scholarly journals TN HYDROGELS AS A POTENTIAL ANTI-INFLAMMATORY DRUG DELIVERY SYSTEM TARGETED TO OSTEOARTHRITIC KNEES

2021 ◽  
Vol 57 (2) ◽  
pp. 74-85
Author(s):  
Katlynn Bussett ◽  
◽  
Katherine Goebel ◽  
Victoria Lee ◽  
Lindsey Alumbaugh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cyclic Loading ◽  
Drug Delivery System ◽  
Motion Capture ◽  
Delivery System ◽  
Force Plate ◽  
The United States ◽  
Antiinflammatory Drug ◽  
Human Knee ◽  
Human Knee Joint

Arthritis affects 26.3% of adults and approximately 50,000 children in the United States [1]. Hydrogel drug-delivery systems have been considered as a viable option for drug delivery to arthritic articular cartilage in the knee. To determine physiologically relevant loading, a Qualisys motion capture system was used to analyze the gait of college-aged females as they took several steps on a flat surface, then stepped onto a force plate. The motion capture and force plate data was used to determine maximum force exerted on the knee during normal gait. Three different alginate-based hydrogels, where the superior one had a triple interpenetrating graphene oxide network (TN hydrogels), were investigated for use as an antiinflammatory drug delivery system in a human knee joint. Physiologically relevant cyclic loading was performed to ensure that the TN hydrogel could withstand the force exerted in the knee. The TN hydrogel experienced a change in energy of 50% after cyclic loading (10.6 ± 15.0 Pa) and survived high stresses of 4 kPa, which is 80 magnitudes larger than observable gait forces as measured in this study. From a mechanical perspective, TN hydrogel appears to be mechanically viable for arthritis drug delivery. In addition, based on calculations and Flory-Rehner equations, the pore size of the TN hydrogel is adequate for encapsulating most NSAIDs, which have a molecule size ≤ 5μm.

scholarly journals Sustained drug delivery system in fish and the potential for use of PLGA microparticles: a review

2019 ◽  
Vol 64 (No. 7) ◽  
pp. 287-293
Author(s):  
J Matejkova ◽  
P Podhorec
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hormonal Treatment ◽  
The United States ◽  
Pharmaceutical Products ◽  
European Medicines Agency ◽  
Sustained Drug Delivery ◽  
Plga Microparticles

Many fish species display some form of reproductive disorder in captivity. Captive fish reared in conditions outside the natural spawning environment show a failure of the pituitary to release the maturational gonadotropin luteinizing hormone thus necessitating administration of the hormone to induce spawning. A controlled sustained-release delivery system can conquer the issue of short half-life of gonadotropin releasing hormone (GnRH) in blood and avoid the necessity of using re-injections. Sustained release of GnRHa can induce long-term enhancement in semen production and multiple spawning in species with asynchronous or multiple batch group synchronous ovarian physiology. The most recent development is the incorporation of GnRHa into microparticles of biodegradable polymers that release the drug during a certain period of time ranging from days to weeks. The most attractive polymeric candidate used as a carrier for administering a pharmaceutical products is poly(lactic-co-glycolic acid); (PLGA). PLGA has excellent biodegradability and biocompatibility and is generally recognised as safe by international regulatory agencies including the European Medicines Agency and the United States Food and Drug Administration. This review describes methods of hormonal treatment in fish, highlights the advantage of sustained drug delivery system and discusses the potential of PLGA microparticles as a tool for achieving successful reproduction.

Hexosomes based on cholesterol and phosphatidylcholine: a new drug delivery system for curcumin release

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug

Development and Evaluation of Floating Pulsatile Drug Delivery System Using Meloxicam

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
ShirishaG. Suddala ◽  
S. K. Sahoo ◽  
M. R. Yamsani
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lag Time ◽  
Oral Dosage ◽  
Lag Phase ◽  
Pulsatile Drug Delivery

Objective: The objective of this research work was to develop and evaluate the floating– pulsatile drug delivery system (FPDDS) of meloxicam intended for Chrono pharmacotherapy of rheumatoid arthritis. Methods: The system consisting of drug containing core, coated with hydrophilic erodible polymer, which is responsible for a lag phase for pulsatile release, top cover buoyant layer was prepared with HPMC K4M and sodium bicarbonate, provides buoyancy to increase retention of the oral dosage form in the stomach. Meloxicam is a COX-2 inhibitor used to treat joint diseases such as osteoarthritis and rheumatoid arthritis. For rheumatoid arthritis Chrono pharmacotherapy has been recommended to ensure that the highest blood levels of the drug coincide with peak pain and stiffness. Result and discussion: The prepared tablets were characterized and found to exhibit satisfactory physico-chemical characteristics. Hence, the main objective of present work is to formulate FPDDS of meloxicam in order to achieve drug release after pre-determined lag phase. Developed formulations were evaluated for in vitro drug release studies, water uptake and erosion studies, floating behaviour and in vivo radiology studies. Results showed that a certain lag time before drug release which was due to the erosion of the hydrophilic erodible polymer. The lag time clearly depends on the type and amount of hydrophilic polymer which was applied on the inner cores. Floating time and floating lag time was controlled by quantity and composition of buoyant layer. In vivo radiology studies point out the capability of the system of longer residence time of the tablets in the gastric region and releasing the drug after a programmed lag time. Conclusion: The optimized formulation of the developed system provided a lag phase while showing the gastroretension followed by pulsatile drug release that would be beneficial for chronotherapy of rheumatoid arthritis and osteoarthritis.

Validation of A Simple HPLC-UV Method For the Quantification of Andrographolide in Self-Nano Emulsifying Drug Delivery System (Snedds) For Dissolution Study

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
Syukri Y ◽  
Afetma D. W. ◽  
Sirin M. ◽  
Fajri R. ◽  
Ningrum A. D. K. ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gastric Fluid ◽  
Hplc Method ◽  
Good Precision ◽  
Intestinal Fluid ◽  
Dissolution Medium ◽  
Relative Standard ◽  
Sufficient Precision

This research aim to validation of a simple, rapid and accurate HPLC-UV method for the quantification of andrographolide isolated from Andrographis paniculata Ness in Self Nano Emulsifying Drug Delivery System (SNEDDS) formulation during the dissolution test. The assay was performed using a XTerra® MS C18 column (150 mm X 4.6 mm, five μm) with a mobile phase of methanol and water (70: 30), at 0.8 mL/min flow rate and UV detection of 229 nm. Simulation gastric fluid (SGF) and intestinal fluid (SIF) were prepared as dissolution medium. The validation parameter was conducted including the test on linearity, precision, accuracy, LOD, and LOQ. The result showed an excellent linearity with r = 0.999 and good selectivity for both medium dissolution. The method showed sufficient precision, with a relative standard deviation (RSD) smaller than % Horwitz. The accuracy reported as % recovery was found to be 102.61 and 101.17 % in each SGF and SIF dissolution medium. LOD and LOQ were found 0.46 and 1.40 in SGF medium, 0.87 and 2.64 in SIF medium. In conclusion, the HPLC method developed showed specificity and selectivity with linearity in the working range, good precision and accuracy and suitable for quantification andrographolide in SNEDDS formulation.

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