
pp. 37-42 ◽  
Author(s):  
Rodolfo Borges dos Reis ◽  
Adauto Jose Cologna ◽  
Roberto Dias Machado ◽  
Marcos Tobias Machado ◽  
Lucas Nogueira ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Bladder Dysfunction ◽  
Short Form ◽  
Urodynamic Testing ◽  
International Consultation ◽  
Significant Difference ◽  
Group 3 ◽  
The Mean ◽  
Group 2 ◽  
Group 1

PURPOSE: To analyze the correlation between the "International Consultation on Incontinence Questionnaire-Short Form" (ICIQ-UISF) survey and the urodynamic findings in men with urinary incontinence (UI) following radical prostatectomy (RP). METHODS: 88 men who presented post-RP UI for a minimum of 1 year were enrolled prospectively. All answered the ICIQ-UISF survey and underwent urodynamic testing. Patients were divided in 3 Groups according to their urodynamic diagnosis: Group 1, patients with sphincteric incontinence (SI) alone; Group 2, patients with mixed UI (SI + Bladder Dysfunction (BD)); and Group 3, patients with BD alone. Data were analyzed using SPSS v16.0 software. RESULTS: There were 51 men in Group 1 (57.9%); 30 in Group 2 (34%); and 7 (7.9%) in Group 3. BD was found in 37/88 patients (42%), but it was the main cause of UI in only 14 patients (15.9%). There was no statistically significant difference among the mean ICIQ-UISFs values from groups 1, 2, or 3 (p>0.05). The symptoms of stress incontinence correlated with the urodynamic finding of SI (r = 0.59), and complaints of urinary urgency correlated with the presence of detrusor overactivity (DO) (r = 0.37), but these complaints did not predict the main cause of UI. CONCLUSION: The etiology of UI following RP cannot be predicted by the ICIQ-UISF survey. Symptoms of stress and urge incontinence predict the findings of SI and DO on urodynamic tests, but they cannot ascertain the main cause of UI. Urodynamic testing remains the gold standard to assess the etiology of post-RP UI.

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