scholarly journals Vitamin D and proinflammatory cytokines in newborns from mothers with endocrine disorders

2019 ◽  
pp. 66-69
Author(s):  
I. N. Zakharova ◽  
V. A. Kuryaninova ◽  
N. Е. Verisokina ◽  
R. A. Atanesyan ◽  
L. Ya. Klimov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Proinflammatory Cytokines ◽  
Control Group ◽  
Endocrine Disorders ◽  
Laboratory Observation ◽  
Normal Body Weight ◽  
In Pregnancy

Objective: The objective is a comparative analysis of vitamin D content and level of proinflammatory cytokines in infants born by mothers with endocrine disorders, and in infants of women with normal body weight.Methods: The clinic-anthropometrical and laboratory observation of 78 children born in Stavropol Regional Clinical Perinatal Centre: 36 infants were born by women with obesity and 18 – by women with gestational diabetes mellitus associated with obesity, 24 – by women who did not have obesity and clinical and laboratory signs of intolerance to glucose (control group). The level of calcidiol and interleukin 1β and 6 were determined in blood serum.Results: The content of vitamin D in infants born by healthy women was higher than in infants born by mothers with gestational diabetes mellitus associated with obesity and by mothers with obesity. Infants born by mothers with obesity had higher level of proinflammotary cytokines than those of control group.Conclusions: Children, born by mothers with endocrine disorders, have lower level of calcidiol and require postnatal prevention of vitamin D deficiency. Also it is necessary to take vitamin D during the pregnancy to prevent complications in pregnancy and neonatal pathology.

scholarly journals Hypovitaminosis D in pregnancy and its correlation with preeclampsia and gestational diabetes mellitus

2017 ◽  
Vol 6 (3) ◽  
pp. 890 ◽  
Author(s):  
Ankita Kumari ◽  
Shaila Mitra ◽  
Harish C Tiwari ◽  
Reena Srivastav
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Health Concern ◽  
Control Group ◽  
The Impact

Background: Hypovitaminosis D has been associated with a number of adverse pregnancy outcomes, and has been recognised as a public health concern. The objective of this study was to determine the impact of Vitamin D deficiency on maternal complications like gestational diabetes mellitus (GDM) and preeclampsia (PE) among pregnant women.Methods: This was a case control study undertaken at antenatal clinics and indoor of BRD Medical College, Gorakhpur, Uttar Pradesh, India. Two maternal blood samples, one at <20 weeks and other at term along with cord blood at delivery were taken. Patients were classified into preeclampsia (n=60), gestational diabetes mellitus (n=35) and control group (n=180) after abstracting past medical records at delivery. Vitamin D was estimated by 25- Hydroxyvitamin D125 RIA kit and categorized according to ACOG criteria. Statistical analysis was done by using chi square test, binary logistic regression and Pearson’s correlation coefficient to compare between two variables. P<0.05 was considered statistically significant.Results: Out of 275 women included in the study, 78% of women were Vitamin D deficient. Mean serum vitamin D was significantly lower among preeclamptic women 11.53±6.22 ng/ml and GDM women 12.62±6.69 ng/ml as compared to controls 24.25±14.44 ng/ml (median=18.2 ng/ml) (P<0.05). Vitamin D deficiency was significantly higher in pregnant women GDM (94.28% vs 68.3%) and preeclampsia (96.67% vs 68.3%) when compared to uncomplicated group.Conclusions: Maternal vitamin D deficiency is highly prevalent in early pregnancy and is significantly associated with elevated risk for GDM and preeclampsia.

scholarly journals Vitamin D deficiency in pregnancy and gestational diabetes mellitus

2012 ◽  
Vol 207 (3) ◽  
pp. 182.e1-182.e8 ◽  
Author(s):  
Heather H. Burris ◽  
Sheryl L. Rifas-Shiman ◽  
Ken Kleinman ◽  
Augusto A. Litonjua ◽  
Susanna Y. Huh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
In Pregnancy

scholarly journals Serum Vitamine D3 Level in Women with Gestational Diabetes Mellitus

2021 ◽  
pp. 90-98
Author(s):  
Riham M. Enab ◽  
Amal A. El Sokary ◽  
Heba A. Mourad ◽  
Amal E. Mahfouz
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Control Group ◽  
Study Group ◽  
Significant Difference

Background: Vitamin D3 is synthesized in skin and sequentially metabolized in liver and kidney in humans. It is well known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. The primary objective of this study was to evaluate vitamin D3 level in pregnant women who were suffering from gestational diabetes mellitus and comparing it with the control groups. Materials and Methods: This case control study was conducted on 100 pregnant women who were attending the inpatient and outpatient clinics of Obstetrics department, Tanta University Hospital, who were divided into two equal groups.Group A (control group): Fifty apparently healthy pregnant women at 24th-28th weeks of gestation. Group B (study group): Fifty pregnant women had gestational diabetes. Results: There is significant increase between the two studied groups according to HbA1c, also there is decrease between the two groups as regards VIT D. Mean HbA1c % was statistically significant higher in the study group versus control group. There was statistical significant difference noted between mean serum level of vitamin D among the two studied groups. A statistically significant negative correlation was observed between serum 25 OH vitamin D and HbA1c among our cases (r=- 0.745) (p ≤ 0.001). Mean serum vitamin D was significantly lower in cases with complications than those with normal outcome. Conclusion: Vitamin D deficiency may have a positive relationship with gestational diabetes mellitus.

scholarly journals Hypovitaminosis D Is Associated with Some Metabolic Indices in Gestational Diabetes Mellitus

2020 ◽  
Vol 5 (2) ◽  
pp. 1-14
Author(s):  
Ayobola Abimbola Sonuga ◽  
Oyebola Oluwagbemiga Sonuga
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Glucose Intolerance ◽  
Serum Insulin ◽  
Hypovitaminosis D ◽  
Control Group ◽  
The Relationship

Background: Gestational diabetes mellitus (GDM), a pregnancy complication, is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Vitamin D deficiency and insufficiency has recently been recognized as a contributing factor to the pathogenesis of GDM, and this link might be associated with hyperglycemia, insulin resistance, and inflammation, which are implicated in GDM. Objectives: This study aims at investigating the relationship between vitamin D, fasting plasma glucose (FPG), insulin, zinc, ferritin, and high-sensitivity C-reactive protein (CRP) in GDM. Method: A case-control study in which 80 women attending the antenatal clinic of University College Hospital (UCH), Ibadan, Nigeria, were recruited; the women were grouped into controls (40 nondiabetic pregnant women) and cases (40 pregnant women with GDM). Blood samples were taken at the second trimester, and metabolites were quantified by standard laboratory methods. Student’s t test and Pearson correlation were used to compare variables and determine the relationship between variables, respectively. Results: Results showed significant (p < 0.05) low levels of serum vitamin D and zinc, and significant (p < 0.05) higher levels of FPG and serum insulin, ferritin, and CRP in the GDM group compared to the control group. In the GDM group, a positive weak relationship was observed between vitamin D and zinc (r = 0.18, p < 0.05), while vitamin D was inversely correlated with FPG, serum insulin, ferritin, and CRP (r = –0.23, –0.21, –0.20, –0.46, respectively, p < 0.05). Conclusion: This study suggests that hypovitaminosis D might be associated with glucose intolerance, insulin insensitivity, and inflammation, which are factors implicated in the development and progression of GDM.

scholarly journals The Effect of a Single Mega dose Injection of Vitamin D on serum Adiponectin concentration at First Gestational Diabetes Mellitus: A Randomized Controlled Clinical Trial

2019 ◽  
Author(s):  
Mahdieh Hosseinzadeh ◽  
Elham Razmpush ◽  
Elham Shareghfarid ◽  
Elham Hosseinzadeh ◽  
Hossein Hadinedoushan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Trial ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Intramuscular Injection ◽  
Intervention Group ◽  
Control Group ◽  
P Value ◽  
Adiponectin Concentration

Abstract Background: vitamin D is being increasingly recognized for its important non-skeletal functions including endocrine actions. This study investigated if a single, large, intramuscular post‐artum injection of vitamin D improve adiponectin levels among women with gestational diabetes mellitus (GDM). Methods: A total of 45 pregnant women with GDM participated in this randomized clinical trial. They were randomly divided into intervention and control group. The intervention group received an intramuscular injection of 300,000 IU of vitamin D during 3 to 10 days after their child delivery, but controls did not. Serum 25‐hydroxyvitamin D, fasting blood glucose, HbA1c and serum adiponectin were measured at baseline and after 3 months of intervention. Results: Serum 25 OH vitamin D increase significantly in the intervention but not in the control group from 24.25 to 62.10 (nmol/l) (p-value< 0.01). Comparison in within group showed that adiponectin level increased significantly only among intervention group after the vitamin D injection from 7.45 to 8.98 (ngr/dl) (P-value=0.01), while between group comparisons showed no significant differences in adiponectin concentration after the intervention (P-value<0.05). Between and within group comparisons reported no significant alterations in the levels of glycated hemoglobin (HbA1c) and FPG (fasting plasma glucose), as well. Conclusions: The 300,000 IU single dose of intramuscular injection of vitamin D is regarded as an effective procedure to improve vitamin D status which significantly increased the adiponectin levels among mothers with gestational diabetes after delivery. Trial registration: The trial was registered in Iranian Registry of Clinical Trials available at http://www.irct.ir. The reference number is IRCT138902113840N1.

Serum vitamin D receptor levels in gestational diabetes mellitus

2018 ◽  
Vol 42 (4) ◽  
pp. 149-154
Author(s):  
Seçkin Özgür Tekeli ◽  
Feyza Yağmur Tekeli ◽  
Onur Erol ◽  
Hamit Yaşar Ellidag ◽  
Esin Eren ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Serum Vitamin ◽  
Receptor Expression ◽  
Control Group ◽  
Significant Difference ◽  
25 Oh Vitamin D

AbstractBackgroundVitamin D affects glucose metabolism by increasing insulin secretion and insulin receptor expression. Also, it exerts these effects by binding to its primary receptor, the vitamin D receptor (VDR). In this preliminary study, we aimed to examine serum 25-(OH) vitamin D3and serum VDR levels in gestational diabetes mellitus (GDM) patients.MethodsBlood samples were obtained during 24–28 weeks of pregnancy from patients with GDM (n=30) and age, body mass index (BMI), and gestational age-matched control subjects (n=33). Both groups were examined for changes in the levels of glucose, insulin, glycated hemoglobin (bA1c), 25-(OH) vitamin D3and VDR.ResultsThere were no significant differences in serum 25-(OH) vitamin D3and fasting insulin levels between the control and GDM groups (p=0.115, p=0.182). But serum VDR levels were significantly higher in the GDM group than in the control group (p=0.001).ConclusionsAlthough there was no significant difference between the two groups regarding 25-(OH) vitamin D3levels, it is notable that VDR levels were higher in GDM patients. To further define the role of vitamin D in the prophylaxis and treatment of GDM, it may be useful to conduct more extensive studies on VDR.

IGFs and IGF-Binding Proteins in Pregnancy and Gestational Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1412-P
Author(s):  
KATEřINA ANDERLOVÁ ◽  
PATRIK SIMJAK ◽  
ANNA CINKAJZLOVA ◽  
JANA KLOUCKOVA ◽  
HELENA KRATOCHVILOVA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Binding Proteins ◽  
Igf Binding Proteins ◽  
Igf Binding ◽  
In Pregnancy

Thyroid Dysfunction in Pregnant Women with Gestational Diabetes Mellitus

2020 ◽  
Vol 16 (8) ◽  
pp. 895-899 ◽  
Author(s):  
Shahin Safian ◽  
Farzaneh Esna-Ashari ◽  
Shiva Borzouei
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Thyroid Dysfunction ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Free T4 ◽  
Significant Difference ◽  
Experimental Group

Aims: Investigation thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus. Background: This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti- TPO) antibodies in pregnant women with gestational diabetes mellitus (GDM). Method: A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24–28 weeks of gestation. Data analysis was then carried out using SPSS ver. 22. Result: There was a significant difference between the experimental group (38.4%) and the control group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008). Conclusion: Thyroid disorders are observed in pregnant women with GDM more frequently than healthy individuals and it may be thus reasonable to perform thyroid tests routinely.

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