Faculty Opinions recommendation of Associations of BMI and adipose tissue area and density with incident mobility limitation and poor performance in older adults.

Author(s):  
Mikael Fogelholm
2014 ◽  
Vol 99 (5) ◽  
pp. 1059-1065 ◽  
Author(s):  
Rachel A Murphy ◽  
Ilse Reinders ◽  
Thomas C Register ◽  
Hilsa N Ayonayon ◽  
Anne B Newman ◽  
...  

2009 ◽  
Vol 169 (12) ◽  
pp. 1507-1516 ◽  
Author(s):  
T. M. Manini ◽  
J. E. Everhart ◽  
K. V. Patel ◽  
D. A. Schoeller ◽  
S. Cummings ◽  
...  

2020 ◽  
pp. 1-5
Author(s):  
O. Addison

Background: High levels of intramuscular adipose tissue and low levels of capillarization are both predicative of low muscle and mobility function in older adults, however little is known about their relationship. Objectives: The purpose of this study was to examine the relationship of intramuscular adipose tissue and capillarization in older adults. Setting: An outpatient medical center. Participants: Forty-seven sedentary adults (age 59.9 ± 1.0 years, BMI 32.0 ± 0.7 kg/m2, VO2max 22.4 ± 0.7 ml/kg/min); Measurements: All participants underwent CT scans to determine intramuscular adipose tissue and muscle biopsies to determine capillarization in the mid-thigh. A step-wise hierarchical linear regression analysis was used to examine the contributions of age, sex, race, body mass index, 2-hour postprandial glucose, VO2max, and muscle capillarization, to the variability in intramuscular adipose tissue. Results: The predictors as a group accounted for 38.1% of the variance in intramuscular adipose tissue, with body mass index and capillarization each significantly contributing to the final model (P<0.001). The part correlation of body mass index with intramuscular adipose tissue was r = 0.47, and the part correlation of capillarization with intramuscular adipose tissue was r = 0.39, indicating that body mass index and capillarization explained 22.1%, and 15.2% of the variance in intramuscular adipose tissue. Conclusions: While increased muscle capillarization is typically thought of as a positive development, in some clinical conditions, such as tendinopathies, an increase in capillarization is part of the pathological process related to expansion of the extracellular matrix and fibrosis. This may also be an explanation for the surprising finding that high capillarization is related to high levels of intramuscular adipose tissue. Future studies are necessary to determine the relationship of changes in both capillarization and intramuscular adipose tissue after interventions, such as exercise.


Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Jung H Lee ◽  
Hyeon C Kim ◽  
Jee-Seon Shim ◽  
Myung H Lee ◽  
Bo M Song ◽  
...  

Introduction: Several studies have examined the association between adipose tissue distribution and atherosclerosis. However, the effect of smoking on this association has not been evaluated yet. Hypothesis: We assessed the hypothesis that there is positive association between the ratio of visceral and subcutaneous adipose tissue areas and carotid intima media thickness (CIMT), and the association can be modified according to gender and smoking status in South Korea. Methods: A total of 1,606 middle-aged participants without cardiovascular disease were enrolled in this cross-sectional study from 2013 to 2015 in South Korea (568 men; 1,038 women). The CIMT of study participants was measured using B-mode ultrasonography at distal right common carotid artery, based on a predetermined protocol. We measured the abdominal adipose tissue distribution of study participants using computerized tomography. The area of adipose tissue at L4 vertebrae level was calculated, and the area of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were separated by abdominal wall. Then, we calculated the ratio of VAT and SAT (VAT/SAT) area. Other major cardiovascular risk factors were measured by standardized questionnaire, physical exam and fasting blood analysis. Smoking status of study participants was classified into three groups: current, former and never smokers. For evaluating the association between adipose tissue area and CIMT, we used multiple linear regressions. Separated analyses based on gender and smoking status were also performed. Results: Mean CIMT of study participants was 0.62 mm (SD, 0.12 mm), and mean VAF/SAF ratio of study participants was 0.62 (SD, 0.29). The prevalence of current smoker was 36.8% (209 of 568) for men, and 4.1% (42 of 1038) for women. In our multiple linear regression models, the VAT/SAT ratio showed statistically significant positive β-coefficient for total participants (β =8.62, p=0.008): showing significant for men (β =15.95, p=0.001) and not for women (β =3.15, p=0.377). When considering men only with respect to smoking status, the association between VAT/SAT ratio and CIMT was significant for current smokers (β=30.37, p<0.001), while it was not for never smokers (β=0.62, p=0.958) and former smokers (β=12.84, p=0.119). There was no significant interaction for gender and also for smoking status for men (p for interaction>0.05). Conclusions: In conclusion, the VAT/SAT ratio was positively associated with CIMT, and more preeminent positive association was observed for current men smokers than for never and former men smokers. The results of this study supported the need of smoking cessation to prevent atherosclerosis by adipose tissue distribution, especially for men.


2019 ◽  
Vol 48 (Supplement_3) ◽  
pp. iii1-iii16
Author(s):  
John Barton ◽  
Suzanne Timmons ◽  
Salvatore Tedesco ◽  
Marco Sica ◽  
Colum Crowe ◽  
...  

Abstract Background Wrist-worn activity trackers have experienced a tremendous growth lately. Robust studies of the comparative accuracy of currently available, mainstream trackers, in young adults versus older adults are still scarce in literature. This study explores the performance of ten trackers estimating steps, travelled distance, and heart-rate measurements against gold-standards in two cohorts of young and old adults. Methods Overall, 38 subjects completed a structured protocol involving walking tasks, simulated household activities, and sedentary activities, including less standardised activities, such as dusting, vacuuming, or playing cards, in order to simulate real-life scenarios. Both wrist-mounted and chest/waist-mounted devices were considered. Gold-standards included treadmill, waist-mounted pedometer, ECG-based chest strap, direct observation or video recording according to the activity and parameter. Results Every tracker shows a decreasing accuracy with slower walking speed, which resulted in a significant step under-counting. Large mean absolute percentage error (MAPE) was displayed by every monitor at slower walking speeds. During household activities, the MAPE in young adults climbing up/down-stairs ranged from 3.91-11.41% and 4.34-11.92% (dominant and non-dominant arm), respectively. However, for the same activities older adults displayed a larger MAPE, at 8.38-19.3% and 10.06-19.01%, respectively. Chest-worn or waist-worn devices had more uniform performance. However, unstructured activities (dusting, vacuuming, playing cards), and accuracy in people using a walking aid represent a challenge for all consumer-level trackers as evidenced by large MAPE. Poor performance in travelled distance estimation was also evident during walking at low speeds and household activities for both cohorts. Conclusion This study shows a number of limitations to current, mainstream consumer-level wrist-based activity trackers, requiring caution if adopted in healthcare, whether clinical or research. This study demonstrates the particular deficits in commercial devices for use in an aging population, and provides some indications on how to best measure these health parameters in this population.


Obesity ◽  
2007 ◽  
Vol 15 (12) ◽  
pp. 3122-3132 ◽  
Author(s):  
Annemarie Koster ◽  
Brenda W. J. H. Penninx ◽  
Anne B. Newman ◽  
Marjolein Visser ◽  
Coen H. van Gool ◽  
...  

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