scholarly journals PERBANDINGAN LAJU NADI PADA AKHIR INTUBASI YANG MENGGUNAKAN PREMEDIKASI FENTANIL ANTARA 1μg/kgBB DENGAN 2μg/kgBB PADA ANESTESIA UMUM

e-CliniC ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Kasman Ibrahim

Abstract : Endotracheal intubation is an act that many use in general anesthesia. This intubation can cause excessive sympathetic and sympathoadrenalreflex which can increase heart rate, blood pressure, pulse, and dysrhythmia. Fentanyl is one medicine that decrease the cardiovascular response. This research aims to determine the differences on pulse rate in giving the fentanyl 1μg/kgBB with 2μg/kgBB post intubation. This was a prospective analytic study, with a sample size of 30 patients, divided into two groups, each of 15 patient. Group I received 1μg/kgBB intravenously and group II fentanyl 2μg/kgBB intravenously. Pulse rate were recorded before and 1, 2, 3, 5 minutes after intubation. The data is analyzed with T-test significance level p < 0,15. The results showed that the mean of the pulse rate before intubation in group I 86,80 beats/minute, group II 91,73 beats/minute. One minute post intubation group I 98,40 beats/minute, group II 99,80 beats/minute. Two minutes post intubation group I 95,33 beats/minute, group II 93,27 beats/minute. Three minutes post intubation group I 89,93 beats/minute, group II 89,40 beats/minute. Five minutes post intubation group I 91,13 beats/minute, group II 85,27 beats/minute. Conclusion: Premedication fentanyl 2μg/kgBB intravenously is faster to stabilize the response to cardiovascular (pulse rate) in endotracheal intubation compared to 1μg/kgBB dose intravenously.Keywords : fentanyl, endotracheal intubation, pulse rateAbstrak : Intubasi endotrakeal merupakan tindakan yang banyak dilakukan pada anestesia umum. Tindakan intubasi ini sering menimbulkan refleks simpatis dan simpatoadrenal yang berlebihan yang dapat meningkatkan laju jantung, tekanan darah, nadi, dan disritmia.Fentanil merupakan salah satu obat untuk mengurangi respon kardiovaskular.Penelitian ini bertujuan untuk mengetahui perbedaan laju nadi pada pemberian fentanil 1μg/kgBB dengan 2μg/kgBB pasca intubasi. Penelitian ini merupakan studi analitik prospektif, dengan jumlah sampel 30 pasien yang dibagi menjadi dua kelompok, masing- masing 15 pasien. Kelompok I diberikan fentanil 1μg/kgBB intravena dan kelompok II fentanil 2μg/kgBB intravena. Laju nadi dicatat sebelum dan 1, 2, 3, 5 menit setelah intubasi. Data di analisis dengan T-test derajat kemaknaan p< 0,15. Hasil penelitian memperlihatkan nilai rata-rata laju nadi sebelum intubasi pada kelompok I 86,80 kali/menit, kelompok II 91,73 kali/menit. Satu menit pasca intubasi kelompok I 98,40 kali/menit, kelompok II 99,80 kali/menit.Dua menit pasca intubasi kelompok I 95,33 kali/menit, kelompok II 93,27 kali/menit.Tiga menit pasca intubasi kelompok I, 89,93 kali/menit kelompok II 89,40 kali/menit.Lima menit pasca intubasi kelompok I 91,13 kali/menit, kelompok II 85,27 kali/menit. Simpulan: Premedikasi fentanil 2μg/kgBB intravena lebih cepat menstabilkan respon terhadap kardiovaskuler (laju nadi) pada tindakan intubasi endotrakeal dibandingkan dosis 1μg/kgBB intravena.Kata kunci : fentanil, intubasi endotrakeal, laju nadi

1970 ◽  
Vol 6 (2) ◽  
pp. 40-43 ◽  
Author(s):  
MT Mollick ◽  
MD Hossain ◽  
NP Ali

A prospective comparative study was done on lignocaine versus lignocaine with pethidine to observe the effect on cardiovascular response to laryngoscopy and endotracheal intubation. One hundred such elective surgical patients of active age group (16 - 60 years) having American Society of Anaesthesiologist (ASA) physical status I & II irrespective of surgical procedure were randomly assigned to one of the two groups of 50 each. Group I received injection lignocaine 1 mg/kg intravenously 02 minutes before induction of general anaesthesia. Patients in group II received injection pethidine 1 mg/kg body weight and injection lignocaine 1 mg/kg body weight intravenously 02 minutes before induction of general anaesthesia. Haemodynamic parameter i.e. blood pressures (systolic blood pressure, diastolic blood pressure and mean blood pressure), heart rate, rate pressure product were monitored after 1st, 3rd, 5th minutes following intubation. There were statistically significant (p<0.001) increase in blood pressures, heart rate and rate pressure product in group I i.e. pretreatment with 1 mg/kg body weight intravenous lignocaine and remained so after 5 minutes. On the other hand there were no statistically significant (p>0.05) increase in heart rate, blood pressures and rate pressure product in group II, where pretreatment done with pethidine 1 mg/kg body weight with lignocaine 1 mg/kg body weight and the values returned control level before 5 minutes. The study showed that pethidine 1 mg/kg body weight with lignocaine 1 mg/kg body weight pretreatment suppresses the cardiovascular response due to laryngoscopy and intubation. Key words: Cardiovascular response; laryngoscopy; lignocaine with pethidine. DOI: 10.3329/jafmc.v6i2.7274JAFMC Bangladesh. Vol 6, No 2 (December) 2010 pp.40-43


2014 ◽  
Vol 2 (2) ◽  
pp. 250
Author(s):  
Yanuarita Widi Astuti ◽  
Ali Mustadi

<p class="PRIMAJUDULArtikelEnglish">Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan media film animasi terhadap keterampilan menulis karangan narasi siswa kelas V SD. Jenis penelitian ini adalah <em>quasi experiment </em>dengan desain <em>pretest-posttest control group desain.</em> Hasil penilaian menunjukkan kelompok kontrol memperoleh rata-rata skor pretes 27,92 dan postes 29,51, kelompok eksperimen I memperoleh rata-rata skor pretes 27,95 dan postes 31,73, sedangkan kelompok eksperimen II memperoleh rata-rata skor pretes 27,75 dan postes 31,33. Peningkatan rata-rata skor yang diperoleh kelompok kontrol sebesar 1,59. Peningkatan rata-rata skor kelompok eksperimen I sebesar 3,78 dan peningkatan rata-rata skor kelompok eksperimen II sebesar 3,58. Hasil uji t kelompok kontrol dan kelompok eksperimen I diketahui nilai signifikansi 0,000 &lt; 0,05. Hasil uji t kelompok kontrol dan kelompok eksperimen II menunjukkan nilai signifikansi 0,000 &lt; 0,05. Hasil <em>Anova </em>menunjukkan nilai signifikansi 0,000 &lt; 0,05. Dari data tersebut dapat disimpulkan terdapat pengaruh penggunaan media film animasi terhadap keterampilan menulis karangan narasi siswa kelas V SD.</p> <p class="PRIMAABSTRAKKeywords">___________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________</p><p class="PRIMAABSTRAKKeywords"><strong>EFFECTS OF THE USE OF ANIMATION FILM MEDIA ON THE NARRATIVE TEXT WRITING SKILL OF GRADE V STUDENTS OF ESs</strong></p><p class="PRIMAABSTRAKJudulEnglish"><strong>ABSTRACT</strong></p> <p class="PRIMAABSTRAKBodyEnglish">This study is to find out the effects of the use of animation film media on the narrative text writing skill of Grade V students of elementary schools (ESs). This study was a quasi-experimental employing the pretest-posttest control group design. The results of the study show the control group attained a pretest mean score of 27.92 and a posttest mean score of 29.51; experimental group I attained a pretest mean score of 27.95 and a posttest mean score of 37.73 while experimental group II attained a pretest score of 27.75 and a posttest mean score 31.33. The mean gain score attained by the control group was 1.59. The mean gain score attained by experimental group I was 3.78, and that by experimental group II was 3.58. The results of the t-test for the control group and experimental group I showed a significance value of 0.000 &lt; 0.05. The results of the t-test for the control group and experimental group II show a significance value of 0.000 &lt; 0.05. The result of ANOVA shows a significance value of 0.000 &lt; 0.05. Based on the data, it can be concluded that there are effects of the use of animation film media on the narrative text writing skill of Grade V students of ESs.</p> <strong>Keywords: </strong>animation film media, text writing skill<br />


2015 ◽  
Vol 16 (5) ◽  
pp. 372-375 ◽  
Author(s):  
Adelson Mota de Aguiar ◽  
Arilton Mota de Aguiar ◽  
Célia Regina Maio Pinzan-Vercelino ◽  
Fausto Silva Bramante

ABSTRACT Aim This study sought to compare the fracture resistance of three trademarked orthodontic mini-implants in the transmucosal profile region. Thirty-six mini-implants of three different brands, separated into groups I, II and III, were tested. Each group consisted of 12 mini-implants of 6 mm in length. The mean diameter and length of the transmucosal profile of the mini-implants were 1.90 and 2.0 mm in group I, 1.77 and 1.0 mm in group II and 1.50 and 1.0 mm in group III, respectively. The tests were performed on a universal testing machine in compression mode, with a 2,000 kgf load, a speed of 4.0 mm per minute and a chisel-shaped active tip, which acted crosssectionally on the transmucosal profile. Single-criterion analysis of variance was used to compare the three brands. A significance level of 5% and test power of 80% were adopted. The mean fracture resistance achieved by the mini-implants was 172.03 ± 25.59 N for group I, 162.35 ± 30.81 N for group II and 139.69 ± 42.99 N for group III. There was no statistically significant difference in mean fracture resistance among the tested mini-implant brands. Conclusion The transmucosal profile diameter does not seem to be a deciding factor in the choice of mini-implants to minimize the risk of fractures. Clinical significance Although being an in vitro study it is possible to believe that this new brand has a very satisfactory resistance to fracture and enables its use with great efficiency. How to cite this article de Aguiar AM, Bramante FS, de Aguiar AM, Pinzan-Vercelino CRM. Evaluation of Fracture Resistance of Orthodontic Mini-implants in the Transmucosal Profile Region. J Contemp Dent Pract 2015;16(5):372-375.


1992 ◽  
Vol 68 (04) ◽  
pp. 404-406 ◽  
Author(s):  
Kagehiro Amano ◽  
Masaki Tateyama ◽  
Hiroshi Inaba ◽  
Katsuyuki Fukutake ◽  
Michio Fujimaki

SummaryPlasma thrombomodulin (TM) has attracted considerable attention as a marker of endothelial cell membrane injury. We examined fluctuations in plasma TM levels in patients receiving therapy for the disseminated intravascular coagulation syndrome (DIC) using an enzyme immunoassay. Sixty healthy controls and 18 patients with DIC were studied.The mean ± SD of the TM values initially measured immediately after the onset of DIC was 42.00 ± 20.85 ng/ml, which was markedly increased as compared with the control value of 15.36 ±4.85 ng/ml (p <0.001).Fluctuations in the TM levels over time were studied after dividing the patients according to the presence or absence of improvement in the underlying disease and improvement or lack thereof in the coagulation findings. Group I showed improvement in both categories, Group II showed improvement only in the latter, and Group III showed no improvement in either category.In Group I, the mean ± SD of initial measured TM levels was 37.02 ±10.12 ng/ml and the mean of final values decreased to 58.9% of the initial value. This decrease was significant by paired Student’s t-test (p <0.01). The initial value in Group II was 45.86 ± 18.86 ng/ml and the final values increased to 117.0% of the initial values, this difference was not significant. The initial value in Group III was 44.48 ±21.53 ng/ml and the final values increased to 143.4% of the former. This increase was significant by paired Student’s t-test (p <0.05). The difference in % fluctuations between Group I and Group III was significant by Wilcoxon’s test (p <0.01).These results suggest that the measurement of plasma TM can be useful in the management of DIC.


2012 ◽  
Vol 5 (1) ◽  
pp. 37-43
Author(s):  
ABMM Alam ◽  
M Moniruzzaman ◽  
MB Alam ◽  
N Islam ◽  
F Khatoon ◽  
...  

Background: CIN has gained increased attention in the clinical setting, particularly during cardiac intervention but also in many other radiological procedures in which iodinated contrast media are used. There is at present good clinical evidence from well-controlled randomized studies that CIN is a common cause of acute renal dysfunction.Methodology: This was a prospective study conducted among the patients who underwent coronary angiography and percutaneous coronary intervention in the Department of Cardiology, Dhaka Medical College Hospital during January 2010 to December 2010. A total of 111 patients age range from 25 to 75 years were included in the study. Serum creatinine level at baseline and at the end of 48 hours was done in all these patients. Study population was divided into two groups according to development of acute kidney injury (AKI). Group-I = AKI, Group II = Not developed AKI. Results: AKI developed 11.7% of the study patient. DM and Preexisting renal insufficiency were significantly higher in group I patients. HTN was (61.5% Vs 44.9%) higher in group I but not significantly. History of ACE inhibitor/ARB, NSAID intake and LVEF <40% were significantly higher in group I patients. The mean±SD volume of CM (Contrast Media) were 156.9±44.8 ml and 115.4±30.0 ml in group I and group II respectively, which was significant. The mean±SD of serum creatinine after 48-72 hours of CAG/PCI was 1.4±0.37 mg/dl and 1.1±0.2 mg/dl in group I and group II respectively. The serum creatinine level increased significantly (p<0.05) after 48-72 hours of CAG/PCI in group I. In group II, S. creatinine level increased but not significant (p>0.05). Impaired renal function was found 76.9% and 2.0% in group I and group II respectively. DM, HTN, preexisting renal insufficiency, ACE inhibitor/ARB, NSAIDs, contrast volume (>150 ml), eGFR (<60 ml/min/ 1.73m2) and LVEF (<40%) are significantly (p0.05) associated for CIN development.Conclusion: CIN is an iatrogenic but preventable disorder results from the administration of contract media. Although rare in the general population, CIN occurs frequently in patients with underlying renal dysfunction and diabetes. In patients with pre angiographic normal renal function, the prevalence is low but in pre-existing renal impairment it may pose a serious threat. Thus risk factors are synergistic in their ability to predispose to the development of CIN. A careful risk-benefit analysis must always be performed prior to the administration of contrast media to patients at risk for CIN. DOI: http://dx.doi.org/10.3329/cardio.v5i1.12227 Cardiovasc. j. 2012; 5(1): 37-43


2019 ◽  
Vol 2 (3) ◽  
pp. 137-141
Author(s):  
Padma Raj Dhungana ◽  
Rajesh Adhikari ◽  
Prem Raj Pageni ◽  
Apsara Koirala ◽  
Anand Nepal

Background: Labor is a naturally occurring physiological process associated with uterine contractions, effacement, dilatation of cervix and descent of presenting part. Drotaverine hydrochloride is a non-anticholinergic isoquinoline derivative which acts by elevating intracellular cyclic Adenosine Mono Phosphate (cAMP) and cyclic Guanosine Mono Phosphate (cGMP) promoting smooth muscle relaxation. Materials and Method: This was a hospital based prospective study on effectiveness of Drotaverine Hydrochloride on enhancing dilatation of cervix and acceleration of active phase of labor. The sample size was 100. Fifty cases of women in active phase of labor received injection drotaverine hydrochloride 40 mg (group i) and fifty cases of women did not receive any drug (group ii) among those at term with singleton pregnancy and vertex presentation. Variables like maternal age, interval between administration of drug and delivery, mode of delivery, apgar score at 5 minutes, NCU (Neonatal Care Unit) admission and neonatal outcomes were recorded. Data analysis was done with the help of SPSS program. Results: The mean interval between drug administration to delivery in primipara and multipara in group i was 3.05 hours and 2.31 hours while in group ii was 4.5 hours and 3.75 hours respectively. The mean interval between drug administration and delivery was shorter in both groups of multipara. In group i, 96% had normal delivery and 4 % had vacuum delivery and in group ii 90% and 10% had normal delivery and vacuum delivery respectively. None of the participants had caeserian section. There were no perinatal mortalities. Conclusion: The administration of drug Drotaverine Hydrochloride is effective in shortening duration of labor with favorable feto-maternal outcome.  


2010 ◽  
Vol 12 (5) ◽  
pp. 525-532 ◽  
Author(s):  
Kyeong Hwan Kim ◽  
Sang-Ho Lee ◽  
Dong Yeob Lee ◽  
Chan Shik Shim ◽  
Dae Hyeon Maeng

Object The purpose of the present study was to evaluate the efficacy of anterior polymethylmethacrylate (PMMA) cement augmentation in instrumented anterior lumbar interbody fusion (ALIF) for patients with osteoporosis. Methods Sixty-two patients with osteoporosis who had undergone single-level instrumented ALIF for spondylolisthesis and were followed for more than 2 years were included in the study. The patients were divided into 2 groups: instrumented ALIF alone (Group I) and instrumented ALIF with anterior PMMA augmentation (Group II). Sixty-one patients were interviewed to evaluate the clinical results, and plain radiographs and 3D CT scans were obtained at the last follow-up in 46 patients. Results The mean degree of cage subsidence was significantly higher in Group I (19.6%) than in Group II (5.2%) (p = 0.001). The mean decrease of vertebral body height at the index level was also significantly higher in Group I (10.7%) than in Group II (3.9%) (p = 0.001). No significant intergroup differences were observed in the incidence of radiographic adjacent-segment degeneration (ASD) or in terms of pain and functional improvement. The incidences of clinical ASD (23% in Group I and 10% in Group II) were not significantly different. There was 1 case of nonunion and 3 cases of screw migration in Group I, but none resulted in implant failure. Conclusions Anterior PMMA augmentation during instrumented ALIF in patients with osteoporosis was useful to prevent cage subsidence and vertebral body collapse. In addition, PMMA augmentation did not increase the nonunion rate and incidence of ASD.


2004 ◽  
Vol 23 (8) ◽  
pp. 413-419 ◽  
Author(s):  
Cetin Kaymak ◽  
Ela Kadioglu ◽  
Hulya Basar ◽  
Semra Sardas

In this study, genotoxic effects of repeated sevoflurane anaesthesia were investigated in rabbits with or without antioxidant supplementation. Twenty-one New Zealand male rabbits were included in the study and randomized into three groups as: placebo treated (Group I), vitamin E supplemented (Group II) and selenium supplemented (Group III). Vitamin E and selenium were given intraperitoneally for 15 days before anaesthesia treatment. Anaesthesia was administered using 3% sevoflurane in 4 L/min oxygen for a 3-hour period and continued for 3 days. Blood samples were collected before anaesthesia (Sample 1), after the first, second and third days of sevoflurane administration (Sample 2, Sample 3 and Sample 4 respectively) and the last samples were taken 5 days after the last sevoflurane administration (Sample 5). Genotoxic damage was examined using the comet assay. The degree of damage is assessed by grading the cells into three categories of no migration (NM), low migration (LM) and high migration (HM) depending on the fraction of DNA pulled out into the tail under the influence of the electric field. The number of comets in each sample was calculated (1 × number of comets in category NM + 2 × number of comets in category LM + 3 ×number of comets in category HM) and expressed as the total comet score (TCS), which summarizes the damage frequencies. In Group I, a significant increase in the mean TCSs was observed for Samples 3 and 4 as compared with Sample 1. However, there were no significant differences between Samples 1, 2 and 5. The mean TCS of Sample 4 was significantly higher than Sample 1, 2 and 3 in Group II. Group III demonstrated no significant mean TCSs for any experimental conditions. Statistical differences were also observed between the groups with significant P values. This experimental study points out the presence of DNA damage with repeated sevoflurane anaesthesia and the genoprotective role of antioxidant supplementation on DNA damage in mononuclear leukocytes of rabbits by highly sensitive comet assay.


1998 ◽  
Vol 39 (5) ◽  
pp. 538-542 ◽  
Author(s):  
R. Andresen ◽  
S. Radmer ◽  
D. Banzer

Objective: the clinical value of spinal quantitative CT (sQCT) and the structural patterns of the vertebral bone were studied Material and Methods: sQCT was performed on 246 patients with a mean age of 57 years for whom conventional lateral radiographies of the thoracic and lumbar spine were available. All patients were suffering from back pain of unknown etiology. the bone mineral density (BMD) of the midvertebral section of 3 lumbar vertebral bodies was determined by means of single-energy-(SE)-weighted QCT (85 kV). Spongiosa architecture and density profile analyses were made in the axial images. This was contrasted to BMD values ascertained in SE QCT. the mean BMD was compared to the number of fractures and the patients were divided into three groups: group I — no fracture; group II — one fracture; and group III 1 fracture Results: the mean BMD was: 134.3 (74.1–187.5) mg hydroxyapatite (HA)/ml in group I; 79.6 (58.6–114.3) mg HA/ml in group II; and 52.4 (13.1–79.1)mg HA/ml in group III. A significant deterioration in spongiosa structure was found with increasing demineralization: strongly rarefied patterns predominated in the fracture groups II and III Conclusion: sQCT provides a good risk assessment of the occurrence of vertebral body insufficiency fractures


1960 ◽  
Vol 11 (1) ◽  
pp. 75 ◽  
Author(s):  
M Wodzicka

The monthly wool growth of three groups of rams was studied at Beltsville, Maryland. Group I received natural daylight (at 38° 53' N.) and was shorn monthly. Group II had a 7:17 hours of daylight to hours of darkness rhythm and was shorn every 6 months, once in winter and once in summer. Group III received natural daylight and was likewise shorn every 6 months. The rams of all groups produced more wool in summer than in winter. This difference was significant (P<0.001). The mean body weight and food intake were both greater in the winter months, which indicated that the seasonal rhythm of wool growth was not a consequence of poorer feeding in winter. The rams which were shorn monthly (group I) grew considerably more wool than the other two groups, but the difference was not statistically significant. The short-day treatment of group II did not increase the annual wool production nor decrease the seasonal rhythm of wool growth. The balance of evidence from this and other experiments indicates that temperature rather than light controls the seasonal rhythm of wool growth.


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