scholarly journals Perbandingan Nilai Hazard Kejadian Tsunami di Indonesia Berdasarkan Posisi Garis Khatulistiwa (Katalog Tsunami Indonesia 1802 - 2018)

2021 ◽  
Vol 12 (1) ◽  
pp. 33
Author(s):  
Samsul Anwar
Keyword(s):  
Volcanic Eruptions ◽  
Northern Region ◽  
Hazard Ratio ◽  
Southern Region ◽  
Disaster Mitigation ◽  
Proportional Hazard ◽  
Proportional Hazard Model ◽  
Tectonic Plates ◽  
Cox Proportional Hazard ◽  
The Relationship

ABSTRAKIndonesia merupakan salah satu negara yang rawan terjadinya tsunami. Berdasarkan Katalog Tsunami BMKG, sepanjang tahun 1802 hingga 2018 telah terjadi 219 tsunami di Indonesia. Dengan mempelajari kejadian tsunami pada masa lalu berarti merupakan salah satu langkah mitigasi bencana dalam upaya meminimalisir kerugian yang disebabkan oleh tsunami pada masa yang akan datang. Tujuan penelitian ini adalah menghitung nilai hazard rasio kejadian tsunami berdasarkan lokasi kejadiannya relatif terhadap garis khatulistiwa. Model Cox Proportional Hazard (Cox PH) menunjukkan bahwa tsunami di wilayah selatan garis khatulistiwa cenderung 50,5% lebih cepat terjadi dibandingkan dengan wilayah utara. Hal ini disebabkan karena wilayah selatan berpotensi lebih besar akan terjadinya kejadian tsunamigenik termasuk gempa bumi, erupsi gunungapi dan penyebab lainnya dari pada wilayah utara. Adanya zona subduksi aktif akibat pertemuan lempeng tektonik Indo-Australia dan Eurasia di wilayah selatan meningkatkan potensi terjadinya tsunamigenik di wilayah tersebut. Penelitian lebih lanjut diperlukan untuk menjelaskan hubungan antara garis khatulistiwa dengan kejadian tsunamigenik di Indonesia.Kata kunci: garis khatulistiwa, hazard rasio, Indonesia, model cox ph, tsunami, tsunamigenikABSTRACTIndonesia is a tsunami-prone country. Based on the BMKG Tsunami Catalog, from 1802 to 2018 there were 219 tsunamis in Indonesia. By studying tsunami events in the past means one disaster mitigation measure in an effort to minimize losses caused by tsunamis in the future. The objective of the study is to measure the tsunami hazard ratio based on its location relative to the equator position. Cox Proportional Hazard Model (Cox PH) showed that tsunamis in the southern area tended to happen 50.5% faster compared to the northern area. This is because the southern region has greater potential for tsunamigenic events including earthquakes, volcanic eruptions, and other causes than the northern region. The existence of an active subduction zone due to the confluence of Indo-Australian and Eurasian tectonic plates in the southern region increases the potential for tsunamigenic events in the region. Further research is necessarily needed to explain the relationship between the equator and tsunamigenic events in Indonesia.Keywords: equator, hazard ratio, Indonesia, cox ph model, tsunami, tsunamigenic

Age at onset and outcome in schizophrenia are related to the degree of familial loading

1998 ◽  
Vol 173 (6) ◽  
pp. 494-500 ◽  
Author(s):  
Jaana M. Suvisaari ◽  
Jari Haukka ◽  
Antti Tanskanen ◽  
Jouko K. Lönnqvist
Keyword(s):  
Mixed Models ◽  
Early Onset ◽  
Disability Pension ◽  
Psychotic Disorders ◽  
Age At Onset ◽  
Cox Proportional Hazard Model ◽  
Proportional Hazard ◽  
Proportional Hazard Model ◽  
Cox Proportional Hazard ◽  
The Relationship

BackgroundRecent research suggests that high familial loading is associated with early onset of schizophrenia. Results concerning outcome have been controversial.MethodWe assessed the relationship between familial loading, age at onset and outcome in all Finnish patients with schizophrenia born between 1950 and 1969. Patients and their first-degree relatives were identified using nationwide registers. Familial loading scores were calculated for schizophrenia and for combined psychotic disorders, and patients were accordingly classified into three groups: high (n = 761), intermediate (n = 14 247), and low familial loading (n = 725). Linear mixed models and the Cox proportional hazard model were used in the analyses.ResultsOnset was earliest, hospitalisation longest and risk of retirement in receipt of a disability pension highest in the group with high familial loading, with opposite extremes found in the group with low familial loading.ConclusionsHigh familial loading for schizophrenia is associated with early onset and poor outcome of schizophrenia.

scholarly journals Human epididymis protein 4 is a new biomarker to predict the prognosis of progressive fibrosing interstitial lung disease

2020 ◽  
Author(s):  
Naoki Nishiyama ◽  
Masahiro Masuo ◽  
Yoshihisa Nukui ◽  
Tomoya Tateishi ◽  
Mitsuhiro Kishino ◽  
...  
Keyword(s):  
Prospective Observational Study ◽  
Interstitial Lung Diseases ◽  
Proportional Hazard ◽  
Proportional Hazard Model ◽  
High Resolution Computed Tomography ◽  
Human Epididymis Protein 4 ◽  
Derivation Cohort ◽  
Human Epididymis ◽  
Cox Proportional Hazard ◽  
The Relationship

Abstract BACKGROUND The clinical course and prognosis of progressive fibrosing interstitial lung diseases ( PF-ILDs) vary from individual to individual. Predictive serum biomarkers for the management of the disease are needed. Serum human epididymis protein 4 (HE4) has been reported to be elevated in patients with IPF, yet its clinical utility has not been elucidated. We evaluated whether serum HE4 could be a biomarker for patients with PF-ILD. METHODS Serum HE4 was measured in a retrospective study that consisted of 34 patients with PF-ILD and 40 healthy volunteers. The relationship between serum HE4 levels and clinical parameters or prognosis was investigated. To validate the significance of the results, a prospective observational study that consisted of 37 patients with PF-ILD and 40 control patients without PF-ILD was performed.RESULTS Serum HE4 was higher in patients with PF-ILD than in health volunteers ( P < 0.01). A correlation of the serum HE4 levels with the extent of honeycombing on chest high-resolution computed tomography was identified (r = 0.41, P = 0.015). In multivariate analysis by the Cox proportional hazard model, higher HE4 levels (> 238 pmol/l) were associated with elevated mortality risk (HR 7.27, 95% CI 1.56-34.0, P = 0.01 in the derivation cohort; HR 44.3, 95% CI 4.19-468, P < 0.01 in validation cohort). CONCLUSIONS Serum HE4 levels may serve as a new diagnostic and prognostic biomarker for patients with PF-ILD.

scholarly journals Human epididymis protein 4 is a new biomarker to predict the prognosis of progressive fibrosing interstitial lung disease

2020 ◽  
Author(s):  
Naoki Nishiyama ◽  
Masahiro Masuo ◽  
Yoshihisa Nukui ◽  
Tomoya Tateishi ◽  
Mitsuhiro Kishino ◽  
...  
Keyword(s):  
Prospective Observational Study ◽  
Interstitial Lung Diseases ◽  
Proportional Hazard ◽  
Proportional Hazard Model ◽  
High Resolution Computed Tomography ◽  
Human Epididymis Protein 4 ◽  
Derivation Cohort ◽  
Human Epididymis ◽  
Cox Proportional Hazard ◽  
The Relationship

Abstract BACKGROUND The clinical course and prognosis of progressive fibrosing interstitial lung diseases ( PF-ILDs) vary from individual to individual. Predictive serum biomarkers for the management of the disease are needed. Serum human epididymis protein 4 (HE4) has been reported to be elevated in patients with IPF, yet its clinical utility has not been elucidated. We evaluated whether serum HE4 could be a biomarker for patients with PF-ILD.METHODS Serum HE4 was measured in a retrospective study that consisted of 34 patients with PF-ILD and 40 healthy volunteers. The relationship between serum HE4 levels and clinical parameters or prognosis was investigated. To validate the significance of the results, a prospective observational study that consisted of 37 patients with PF-ILD and 40 control patients without PF-ILD was performed.RESULTS Serum HE4 was higher in patients with PF-ILD than in health volunteers ( P < 0.01). A correlation of the serum HE4 levels with the extent of honeycombing on chest high-resolution computed tomography was identified (r = 0.41, P = 0.015). In multivariate analysis by the Cox proportional hazard model, higher HE4 levels (> 238 pmol/l) were associated with elevated mortality risk (HR 7.27, 95% CI 1.56-34.0, P = 0.01 in the derivation cohort; HR 44.3, 95% CI 4.19-468, P < 0.01 in validation cohort).CONCLUSIONS Serum HE4 levels may serve as a new diagnostic and prognostic biomarker for patients with PF-ILD.

Incorporating molecular markers in standard prognostic models for DLBCL patients using real-world data.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e19251-e19251
Author(s):  
Shivam Mathura ◽  
Vicki Kay Fung ◽  
Keshava Dilwali ◽  
Ashwin Subramanian Lakshmanan
Keyword(s):  
Monoclonal Antibody ◽  
Molecular Markers ◽  
Risk Group ◽  
Risk Groups ◽  
Cox Proportional Hazard Model ◽  
Proportional Hazard ◽  
Proportional Hazard Model ◽  
Real World Data ◽  
Cox Proportional Hazard ◽  
The Relationship

e19251 Background: NCCN-IPI is a prognostic scoring system that outperforms other risk classification mechanisms in diffuse large B-cell lymphoma (DLBCL) but does not consider the molecular profile of patients. We evaluated the predictive value of NCCN-IPI and clinically relevant molecular markers on the overall survival (OS) of patients with diagnosed DLBCL in real-world data (RWD). Methods: Patients diagnosed with DLBCL were identified in the COTA RWD population, and then subset to those with sufficient attributes to calculate NCCN-IPI at diagnosis (age, stage, LDH ratio, performance status, extranodal disease) and those who received a monoclonal antibody targeting CD20 (n = 383). This population was further filtered to patients tested for BCL-2, BCL-6, and C-MYC (n = 176). Disease characteristics were summarized using descriptive statistics and chi-square tests of independence were performed to assess the relationship between NCCN-IPI Risk-Group and molecular marker results. A Cox proportional hazard model was used to identify prognostic features of OS. Results: There were statistically significant relationships between NCCN-IPI Risk-Group and both BCL-2 (p = 0.007) and C-MYC (p < 0.001) after Bonferroni correction for the number of molecular markers tested. A Cox proportional hazard model with the three molecular markers as covariates revealed a statistically significant correlation between the presence of C-MYC alteration and decreased OS (HR = 2.02, CI: 1.24-3.32, p = 0.005). However, when NCCN-IPI Risk-Group was added as a covariate, the relationship between C-MYC and OS was no longer significant. The hazard ratios associated with high-intermediate and high risk groups were larger than that of the low-intermediate group. All three of these risk groups were statistically significant in the model (p < 0.038). Conclusions: The inclusion of molecular markers to the NCCN-IPI prognostic model did not increase predictive power in this RWD cohort. We validated the NCCN-IPI model and found it to be a robust tool for classifying risk and estimating OS in patients who have received a CD20 monoclonal antibody. A larger sample size would increase power to further explore the impact of molecular markers on overall survival. [Table: see text]

Gout and a Subsequent Increased Risk of Erectile Dysfunction in Men Aged 64 and Under: A Nationwide Cohort Study in Taiwan

2015 ◽  
Vol 42 (10) ◽  
pp. 1898-1905 ◽  
Author(s):  
Yung-Fu Chen ◽  
Hsuan-Hung Lin ◽  
Chuan-Chin Lu ◽  
Chin-Tung Hung ◽  
Ming-Huei Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Erectile Dysfunction ◽  
General Population ◽  
Study Cohort ◽  
Proportional Hazard ◽  
Proportional Hazard Model ◽  
Cox Proportional Hazard ◽  
Increased Risk ◽  
Dose Response Effect ◽  
The Relationship

Objective.Few studies have examined the relationship between gout and erectile dysfunction (ED). We investigated whether patients with gout exhibited an increased risk of ED.Methods.This longitudinal nationwide cohort study investigated the incidence and risk of ED in 19,368 men with gout who were newly diagnosed between January 2002 and December 2008. A total of 77,472 controls without gout were randomly selected from the general population and frequency-matched according to age and sex. The patients were followed up from the date on which they were included in the study cohort to the date of an ED event, censoring, or December 31, 2010. We conducted the Cox proportional hazard model to estimate the effects of gout on ED risk including age and comorbidities.Results.The gout cohort exhibited a 1.21-fold adjusted HR of subsequent ED development compared with the non-gout cohort (95% CI 1.03–1.44). The incidence of ED increased with age in both cohorts and was higher among the patients in the gout cohort than among those in the non-gout cohort. Compared to the patients without gout and comorbidities, the patients with both gout and any type of comorbidity exhibited a 2.04-fold risk of developing ED (95% CI 1.63–2.57). Further, the patients with gout who had numerous comorbidities exhibited the dose-response effect in developing ED.Conclusion.This nationwide cohort study revealed that ED risk is significantly higher in patients with gout than in the general population.

scholarly journals Comparing the 12-month patency of low- versus high-pressure dilation in failing arteriovenous fistulae: A prospective multicenter trial (YOROI study)

2018 ◽  
Vol 19 (5) ◽  
pp. 477-483 ◽  
Author(s):  
Koki Wakamoto ◽  
Shigehiro Doi ◽  
Ayumu Nakashima ◽  
Toru Kawai ◽  
Yasufumi Kyuden ◽  
...  
Keyword(s):  
High Pressure ◽  
Patency Rate ◽  
Hazard Model ◽  
Low Pressure ◽  
Hazard Ratio ◽  
Cox Proportional Hazard Model ◽  
Proportional Hazard ◽  
Pressure Group ◽  
Proportional Hazard Model ◽  
Cox Proportional Hazard

Purpose: This study was performed to investigate the effect of the balloon dilation pressure on the 12-month patency rate in patients with failed arteriovenous fistulas undergoing hemodialysis. Materials and methods: In this multicenter, prospective, randomized trial, the 4-mm-diameter YOROI balloon was used for dilation of stenotic lesions. The balloons were inflated to a pressure of 8 atm (low-pressure group) or 30 atm to achieve complete expansion (high-pressure group). The 12-month patency rate after balloon angioplasty was analyzed by the Kaplan–Meier method and log-rank test and/or a Cox proportional hazard model. We also investigated the dilation pressure required to achieve complete expansion in the high-pressure group. Results: In total, 71 patients were enrolled and allocated to either the low-pressure group (n = 34) or the high-pressure group (n = 37). The 12-month patency rates showed no significant difference between the low- and high-pressure groups (47% and 49%, respectively; p = 0.87). In the low-pressure group, the patency rate was not different between patients with complete dilation and residual stenosis (44% and 50%, respectively; p = 0.87). The Cox proportional hazard model revealed that the 12-month patency rate was associated with the stenosis diameter (hazard ratio 0.36; p = 0.001) and the presence of diabetes (hazard ratio 0.33; p = 0.018). Finally, the pressure required to achieve complete dilation was ≤20 atm in 76% of patients and ≤30 atm in 97% of patients. One patient required a dilation pressure of >30 atm. Conclusion: The patency rate does not differ between low-pressure dilation and high-pressure dilation.

scholarly journals No Increased Risk of Alopecia in Ankylosing Spondylitis Patients: A Population-based Cohort Study in Taiwan

2020 ◽  
Author(s):  
Jason Peijer Hsieh ◽  
Hsi-Kai Tsou ◽  
Yung-Heng Lee ◽  
Yu-Hsun Wang ◽  
James Cheng-Chung Wei
Keyword(s):  
Statistical Significance ◽  
Hazard Model ◽  
Population Based ◽  
Hazard Ratio ◽  
Cox Proportional Hazard Model ◽  
Proportional Hazard ◽  
Proportional Hazard Model ◽  
Negative Results ◽  
Cox Proportional Hazard ◽  
Increased Risk

Abstract Background: Investigate the association between AS and alopecia.Methods: Using over 1,000,000 patients’ data from Taiwan Longitudinal Health Insurance Database, we selected the sample with ICD code, diagnosing date, index date, and propensity score matching. We had 3,640 patients with AS and 14,560 non-AS controls. Cox proportional hazard model and Kaplan-Meier analysis were used to present the results.Results: The crude and adjusted hazard ratio of AS for developing alopecia showed no statistical significance in the Cox proportional hazard model [crude hazard ratio (HR) 1.16, 95% CI 0.67-1.99; adjusted HR 1.16, 95% CI 0.67-1.98]. Negative results were found as well in subgroup analysis (Age 20-40: HR 1.03, 95% CI 0.53-2.01; Age≧40: HR 1.49, 95% CI 0.58-3.80; Female: HR 1.17, 95% CI 0.43-3.17; Male: HR 1.15, 95% CI 0.61-2.19). A significant positive correlation was found between atopic dermatitis and alopecia (adjusted HR 8.05, 95% CI 1.11-58.14).Conclusions: No increased risk of alopecia was observed in AS patients

scholarly journals Does experience exert impact on a public-private partnership performance? The case of Poland

Equilibrium ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. 509-522
Author(s):  
Joanna Węgrzyn
Keyword(s):  
Positive Relationship ◽  
Value Added ◽  
Cox Proportional Hazard Model ◽  
Proportional Hazard ◽  
Proportional Hazard Model ◽  
The Past ◽  
Cox Proportional Hazard ◽  
Factors Influencing ◽  
Operation Phase ◽  
The Relationship

Research background: Researchers traditionally assume that learning is a product of experience. In general, it means that learning can only take place through the attempt to solve a problem and therefore only takes place during activity (Arrow, 1962). On the ground of organizational theory, it has two implications. First, we can agree that repeated activity requires less effort. Second, we can argue that firms undertake activities, with which they have been the most successful in the past and that they expect to be the most successful in the future. Purpose of the article: The aim of the research is twofold. Firstly, this article aims to investigate if we can identify a relationship between the experience in PPP projects and the performance of initiatives of this kind. Secondly, the article aims to provide an interpretation of the relationship between experience and PPP performance. Methods: This research investigates factors influencing the survival of PPP projects in Poland over the period 2009–2015. Cox proportional hazard model is utilized to distinguish between PPPs that succeeded to the operation phase and those that were canceled on the procurement stage. Findings & Value added: The research confirms the existence of a positive relationship between experience in PPP and the outcome of a PPP development.

scholarly journals Effect of Birth Interval on Neonatal and Post Neonatal Mortality in Bangladesh

2017 ◽  
Vol 65 (1) ◽  
pp. 35-39
Author(s):  
Radia Taisir ◽  
Most Fatima Tuz Zahura ◽  
Wasimul Bari
Keyword(s):  
Regression Analysis ◽  
Neonatal Mortality ◽  
Birth Interval ◽  
Cox Proportional Hazard Model ◽  
Proportional Hazard ◽  
Proportional Hazard Model ◽  
Index Child ◽  
Cox Proportional Hazard ◽  
Previous Birth ◽  
The Relationship

This study investigates the relationship between previous birth interval and infant mortality using the data extracted from the Bangladesh Demographic and Health Survey (BDHS), 2011. For the purpose of regression analysis, the Cox proportional hazard model has been used. Results demonstrate significant effects of previous birth interval on neonatal mortality, but not on post neonatal mortality. If the previous birth interval is less than two years or greater than three years, the index child experiences high risk of neonatal mortality. Dhaka Univ. J. Sci. 65(1): 35-39, 2017 (January)

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