scholarly journals Multiplex NanoSPR Molecular Biosensor for Blood Cytokine Monitoring

2021 ◽  
Author(s):  
Agha Zeeshan Mirza
Keyword(s):  
Clinical Testing ◽  
Protein Biomarkers ◽  
New Approaches ◽  
Cytokine Detection ◽  
Highly Sensitive ◽  
Duration Of Disease ◽  
Detection Capabilities ◽  
Current Detection ◽  
Cytokine Quantification

Cytokines, as protein biomarkers, have essential functions in the diagnosis, identification, and healing of a broad range of syndromes. For the specific and accurate monitoring of immune conditions, which change rapidly throughout the duration of disease, sophisticated sensors for detecting cytokines are essential and will assist in clinical testing and studies of various diseases. The present manuscript briefly discusses fundamental principles applied to the development of tools for cytokine detection and new biomarker development. The latest developments in the technologies for highly sensitive and multiplexed cytokine quantification, with current detection capabilities across a broad, vibrant array, are also discussed. Finally, nanomaterial-based cytokine sensors, currently considered new approaches, are presented from the perspective of optimizing the sensitivity and multiplexity of cytokine detection.

A target-responsive autonomous aptamer machine biosensor for enzyme-free and sensitive detection of protein biomarkers

2018 ◽  
Vol 6 (24) ◽  
pp. 4146-4150 ◽  
Author(s):  
Mengqi Zou ◽  
Daxiu Li ◽  
Ruo Yuan ◽  
Yun Xiang
Keyword(s):  
Sensitive Detection ◽  
Protein Biomarkers ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

Target-triggered operation of an aptamer machine leads to amplified and highly sensitive detection of protein biomarkers.

scholarly journals Highly sensitive biomarker biosensor for early detection of cancer biomarkers

2021 ◽  
Author(s):  
Jaydev Upponi ◽  
Tiziana Musacchio ◽  
Salome Siavoshi ◽  
Asanterabi Malima ◽  
Cihan Yilmaz ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Early Detection ◽  
Carcinoembryonic Antigen ◽  
Early Detection Of Cancer ◽  
Cancer Biomarkers ◽  
Diagnostic Tools ◽  
Detection Systems ◽  
Highly Sensitive ◽  
Current Detection ◽  
Insufficient Sensitivity

Abstract Biomarkers are emerging as potentially important diagnostic tools for cancer and many other diseases. However, many current detection systems for suffer from insufficient sensitivity. To address this concern, we developed a highly sensitive biosensor, featuring monoclonal antibody-coated polystyrene nanobeads assembled in the trenches of a microchip, for the detection of cancer biomarkers. These biosensors detected nucleosomes and carcinoembryonic antigen in serum at concentrations of 62.5 and 15.6 pg/mL, respectively. Very low detection limits that suggest such devices might be beneficial for the early detection of tumors and for monitoring of patients in remission.

Nano Monitors for Identification of Vulnerable Cardio-vascular Plaque

2006 ◽  
Vol 926 ◽  
Author(s):  
Shalini Prasad ◽  
Thomas Barrett ◽  
John Carruthers
Keyword(s):  
Complex Disease ◽  
Plaque Rupture ◽  
Coronary Plaque ◽  
Label Free ◽  
Protein Markers ◽  
Protein Biomarkers ◽  
Alumina Membrane ◽  
Non Invasive ◽  
Highly Sensitive ◽  
Cardio Vascular

AbstractWe describe highly sensitive, non–invasive, label-free, electrical detection of protein biomarkers using nanoporous alumina membrane based electrochemical conductance based devices. The principle of operation of these sensors are based on electrochemical conductance varitions associated with the binding of antibody-antigen complexes to a metallic substrate.In these devices distinct pore clusters are selectively surface functionalized with specific antibodies, that are in turn are incorporated into micro scale arrays. Protein markers were routinely detected at nanomolar concentrations. This opens the potential for developing highly sensitive and selective biomarker detection assays in clinically relevant samples for diagnosis of complex disease state like vulnerable coronary plaque rupture that results in poor post surgical outcomes and other complex diseases.

Highly Sensitive Diagnostic Assay for the Detection of Protein Biomarkers Using Microresonators and Multifunctional Nanoparticles

ACS Nano ◽  
2012 ◽  
Vol 6 (5) ◽  
pp. 4375-4381 ◽  
Author(s):  
Jinmyoung Joo ◽  
Donghoon Kwon ◽  
Changyong Yim ◽  
Sangmin Jeon
Keyword(s):  
Diagnostic Assay ◽  
Multifunctional Nanoparticles ◽  
Protein Biomarkers ◽  
Highly Sensitive

scholarly journals Can new immunoassay techniques improve bladder cancer diagnostics With protein biomarkers?

2021 ◽  
Vol 7 ◽  
Author(s):  
Yuri M. Shlyapnikov ◽  
Ekaterina A. Malakhova ◽  
Andrey Z. Vinarov ◽  
Andrey A. Zamyatnin ◽  
Elena A. Shlyapnikova
Keyword(s):  
Experimental Data ◽  
Bladder Cancer ◽  
Diagnostic Tests ◽  
Current Knowledge ◽  
Test System ◽  
Cancer Diagnostics ◽  
Published Data ◽  
Protein Biomarkers ◽  
Low Concentrations ◽  
Highly Sensitive

The search for new diagnostic tests for cancer or ways to improve existing tests is primarily driven by the desire to identify the disease as early as possible. In this report, we summarize the current knowledge of the most promising diagnostic protein bladder cancer (BC) markers reported over the last decade. Unfortunately, analysis of published data suggests that a reliable, highly sensitive biomarker test-system based on ELISA for detecting BC has not yet been developed. The use of more sensitive assays to detect ultra-low concentrations of biomarkers not available for ELISA, could be very beneficial. Based on the literature and pilot experimental data, we conclude that a highly sensitive immunoassay using microarrays and magnetic labels, could be an effective and cheap technique suitable for the detection of diagnostically relevant BC biomarkers.

BIOSENSING AND MEDICAL DIAGNOSTICS BASED ON ULTRA SENSITIVE OPTICAL AND MAGNETIC MEASUREMENTS

2021 ◽  
Vol 1 (19) ◽  
pp. 238-240
Author(s):  
A.V. Orlov ◽  
V.A. Bragina ◽  
N.V. Gyteneva ◽  
M.P. Nikitin ◽  
B.G. Gorshkov
Keyword(s):  
Food Safety ◽  
Magnetic Measurements ◽  
Detection Limits ◽  
Medical Diagnostics ◽  
Protein Biomarkers ◽  
Safety Control ◽  
Analytical Applications ◽  
Highly Sensitive

Highly sensitive methods of optical and magnetic measurements have been developed and tested for analytical applications, medical diagnostics, food safety control, etc. The achieved detection limits are unique for express assays: DNA - 6 × 10-19 mol (without amplification), haptens - 16 fg/ml, protein biomarkers - 4 pg/ml.

scholarly journals A highly sensitive wide-range weak current detection circuit for implantable glucose monitoring

2016 ◽  
Vol 13 (8) ◽  
pp. 20150616-20150616 ◽  
Author(s):  
Xi Tan ◽  
Sizheng Chen ◽  
Xiao Yan ◽  
Yibo Fan ◽  
Hao Min ◽  
...  
Keyword(s):  
Glucose Monitoring ◽  
Weak Current ◽  
Highly Sensitive ◽  
Wide Range ◽  
Detection Circuit ◽  
Current Detection

Cascaded multiple recycling amplifications for aptamer-based ultrasensitive fluorescence detection of protein biomarkers

The Analyst ◽  
2019 ◽  
Vol 144 (22) ◽  
pp. 6635-6640 ◽  
Author(s):  
Yao Qin ◽  
Daxiu Li ◽  
Ruo Yuan ◽  
Yun Xiang
Keyword(s):  
Fluorescence Detection ◽  
Protein Biomarkers ◽  
Mucin 1 ◽  
Highly Sensitive ◽  
Multiple Recycling

Target-induced cascaded multiple recycling amplifications lead to aptamer-based and highly sensitive fluorescence detection of mucin 1.

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