EXPRESSION OF SOME IMMUNOLOGIC MARKERS FOR THE DIAGNOSIS OF SUSPECTED LYMPHOID LESIONS OF LYMPHOMA

2018 ◽  
Vol 8 (4) ◽  
pp. 28-33
Author(s):  
Mao Nguyen Van ◽  
Thao Le Thi Thu
Keyword(s):  
Correct Diagnosis ◽  
Tumour Cells ◽  
The Body ◽  
The Other ◽  
Cervical Region ◽  
Cross Sectional ◽  
Immunologic Markers ◽  
Microscopic Features ◽  
Poor Differentiation ◽  
Benign Tumours

Background: In practice it was difficult or impossible to have a correct diagnosis for the lymphoid proliferation lesions based on only H.E standard histopathology. In addition to histopathology, the application of immunohistochemistry was indispensable for the definitive diagnosis of the malignant or benign tumours and the origin of the tumour cells as well. Objectives: 1. To describe the gross and microscopic features of the suspected lesions of lymphoma; 2. To asses the expression of some immunologic markers for the diagnosis and classification of the suspected lesions of lymphoma. Materials and Method: Cross-sectional research on 81 patients diagnosed by histopathology as lymphomas or suspected lesions of lymphoma, following with immunohistopathology staining of 6 main markers including LCA, CD3, CD20, Bcl2, CD30 and AE1/3. Results: The most site was lymph node 58.1% which appeared at cervical region 72.3%, then the stomach 14.9% and small intestine 12.4%. The other sites in the body were met with lower frequency. Histopathologically, the most type of the lesions was atypical hyperplasia of the lymphoid tissue suspecting the lymphomas 49.4%, lymphomas 34.5%, the other diagnoses were lower including inflammation, poor differentiation carcinoam not excluding the lymphomas, lymphomas differentiating with poor differentiation carcinomas. Immunohistochemistry showed that, LCA, CD3, CD20, Bcl2, CD30 and AE1/3 were all positive depending on such type of tumours. The real lymphomas were 48/81 cases (59.3%), benign ones 35.8% and poor differentiated carcinomas 4.9%. Conclusion: Immunohistochemistry with 6 markers could help to diagnose correctly as benign or malignant lesions, classify and determine the origin of the tumour cells as lymphocytes or epithelial cells diagnosed by histopathology as lymphomas or suspected lesions of lymphomas. Key words: histopathology, immunohistochemistry, lymphomas, poor differentiated carcinomas, hyperplasia, atypicality

HISTOPATHOLOGICALANALYSIS OF TUMOURS AND TUMOUR-LIKE LESIONS OF COLON AND RECTUM

2021 ◽  
pp. 9-11
Author(s):  
Durga Nand Jha ◽  
Hari Shankar Mishra ◽  
Ajit Kumar Chaudhary ◽  
Debarshi Jana
Keyword(s):  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Malignant Tumour ◽  
Juvenile Polyp ◽  
Tubular Adenoma ◽  
Malignant Tumours ◽  
Cross Sectional ◽  
Colorectal Biopsies ◽  
Colon And Rectum ◽  
Benign Tumours

Background:Tumours and tumour like lesions of the colon and rectum have overlapping clinical presentation and may be difcult to diagnose on clinical grounds alone. Histopathological examination although helpful to arrive at correct diagnosis, at times may be difcult and may require ancillary tests such as immunohistochemistry. Materials and Methods: A prospective cross sectional study enrolled 125 cases of colorectal biopsies after histopathological conrmation of tumours and tumour like lesions. The specimens were received at the Department of Pathology, DMCH, Laheriasarai, Bihar from December 2019 to November 2020. Results: Out of 125 cases, 32 cases were benign tumours, 36 cases were malignant tumours and 57 cases were tumour like lesions. Most common age range was 51-60 years with mean age of 38 years. Males comprised 76.74% and females 23.26% with ratio of 3:1. Juvenile polyp was the commonest lesion. Among benign tumours, tubular adenoma was the most common (19.2%), adenocarcinoma was most common malignant tumour (25.6%) and juvenile polyp was the most common tumour like lesion (27.2%). Left side was most common side (66.67%) and rectum was the most common site (48.8%). Conclusions: The commonest indications for colorectal biopsies were tumours and tumour like lesions. Juvenile polyp was the most common tumour like lesion, tubular adenoma was the most common benign tumour and adenocarcinoma was the most common malignant tumour. Histopathological examination is a gold standard for conrmation of all tumour and tumours like lesions of colon and rectum.

Association Between Body Composition with Pulmonary Function Tests

2020 ◽  
Author(s):  
Hamidreza Pouragha ◽  
Hosein Kazemi ◽  
Gholamreza Pouryaghoub ◽  
Ramin Mehrdad
Keyword(s):  
Body Composition ◽  
Pulmonary Function ◽  
Visceral Fat ◽  
Pulmonary Function Tests ◽  
Bioelectrical Impedance ◽  
The Body ◽  
Fat Free Mass ◽  
The Other ◽  
Inverse Association ◽  
Cross Sectional

Abstract Background: Why is bodyweight not a predictor of lung function, however, height, sex, race, and age are predictors of lung capacity and function. In this study, we want to investigate the association between body composition and pulmonary function. And as much as possible, answer the question of why bodyweight is not predictive of lung function.Method: This cross-sectional study was performed among 2967 employees of Tehran University of Medical Sciences (TUMS) who participated in the TUMS Employees Cohort (TEC) study. The body composition of the participants was measured using the Bioelectrical Impedance Analysis (BIA) method. Anthropometric variables were also measured as a confounder. The pulmonary function of participants was assessed by a forced spirometry test.Results: The correlation of BIA values including fat-free mass and total body water with a pulmonary function such as FEV1, FVC, and FEF25-75 is higher than most anthropometric values such as weight, wrist circumference, and the waist to hip ratio. Also, in regression analysis, age and sex had an association with pulmonary function, but the weight did not show a significant relationship. On the other hand, fat-free mass and visceral fat were significantly associated with pulmonary function. One is direct and the other is inverse.Conclusion: The hypothesis that the results of this study created in the minds of the authors were that; The direct association of fat-free mass with pulmonary function may be ineffective by the inverse association of visceral fat with pulmonary function, leading to a lack of association between weight and pulmonary function.

CFD Solution of a Two-Canopy Parachute in a Top-to-Top Formation With a Vent of Air From One of Its Canopy

2008 ◽  
Author(s):  
Mohammad J. Izadi
Keyword(s):  
Cross Sectional Area ◽  
The Body ◽  
The Other ◽  
Bluff Bodies ◽  
Variable Cross ◽  
Sectional Area ◽  
Cross Sectional ◽  
Drag Forces ◽  
Varied Form ◽  
Two Bodies

A CFD study of a 3 Dimensional flow field around two bodies (Two Canopies of a Parachutes) as two bluff bodies in an incompressible fluid (Air) is modeled here. Formations of these two bodies are top-to-top (One on the top of the other) with respect to the center of each other. One canopy with a constant cross sectional area with a vent of air at its apex, and the other with a variable cross sectional area with no vent is studied here. Vertical distances of these two bodies are varied form zero to half, equal, double and triple radius of the body with a vent on it. The flow condition is considered to be 3-D, unsteady, turbulent, and incompressible. The vertical distances between the bluff bodies, cross sectional area, and also vent ratio of bluff bodies are varied here. The drag forces with static pressures around the two bodies are calculated. From the numerical results, it can be seen that, the drag coefficient is constant on the range of zero to twenty percent of the vent ratio and it decreases for higher vent ratios for when the upper parachute is smaller than the lower one, and it increases for when the upper parachute is larger than the lower one. Both Steady and Unsteady cases gave similar results especially when the distance between the canopies is increased.

Association between body composition and pulmonary function tests among health care workers in Iran

2021 ◽  
Vol 17 ◽  
Author(s):  
Hamidreza Pouragha ◽  
Hosein Kazemi ◽  
Gholamreza Pouryaghoub ◽  
Ramin Mehrdad
Keyword(s):  
Body Composition ◽  
Lung Function ◽  
Pulmonary Function ◽  
Visceral Fat ◽  
Pulmonary Function Tests ◽  
The Body ◽  
Fat Free Mass ◽  
The Other ◽  
Cross Sectional ◽  
Function Tests

Background: Why is bodyweight not a predictor of lung function, while height, sex, race, and age are predictors of lung capacity and function? In this study, we want to investigate the association between body composition and pulmonary function. And, as much as possible, answer the question of why bodyweight is not predictive of lung function. Methods: This cross-sectional study was performed among 2967 employees of Tehran University of Medical Sciences (TUMS) who participated in the TUMS Employees Cohort (TEC) study. The body composition of the participants was measured using the Bioelectrical Impedance Analysis (BIA) method. Anthropometric variables were also measured as a confounder. The pulmonary function of participants was assessed by a forced spirometry test. Results: The correlation of BIA values including fat-free mass and total body water with a pulmonary function such as FEV1, FVC, and FEF25-75 is higher than most anthropometric values such as weight, wrist circumference, and the waist to hip ratio. Also, in regression analysis, age and sex had an association with pulmonary function, but the weight did not show a significant relationship. On the other hand, fat-free mass and visceral fat were significantly associated with pulmonary function. One is direct and the other is inverse. Conclusion: We observed a negative association between visceral fat and pulmonary function tests and a direct association between Fat-free mass pulmonary function tests (FEV1 and FVC) adjusted for age, sex, and anthropometric indices.

scholarly journals Chiropractic students in Denmark and their adherence to chiropractic conservatism: A cross-sectional study

2020 ◽  
Author(s):  
Casper Glissmann Nim ◽  
Henrik Hein Lauridsen ◽  
Søren O'Neill ◽  
Guillaume Goncalves ◽  
Rikke Krüger Jensen ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Private College ◽  
The Body ◽  
The Other ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Group 4 ◽  
The University ◽  
Chiropractic Students ◽  
Academic Year

Abstract Background The chiropractic profession is split between those practicing evidence-informed and those whose practice is honed by vitalism. The latter has been coined ‘chiropractic conservatism’. Concerningly, this behavior is also present in students, as a recent survey conducted on students from a European private chiropractic college showed that chiropractic conservatism was the norm. This was also present in two Australian university-based institutions not associated to a medial faculty. In Denmark, the chiropractic program is university-based and firmly embedded in a medical faculty. We were curious if the same levels of conservatism were present in this setup. The objectives of this study were to establish the level of conservatism in Danish chiropractic students, to investigate if this was linked to year of study, and to compare the results from previous studies on the university and non-university-based institutions. Methods A cross-sectional survey on 122 (73%) 3rd to 5th year chiropractic students attending the University of Southern Denmark was conducted. Information about the project was sent out on October 1st, 2019. Participants were provided with a questionnaire consisting of 10 items concerning chiropractic conservatism. All ten answers were dichotomized into appropriate/inappropriate and summed up. This score was used in a linear regression to determine the association with academic year of study. The level of conservatism was thereafter categorized into four groups (group 1 indicating low levels of conservatism and group 4 indicating high levels of conservatism). These results were compared systematically to those of the previous studies. Results In general, the Danish chiropractic students had low conservatism scores, and this decreased with increased year of study. Seventy percent of the students were placed in the two lowest conservative groups . The Danish students answered consistently, on 3 out of 5 items, with the other university-based programs, both agreeing that adjustments can make the body function at 100% and that they can improve the health of infants. An inverse relationship was observed with the private college, whose students were primarily placed in the highest conservatism group. Conclusions The Danish chiropractic students did not show the same level of conservatism as the private college, but were more comparable to the other university-based programs. Despite a favorable environment, some students were still linked with some conservative thinking, but this did decrease with increasing year of study.

scholarly journals Arthritis

2021 ◽  
pp. 149-168
Author(s):  
Andrew J. Grainger ◽  
Charles S. Resnik
Keyword(s):  
Correct Diagnosis ◽  
Clinical Information ◽  
The Body ◽  
Joint Disease ◽  
Joint Involvement ◽  
Imaging Features ◽  
Cross Sectional ◽  
Conventional Radiograph ◽  
Cross Sectional Imaging ◽  
Hands And Feet

AbstractImaging plays an important role in the diagnosis and management of joint disease. However, to accurately diagnose the underlying cause of a patient’s arthritis, consideration must be given to the clinical information available as well as to the imaging features of the disease. The pattern of joint involvement in each case is particularly important, with consideration of the number of joints involved, whether or not the joints are affected symmetrically on both sides of the body, and which specific joints are affected. In cases of peripheral arthritis involving the small joints of the hands and feet, the distribution of joint disease detected on the radiograph is often as important in making the correct diagnosis as the radiographic features of the disease.While cross-sectional imaging modalities have an important role to play, the conventional radiograph remains fundamental to the diagnosis of joint disease and is commonly the first imaging investigation undertaken.

scholarly journals ESTIMATED EXPOSURE OF SPINE SURGEONS TO RADIATION

2021 ◽  
Vol 20 (3) ◽  
pp. 181-184
Author(s):  
CARLOS ALEXANDRE BOTELHO DO AMARAL ◽  
RICARDO ALVES ANDRADE ◽  
PEDRO JOSÉ LABRONICI
Keyword(s):  
Prospective Study ◽  
Orthopedic Surgery ◽  
The Body ◽  
The Other ◽  
Cervical Region ◽  
Exposure Level ◽  
X Rays ◽  
Level Of Evidence ◽  
Lead Apron ◽  
Comparative Prospective Study

ABSTRACT Objective To estimate the amount of radiation received and accumulated in the bodies of two surgeons, one being the responsible surgeon and the other the assistant, performing spine surgery procedures over a period of 25 years. Methods Seventy-two spinal surgeries were performed during a seven-month period and the radiation loads were measured in both surgeons. The measurement of radiation was captured in fluoroscopy in anteroposterior and lateral incidences. The surgeon and the assistant used two dosimeters, one in the cervical region protecting the thyroid and the other on the lead apron in the genital region. The radioactive loads were measured in millisieverts and the accumulated charges were recorded monthly in both regions of the body in the two surgeons for seven months and the means for the work periods (1, 5, 10, 15, 20 and 25 years) were estimated. Results It was observed that in the surgeon the average accumulated radiation loads were 131.9% and 176.92% higher than those of the assistant in the cervical and genital regions, respectively. Conclusion While the use of X-rays is indispensable in routine orthopedic surgery, we have to consider the development of techniques of protection, rigor and discipline in the use of safety materials for surgeons. Preventive exposure reduction measures such as using thyroid protection equipment and turning the head away from the patient during fluoroscopy, among others, should be mandatory to promote less radiation exposure. Level of evidence II; Comparative prospective study.

scholarly journals A PECULIAR CONFIGURATION OF AGRANULAR RETICULUM (CANALICULATE LAMELLAR BODY) IN THE RAT PINEALOCYTE

1967 ◽  
Vol 33 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Huai-San Lin
Keyword(s):  
Lamellar Body ◽  
Cell Types ◽  
The Body ◽  
The Other ◽  
Annulate Lamellae ◽  
Lamellar Bodies ◽  
Cross Sectional ◽  
Cytoplasmic Structure ◽  
Hexagonal Arrangement ◽  
Flat Cisternae

A cytoplasmic structure exhibiting a peculiar configuration of agranular reticulum has been found in the rat pinealocyte, and has been designated a canaliculate lamellar body. It consists of a number of fenestrated, flat cisternae which are closely spaced. They bear some distant resemblance to the annulate lamellae previously reported in a variety of cell types. Profiles of stacks of lamellae in a plane of section always display two distinct aspects, the surface and the cross-sectional views of flat cisternae. A surface view shows the hexagonal arrangement of pores or fenestrations. The pores in successive lamellae are aligned precisely, one behind the other, so that clear, cylindrical channels are seen running perpendicular to the lamellae as indicated by transverse sections of the lamellar stacks. Large canaliculate lamellar bodies are composed of many extended series of lamellar stacks which pursue a tortuous course and cross one another. Occasionally the canaliculate lamellar body is located deep in a nuclear invagination, which reminds one of the so-called nuclear pellets (Kernkugeln) reported by light microscopy. The functional significance of the body is unknown.

X-ray micro tomography in the scanning electron microscope

1978 ◽  
Vol 36 (1) ◽  
pp. 106-107 ◽  
Author(s):  
W. Brünger
Keyword(s):  
Electron Beam ◽  
Electron Microscope ◽  
Scanning Electron Microscope ◽  
Target Surface ◽  
The Body ◽  
X Rays ◽  
Cross Sectional ◽  
X Ray ◽  
Micro Tomography ◽  
Scanning Electron

Reconstructive tomography is a new technique in diagnostic radiology for imaging cross-sectional planes of the human body /1/. A collimated beam of X-rays is scanned through a thin slice of the body and the transmitted intensity is recorded by a detector giving a linear shadow graph or projection (see fig. 1). Many of these projections at different angles are used to reconstruct the body-layer, usually with the aid of a computer. The picture element size of present tomographic scanners is approximately 1.1 mm2.Micro tomography can be realized using the very fine X-ray source generated by the focused electron beam of a scanning electron microscope (see fig. 2). The translation of the X-ray source is done by a line scan of the electron beam on a polished target surface /2/. Projections at different angles are produced by rotating the object.During the registration of a single scan the electron beam is deflected in one direction only, while both deflections are operating in the display tube.

Gender determination of caucasoid hair using image analysis

1993 ◽  
Vol 51 ◽  
pp. 216-217
Author(s):  
T.B. Ball ◽  
W.M. Hess
Keyword(s):  
Image Analysis ◽  
Cross Sections ◽  
Scalp Hair ◽  
The Body ◽  
Equivalent Diameter ◽  
Cross Sectional ◽  
Hair Samples ◽  
Length Width ◽  
Morphological Differences

It has been demonstrated that cross sections of bundles of hair can be effectively studied using image analysis. These studies can help to elucidate morphological differences of hair from one region of the body to another. The purpose of the present investigation was to use image analysis to determine whether morphological differences could be demonstrated between male and female human Caucasian terminal scalp hair.Hair samples were taken from the back of the head from 18 caucasoid males and 13 caucasoid females (Figs. 1-2). Bundles of 50 hairs were processed for cross-sectional examination and then analyzed using Prism Image Analysis software on a Macintosh llci computer. Twenty morphological parameters of size and shape were evaluated for each hair cross-section. The size parameters evaluated were area, convex area, perimeter, convex perimeter, length, breadth, fiber length, width, equivalent diameter, and inscribed radius. The shape parameters considered were formfactor, roundness, convexity, solidity, compactness, aspect ratio, elongation, curl, and fractal dimension.

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