Faculty Opinions recommendation of Effects of chronic coffee consumption on glucose kinetics in the conscious rat.

2007 ◽  
Author(s):  
Michael Clark
Keyword(s):  
Coffee Consumption ◽  
Glucose Kinetics ◽  
Conscious Rat

Effects of chronic coffee consumption on glucose kinetics in the conscious rat

2007 ◽  
Vol 85 (8) ◽  
pp. 823-830 ◽  
Author(s):  
J. Shearer ◽  
E.A. Sellars ◽  
A. Farah ◽  
T.E. Graham ◽  
D.H. Wasserman
Keyword(s):  
Coffee Consumption ◽  
Epidemiological Studies ◽  
Whole Body ◽  
Metabolic Clearance ◽  
Sprague Dawley ◽  
Glucose Kinetics ◽  
Conscious Rat ◽  
Beneficial Effects ◽  
Decaffeinated Coffee

Epidemiological studies indicate that regular coffee consumption reduces the risk of developing type 2 diabetes. Despite these findings, the biological mechanisms by which coffee consumption exerts these effects are unknown. The aim of this study was twofold: to develop a rat model that would further delineate the effects of regular coffee consumption on glucose kinetics, and to determine whether coffee, with or without caffeine, alters the actions of insulin on glucose kinetics in vivo. Male Sprague–Dawley rats were fed a high-fat diet for 4 weeks in combination with one of the following: (i) drinking water as placebo (PL), (ii) decaffeinated coffee (2 g/100 mL) (DC), or (iii) alkaloid caffeine (20 mg/100 mL) added to decaffeinated coffee (2 g/100 mL) (CAF). Catheters were chronically implanted in a carotid artery and jugular vein for sampling and infusions, respectively. Recovered animals (5 days postoperative) were fasted for 5 h before hyperinsulinemic-euglycemic clamps (2 mU·kg–1·min–1). Glucose was clamped at 6 mmol/L and isotopes (2-deoxy-[14C]glucose and [3-3H]glucose) were administered to obtain indices of whole-body and tissue-specific glucose kinetics. Glucose infusion rates and measures of whole-body metabolic clearance were greater in DC than in PL or CAF, indicating increased whole-body insulin sensitivity. As the only difference between DC and CAF was the addition of alkaloid caffeine, it can be concluded that caffeine antagonizes the beneficial effects of DC. Given these findings, decaffeinated coffee may represent a nutritional means of combating insulin resistance.

Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
G Wiltberger ◽  
U Lange ◽  
H Hau ◽  
D Seehofer ◽  
F Krenzien ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Coffee Consumption ◽  
Protective Effects

scholarly journals Coffee consumption and risk of renal cell carcinoma in the NIH-AARP Diet and Health Study

2021 ◽  
Author(s):  
Jongeun Rhee ◽  
Erikka Loftfield ◽  
Neal D Freedman ◽  
Linda M Liao ◽  
Rashmi Sinha ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cox Regression ◽  
Coffee Consumption ◽  
Health Study ◽  
Coffee Intake ◽  
Decaffeinated Coffee ◽  
Incident Cases ◽  
Reduced Risk

Abstract Background Coffee consumption has been associated with a reduced risk of some cancers, but the evidence for renal cell carcinoma (RCC) is inconclusive. We investigated the relationship between coffee and RCC within a large cohort. Methods Coffee intake was assessed at baseline in the National Institutes of Health–American Association of Retired Persons Diet and Health Study. Among 420 118 participants eligible for analysis, 2674 incident cases were identified. We fitted Cox-regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for coffee consumption vs non-drinkers. Results We observed HRs of 0.94 (95% CI 0.81, 1.09), 0.94 (0.81, 1.09), 0.80 (0.70, 0.92) and 0.77 (0.66, 0.90) for usual coffee intake of <1, 1, 2–3 and ≥4 cups/day, respectively (Ptrend = 0.00003). This relationship was observed among never-smokers (≥4 cups/day: HR 0.62, 95% CI 0.46, 0.83; Ptrend = 0.000003) but not ever-smokers (HR 0.85, 95% CI 0.70, 1.05; Ptrend = 0.35; Pinteraction = 0.0009) and remained in analyses restricted to cases diagnosed >10 years after baseline (HR 0.65, 95% CI 0.51, 0.82; Ptrend = 0.0005). Associations were similar between subgroups who drank predominately caffeinated or decaffeinated coffee (Pinteraction = 0.74). Conclusion In this investigation of coffee and RCC, to our knowledge the largest to date, we observed a 20% reduced risk for intake of ≥2 cups/day vs not drinking. Our findings add RCC to the growing list of cancers for which coffee consumption may be protective.

scholarly journals Evaluating Conscious Consumption: A Discussion of a Survey Development Process

2021 ◽  
Vol 13 (6) ◽  
pp. 3339
Author(s):  
Madhavi Venkatesan ◽  
Fenner Dreyfuss-Wells ◽  
Anjali Nair ◽  
Astrid Pedersen ◽  
Vishnu Prasad
Keyword(s):  
Literature Review ◽  
Development Process ◽  
Coffee Consumption ◽  
Consumer Good ◽  
Survey Instrument ◽  
Survey Development ◽  
Behavioral Bias ◽  
Survey Results ◽  
Single Use ◽  
Questions And Responses

This paper is the outcome of a course project for Economics of Sustainability (Northeastern University, Boston, Massachusetts). Facilitated and under the direction of the instructor, course participants designed a survey instrument where questions and responses were developed to be indicators of behavioral bias related to the environment. The consumer good targeted in the survey was convenience-based coffee consumption, and convenience was defined by the use of single-use disposable coffee cups. The discussion highlights the survey development process including literature review-based expectations specific to each question. The paper concludes with next steps, which involve the administration of the instrument and evaluation of the survey results.

Tea and coffee consumption and the risk of urinary stones—a systematic review of the epidemiological data

2021 ◽  
Author(s):  
Yazeed Barghouthy ◽  
Mariela Corrales ◽  
Steeve Doizi ◽  
Bhaskar K. Somani ◽  
Olivier Traxer
Keyword(s):  
Systematic Review ◽  
Coffee Consumption ◽  
Epidemiological Data ◽  
Urinary Stones

scholarly journals Early lactate and glucose kinetics following return to spontaneous circulation after out-of-hospital cardiac arrest

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Pedro Freire Jorge ◽  
Rohan Boer ◽  
Rene A. Posma ◽  
Katharina C. Harms ◽  
Bart Hiemstra ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Physiological Stress ◽  
Spontaneous Circulation ◽  
Strenuous Exercise ◽  
Rapid Rate ◽  
Glucose Kinetics ◽  
Initial Value ◽  
Extreme Stress ◽  
Arterial Ph ◽  
Hospital Cardiac Arrest

Abstract Objective Lactate has been shown to be preferentially metabolized in comparison to glucose after physiological stress, such as strenuous exercise. Derangements of lactate and glucose are common after out-of-hospital cardiac arrest (OHCA). Therefore, we hypothesized that lactate decreases faster than glucose after return-to-spontaneous-circulation (ROSC) after OHCA. Results We included 155 OHCA patients in our analysis. Within the first 8 h of presentation to the emergency department, 843 lactates and 1019 glucoses were available, respectively. Lactate decreased to 50% of its initial value within 1.5 h (95% CI [0.2–3.6 h]), while glucose halved within 5.6 h (95% CI [5.4–5.7 h]). Also, in the first 8 h after presentation lactate decreases more than glucose in relation to their initial values (lactate 72.6% vs glucose 52.1%). In patients with marked hyperlactatemia after OHCA, lactate decreased expediently while glucose recovered more slowly, whereas arterial pH recovered at a similar rapid rate as lactate. Hospital non-survivors (N = 82) had a slower recovery of lactate (P = 0.002) than survivors (N = 82). The preferential clearance of lactate underscores its role as a prime energy substrate, when available, during recovery from extreme stress.

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