Faculty Opinions recommendation of Lung function decline and outcomes in an adult population.

Primary ciliary dyskinesia (PCD) in adults has not been well described. In this retrospective observational study we aimed to characterise a large adult population and identify features associated with disease progression.We retrospectively analysed 151 adult patients at a single tertiary centre at baseline and longitudinally for a median of 7 years.We found significant variation in age at diagnosis (median 23.5 years; range <1–72 years). Older age at diagnosis was associated with impaired baseline forced expiratory volume in 1 s (FEV1) (r= −0.30, p=0.01) and increased Pseudomonas aeruginosa colonisation (difference in medians 17 years (95% CI 4.5–20 years); p=0.002). Lung function decline was estimated at FEV1 decline of 0.49% predicted per year. Lung function decline was associated with ciliary ultrastructure, with microtubular defect patients having the greatest decline (p=0.04). High-resolution computed tomography (HRCT) scores of severity of bronchial wall dilatation (p<0.001) and extent of bronchiectasis (p=0.03) additionally showed evidence of modifying FEV1 decline with age.Our study reveals that a large proportion of adult PCD patients are diagnosed late, with impaired FEV1 and increased P. aeruginosa colonisation. Increased disease burden on HRCT and ciliary ultrastructure may predict progressive lung function decline. This study characterises a large adult PCD population, identifies features associated with disease progression and highlights the need for prospective trials to determine whether early diagnosis of high-risk subgroups alongside optimal management can modify disease progression.

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Lung Function Decline and Outcomes in an Adult Population

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/rccm.200508-1344oc ◽

2006 ◽

Vol 173 (9) ◽

pp. 985-990 ◽

Cited By ~ 73

Author(s):

David M. Mannino ◽

Matthew M. Reichert ◽

Kourtney J. Davis

Keyword(s):

Lung Function ◽

Adult Population ◽

Lung Function Decline

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The impact of birth weight on the level of lung function and lung function decline in the general adult population. The Inter99 study

Respiratory Medicine ◽

10.1016/j.rmed.2015.08.011 ◽

2015 ◽

Vol 109 (10) ◽

pp. 1293-1299 ◽

Cited By ~ 14

Author(s):

Sophie Baumann ◽

Nina Skavlan Godtfredsen ◽

Peter Lange ◽

Charlotta Pisinger

Keyword(s):

Birth Weight ◽

Lung Function ◽

Adult Population ◽

Lung Function Decline ◽

General Adult Population ◽

The Impact

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Faculty Opinions recommendation of Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717986716.793472285 ◽

2013 ◽

Author(s):

Craig Hersh

Keyword(s):

Lung Function ◽

Lung Function Decline ◽

Genome Wide ◽

Genome Wide Study

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RISK FACTORS OF INCREASING LUNG FUNCTION DECLINE IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A REAL-WORLD ANALYSIS

Respirology ◽

10.1111/resp.13207_425 ◽

2017 ◽

Vol 22 ◽

pp. 248-248

Keyword(s):

Risk Factors ◽

Chronic Obstructive Pulmonary Disease ◽

Lung Function ◽

Pulmonary Disease ◽

Real World ◽

Chronic Obstructive ◽

Lung Function Decline ◽

Obstructive Pulmonary Disease

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Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis

Respiratory Research ◽

10.1186/s12931-020-01590-y ◽

2021 ◽

Vol 22 (1) ◽

Cited By ~ 2

Author(s):

D. J. Leeming ◽

F. Genovese ◽

J. M. B. Sand ◽

D. G. K. Rasmussen ◽

C. Christiansen ◽

...

Keyword(s):

Quality Of Life ◽

Extracellular Matrix ◽

Wound Healing ◽

Lung Function ◽

Pulmonary Fibrosis ◽

Interstitial Lung Diseases ◽

Lessons Learned ◽

Lung Function Decline ◽

Tissue Remodelling

AbstractPulmonary fibrosis has been identified as a main factor leading to pulmonary dysfunction and poor quality of life in post-recovery Severe Acute Respiratory Syndrome (SARS) survivor’s consequent to SARS-Cov-2 infection. Thus there is an urgent medical need for identification of readily available biomarkers that in patients with SARS-Cov-2 infection are able to; (1) identify patients in most need of medical care prior to admittance to an intensive care unit (ICU), and; (2) identify patients post-infection at risk of developing persistent fibrosis of lungs with subsequent impaired quality of life and increased morbidity and mortality. An intense amount of research have focused on wound healing and Extracellular Matrix (ECM) remodelling of the lungs related to lung function decline in pulmonary fibrosis (PF). A range of non-invasive serological biomarkers, reflecting tissue remodelling, and fibrosis have been shown to predict risk of acute exacerbations, lung function decline and mortality in PF and other interstitial lung diseases (Sand et al. in Respir Res 19:82, 2018). We suggest that lessons learned from such PF studies of the pathological processes leading to lung function decline could be used to better identify patients infected with SARS-Co-V2 at most risk of acute deterioration or persistent fibrotic damage of the lung and could consequently be used to guide treatment decisions.

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Lung function decline is associated with serum uric acid in Korean health screening individuals

Scientific Reports ◽

10.1038/s41598-021-89678-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Kyung-Min Ahn ◽

Suh-Young Lee ◽

So-Hee Lee ◽

Sun-Sin Kim ◽

Heung-Woo Park

Keyword(s):

Uric Acid ◽

Lung Function ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Forced Expiratory Volume ◽

Linear Regression Models ◽

Lung Function Decline ◽

Health Screenings

AbstractWe performed a retrospective cohort study of 19,237 individuals who underwent at least three health screenings with follow-up periods of over 5 years to find a routinely checked serum marker that predicts lung function decline. Using linear regression models to analyze associations between the rate of decline in the forced expiratory volume in 1 s (FEV1) and the level of 10 serum markers (calcium, phosphorus, uric acid, total cholesterol, total protein, total bilirubin, alkaline phosphatase, aspartate aminotransferase, creatinine, and C-reactive protein) measured at two different times (at the first and third health screenings), we found that an increased uric acid level was significantly associated with an accelerated FEV1 decline (P = 0.0014 and P = 0.037, respectively) and reduced FEV1 predicted % (P = 0.0074 and P = 8.64 × 10–7, respectively) at both visits only in non-smoking individuals. In addition, we confirmed that accelerated forced vital capacity (FVC) and FEV1/FVC ratio declines were observed in non-smoking individuals with increased serum uric acid levels using linear mixed models. The serum uric acid level thus potentially predicts an acceleration in lung function decline in a non-smoking general population.

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