Faculty Opinions recommendation of Monosomes actively translate synaptic mRNAs in neuronal processes.

2020 ◽  
Author(s):  
Utz Fischer
Keyword(s):  
Neuronal Processes

MicroVolt Variations of The Human Brain (Quantitative Electroencephalography) Display Differential Torque Effects During West-East versus North-South Orientation in the Geomagnetic Field

2016 ◽  
Vol 12 (2) ◽  
pp. 4255-4259
Author(s):  
Michael A Persinger ◽  
David A Vares ◽  
Paula L Corradini
Keyword(s):  
Human Brain ◽  
Geomagnetic Field ◽  
Neuronal Cell ◽  
Single Subject ◽  
Additional Energy ◽  
Actual Measurement ◽  
Neuronal Processes ◽  
Basic Physics ◽  
Order Of Magnitude ◽  
The Moment

                The human brain was assumed to be an elliptical electric dipole. Repeated quantitative electroencephalographic measurements over several weeks were completed for a single subject who sat in either a magnetic eastward or magnetic southward direction. The predicted potential difference equivalence for the torque while facing perpendicular (west-to-east) to the northward component of the geomagnetic field (relative to facing south) was 4 μV. The actual measurement was 10 μV. The oscillation frequency around the central equilibrium based upon the summed units of neuronal processes within the cerebral cortices for the moment of inertia was 1 to 2 ms which are the boundaries for the action potential of axons and the latencies for diffusion of neurotransmitters. The calculated additional energy available to each neuron within the human cerebrum during the torque condition was ~10-20 J which is the same order of magnitude as the energy associated with action potentials, resting membrane potentials, and ligand-receptor binding. It is also the basic energy at the level of the neuronal cell membrane that originates from gravitational forces upon a single cell and the local expression of the uniaxial magnetic anisotropic constant for ferritin which occurs in the brain. These results indicate that the more complex electrophysiological functions that are strongly correlated with cognitive and related human properties can be described by basic physics and may respond to specific geomagnetic spatial orientation.

Action and the Problem of Free Will

2017 ◽  
Author(s):  
Shaun Gallagher
Keyword(s):  
Motor Control ◽  
Free Will ◽  
Social Contexts ◽  
Conscious Awareness ◽  
Pure Consciousness ◽  
Control Processes ◽  
Traditional Notion ◽  
Intentional Actions ◽  
Neuronal Processes

This chapter examines the concept of free will as it is discussed in philosophy and neuroscience. It reviews reflective and perceptual theories of agency and argues against neuro-centric conclusions about the illusory nature of free will. Experiments conducted by Benjamin Libet suggest that neural activations prior to conscious awareness predict specific actions. This has been taken as evidence that challenges the traditional notion of free will. Libet’s experiments, arguably, are about motor control processes on an elementary timescale and say nothing about freely willed intentional actions embedded in personal and social contexts that involve longer-term, narrative timescales. One implication of this interpretation is that enactivism is not a form of simple behaviorism. Agency is not a thing reducible to elementary neuronal processes; nor is it an idea or a pure consciousness. It rather involves a structure of complex relations.

scholarly journals Systematic Underreproduction of Time Is Independent of Judgment Certainty

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Martin Riemer ◽  
Darren Rhodes ◽  
Thomas Wolbers
Keyword(s):  
Magnetic Stimulation ◽  
Posterior Parietal Cortex ◽  
Judgment Bias ◽  
Time Discrimination ◽  
Temporal Intervals ◽  
Neuronal Processes ◽  
Posterior Parietal ◽  
Temporal Stimuli ◽  
The Right ◽  
Temporal Judgments

We recently proposed that systematic underreproduction of time is caused by a general judgment bias towards earlier responses, instead of reflecting a genuine misperception of temporal intervals. Here we tested whether this bias can be explained by the uncertainty associated with temporal judgments. We applied transcranial magnetic stimulation (TMS) to inhibit neuronal processes in the right posterior parietal cortex (PPC) and tested its effects on time discrimination and reproduction tasks. The results show increased certainty for discriminative time judgments after PPC inhibition. They suggest that the right PPC plays an inhibitory role for time perception, possibly by mediating the multisensory integration between temporal stimuli and other quantities. Importantly, this increased judgment certainty had no influence on the degree of temporal underreproduction. We conclude that the systematic underreproduction of time is not caused by uncertainty for temporal judgments.

scholarly journals Sublethal Exposure Effects of the Neonicotinoid Clothianidin Strongly Modify the Brain Transcriptome and Proteome in the Male Moth Agrotis ipsilon

Insects ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 152
Author(s):  
Camille Meslin ◽  
Françoise Bozzolan ◽  
Virginie Braman ◽  
Solenne Chardonnet ◽  
Cédric Pionneau ◽  
...  
Keyword(s):  
Sex Pheromone ◽  
Molecular Mechanisms ◽  
Insect Pest ◽  
Agrotis Ipsilon ◽  
Positive Effects ◽  
Male Moth ◽  
Hormetic Effect ◽  
Pest Insects ◽  
Neuronal Processes ◽  
The Brain

Insect pest management relies mainly on neurotoxic insecticides, including neonicotinoids such as clothianidin. The residual accumulation of low concentrations of these insecticides can have positive effects on target pest insects by enhancing various life traits. Because pest insects often rely on sex pheromones for reproduction and olfactory synaptic transmission is cholinergic, neonicotinoid residues could indeed modify chemical communication. We recently showed that treatments with low doses of clothianidin could induce hormetic effects on behavioral and neuronal sex pheromone responses in the male moth, Agrotis ipsilon. In this study, we used high-throughput RNAseq and proteomic analyses from brains of A. ipsilon males that were intoxicated with a low dose of clothianidin to investigate the molecular mechanisms leading to the observed hormetic effect. Our results showed that clothianidin induced significant changes in transcript levels and protein quantity in the brain of treated moths: 1229 genes and 49 proteins were differentially expressed upon clothianidin exposure. In particular, our analyses highlighted a regulation in numerous enzymes as a possible detoxification response to the insecticide and also numerous changes in neuronal processes, which could act as a form of acclimatization to the insecticide-contaminated environment, both leading to enhanced neuronal and behavioral responses to sex pheromone.

scholarly journals Anatomical organization of the lateral cervical nucleus in Artiodactyls

2021 ◽  
Author(s):  
Annamaria Grandis ◽  
Anna Gardini ◽  
Claudio Tagliavia ◽  
Giulia Salamanca ◽  
Jean-Marie Graïc ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Synaptic Activity ◽  
Immunoperoxidase Method ◽  
Somatosensory Information ◽  
Lateral Cervical Nucleus ◽  
Neuronal Processes ◽  
Calbindin D28k ◽  
Oxide Synthase

AbstractThe presence of the lateral cervical nucleus (LCN) in different mammals, including humans, has been established in a number of anatomical research works. The LCN receives its afferent inputs from the spinocervical tract, and conveys this somatosensory information to the various brain areas, especially the thalamus. In the present study, the organization of the calf and pig LCN was examined through the use of thionine staining and immunohistochemical methods combined with morphometrical analyses. Specifically, the localization of calbindin-D28k (CB-D28k) and neuronal nitric oxide synthase (nNOS) in the LCN was investigated using the immunoperoxidase method. Calf and pig LCN appear as a clearly defined column of gray matter located in the three cranial segments of the cervical spinal cord. Thionine staining shows that polygonal neurons represent the main cell type in both species. The calf and pig LCN contained CB-D28k-immunoreactive (IR) neurons of varying sizes. Large neurons are probably involved in the generation of the cervicothalamic pathway. Small CB-D28k-IR neurons, on the other hand, could act as local interneurons. The immunoreactivity for nNOS was found to be mainly located in thin neuronal processes that could represent the terminal axonal portion of nNOS-IR found in laminae III e IV. This evidence suggests that nitric oxide (NO) could modulate the synaptic activity of the glutamatergic spinocervical tracts. These findings suggest that the LCN of Artiodactyls might play an important role in the transmission of somatosensory information from the spinal cord to the higher centers of the brain.

A novel technique for micro-dissection of neuronal processes

2000 ◽  
Vol 98 (2) ◽  
pp. 119-122 ◽  
Author(s):  
Eilon D. Kirson ◽  
Yoel Yaari
Keyword(s):  
Novel Technique ◽  
Neuronal Processes

The role of exploratory mechanisms in evolution

1995 ◽  
Vol 349 (1329) ◽  
pp. 297-297
Keyword(s):  
Dynamic Instability ◽  
Specific Mechanism ◽  
Cellular Mechanisms ◽  
Selection Processes ◽  
Wide Range ◽  
Rapid Changes ◽  
Neuronal Processes ◽  
History Of ◽  
Variation And Selection

Many cellular mechanisms use a process of variation and selection to generate specific patterns. Among these, dynamic instability of microtubules has been shown to employ a specific mechanism to intentionally generate variation. In many systems the growth of neurons or neuronal processes is excessive, the final connections being established by stabilization of functional interactions. When changes in neuronal networks take place, such as in metamorphosis, use is made of the plasticity of neuronal connectivity. In the immune system, specific responses are generated by variation and selection. Processes that explore a wide range of conditions and a wide range of structures can be called exploratory processes. These are very robust and capable of responding to damage, variability in the environment and ontogenic changes in the organisms. Such robustness would be useful for adapting to changes that occur during phylogenetic changes as well. Given the extensive history of extinction and radiation in evolution, it may be supposed that these mechanisms have themselves been selected for their capacity to survive rapid changes in the organism and for their ability to generate cellular variation.

Pitch related to spectral edges of broadband signals

1992 ◽  
Vol 336 (1278) ◽  
pp. 375-382 ◽  
Keyword(s):  
Fundamental Frequency ◽  
Basilar Membrane ◽  
Comparison Tone ◽  
Harmonic Signals ◽  
Wide Range ◽  
Spectral Components ◽  
Neuronal Processes ◽  
Low Pass ◽  
Harmonic Components ◽  
Hearing System

A complex tone often evokes a pitch sensation associated with its extreme spectral components, besides the holistic pitch associated with its fundamental frequency. We studied the edge pitch created at the upper spectral edge of complexes with a low-pass spectrum by asking subjects to adjust the frequency of a sinusoidal comparison tone to the perceived pitch. Measurements were performed for different values of the fundamental frequency and of the upper frequency of the complex as well as for three different phase relations of the harmonic components. For a wide range of these parameters the subjects could adjust the comparison tone with a high accuracy, measured as the standard deviation of repeated adjustments, to a frequency close to the nominal edge frequency. The detailed dependence of the matching accuracy on temporal parameters of the harmonic complexes suggests that the perception of the edge pitch in harmonic signals is related to the temporal resolution of the hearing system. This resolution depends primarily on the time constants of basilar-membrane filters and on additional limitations due to neuronal processes.

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