SOME CHARACTERISTICS OF AGE, ULTRASOUND AND THE RELATION BETWEEN THE PSA DENSITY AND THE HISTOPATHOLOGY OF BENIGN NODULAR PROSTATIC HYPERPLASIA AND PROSTATIC CARCINOMA

2016 ◽  
pp. 35-42
Author(s):  
Van Mao Nguyen
Keyword(s):  
Prostatic Carcinoma ◽  
Cross Sectional Study ◽  
Prostatic Hyperplasia ◽  
Average Weight ◽  
Cross Sectional ◽  
Psa Density ◽  
Nodular Hyperplasia ◽  
Prostatic Diseases ◽  
Total Psa ◽  
Meaningful Role

Background: PSA density by the ratio of tPSA/prostatic volume plays a meaningful role for the orientation of diagnosis and the screening of the prostatic diseases, especially for the prostatic carcinoma and benign nodular hyperplasia. Objectives: - To describe some characteristics of the age, ultrasound of the patient with the prostatic carcinoma and benign nodular hyperplasia; - To determine the relation between PSA density and the histopathology of the patient with the prostatic carcinoma and benign nodular hyperplasia. Materials and Method: cross-sectional study on 70 patients including 35 cases with benign nodular prostatic hyperplasia and 35 ones with carcinoma of the prostate. Results: The average age was the same between 2 groups of the diseases, 73 for prostatic carcinoma and 75 for benign nodular hyperplasia. 100% of the lesions was discovered by ultrasound, the average weight of the carcinoma and benign nodular hyperplasia was 57.3g and 46.9g respectively. The tPSA density was higher in carcinoma than in benign nodular hyperplasia (1.22 vs 0.10); With the tPSA density threshold >0.15, the prostatic carcinoma accounting for 78.4%, then the benign group only 21.6%; the Sensitivity and the Specificity were 82.9% and 77.1% respectively. Conclusions: PSA density should be applied for the diagnosis and the screening of the prostatic tumors beside the tPSA test. Key words: tPSA (total PSA), PSA density, ultrasound, prostatic carcinoma, benign nodular prostatic hyperplasia.

scholarly journals Physical activity and weight following car ownership in Beijing, China: quasi-experimental cross sectional study

BMJ ◽  
2019 ◽  
pp. l6491 ◽  
Author(s):  
Michael L Anderson ◽  
Fangwen Lu ◽  
Jun Yang
Keyword(s):  
Physical Activity ◽  
Cross Sectional Study ◽  
Global City ◽  
Car Ownership ◽  
Average Weight ◽  
Sectional Study ◽  
Cross Sectional ◽  
Experimental Cross ◽  
Quasi Experimental ◽  
Beijing China

AbstractObjectiveTo determine the implications of car ownership for physical activity and weight in a global city.DesignQuasi-experimental cross sectional study.SettingBeijing, China, 2011-15.ParticipantsPeople aged 18 and older from a random sample of households who had entered a permit lottery to purchase a vehicle between January 2011 and November 2015.InterventionsPermit allowing purchase of a vehicle within six months of permit issuance.Main outcome measuresTransit use (number of subway and bus rides each week), physical activity (minutes of walking or bicycling each day), and weight, measured once in early 2016.ResultsOf 937 people analysed in total, 180 had won a permit to purchase a new vehicle. Winning the permit lottery resulted in the purchase of an additional vehicle 91% of the time (95% confidence interval 89% to 94%; P<0.001). About five years after winning, winners took significantly fewer weekly transit rides (−2.9 rides (−5.1 to −0.7); P=0.01) and walked and cycled significantly less (−24.2 minutes (−40.3 to −8.1); P=0.003) than those who did not win the lottery. Average weight did not change significantly between lottery winners and losers. Among those aged 50 and older, however, winners’ weight had increased relative to that of losers (10.3 kg (0.5 to 20.2); P=0.04) 5.1 years after winning.ConclusionsThese data indicate that vehicle ownership in a rapidly growing global city led to long term reductions in physical activity and increase in weight. Continuing increases in car use and ownership in developing and middle income countries could adversely affect physical health and obesity rates.

scholarly journals The Combination of Human Glandular Kallikrein and Free Prostate-specific Antigen (PSA) Enhances Discrimination Between Prostate Cancer and Benign Prostatic Hyperplasia in Patients with Moderately Increased Total PSA

1999 ◽  
Vol 45 (11) ◽  
pp. 1960-1966 ◽  
Author(s):  
Angeliki Magklara ◽  
Andreas Scorilas ◽  
William J Catalona ◽  
Eleftherios P Diamandis
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Prostate Specific Antigen ◽  
Prostatic Carcinoma ◽  
Specific Antigen ◽  
Area Under The Curve ◽  
Prostatic Hyperplasia ◽  
Free Psa ◽  
Glandular Kallikrein ◽  
Total Psa

Abstract Background: Prostate-specific antigen (PSA) is the most reliable tumor marker available and is widely used for the diagnosis and management of prostate cancer. Unfortunately, PSA cannot distinguish efficiently between benign and malignant disease of the prostate, especially within the range of 4–10 μg/L. Among the refinements developed to enhance PSA specificity is the free/total PSA ratio, which is useful in discriminating between the two diseases within the diagnostic “gray zone”. Recent data indicate that human glandular kallikrein (hK2), a protein with high homology to PSA, may be an additional serum marker for the diagnosis and monitoring of prostate cancer. Methods: We analyzed 206 serum samples (all before treatment was initiated) from men with histologically confirmed benign prostatic hyperplasia (n = 100) or prostatic carcinoma (n = 106) with total PSA in the range of 2.5–10 μg/L. Total and free PSA and hK2 were measured with noncompetitive immunological procedures. Statistical analysis was performed to investigate the potential utility of the various markers or their combinations in discriminating between benign prostatic hyperplasia and prostatic carcinoma. Results: hK2 concentrations were not statistically different between the two groups of patients. There was a strong positive correlation between hK2 and free PSA in the whole patient population. hK2/free PSA ratio (area under the curve = 0.69) was stronger predictor of prostate cancer than the free/total PSA ratio (area under the curve = 0.64). At 95% specificity, the hK2/free PSA ratio identified 30% of patients with total PSA between 2.5–10 μg/L who had cancer. At 95% specificity, the hK2/free PSA ratio identified 25% of patients with total PSA between 2.5 and 4.5 μg/L who had cancer. Conclusions: Our data suggest that hK2 in combination with free and total PSA can enhance the biochemical detection of prostate cancer in patients with moderately increased total PSA concentrations. More specifically, the hK2/free PSA ratio appears to be valuable in identifying a subset of patients with total PSA between 2.5 and 4.5 μg/L who have high probability of cancer and who should be considered for biopsy.

scholarly journals High-risk pregnancy: effectiveness of personalized pregravid preparation and positive perinatal experience

2021 ◽  
pp. 34-41
Author(s):  
G.S. Manasova ◽  
N.V. Didenkul ◽  
N.V. Kuzmyn
Keyword(s):  
First Trimester ◽  
Evidence Base ◽  
Cross Sectional Study ◽  
Convincing Evidence ◽  
Controlled Study ◽  
Average Weight ◽  
Cross Sectional ◽  
Planning Stage ◽  
Risk Pregnancy ◽  
Significant Difference

Research objective: to study the possibilities of improving perinatal results by optimizing pergravid preparation in women with high perinatal risk.Materials and methods. The first stage – a cross-sectional study – consisted in determining the vitamin D (VD) status and assessing the course of pregnancy in 459 women in the II and III trimester; the second stage was a randomized controlled study of women with VD deficiency in group IIA (planning stage, 54 women) and IIB (I trimester, 60 women), who received the vitamin and mineral complex (VMC) Pregna-5 with a high calcitriol content and perinatal results were evaluated. VD in the blood was determined by the enzyme-linked immunosorbent assay.Results. VD level was optimal only in 30.7% of pregnant women (group ІА), in 69.3% of women its insufficiency or deficiency was found (group ІB). The frequency of threatened termination (9.9 vs. 45.6%; p < 0.01), preeclampsia (2.0 vs. 11%; p < 0.05), intrauterine growth retardation (7% only in group IIB, p < 0.01) was significantly higher against the background of BD deficiency. Normalization of the VD level (groups IIA and IIB) after VMC administration was observed within 1–3 months. Pregnancy complications value was higher in the group where the VMC was started in the first trimester: early gestosis (15 vs. 28.57%; p < 0.05), the threat of termination (22.2 vs. 36.7%; p < 0.05), bacterial vaginosis (7.4 vs. 31.7%; p < 0.05), placental dysfunction (18.5 vs. 40.0%; p <0.01), placental pathology in group IIB was detected 2–3 times more often. The differences between the preeclampsia (1.9 vs. 6.7%; p > 0.05) and anemia (16.6 vs. 28.3%; p > 0.05) were insignificant. Analysis of the childbirth results showed a significantly higher frequency of cesarean sections in group IIB (38.3 vs. 22.2%; p < 0.05), the average weight of newborns was less (3299.11 ± 128 g vs. 3643.24 ± 136 g; p < 0.01). The most effective was the VMC start at the stage of pregnancy planning (F = 13.35482; p = 0.000016); a significant difference was revealed in the course of pregnancy in the groups where VMC started in the first, second and third trimesters of pregnancy (Q = 4.67, p = 0.00458).Conclusions. Timely donation of VMC with a high content of cholecalciferol in women with high perinatal risk may lead to a positive course of pregnancy. Further research is required to obtain a convincing evidence base.

scholarly journals Grading Of Prostate Volume And International Prostatic Symptom Score (IPSS) In A Subset Of Karachi Population

2018 ◽  
Vol 09 (01) ◽  
pp. 30-33
Author(s):  
Iffat Raza ◽  
Mahrukh Kamran ◽  
Sadaf Shaheen
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Symptom Score ◽  
Prostate Volume ◽  
Severe Symptom ◽  
Cross Sectional Study ◽  
Prostatic Hyperplasia ◽  
Sectional Study ◽  
Cross Sectional ◽  
International Prostatic Symptom Score ◽  
Symptom Group

Objective: Analyze grading of IPSS (International Prostatic Symptom Score) and PV (Prostate Volume) of BPH patients in a subset of Karachi Population. Methodology: A 103 Benign prostatic hyperplasia(BPH) patients were recruited. A cross-sectional study was done Prostate Volume was recorded along with their IPSS also noted. Result: Among BPH patients 25.2% patients had prostate volume of 25 to 30 ml , 52.5% of patient had prostate volume of 30 to 50ml and 22.3% of patients had prostate volume above 50 ml. In IPSS grading 82.5% patients were under moderate symptom group and 17.5% were under severe symptom group. Conclusion: International Prostatic Symptom Score continues to increase as Prostate volume increases

scholarly journals Frequency of Weight Gain and its Impact in Adults during Lockdown: A Cross- Sectional Study

Esculapio ◽  
2021 ◽  
Vol 16 (4 (oct 2020 - dec 2020)) ◽  
Author(s):  
Uswah Bokhari ◽  
Uswah Shoaib ◽  
Sana Tariq ◽  
Sehar Khauteja Khan ◽  
Fatima Syed ◽  
...  
Keyword(s):  
Body Image ◽  
Weight Gain ◽  
Sedentary Lifestyle ◽  
Self Esteem ◽  
Cross Sectional Study ◽  
Daily Activities ◽  
Average Weight ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lack Of Exercise

Objectives: The current lockdown in the country has led to a sedentary lifestyle because of a shift of daily activities online and a fear of contracting the illness leading to isolation inside homes; Hence an expected change in weight of the general population. This study aims to determine the frequency of weight gain and its impact in adults during the current lockdown of COVID-19. Methods: Participants selected from the ages of 18-25 from different universities of Pakistan were sent questionnaires via WhatsApp, posted online using Microsoft Forms. A total of 157 responses were attained. Results: Among the 157 participants the average weight before the lockdown was 61.95 kgs and after the lockdown was 64.99kgs so there was an increase of 3.016 kgs whereas 18.5% of the sample maintained their weight and 37.6% were reported to have lost weight. The results also depict a 1.6% increase in impairment of body image. Conclusion: We concluded that the Lockdown due to the COVID-19 pandemic has caused a gain in the weight and lowered self-esteem with regard to body image of most young adults in Pakistan due to many factors including higher food intake, lack of exercise and also emotional distress. Key words: Obesity, Weight gain, Lockdown, Body Image. How to Cite: Bokhar U, Shoaib U, Tariq S, Khan S.K, Syed F, Amin B, Ijaz F, Aftab R.K. Frequency of weight gain and its impact in adults during lockdown: a cross sectional study. Esculapio.2020;16(04):110-115.

Awareness among Saudi Arabian parents of the relationship between Monosodium Glutamate intake and increasing Body Weight

2021 ◽  
pp. 5270-5273
Author(s):  
Nasser Hadal Alotaibi ◽  
Abdulaziz I. Alzarea ◽  
Nabeel K. Alruwaili ◽  
Dibya sundar panda ◽  
Mohamed A. Abdulwahab ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
United Arab Emirates ◽  
Fast Food ◽  
Public Awareness ◽  
Monosodium Glutamate ◽  
Cross Sectional Study ◽  
Average Weight ◽  
Chi Square ◽  
Cross Sectional ◽  
Gender Categories

Monosodium glutamate (MSG) is an amino acid which is widely used and approved as a flavor enhancer for a broad range of food. Glutamate receptor can be stimulated excessively to cause diabetes and cancer. MSG is associated with metabolic syndrome in humans. The main purpose of this study is to find a possible correlation between monosodium glutamate and signs of overweight among young children in Saudi Arabia. An electronic cross-sectional study was conducted in 2016 in Jeddah, Saudi Arabia. Participants consisted of 572 Saudi parents of children aged between 6-18 years. Data analysis was done using t-test and chi-square test. Overweight children population was found to be relatively small in Saudi Arabia compared to other gulf countries such as United Arab Emirates (UAE) (40%). There is a statistically significant relationship between average weight and a preference for fast food at home. It is strongly recommended to reduce the amount of MSG taken in fast foods and snacks and some types of sweets for the prevention from associated chronic diseases such as cancer, diabetes, obesity, and others. Moreover, increasing public awareness about obesity and its main causes by putting posters in public places. Announcing detailed information on the causes of obesity in local magazines. Doing the study in other age/gender categories like women and elderly.

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