ELEVATED PSEUDOCHOLINESTERASE LEVELS IN HYPERTHYROIDISM

Background : Serum Pseudocholinesterase levels are used as an indicator of exposure to various insecticide poisoning. Pseudocholinesterase is a glycoprotein enzyme, produced by liver and circulating in plasma. Pseudocholinesterase plays a role in metabolic degradation of exogenous choline ester drugs. Studies have also shown association of many pathological conditions such as liver disease, obesity, nodular goitre with Pseudocholinesterase levels. The present study was carried out to evaluate the serum Pseudocholinesterase levels in newly diagnosed hypothyroid and hyperthyroid patients. Methodology : A Case control study was done on newly diagnosed hypothyroid and hyperthyroid patients (17 hypothyroid and 17 hyperthyroid patients and 17 healthy volunteers) Results: The age group of the population under study was 20-40 years. The serum levels of TSH in normal, hypothyroid and hyperthyroid groups were 2.5±1.0 uIU/mL, 13±7.3 uIU/mL and 0.22±0.15 uIU/mL. The serum values of Pseudocholinesterase in normal, hypothyroid and hyperthyroid groups were 4038±1157U/L, 4663±1376U/L, 13781±1840U/L respectively, Serum Pseudocholinesterase levels showed signicant increase (3.4 times higher than normal) in hyperthyroid group (p<0.0001). We found a signicant negative correlation between serum Pseudocholinesterase levels and TSH levels (Spearman r coefcient = -0.5; p<0.0001) Conclusion: High Serum Pseudocholinesterase levels can be used as an indicator to screen disruption in thyroid activity.

Download Full-text

Changes in serum levels of Apo AIV in patients with newly diagnosed hyperthyroidism and hypothyroidism: a preliminary study

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2020-0044 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Mahmoud Ali Kaykhaei ◽

Avadan Ghezel ◽

Alireza Ansari-Moghaddam ◽

Mahnaz Sandoughi ◽

Vahid Sheikhi ◽

...

Keyword(s):

Case Control Study ◽

Serum Levels ◽

Control Group ◽

Newly Diagnosed ◽

Significant Difference ◽

Preliminary Study ◽

And Control ◽

First Time ◽

Hyperthyroid Patients ◽

Control Study

Abstract Objectives Apolipoprotein AIV has a role in chylomicrons and lipid secretion and catabolism. Also, Apo-AIV plays a role in the regulation of appetite and satiety. Previous studies on rats have shown that hyperthyroidism and hypothyroidism are associated with significant changes in Apo-AIV serum levels. There has been no research on serum Apo-AIV changes in hyper and hypothyroidism in humans. Methods This case-control study was performed on new patients with hyper and hypothyroidism. Eighteen patients with hyperthyroidism and 18 patients with hypothyroidism enrolled in the study. After 12 weeks treatment blood samples were recruited. If euthyroidism was achieved, serum Apo-AIV level was measured. Eighteen euthyroid healthy individuals without thyroid disease were chosen as the control group from general population. Results Serum levels of Apo-AIV before treatment in hypothyroidism, hyperthyroidism and in the control group were 85.61, 110.66 and 33.51 mg/dL respectively (p<0.001), which was significantly higher in hyperthyroid patients than hypothyroidism and control group. In patients with hyperthyroidism there was a significant decrease in serum levels of Apo-AIV after treatment (p=0.044). However in hypothyroidism a non-significant elevation in serum levels of Apo-AIV was observed (p=0.403). Furthermore, serum levels of Apo-AIV after treatment were significantly higher in both hyperthyroidism and hypothyroidism in comparison to control group (p<0.001). Conclusions The results of this study for the first time showed that the serum level of Apo-AIV is increased in patients with hyperthyroidism and is decreased in patients with hypothyroidism, and after treatment, there was a significant difference with the control group.

Download Full-text

Lower serum levels of bilirubin in the newly diagnosed lung cancer patients: A case-control study in China

Journal of Cancer Research and Therapeutics ◽

10.4103/0973-1482.168179 ◽

2015 ◽

Vol 11 (6) ◽

pp. 168

Author(s):

Wen-Hu Chen ◽

Qian Song ◽

Bing Wang ◽

Sheng Wang ◽

Yi-Min Zhang

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Newly Diagnosed ◽

Lower Serum ◽

Lung Cancer Patients ◽

Control Study

Download Full-text

Neuropathy in Newly Diagnosed Hyperthyroid Patients: A Case-Control Study

International Journal of Current Research and Review ◽

10.31782/ijcrr.2021.13409 ◽

2021 ◽

Vol 13 (04) ◽

pp. 25-28

Author(s):

Ahmad Faraz ◽

Sangeeta Singhal ◽

M. Mobarak Hossain ◽

S. S. Siddiqui

Keyword(s):

Case Control Study ◽

Case Control ◽

Newly Diagnosed ◽

Hyperthyroid Patients ◽

Control Study

Download Full-text

Anti muellerian hormone serum levels in women with endometriosis: A case-control study

Gynecological Endocrinology ◽

10.1080/09513590903159615 ◽

2009 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Omar Shebl ◽

Thomas Ebner ◽

Michael Sommergruber ◽

Andreas Sir ◽

Gernot Tews

Keyword(s):

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Control Study

Download Full-text

Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

British Journal Of Nutrition ◽

10.1017/s0007114521002956 ◽

2021 ◽

pp. 1-26

Author(s):

Xue-min Huang ◽

Yan-hua Liu ◽

Han Zhang ◽

Yuan Cao ◽

Wei-feng Dou ◽

...

Keyword(s):

Vitamin D ◽

Dietary Intake ◽

Pregnant Women ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Serum Concentrations ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

Abstract The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem mass spectrometry. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the ORs of the highest quartile were 0.45 (95%CI: 0.29-0.71, Ptrend = 0.001) for VD dietary intake and 0.26 (95%CI: 0.11-0.60, Ptrend = 0.003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0.02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0.02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.

Download Full-text

Serum otolin-1 as a biomarker for benign paroxysmal positional vertigo: a case-control study

The Journal of Laryngology & Otology ◽

10.1017/s0022215121001274 ◽

2021 ◽

pp. 1-4

Author(s):

D V K Irugu ◽

A Singh ◽

H Yadav ◽

H Verma ◽

R Kumar ◽

...

Keyword(s):

Serum Level ◽

Benign Paroxysmal Positional Vertigo ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Control Group ◽

Positional Vertigo ◽

The Difference ◽

Control Study ◽

Paroxysmal Positional Vertigo

Abstract Objectives This study aimed to evaluate serum otolin-1 levels in patients with benign paroxysmal positional vertigo and to compare these levels with healthy individuals. Method This was a case-control study. After obtaining institutional ethical committee clearance, the serum level of otolin-1 was calculated in adult individuals (18–75 years old) who were divided into group 1 (patients presenting with benign paroxysmal positional vertigo) and group 2 (healthy patients without benign paroxysmal positional vertigo as the control group). Data analysis was carried out to compare the serum levels in the cases and controls. A p-value less than 0.05 was considered significant. Results A total of 70 age-matched individuals (cases, n = 40; controls, n = 30) were included in the study. The mean serum level of otolin-1 was 636.8 pg/ml (range, 259–981 pg/ml) in the group of patients with benign paroxysmal positional vertigo and 236.2 pg/ml (range, 189–370 pg/ml) in the control group. The difference was statistically significant (p = 0.0000). Conclusion The serum levels of otolin-1 in patients with benign paroxysmal positional vertigo are significantly higher compared with individuals without benign paroxysmal positional vertigo.

Download Full-text

PS1323 HIGH SERUM LEVELS OF IL-2R, IL-6 AND TNF ARE ASSOCIATED WITH HIGHER TUMOR BURDEN AND POORER OUTCOME IN PATIENTS WITH NEWLY DIAGNOSED FOLLICULAR LYMPHOMA

HemaSphere ◽

10.1097/01.hs9.0000563572.87349.f2 ◽

2019 ◽

Vol 3 (S1) ◽

pp. 604

Author(s):

P. Mozas ◽

L. Magnano ◽

A. Rivas-Delgado ◽

A. Rivero ◽

I. Dlouhy ◽

...

Keyword(s):

Follicular Lymphoma ◽

Serum Levels ◽

Tumor Burden ◽

High Serum ◽

Newly Diagnosed

Download Full-text

The role of leukotriene modifying agent treatment in neuropsychiatric events of elderly asthma patients: a nested case control study

Asthma Research and Practice ◽

10.1186/s40733-021-00070-4 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Sang Oh Kang ◽

Kyung Hyun Min ◽

Hyun Jeong Kim ◽

Tae Hyeok Kim ◽

Woorim Kim ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Boxed Warning ◽

Control Group ◽

Case Group ◽

Newly Diagnosed ◽

Crude Odds Ratio ◽

Asthma Patients ◽

Nested Case Control ◽

Control Study

Abstract Background In March 2020, the US Food and Drug Administration decided that the dangers related to neuropsychiatric events (NPEs) of montelukast, one of the leukotriene modifying agents (LTMAs), should be communicated through ‘boxed warning’. In case of NPEs, the prevalence has been the highest in elderly people. Because the characteristics of the elderly such as old age itself can act as risk factors. Therefore, an investigation on safety of LTMAs related to NPEs in elderly using LTMAs is needed. Method A nested case-control study using an elderly sample cohort from the Korean National Health Insurance Service database was used. The asthma cohort included asthma patients newly diagnosed between 2003 and 2013. Within the asthma cohort, the case group was defined as patients who were diagnosed with NPEs. Among patients who had never been diagnosed with NPEs, the control group was selected by matching 1:1 by propensity score. Patients who were prescribed LTMAs for 1 year prior to index date were defined as the exposure group. The logistic regression model was used to measure the effect of LTMAs on NPEs. Results We identified 141,165 patients with newly diagnosed asthma, and selected 31,992 patients per each case and control group. Exposure to LTMAs significantly increased the risk of overall NPEs about in comparison with the absence of exposure (crude odds ratio [OR] 1.58, 95% CI 1.50–1.68). After adjusting for confounding factors, the overall NPEs risk increased (adjusted OR, 1.67, 95% CI 1.58–1.78). Conclusion This study suggests that elderly asthma patients prescribed LTMAs had a higher risk of NPEs than patients who were not treated with LTMAs. Therefore, clinicians should be aware of the potential risks of LTMAs.

Download Full-text