Model Regresi Nonparametrik dengan Pendekatan Spline (Studi Kasus: Berat Badan Lahir Rendah di Rumah Sakit Ibu dan Anak Siti Fatimah Makassar)

Pendekatan nonparametrik merupakan suatu pendekatan yang digunakan apabila bentuk hubungan antara variabel respon dan variabel prediktornya tidak diketahui atau tidak adanya informasi mengenai bentuk fungsi regresinya. Spline merupakan suatu teknik yang dilakukan untuk mengestimasi parameter dalam regresi nonparametrik. Penelitian ini bertujuan untuk mengetahui model hubungan antara berat badan lahir rendah dan faktor-faktor yang mempengaruhi berdasarkan model spline. Faktor-faktor tersebut adalah usia ibu, usia kehamilan, dan jarak kehamilan. Data tersebut diperoleh dari rumah sakit ibu dan anak siti Fatimah Makassar tahun 2017. Dimana untuk mendapatkan model spline terbaik langkah awal yang dilakukan adalah menentukan knot dengan nilai Generalized Cross Validation (GCV) yang minimum. Berdasarkan penelitian yang telah dilakukan, dua variabel dinyatakan berpengaruh terhadap berat badan lahir rendah yaitu usia ibu, dan usia kehamilan. Model regresi nonparametrik dengan pendekatan Spline yang terbentuk memiliki koefisien determinasi sebesar 78,19%, serta nilai GCV dengan tiga titik knot yaitu 0.0117.Kata kunci: Regresi Nonparametrik, Spline, Berat Badan Lahir Rendah, Generalized Cross Validation The non-parametric approach is an approach that is used if the form of the relationship between the response variable and the predictor variable is unknown or the absence of information about the shapes of regression functions. The Spline is a technique performed to estimate the parameters in the nonparametric regression. This study aims to determine the model of the relationship between low birth weight and the factors that affect the based on the spline model. Such factors are maternal age, gestational age, and pregnancy distance. The Data is obtained from the mother and child hospital siti Fatimah Makassar 2017. Where to get a spline model best the initial step is to determine the knots with the value of the Generalized Cross Validation (GCV) which is a minimum. Based on the research that has been done, the two variables stated effect against low birth weight, namely age of mother, and gestational age. Nonparametric regression Model with the approach of the Spline that is formed has a coefficient of determination of 78.19 to%, as well as the value of the GCV with a three-point knot that is 0.0117.Keyword : Nonparametric Regression, Spline, Low Birth Weight, Generalized Cross Validation

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Low birth weight, preterm birth and small for gestational age association with adult depression: systematic review and meta-analysis

The British Journal of Psychiatry ◽

10.1192/bjp.bp.113.139014 ◽

2014 ◽

Vol 205 (5) ◽

pp. 340-347 ◽

Cited By ~ 31

Author(s):

Christian Loret De Mola ◽

Giovanny Vinícius Araújo De França ◽

Luciana de Avila Quevedo ◽

Bernardo Lessa Horta

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Premature Birth ◽

Fixed Effects ◽

Meta Analysis ◽

Adult Depression ◽

Meta Analyses ◽

Relationship Of ◽

The Relationship

BackgroundThere is no consensus on the effects that low birth weight, premature birth and intrauterine growth have on later depression.AimsTo review systematically the evidence on the relationship of low birth weight, smallness for gestational age (SGA) and premature birth with adult depression.MethodWe searched the literature for original studies assessing the effect of low birth weight, premature birth and SGA on adult depression. Separate meta-analyses were carried out for each exposure using random and fixed effects models. We evaluated the contribution of methodological covariates to heterogeneity using meta-regression.ResultsWe identified 14 studies evaluating low birth weight, 9 premature birth and 4 SGA. Low birth weight increased the odds of depression (OR = 1.39, 95% CI 1.21–1.60). Premature birth and SGA were not associated with depression, but publication bias might have underestimated the effect of the former and only four studies evaluated SGA.ConclusionsLow birth weight was associated with depression. Future studies evaluating premature birth and SGA are needed.

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Development of Symphysio Fundal Height Curve

Bangladesh Journal of Obstetrics & Gynaecology ◽

10.3329/bjog.v32i1.56729 ◽

2017 ◽

Vol 32 (1) ◽

pp. 20-24

Author(s):

Chowdhury Taslima Nasrein ◽

Ferdousi Begum ◽

Jaglul Haider Khan ◽

Novera Islam ◽

Zahangir Alam

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Gestational Age ◽

Cross Sectional ◽

Medical College ◽

Gestation Age ◽

The Mean ◽

Relationship Of ◽

The Relationship

Objective: To Develop a symphysio fundal height(SFH) curve of pregnant women from 20 weeks of pregnancy onwards; and to find out the relationship of fundal height with different variables. Methodology: A cross-sectional hospital based study was conducted from 1st january 2010 to 31st December 2010 on 159 patients with gestation age less than 20 weeks at entry in the OPD of Department of Obstetric and Gynaecology, Shaheed Suhrawardy Medical College & Hospital, Shere-e Bangla Nagar, Dhaka,Bangladesh. All the patients were followed up till delivery. Results: The measurements of SFH obtained on the basis of 10, 50th and 90th percentiles and the rate of growth of SFH was approximately 5 mm per week from 24 weeks to 36 weeks and thereafter it was 5-6 mm per week till 40 weeks.Patients with higher socioeconomic class had higher symphysio fundal height.SFH is less in younger subjects. SFH increases with increased height,weight,gestational age,gravidity of mothers and birth weight of the baby.Multiparous was predominant and more than one third (34.6%) of the study patients height belonged to 1.51 - 1.60 meters. The mean±SD gestational age was 39.2±1.4 weeks with range from 28 to 41 weeks. Low birth weight was found 17.0% and the mean±SD birth weight was 2.8±0.4 kg with range from 1.9 to 3.8 kg. Bangladesh J Obstet Gynaecol, 2017; Vol. 32(1): 20-24

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Exploring the Relationships in Prenatal Weight Gain, Birth Outcomes, and Postnatal Growth up to 2 Years of Age Using a Longitudinal Cohort in Niger

Current Developments in Nutrition ◽

10.1093/cdn/nzaa054_093 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1021-1021

Author(s):

Kristin Kohlmann ◽

Ousmane Guindo ◽

Issaka Soumana ◽

Rebecca Grais ◽

Sheila Isanaka

Keyword(s):

Weight Gain ◽

Birth Weight ◽

Low Birth Weight ◽

Birth Outcomes ◽

Gestational Age ◽

Small For Gestational Age ◽

Postnatal Growth ◽

Adverse Birth Outcomes ◽

The Relationship ◽

Over Time

Abstract Objectives The first 1000 days of life, from conception until a child's second birthday, is a crucial period during which life-long foundations for good health, growth, and development are established. It has been shown that poor maternal weight gain can contribute to adverse birth outcomes, such as low birth weight, small for gestational age, and prematurity, and such adverse birth outcomes can place children at greater risk for developing wasting and stunting as they age. While it has been suggested that the development of wasting and stunting may be related, the relative impact of poor birth outcomes on weight and height attainment over time is not clear. The objective of this study is to use recently collected longitudinal data to explore the inter-relationships between prenatal weight gain, birth outcomes, and postnatal risk of both wasting and stunting over time. Methods Using longitudinal data nested within a large randomized trial conducted in Madarounfa, Niger, we describe prenatal weight gain, the risk of adverse birth outcomes (preterm, small for gestational age, and low birthweight) and postnatal child growth (weight and length/height) up to 2 years of age. We use binomial regression to examine the relationship between prenatal weight gain and adverse birth outcomes. We use generalized estimating equations to examine the risk of wasting and stunting over time and evaluate potential effect modification of postnatal growth by birth outcomes. Results We followed 2796 mother-child pairs from pregnancy through 2 years of age. We found that 55.9% of the children were born preterm, 6.4% were born small for gestational weight, and 6.8% were born with low birth weight. Using longitudinal analysis, we are examining the relationship between the risk of wasting and stunting over time. Conclusions This analysis will provide evidence to describe the inter-relationships between prenatal weight gain, adverse birth outcomes, and risk of both wasting and stunting over time, with special attention to the inter-relationships between prenatal and postnatal growth. Funding Sources Médecins Sans Frontières-Operational Center Geneva and the Kavli Foundation, Norway.

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Single-course antenatal corticosteroids is related to faster growth in very-low-birth-weight infant

BMC Pregnancy and Childbirth ◽

10.1186/s12884-020-03510-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jiajia Jing ◽

Yiheng Dai ◽

Yanqi Li ◽

Ping Zhou ◽

Xiaodong Li ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Preterm Infants ◽

Gestational Age ◽

Very Low Birth Weight ◽

Postnatal Growth ◽

Weight Increase ◽

Antenatal Corticosteroids ◽

Lung Maturation ◽

Growth Outcomes

Abstract Background Antenatal corticosteroids (ACS) treatment is critical to support survival and lung maturation in preterm infants, however, its effect on feeding and growth is unclear. Prior preterm delivery, it remains uncertain whether ACS treatment should be continued if possible (repeated course ACS), until a certain gestational age is reached. We hypothesized that the association of single-course ACS with feeding competence and postnatal growth outcomes might be different from that of repeated course ACS in very-low-birth-weight preterm infants. Methods A multicenter retrospective cohort study was conducted in very-low-birth-weight preterm infants born at 23–37 weeks’ gestation in South China from 2011 to 2014. Data on growth, nutritional and clinical outcomes were collected. Repeated course ACS was defined in this study as two or more courses ACS (more than single-course). Infants were stratified by gestational age (GA), including GA < 28 weeks, 28 weeks ≤ GA < 32 weeks and 32 weeks ≤ GA < 37 weeks. Multiple linear regression and multilevel model were applied to analyze the association of ACS with feeding and growth outcomes. Results A total of 841 infants were recruited. The results, just in very-low-birth-weight preterm infants born at 28–32 weeks’ gestation, showed both single and repeated course of ACS regimens had shorter intubated ventilation time compared to non-ACS regimen. Single-course ACS promoted the earlier application of amino acid and enteral nutrition, and higher rate of weight increase (15.71; 95%CI 5.54–25.88) than non-ACS after adjusting for potential confounding factors. No associations of repeated course ACS with feeding, mean weight and weight increase rate were observed. Conclusions Single-course ACS was positively related to feeding and growth outcomes in very-low-birth-weight preterm infants born at 28–32 weeks’ gestation. However, the similar phenomenon was not observed in the repeated course of ACS regimen.

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The Prevalence of Necrotizing Enterocolitis and Associated Factors Among Enteral Fed Preterm and Low Birth Weight Neonates Admitted in Selected Public Hospitals in Addis Ababa, Ethiopia: A Cross-sectional Study

Global Pediatric Health ◽

10.1177/2333794x211019695 ◽

2021 ◽

Vol 8 ◽

pp. 2333794X2110196

Author(s):

Sitotaw Molla Mekonnen ◽

Daniel Mengistu Bekele ◽

Fikrtemariam Abebe Fenta ◽

Addisu Dabi Wake

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Necrotizing Enterocolitis ◽

Gestational Age ◽

Associated Factors ◽

Addis Ababa ◽

Cross Sectional Study ◽

Public Hospitals ◽

Sectional Study ◽

Cross Sectional

Necrotizing enterocolitis (NEC) remains to be the most critical and frequent gastrointestinal disorder understood in neonatal intensive care units (NICU). The presented study was intended to assess the prevalence of NEC and associated factors among enteral Fed preterm and low birth weight neonates. Institution based retrospective cross-sectional study was conducted on 350 enteral Fed preterm and low birth weight neonates who were admitted at selected public hospitals of Addis Ababa from March 25/2020 to May 10/2020. The data were collected through neonates’ medical record chart review. A total of 350 participants were enrolled in to the study with the response rate of 99.43%. One hundred eighty-four (52.6%) of them were male. The majority 123 (35.1%) of them were (32 + 1 to 34) weeks gestational age. The prevalence of NEC was (25.4%) (n = 89, [95% CI; 21.1, 30.0]). Being ≤28 weeks gestational age (AOR = 3.94, 95% CI [2.67, 9.97]), being (28 + 1 to 32 weeks) gestational age (AOR = 3.65, 95% CI [2.21, 8.31]), birth weight of 1000 to 1499 g (AOR = 2.29, 95% CI [1.22, 4.33]), APGAR score ≤3 (AOR = 2.34, 95% CI [1.32, 4.16]), prolonged labor (AOR = 2.21, 95% CI [1.35, 6.38]), maternal chronic disease particularly hypertension (AOR = 3.2, 95% CI [1.70, 5.90]), chorioamnionitis (AOR = 4.8, 95% CI [3.9, 13]), failure to breath/resuscitated (AOR = 2.1, 95% CI [1.7, 4.4]), CPAP ventilation (AOR = 3.7, 95% CI [1.50, 12.70]), mixed milk (AOR = 3.58, 95% CI [2.16, 9.32]) were factors significantly associated with NEC. Finally, the prevalence of NEC in the study area was high. So that, initiating the programs that could minimize this problem is required to avoid the substantial morbidity and mortality associated with NEC.

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Diet Quality Is Associated with a High Newborn Size and Reduction in the Risk of Low Birth Weight and Small for Gestational Age in a Group of Mexican Pregnant Women: An Observational Study

Nutrients ◽

10.3390/nu13061853 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1853

Author(s):

María A. Reyes-López. ◽

Carla P. González-Leyva ◽

Ameyalli M. Rodríguez-Cano ◽

Carolina Rodríguez-Hernández ◽

Eloisa Colin-Ramírez ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Nutritional Status ◽

Diet Quality ◽

Gestational Age ◽

Small For Gestational Age ◽

Mexican Women ◽

High Quality ◽

Quality Diet ◽

Newborn Size

A high-quality diet during pregnancy may have positive effects on fetal growth and nutritional status at birth, and it may modify the risk of developing chronic diseases later in life. The aim of this study was to evaluate the association between diet quality and newborn nutritional status in a group of pregnant Mexican women. As part of the ongoing Mexican prospective cohort study, OBESO, we studied 226 healthy pregnant women. We adapted the Alternated Healthy Eating Index-2010 for pregnancy (AHEI-10P). The association between maternal diet and newborn nutritional status was investigated by multiple linear regression and logistic regression models. We applied three 24-h recalls during the second half of gestation. As the AHEI-10P score improved by 5 units, the birth weight and length increased (β = 74.8 ± 35.0 g and β = 0.3 ± 0.4 cm, respectively, p < 0.05). Similarly, the risk of low birth weight (LBW) and small for gestational age (SGA) decreased (OR: 0.47, 95%CI: 0.27–0.82 and OR: 0.55, 95%CI: 0.36–0.85, respectively). In women without preeclampsia and/or GDM, the risk of stunting decreased as the diet quality score increased (+5 units) (OR: 0.62, 95%IC: 0.40–0.96). A high-quality diet during pregnancy was associated with a higher newborn size and a reduced risk of LBW and SGA in this group of pregnant Mexican women.

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Pregnancy Outcome during the First COVID 19 Lockdown in Vienna, Austria

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18073782 ◽

2021 ◽

Vol 18 (7) ◽

pp. 3782

Author(s):

Sylvia Kirchengast ◽

Beda Hartmann

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Pregnancy Outcome ◽

Gestational Age ◽

Very Low Birth Weight ◽

Extremely Low Birth Weight ◽

Negative Effects ◽

Gestational Length ◽

Live Births

The COVID 19 pandemic represents a major stress factor for non-infected pregnant women. Although maternal stress during pregnancy increases the risk of preterm birth and intrauterine growth restriction, an increasing number of studies yielded no negative effects of COVID 19 lockdowns on pregnancy outcome. The present study focused on pregnancy outcome during the first COVID 19 lockdown phase in Austria. In particular, it was hypothesized that the national lockdown had no negative effects on birth weight, low birth weight rate and preterm birth rate. In a retrospective medical record-based single center study, the outcome of 669 singleton live births in Vienna Austria during the lockdown phase between March and July 2020 was compared with the pregnancy outcome of 277 live births at the same hospital during the pre-lockdown months of January and February 2020 and, in addition, with the outcome of 28,807 live births between 2005 and 2019. The rate of very low gestational age was significantly lower during the lockdown phase than during the pre-lockdown phase. The rate of low gestational age, however, was slightly higher during the lockdown phase. Mean birth weight was significantly higher during the lockdown phase; the rates of low birth weight, very low birth weight and extremely low birth weight were significantly lower during the lockdown phase. In contrast, maternal gestational weight gain was significantly higher during the lockdown phase. The stressful lockdown phase in Austria seems to have no negative affect on gestational length and newborn weight among non-infected mothers.

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